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Lista de obras de Umberto Malapelle

A Simplified Genomic Profiling Approach Predicts Outcome in Metastatic Colorectal Cancer

artículo científico publicado en 2019

ALK and ROS1 testing on lung cancer cytologic samples: Perspectives

artículo científico publicado en 2017

Analysis of differential miRNA expression in primary tumor and stroma of colorectal cancer patients.

artículo científico publicado en 2014

Antitumor Efficacy of Dual Blockade of EGFR Signaling by Osimertinib in Combination With Selumetinib or Cetuximab in Activated EGFR Human NCLC Tumor Models

scientific article published on 08 March 2018

Applications and limitations of oncogene mutation testing in clinical cytopathology

artículo científico publicado en 2013

BRAF Mutations in Lung Cancer

scientific article published on 06 March 2019

BRAF: A Two-Faced Janus

scientific article published on 27 November 2020

CBX7 is a tumor suppressor in mice and humans

artículo científico publicado en 2012

Cell free DNA analysis by SiRe® next generation sequencing panel in non small cell lung cancer patients: focus on basal setting

artículo científico publicado en 2017

Challenges and opportunities of next-generation sequencing: a cytopathologist's perspective

artículo científico

Circulating Tumour Cells in Predictive Molecular Pathology: Focus on Drug-Sensitive Assays and 3D Culture

scientific article published on 13 February 2019

Class 1, 2, and 3 BRAF-Mutated Metastatic Colorectal Cancer: A Detailed Clinical, Pathologic, and Molecular Characterization

artículo científico publicado en 2019

Comparison between two different next generation sequencing platforms for clinical relevant gene mutation test in solid tumours

artículo científico publicado en 2020

Consistency and reproducibility of next-generation sequencing and other multigene mutational assays: A worldwide ring trial study on quantitative cytological molecular reference specimens.

artículo científico publicado en 2017

Consistency and reproducibility of next-generation sequencing in cytopathology: A second worldwide ring trial study on improved cytological molecular reference specimens

scientific article published on 25 April 2019

Cyclin D1 and D3 overexpression predicts malignant behavior in thyroid fine-needle aspirates suspicious for Hurthle cell neoplasms

artículo científico publicado en 2009

Cytological and molecular features of papillary thyroid carcinoma with prominent hobnail features: a case report.

artículo científico publicado en 2012

Cytology in the time of coronavirus disease (covid-19): an Italian perspective

scientific article published on 20 April 2020

Cytology versus histology for programmed death-ligand 1 expression evaluation in the landscape of non-small cell lung cancer patients selection for immunotherapy

artículo científico publicado en 2018

Cytology‐based gene mutation tests to predict response to anti‐epidermal growth factor receptor therapy: A review ⬇️

artículo científico publicado el 9 de noviembre de 2010

Cytopathologists can reliably perform ultrasound-guided thyroid fine needle aspiration: a 1-year audit on 3715 consecutive cases.

artículo científico publicado en 2015

Cytopathology meets basic science

artículo científico publicado en 2015

Detection of epidermal growth factor receptor mutations in circulating tumor DNA: reviewing BENEFIT clinical trial

scientific article published on 01 December 2018

Development of a gene panel for next-generation sequencing of clinically relevant mutations in cell-free DNA from cancer patients.

artículo científico publicado en 2017

Different qualifiers of AUS/FLUS thyroid FNA have distinct BRAF, RAS, RET/PTC, and PAX8/PPARg alterations

artículo científico publicado en 2018

Diffuse large B-cell extranodal lymphoma of the uterine cervix: an incidental pap smear finding with histological and immunohistochemical correlation

artículo científico publicado en 2013

Digital Pathology and PD-L1 Testing in Non Small Cell Lung Cancer: A Workshop Record

artículo científico publicado en 2020

Discordance in RAS mutations between primary colon tumor and metastases: a real event or a matter of methodology?

artículo científico publicado en 2017

EGFR analysis: current evidence and future directions.

artículo científico

EGFR mutant allelic-specific imbalance assessment in routine samples of non-small cell lung cancer

artículo científico publicado en 2015

EGFR mutation detection by microfluidic technology: a validation study

artículo científico publicado en 2013

EGFR mutation detection on lung cancer cytological specimens by the novel fully automated PCR-based Idylla EGFR Mutation Assay.

artículo científico publicado en 2016

EGFR mutation detection on routine cytological smears of non-small cell lung cancer by digital PCR: a validation study

artículo científico publicado en 2016

EGFR mutations detected on cytology samples by a centralized laboratory reliably predict response to gefitinib in non–small cell lung carcinoma patients ⬇️

artículo científico publicado el 18 de junio de 2013

EGFR mutations detection on liquid-based cytology: is microscopy still necessary? ⬇️

artículo científico publicado el 1 de abril de 2012

Editorial: Second Line Treatment of Non-Small Cell Lung Cancer: Clinical, Pathological and Molecular Aspects of Novel Promising Drugs

artículo científico publicado en 2017

Efficacy of continuous EGFR-inhibition and role of Hedgehog in EGFR acquired resistance in human lung cancer cells with activating mutation of EGFR

artículo científico publicado en 2017

Epidermal growth factor receptor test performed on liquid-based cytology lung samples: experience of an academic referral center.

artículo científico publicado en 2014

Evaluation of a novel liquid biopsy-based ColoScape assay for mutational analysis of colorectal neoplasia and triage of FIT+ patients: a pilot study

artículo científico publicado en 2018

Fine-needle aspiration findings in focal (nodular) myositis of a newborn: A case report

artículo científico publicado en 2015

Foamy gland pancreatic ductal adenocarcinoma diagnosed on EUS-FNA: a histochemical, immunohistochemical, and molecular report.

artículo científico publicado en 2012

Fully automated PCR detection of KRAS mutations on pancreatic endoscopic ultrasound fine-needle aspirates.

artículo científico publicado en 2016

How to prepare cytological samples for molecular testing

artículo científico publicado en 2017

Idylla assay and next generation sequencing: an integrated EGFR mutational testing algorithm

scientific article published on 24 May 2018

Immunoglobulin heavy‐chain fluorescence in situ hybridization‐chromogenic in situ hybridization DNA probe split signal in the clonality assessment of lymphoproliferative processes on cytological samples ⬇️

artículo científico publicado el 19 de abril de 2012

Impact of Pre-Analytical Factors on MSI Test Accuracy in Mucinous Colorectal Adenocarcinoma: A Multi-Assay Concordance Study

artículo científico publicado en 2020

Intensive first-line FIr-C/FOx-C association of triplet chemotherapy plus cetuximab in RAS wild-type metastatic colorectal cancer patients: preliminary phase II data and prediction of individual limiting toxicity syndromes by pharmacogenomic biomark

artículo científico publicado en 2019

Ion Torrent next-generation sequencing for routine identification of clinically relevant mutations in colorectal cancer patients.

artículo científico publicado en 2014

Is the Idylla EGFR Mutation Assay feasible on archival stained cytological smears? A pilot study

artículo científico publicado en 2019

KRAS detection on archival cytological smears by the novel fully automated polymerase chain reaction-based Idylla mutation test.

artículo científico publicado en 2017

KRAS mutant allele-specific imbalance (MASI) assessment in routine samples of patients with metastatic colorectal cancer

artículo científico publicado en 2015

KRAS mutation analysis on cytological specimens of metastatic colo-rectal cancer

scientific article published on 01 December 2010

KRAS mutation detection by high-resolution melting analysis significantly predicts clinical benefit of cetuximab in metastatic colorectal cancer ⬇️

artículo científico publicado el 17 de julio de 2012

KRAS testing in metastatic colorectal carcinoma: challenges, controversies, breakthroughs and beyond.

artículo científico

KRAS testing on colo-rectal carcinoma cytological imprints

artículo científico publicado en 2011

KRAS, NRAS and BRAF mutations detected by next generation sequencing, and differential clinical outcome in metastatic colorectal cancer (MCRC) patients treated with first line FIr-B/FOx adding bevacizumab (BEV) to triplet chemotherapy.

artículo científico publicado en 2018

Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases

artículo científico publicado en 2016

Liquid Biopsy and Lung Cancer

artículo científico publicado en 2018

Liquid biopsy as a follow-up tool: Comment on longitudinal monitoring of somatic genetic alterations in circulating cell-free DNA during treatment with epidermal growth factor receptor-tyrosine kinase inhibitors

scientific article published on 10 September 2019

Liquid biopsy for <i>BRAF</i> mutations testing in non-small cell lung cancer: a retrospective study

artículo científico publicado en 2020

Lung adenocarcinoma and its thyroid metastasis characterized on fine-needle aspirates by cytomorphology, immunocytochemistry, and next-generation sequencing.

artículo científico publicado en 2015

Metastasis of colon cancer to the thyroid gland: a case diagnosed on fine-needle aspirate by a combined cytological, immunocytochemical, and molecular approach.

artículo científico publicado en 2010

Microfluidic chip technology applied to fine-needle aspiration cytology samples for IGH clonality assessment

artículo científico publicado en 2019

Microsatellite instability evaluation by automated microfluidic electrophoresis: an update

artículo científico publicado en 2016

Multicentric encapsulated papillary oncocytic neoplasm of the thyroid: A case diagnosed by a combined cytological, histological, immunohistochemical, and molecular approach

artículo científico publicado en 2011

Multiplex digital colour-coded barcode technology on RNA extracted from routine cytological samples of patients with non-small cell lung cancer: pilot study.

artículo científico publicado en 2017

New perspectives in the second-line treatment of non squamous NSCLC patients: Results from a large Italian Lung Cancer Working Group.

artículo científico publicado en 2016

Next Generation Sequencing and Genetic Alterations in Squamous Cell Lung Carcinoma: Where Are We Today?

artículo científico publicado en 2019

Next generation sequencing techniques in liquid biopsy: focus on non-small cell lung cancer patients

artículo científico publicado en 2016

Next-Generation Sequencing in Tumor Diagnosis and Treatment

artículo científico publicado en 2020

Next-generation sequencing in the genomic profiling of synchronous colonic carcinomas: comment on Li et al (2015).

artículo científico publicado en 2015

Next-generation sequencing of lung cancer EGFR exons 18-21 allows effective molecular diagnosis of small routine samples (cytology and biopsy).

artículo científico publicado en 2013

Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives

scientific article published on 13 June 2018

Novel Emerging Molecular Targets in Non-Small Cell Lung Cancer

scientific article published in 2021

Osimertinib

artículo científico publicado en 2018

Outsourcing cytological samples to a referral laboratory for EGFR testing in non-small cell lung cancer: does theory meet practice?

artículo científico publicado en 2014

PAX8 is expressed in anaplastic thyroid carcinoma diagnosed by fine-needle aspiration: a study of three cases with histological correlates.

artículo científico publicado en 2013

PD-L1 expression on routine samples of non-small cell lung cancer: results and critical issues from a 1-year experience of a centralised laboratory

artículo científico publicado en 2019

Patients Selection for Immunotherapy in Solid Tumors: Overcome the Naïve Vision of a Single Biomarker.

artículo científico publicado en 2019

Performance analysis of SiRe next-generation sequencing panel in diagnostic setting: focus on NSCLC routine samples

artículo científico publicado en 2018

Performance of EGFR mutant-specific antibodies in different cytological preparations: a validation study.

artículo científico publicado en 2014

Precision Prevention and Cancer Interception: The New Challenges of Liquid Biopsy

artículo científico publicado en 2020

Predictive biomarkers for molecular pathology in lung cancer

artículo científico publicado en 2020

Predictive molecular pathology in the time of COVID-19

scientific article published on 19 May 2020

Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe

artículo científico publicado en 2020

Preparation of thyroid FNA material for routine cytology and BRAF testing: a validation study

artículo científico publicado en 2010

Profile of the Roche cobas® EGFR mutation test v2 for non-small cell lung cancer.

artículo científico publicado en 2017

Prognostic Factors and Biomarkers of Responses to Immune Checkpoint Inhibitors in Lung Cancer

artículo científico publicado en 2019

RNA-Based Assay for Next-Generation Sequencing of Clinically Relevant Gene Fusions in Non-Small Cell Lung Cancer

scientific article published on 04 January 2021

Reliability and reproducibility among different platforms for tumour BRCA testing in ovarian cancer: a study of the Italian NGS Network

artículo científico publicado en 2020

Restoration of CBX7 expression increases the susceptibility of human lung carcinoma cells to irinotecan treatment.

artículo científico publicado en 2015

Role of Cytomorphology in the Era of Liquid Biopsy

scientific article published on 03 April 2019

SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer.

artículo científico publicado en 2015

Sanger sequencing in routine KRAS testing: a review of 1720 cases from a pathologist's perspective.

artículo científico publicado en 2012

Setting up and exploitation of a nano/technological platform for the evaluation of HMGA1b protein in peripheral blood of cancer patients

artículo científico publicado en 2018

Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models ⬇️

artículo científico publicado el 19 de noviembre de 2012

Targeting Immune-Related Biological Processes in Solid Tumors: We do Need Biomarkers ⬇️

scientific article published on 01 November 2019

Targeting immune checkpoints in non small cell lung cancer.

artículo científico publicado en 2018

The Cause of Death of a Child in the 18th Century Solved by Bone Microbiome Typing Using Laser Microdissection and Next Generation Sequencing

artículo científico publicado en 2017

The Reproducibility of the Immunohistochemical PD-L1 Testing in Non-Small-Cell Lung Cancer: A Multicentric Italian Experience

article

There is still a role for cytology in the 'liquid biopsy' era. A lesson from a TKI-treated patient showing adenocarcinoma to squamous cell carcinoma transition during disease progression.

artículo científico publicado en 2017

Thyroid cytology smear slides: An untapped resource for ThyroSeq testing

artículo científico publicado en 2020

USP7 inhibitors, downregulating CCDC6, sensitize lung neuroendocrine cancer cells to PARP-inhibitor drugs

artículo científico publicado en 2016

UbcH10 expression can predict prognosis and sensitivity to the antineoplastic treatment for colorectal cancer patients

artículo científico publicado en 2015

UbcH10 overexpression in human lung carcinomas and its correlation with EGFR and p53 mutational status.

artículo científico publicado en 2012

UbcH10 overexpression is less pronounced in older colorectal cancer patients

artículo científico publicado en 2016

Warthin Tumor with Signet-Ring Cell Features as a Pitfall in Salivary Gland Cytopathology ⬇️

artículo científico publicado el 25 de abril de 2013

Young investigator challenge: Can the Ion AmpliSeq Cancer Hotspot Panel v2 be used for next-generation sequencing of thyroid FNA samples?

artículo científico publicado en 2016

miR-155 is positively regulated by CBX7 in mouse embryonic fibroblasts and colon carcinomas, and targets the KRAS oncogene.

artículo científico publicado en 2017

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