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Lista de obras de Douglas Kell

'Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries

artículo científico publicado en 2008

A 'rule of 0.5' for the metabolite-likeness of approved pharmaceutical drugs

artículo científico publicado en 2014

A Bacterial Component to Alzheimer’s-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease

artículo científico publicado en 2016

A Dormant Microbial Component in the Development of Preeclampsia

artículo científico publicado en 2016

A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols

artículo científico publicado en 2008

A Quantitative Survey of Bacterial Persistence in the Presence of Antibiotics: Towards Antipersister Antimicrobial Discovery

scientific article published on 13 August 2020

A bacterial cytokine

artículo científico publicado en 1998

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

artículo científico publicado en 2019

A community-driven global reconstruction of human metabolism.

artículo científico publicado en 2013

A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology

artículo científico publicado en 2008

A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations

scientific article (publication date: 2001)

A general model of error-prone PCR

article

A method for integrating and ranking the evidence for biochemical pathways by mining reactions from text

artículo científico publicado en 2013

A minimal hypothesis for membrane-linked free-energy transduction. The role of independent, small coupling units

artículo científico publicado en 1984

A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes

scientific article published on 04 July 2013

A novel inhibitor of NADH dehydrogenase in Paracoccus denitrificans.

artículo científico publicado en 1982

A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy

artículo científico publicado en 2013

A proposed framework for the description of plant metabolomics experiments and their results

article

A systematic approach to modeling, capturing, and disseminating proteomics experimental data

artículo científico publicado en 2003

A systematic survey of the response of a model NF-κB signalling pathway to TNFα stimulation.

artículo científico publicado en 2011

A weak pulsed magnetic field affects adenine nucleotide oscillations, and related parameters in aggregating Dictyostelium discoideum amoebae.

artículo científico publicado en 1999

Absolute quantification of the glycolytic pathway in yeast: deployment of a complete QconCAT approach

artículo científico publicado en 2011

Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide

artículo científico publicado en 2016

Adam (robot scientist)

robot de Ross D. King, Stephen Muggleton, Douglas Kell y Stephen Oliver

Adoption of the transiently non-culturable state--a bacterial survival strategy?

artículo científico publicado en 2003

Alignment by numbers: sequence assembly using compressed numerical representations

An adenine nucleotide translocase in the procaryote Methanobacterium thermoautotrophicum

artículo científico publicado en 1980

An analysis of a 'community-driven' reconstruction of the human metabolic network

artículo científico publicado en 2013

An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals

artículo científico publicado en 2018

Anaesthetic function

Analysing and Navigating Natural Products Space for Generating Small, Diverse, But Representative Chemical Libraries

artículo científico publicado en 2017

Analysis of a complete DNA-protein affinity landscape

artículo científico publicado en 2009

Analysis of aptamer sequence activity relationships

artículo científico publicado en 2008

Analysis of drug-endogenous human metabolite similarities in terms of their maximum common substructures

artículo científico publicado en 2017

Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers

artículo científico publicado en 2008

Aptamer evolution for array-based diagnostics

artículo científico publicado en 2009

Arcadia: a visualization tool for metabolic pathways

artículo científico publicado en 2010

Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

artículo científico publicado en 2008

Author Correction: Hitchhiking into the cell

scientific article published on 08 April 2020

Automated manipulation of systems biology models using libSBML within Taverna workflows

artículo científico publicado en 2007

Automated tracking of gene expression in individual cells and cell compartments.

artículo científico publicado en 2006

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

artículo científico publicado en 2011

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

scientific article published in 2011

Automatic tracking of biological cells and compartments using particle filters and active contours

article published in 2006

Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris

article published in 2019

Bacterial dormancy and culturability: the role of autocrine growth factors

artículo científico publicado en 2000

Bayesian inference of the sites of perturbations in metabolic pathways via Markov chain Monte Carlo

artículo científico publicado en 2008

Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytracker™ stains.

artículo científico publicado en 2018

Breeding crop plants with deep roots: their role in sustainable carbon, nutrient and water sequestration

artículo científico publicado el 3 de agosto de 2011

Butyricin 7423 and the membrane H+-ATPase of Clostridium pasteurianum

artículo científico publicado en 1982

Calling International Rescue: knowledge lost in literature and data landslide!

artículo científico publicado en 2009

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

artículo científico publicado en 2008

Changes in the metabolic footprint of placental explant-conditioned culture medium identifies metabolic disturbances related to hypoxia and pre-eclampsia.

artículo científico publicado en 2009

Changes in the metabolic footprint of placental explant-conditioned medium cultured in different oxygen tensions from placentas of small for gestational age and normal pregnancies

artículo científico publicado en 2010

Channelling can decrease pool size

artículo científico publicado en 1992

Closed-loop, multiobjective optimization of analytical instrumentation: gas chromatography/time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations.

artículo científico publicado en 2005

Closed-loop, multiobjective optimization of two-dimensional gas chromatography/mass spectrometry for serum metabolomics

artículo científico publicado en 2007

Commentary on "Rapid identification of Streptococcus and Enterococcus species using diffuse reflectance-absorbance Fourier transform infrared spectroscopy and artificial neural networks".

artículo científico publicado en 2017

Comparative genomic assessment of novel broad-spectrum targets for antibacterial drugs

artículo científico publicado en 2004

Comprehensive Natural Products Chemistry, Volume 4: Amino Acids, Peptides, Porphyrins and Alkaloids

Computational cluster validation in post-genomic data analysis

artículo científico publicado en 2005

Computing exponentially faster: implementing a non-deterministic universal Turing machine using DNA.

artículo científico publicado en 2017

Concussion's impact

Confirmation by using mutant strains that the membrane-bound H(+)-ATPase is the major source of non-linear dielectricity in Saccharomyces cerevisiae

artículo científico publicado en 1991

Consensus rank orderings of molecular fingerprints illustrate the most genuine similarities between marketed drugs and small endogenous human metabolites [...]

artículo científico publicado en 2017

Consensus rank orderings of molecular fingerprints illustrate the most genuine similarities between marketed drugs and small endogenous human metabolites, but highlight exogenous natural products as the most important natural drug transporter substra

Continuous monitoring of the electrical potential across energy-transducing membranes using ion-selective electrodes. Application to submitochondrial particles and chromatophores

artículo científico publicado en 1978

Controlled vocabularies and semantics in systems biology

artículo científico publicado en 2011

Convergent evolution to an aptamer observed in small populations on DNA microarrays

artículo científico publicado en 2010

Correction of mass spectral drift using artificial neural networks

artículo científico publicado en 1996

Correction of the influence of baseline artefacts and electrode polarisation on dielectric spectra

artículo científico publicado en 2000

Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson's Disease, Alzheimer's Disease and Type 2 Diabetes Mellitus

artículo científico publicado en 2018

Corrigendum to "Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery" [Drug Discov. Today 19 (2014), 171-182.

artículo científico publicado en 2014

Coupling factor B and the bovine mitochondrial H+-ATP synthase

Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes

scientific article published on 21 July 2020

Culturability of Mycobacterium tuberculosis cells isolated from murine macrophages: a bacterial growth factor promotes recovery

scientific article published on 01 December 2000

DeepGraphMolGen, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach

artículo científico publicado en 2020

Defrosting the digital library: bibliographic tools for the next generation web.

artículo científico publicado en 2008

Detection and identification of novel metabolomic biomarkers in preeclampsia

artículo científico publicado en 2008

Detection of the dipicolinic acid biomarker in Bacillus spores using Curie-point pyrolysis mass spectrometry and Fourier transform infrared spectroscopy

artículo científico publicado en 2000

Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae

artículo científico publicado en 2009

Development and Performance of a Gas Chromatography−Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum

article

Development of a robust and repeatable UPLC-MS method for the long-term metabolomic study of human serum

artículo científico publicado en 2009

Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases

artículo científico publicado en 2014

Dielectric spectroscopy as a tool for the measurement of the formation of biofilms and of their removal by electrolytic cleaning pulses and biocides

article

Differentiation of Micromonospora isolates from a coastal sediment in Wales on the basis of Fourier transform infrared spectroscopy, 16S rRNA sequence analysis, and the amplified fragment length polymorphism technique

artículo científico publicado en 2004

Differentiation of Phytophthora infestans sporangia from other airborne biological particles by flow cytometry.

artículo científico publicado en 2002

Diffusion of protein complexes in prokaryotic membranes: fast, free, random or directed?

Discrimination between methicillin-resistant and methicillin-susceptible Staphylococcus aureus using pyrolysis mass spectrometry and artificial neural networks.

artículo científico publicado en 1998

Discrimination of Aerobic Endospore-forming Bacteria via Electrospray-Ionization Mass Spectrometry of Whole Cell Suspensions

scientific article published on 01 September 2001

Discrimination of modes of action of antifungal substances by use of metabolic footprinting.

artículo científico publicado en 2004

Do bacteria need to communicate with each other for growth?

artículo científico publicado en 1996

Dormant microbes: time to revive some old ideas

artículo científico publicado en 2009

Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

artículo científico publicado en 2011

Efficient improvement of silage additives by using genetic algorithms

artículo científico publicado en 2000

Energetic evolution of cellular Transportomes.

artículo científico publicado en 2018

Engineering the "Missing Link" in Biosynthetic (-)-Menthol Production: Bacterial Isopulegone Isomerase.

artículo científico publicado en 2018

Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine

artículo científico publicado en 2017

Enzyme kinetics informatics: from instrument to browser

artículo científico publicado en 2010

Erratum: The Systems Biology Graphical Notation

scholarly article published in Nature Biotechnology

Eryptosis as a marker of Parkinson's disease

artículo científico publicado en 2014

Erythrocyte, Platelet, Serum Ferritin, and P-Selectin Pathophysiology Implicated in Severe Hypercoagulation and Vascular Complications in COVID-19

scientific article published on 03 November 2020

Estimation of Microbial Viability Using Flow Cytometry

artículo científico publicado en 2004

Event extraction for systems biology by text mining the literature

artículo científico publicado en 2010

Event-based text mining for biology and functional genomics

artículo científico publicado en 2015

Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes.

artículo científico publicado en 2014

Evolutionary algorithms and synthetic biology for directed evolution: commentary on "on the mapping of genotype to phenotype in evolutionary algorithms" by Peter A. Whigham, Grant Dick, and James Maclaurin

artículo científico publicado en 2017

Explanatory Optimization of Protein Mass Spectrometry via Genetic Search

artículo científico publicado en 2003

Exploiting genomic knowledge in optimising molecular breeding programmes: algorithms from evolutionary computing

artículo científico publicado en 2012

Extracting semantically enriched events from biomedical literature

artículo científico publicado en 2012

Facilitating the development of controlled vocabularies for metabolomics technologies with text mining

artículo científico publicado en 2008

Fast automatic registration of images using the phase of a complex wavelet transform: application to proteome gels

artículo científico publicado en 2004

Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.

artículo científico publicado en 2013

Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly

artículo científico publicado en 2015

Flow-injection electrospray ionization mass spectrometry of crude cell extracts for high-throughput bacterial identification

artículo científico publicado en 2002

Fluorescent brighteners: novel stains for the flow cytometric analysis of microorganisms.

artículo científico publicado en 1997

Formulation and some biological uses of a buffer mixture whose buffering capacity is relatively independent of pH in the range pH 4–9

artículo científico publicado en 1980

From code to mode for orphan genes

article

Functional genomic hypothesis generation and experimentation by a robot scientist

artículo científico publicado en 2004

Functional genomics via metabolic footprinting: monitoring metabolite secretion by Escherichia coli tryptophan metabolism mutants using FT-IR and direct injection electrospray mass spectrometry

artículo científico publicado en 2003

Further developments towards a genome-scale metabolic model of yeast

artículo científico publicado en 2010

GeneGenie: optimized oligomer design for directed evolution

artículo científico publicado en 2014

GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries

artículo científico publicado en 2019

Genetic algorithms as a method for variable selection in multiple linear regression and partial least squares regression, with applications to pyrolysis mass spectrometry

scholarly article by David I Broadhurst et al published August 1997 in Analytica Chimica Acta

Genetic programming as an analytical tool for non-linear dielectric spectroscopy.

artículo científico publicado en 1999

Genetic programming:  a novel method for the quantitative analysis of pyrolysis mass spectral data

artículo científico publicado en 1997

Genetics and iron in the systems biology of Parkinson's disease and some related disorders

artículo científico

Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals importance of recycling in maintaining cell viability

article

Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast

artículo científico publicado en 2011

Genomic computing. Explanatory analysis of plant expression profiling data using machine learning

artículo científico publicado en 2001

Genotype-phenotype mapping: genes as computer programs

artículo científico publicado en 2002

Going places: forced and natural molecular evolution.

artículo científico publicado en 1996

Growth control of the eukaryote cell: a systems biology study in yeast

artículo científico publicado en 2007

Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era

artículo científico publicado en 2003

Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops

artículo científico publicado en 2005

High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer's disease.

artículo científico publicado en 2013

High-throughput classification of yeast mutants for functional genomics using metabolic footprinting.

artículo científico publicado en 2003

High-throughput metabolic fingerprinting of legume silage fermentations via Fourier transform infrared spectroscopy and chemometrics

artículo científico publicado en 2004

Histometrics: Improvement of the dynamic range of fluorescently stained proteins resolved in electrophoretic gels using hyperspectral imaging

artículo científico publicado en 2001

Hitchhiking into the cell

scientific article published on 01 April 2020

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion

artículo científico publicado en 2014

Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles

artículo científico publicado en 2006

Hydrodynamic deposition: A novel method of cell immobilization

artículo científico publicado en 1990

Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures.

artículo científico publicado en 2007

If you've got it, flaunt it--rapid screening for microbial biocatalysts.

artículo científico publicado en 1997

Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father

artículo científico publicado en 2017

Implications of endogenous roles of transporters for drug discovery: hitchhiking and metabolite-likeness

artículo científico publicado en 2016

Implications of the dominant role of transporters in drug uptake by cells

artículo científico publicado en 2009

Improving metabolic flux predictions using absolute gene expression data

artículo científico publicado en 2012

In silico modelling of directed evolution: Implications for experimental design and stepwise evolution

artículo científico publicado en 2008

Individuality, phenotypic differentiation, dormancy and 'persistence' in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology

artículo científico publicado en 2015

Information management for high content live cell imaging

artículo científico publicado en 2009

Information-theoretic sensitivity analysis: a general method for credit assignment in complex networks

artículo científico

Insights into the behaviour of systems biology models from dynamic sensitivity and identifiability analysis: a case study of an NF-kappaB signalling pathway

artículo científico publicado en 2006

Intelligent host engineering for metabolic flux optimisation in biotechnology

artículo científico publicado en 2021

Interactions among oscillatory pathways in NF-kappa B signaling

artículo científico publicado en 2011

Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli

artículo científico publicado en 2019

Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer's Type Dementia

scholarly article by Lesha Pretorius et al published 2018 in Frontiers in Neuroscience

Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson's Disease

artículo científico publicado en 2020

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

artículo científico publicado en 2009

Journal club. A systems biologist ponders how disparate ideas can sometimes come together beautifully

artículo científico publicado en 2009

KiPar, a tool for systematic information retrieval regarding parameters for kinetic modelling of yeast metabolic pathways

artículo científico

Lipopolysaccharide-Binding Protein (LBP) Can Reverse The Amyloid State Of Fibrin Seen Or Induced In Parkinson's Disease: Implications For Its Aetiology

scholarly article published 4 April 2017

Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease.

artículo científico publicado en 2018

Lipopolysaccharide-binding protein (LBP) reverses the amyloid state of fibrin seen in plasma of type 2 diabetics with cardiovascular co-morbidities.

artículo científico

Localized energy coupling during photophosphorylation by chromatophores ofRhodopseudomonas capsulata N22

artículo científico publicado en 1982

Macromolecular interactions: tracing the roots

scientific article published on 01 February 2001

Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability

artículo científico publicado en 2017

Making cells work — metabolic engineering for everyone

artículo científico publicado en 1997

Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3×Tg Alzheimer mouse model

artículo científico publicado en 2017

Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics

artículo científico publicado en 2009

MassGenie: A Transformer-Based Deep Learning Method for Identifying Small Molecules from Their Mass Spectra

artículo científico publicado en 2021

Matrix method for determining steps most rate-limiting to metabolic fluxes in biotechnological processes.

artículo científico publicado en 1987

MeMo: a hybrid SQL/XML approach to metabolomic data management for functional genomics

artículo científico publicado en 2006

Measurement by a flow dialysis technique of the steady-state proton-motive force in chromatophores from Rhodospirillum rubrum. Comparison with phosphorylation potential

artículo científico publicado en 1978

Mechanisms for the interaction between nonstationary electric fields and biological systems I. Linear dielectric theory and its limitations

article

Mechanisms for the interaction between nonstationary electric fields and biological systems II. Nonlinear dielectric theory and free-energy transduction

article

Membrane Transporters Involved in the Antimicrobial Activities of Pyrithione in Escherichia coli

artículo científico publicado en 2021

Membrane tension

artículo científico publicado en 1996

Membrane transporter engineering in industrial biotechnology and whole cell biocatalysis

artículo científico publicado en 2015

Mental health: Drug search on risky path

artículo científico publicado en 2014

MetMaxStruct: A Tversky-Similarity-Based Strategy for Analysing the (Sub)Structural Similarities of Drugs and Endogenous Metabolites

artículo científico publicado en 2016

Metabolic control analysis and engineering of the yeast sterol biosynthetic pathway

artículo científico publicado en 2002

Metabolic control theory: its role in microbiology and biotechnology

scholarly article by Douglas Kell published in October 1986

Metabolic footprinting and systems biology: the medium is the message

artículo científico publicado en 2005

Metabolic footprinting as a tool for discriminating between brewing yeasts

article

Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system

artículo científico publicado en 2008

Metabolic profiling uncovers a phenotypic signature of small for gestational age in early pregnancy

artículo científico publicado en 2011

Metabolic profiling using direct infusion electrospray ionisation mass spectrometry for the characterisation of olive oils

artículo científico publicado en 2002

Metabolites do social networking

artículo científico publicado el 1 de enero de 2011

Metabolomic biomarkers: search, discovery and validation

Metabolomics and machine learning: explanatory analysis of complex metabolome data using genetic programming to produce simple, robust rules

artículo científico publicado en 2002

Metabolomics and systems biology: making sense of the soup

artículo científico publicado en 2004

Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery

artículo científico publicado en 2014

Metabolomics by numbers: acquiring and understanding global metabolite data

artículo científico publicado en 2004

Metabolomics, machine learning and modelling: towards an understanding of the language of cells.

artículo científico publicado en 2005

Microbes and Alzheimer's Disease

artículo científico publicado en 2016

Mining metabolites: extracting the yeast metabolome from the literature

artículo científico publicado en 2010

Molecular phenotyping of a UK population: defining the human serum metabolome

artículo científico publicado en 2015

Monitoring of complex industrial bioprocesses for metabolite concentrations using modern spectroscopies and machine learning: application to gibberellic acid production

artículo científico publicado en 2002

Mosaic protonic coupling hypothesis for free energy transduction.

artículo científico publicado en 1984

Multiobjective optimization in bioinformatics and computational biology

artículo científico publicado en 2007

Muralytic activity of Micrococcus luteus Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitation

artículo científico publicado en 2006

New materials and technology for cell immobilization

artículo científico publicado en 1991

New materials and technology for cell immobilization

artículo científico publicado en 1992

No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases.

artículo científico publicado en 2018

Non-linear dielectric spectroscopy: antifouling and stabilisation of electrodes by a polymer coating

Non-linear optimization of biochemical pathways: applications to metabolic engineering and parameter estimation

artículo científico publicado en 1998

Non-linear systems: Coherent excitation in biology

artículo científico publicado en 1983

On harmonic generation in nonlinear biological systems

article

On proton-coupled information transfer along the surface of biological membranes and the mode of action of certain colicins

scholarly article by Douglas Kell published in May 1981

On resuscitation from the dormant state of Micrococcus luteus.

artículo científico publicado en 1998

On the Mode of Action of the Bacteriocin Butyricin 7423. Effects on Membrane Potential and Potassium-Ion Accumulation in Clostridium pasteurianum

artículo científico publicado en 1982

On the analysis of the inverse problem of metabolic pathways using artificial neural networks.

artículo científico publicado en 1996

On the dielectrically observable consequences of the diffusional motions of lipids and proteins in membranes. 1. Theory and overview.

artículo científico publicado en 1985

On the dielectrically observable consequences of the diffusional motions of lipids and proteins in membranes. 2. Experiments with microbial cells, protoplasts and membrane vesicles.

artículo científico publicado en 1985

On the effects of thiocyanate and venturicidin on respiration-driven proton translocation in Paracoccus denitrificans

artículo científico publicado en 1984

On the functional proton current pathway of electron transport phosphorylation

artículo científico publicado el 3 de julio de 1979

On the optimization of classes for the assignment of unidentified reading frames in functional genomics programmes: the need for machine learning.

artículo científico publicado en 2000

On the permeability to weak acids and bases of the cytoplasmic membrane of Clostridiumpasteurianum

scientific article published on 01 March 1981

On the physiological significance of metabolite channelling: If, how, and where, but not why

artículo científico publicado en 1991

On the role of enzyme kinetic parameters in determining the effectiveness with which channelling can decrease the size of a metabolite pool

artículo científico publicado en 1993

On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death

artículo científico publicado en 2015

Optimal construction of a fast and accurate polarisable water potential based on multipole moments trained by machine learning.

artículo científico publicado en 2009

Oscillations in NF-kappaB signaling control the dynamics of gene expression

artículo científico publicado en 2004

Oscillatory, stochastic and chaotic growth rate fluctuations in permittistatically controlled yeast cultures.

artículo científico publicado en 1996

Oxidation-reduction properties of coenzyme M (2-mercaptoethane sulphonate) at the mercury electrode

artículo científico publicado en 1979

Parkinson’s disease: a systemic inflammatory disease accompanied by bacterial inflammagens

scholarly article published 24 May 2019

PartsGenie: an integrated tool for optimising and sharing synthetic biology parts

scholarly article published 15 September 2017

PartsGenie: an integrated tool for optimizing and sharing synthetic biology parts

scholarly article by Neil Swainston published in February 2018

Path2Models: large-scale generation of computational models from biochemical pathway maps

artículo científico publicado en 2013

Performing statistical analyses on quantitative data in Taverna workflows: an example using R and maxdBrowse to identify differentially-expressed genes from microarray data

artículo científico publicado en 2008

Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only

artículo científico publicado en 2011

Pheromones, social behaviour and the functions of secondary metabolism in bacteria

artículo científico publicado en 1995

Physical Aspects of Protein Interactions

scholarly article by Douglas Kell published in November 1979

Physiological studies on the solid-state quinoa tempe fermentation, using on-line measurements of fungal biomass production

article

Plant seed classification using pyrolysis mass spectrometry with unsupervised learning: The application of auto-associative and Kohonen artificial neural networks

article

Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics

artículo científico publicado en 2015

Predicting the points of interaction of small molecules in the NF-κB pathway

artículo científico publicado en 2011

Predictive models for population performance on real biological fitness landscapes

artículo científico publicado en 2010

Prevalence of readily detected amyloid blood clots in 'unclotted' Type 2 Diabetes Mellitus and COVID-19 plasma: a preliminary report

scientific article published on 17 November 2020

Primary and secondary metabolism, and post-translational protein modifications, as portrayed by proteomic analysis of Streptomyces coelicolor

artículo científico publicado en 2002

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

article

Profound morphological changes in the erythrocytes and fibrin networks of patients with hemochromatosis or with hyperferritinemia, and their normalization by iron chelators and other agents.

artículo científico publicado en 2014

Progress being made on standards for use in data sharing

artículo científico publicado en 2008

Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting

artículo científico publicado en 2016

Proton-coupled energy transduction by biological membranes. Principles, pathways and praxis

article

Proximate parameter tuning for biochemical networks with uncertain kinetic parameters

artículo científico publicado en 2007

Publishing: Reviews turn facts into understanding

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Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription

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Pyrolysis mass spectrometry and its applications in biotechnology.

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Quantification of microbial productivity via multi-angle light scattering and supervised learning

artículo científico publicado en 1998

Quantifying heterogeneity: flow cytometry of bacterial cultures

artículo científico publicado en 1991

Quantitative Problems in Biochemistry (Sixth Edition)

scholarly article by Douglas Kell published in December 1981

Quantitative approaches to the analysis of the control and regulation of microbial metabolism

artículo científico publicado en 1991

Rapid analysis of the expression of heterologous proteins in Escherichia coli using pyrolysis mass spectrometry and Fourier transform infrared spectroscopy with chemometrics: application to alpha 2-interferon production.

artículo científico publicado en 1999

Rapid and quantitative analysis of recombinant protein expression using pyrolysis mass spectrometry and artificial neural networks: application to mammalian cytochrome b5 in Escherichia coli.

artículo científico publicado en 1994

Rapid and quantitative detection of the microbial spoilage of meat by fourier transform infrared spectroscopy and machine learning

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Rapid authentication of animal cell lines using pyrolysis mass spectrometry and auto-associative artificial neural networks

artículo científico publicado en 1996

Rapid identification of Streptococcus and Enterococcus species using diffuse reflectance-absorbance Fourier transform infrared spectroscopy and artificial neural networks.

artículo científico publicado en 1996

Rapid identification using pyrolysis mass spectrometry and artificial neural networks of Propionibacterium acnes isolated from dogs.

artículo científico publicado en 1994

Rapid screening for metabolite overproduction in fermentor broths, using pyrolysis mass spectrometry with multivariate calibration and artificial neural networks.

artículo científico publicado en 1994

Real-time monitoring of the accretion of Rhizopus oligosporus biomass during the solid-substrate tempe fermentation

artículo científico publicado en 1991

Recon 2.2: from reconstruction to model of human metabolism

artículo científico publicado en 2016

Response to 'The Need for Speed', by Matsson et al.

artículo científico publicado en 2016

Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers

artículo científico publicado en 2010

SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals

artículo científico publicado en 2016

Sample preparation in matrix-assisted laser desorption/ionization mass spectrometry of whole bacterial cells and the detection of high mass (>20 kDa) proteins

artículo científico publicado en 2002

Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis

artículo científico publicado en 2002

Scientific discovery as a combinatorial optimisation problem: how best to navigate the landscape of possible experiments?

artículo científico publicado en 2012

Screen idols: faster, smaller, cheaper and smarter

artículo científico publicado en 2000

Screensavers: trends in high-throughput analysis

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Secretion of an antibacterial factor during resuscitation of dormant cells inMicrococcus luteus cultures held in an extended stationary phase

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Selective detection of proteins in mixtures using electrospray ionization mass spectrometry: influence of instrumental settings and implications for proteomics

artículo científico publicado en 2004

Selenzyme: Enzyme selection tool for pathway design

artículo científico publicado en 2018

Selenzyme: Enzyme selection tool for pathway design

Sensitivity analysis of parameters controlling oscillatory signalling in the NF-kappaB pathway: the roles of IKK and IkappaBalpha

artículo científico publicado en 2004

Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation

artículo científico publicado en 2019

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

scientific article published on 01 April 2014

Short- and long-term dynamic responses of the metabolic network and gene expression in yeast to a transient change in the nutrient environment

artículo científico publicado en 2012

Single-nucleotide polymorphism detection using nanomolar nucleotides and single-molecule fluorescence

artículo científico publicado en 2004

Solvent selection for whole cell biotransformations in organic media.

artículo científico publicado en 1995

Something from nothing: bridging the gap between constraint-based and kinetic modelling

artículo científico publicado en 2007

SpeedyGenes: an improved gene synthesis method for the efficient production of error-corrected, synthetic protein libraries for directed evolution

artículo científico publicado en 2014

Stability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation

artículo científico publicado en 2017

Stimulation by potassium ions of the growth of Rhizopus oligosporus during liquid-and solid-substrate fermentations

artículo científico publicado en 1991

Stimulation of the multiplication of Micrococcus luteus by an autocrine growth factor

artículo científico publicado en 1999

Structural Similarities between Some Common Fluorophores Used in Biology, Marketed Drugs, Endogenous Metabolites, and Natural Products

artículo científico publicado en 2020

Substantial fibrin amyloidogenesis in type 2 diabetes assessed using amyloid-selective fluorescent stains

artículo científico publicado en 2017

Synergistic control of oscillations in the NF-kappaB signalling pathway

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Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently

artículo científico publicado en 2015

Systematic functional analysis of the yeast genome

artículo científico publicado en 1998

Systematic integration of experimental data and models in systems biology

artículo científico publicado en 2010

Systems biology, metabolic modelling and metabolomics in drug discovery and development

artículo científico publicado en 2006

Text mining and its potential applications in systems biology

artículo científico publicado en 2006

The Potential of LPS-Binding Protein to Reverse Amyloid Formation in Plasma Fibrin of Individuals With Alzheimer-Type Dementia

artículo científico publicado en 2018

The SuBliMinaL Toolbox: automating steps in the reconstruction of metabolic networks

artículo científico publicado en 2011

The apparent permeabilities of Caco-2 cells to marketed drugs: magnitude, and independence from both biophysical properties and endogenite similarities

artículo científico publicado en 2015

The biology of ergothioneine, an antioxidant nutraceutical

scientific article published on 13 February 2020

The cytochrome P450 complement (CYPome) of Streptomyces coelicolor A3(2).

artículo científico publicado en 2002

The dielectric permittivity at radio frequencies and the bruggeman probe: novel techniques for the on-line determination of biomass concentrations in plant cell cultures

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The dogs that did not bark.

artículo científico publicado en 1994

The dormant blood microbiome in chronic, inflammatory diseases

artículo científico publicado en 2015

The dynamics of electrostatic interactions between membrane proteins

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The effect of heteroscedastic noise on the chemometric modelling of frequency domain data

The estimation of microbial biomass

artículo científico publicado en 1985

The genetic control of growth rate: a systems biology study in yeast.

artículo científico publicado en 2012

The growth and nutrition ofClostridium sporogenesNCIB 8053 in defined media

scientific article published on 01 January 1987

The influence of electrode polarisation on dielectric spectra, with special reference to capacitive biomass measurements:

The inhibition by CO2 of the growth and metabolism of micro-organisms

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The markup is the model: reasoning about systems biology models in the Semantic Web era

artículo científico publicado en 2008

The metabolome 18 years on: a concept comes of age

artículo científico publicado en 2016

The passive electrical properties of biological systems: their significance in physiology, biophysics and biotechnology

artículo científico publicado en 1987

The physiology ofClostridium sporogenesNCIB 8053 growing in defined media

scientific article published on 01 January 1987

The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so.

artículo científico publicado en 2012

The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data

scientific article published on 29 November 2019

The rpf gene of Micrococcus luteus encodes an essential secreted growth factor

artículo científico publicado en 2002

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen).

artículo científico publicado en 2015

The use of dielectric permittivity for the control of the biomass level during biotransformations of toxic substrates in continuous culture.

artículo científico publicado en 1995

The use of nonlinear dielectric spectroscopy to monitor the bioelectromagnetic effects of a weak pulsed magnetic field in real time

artículo científico publicado en 2000

The virtual human: towards a global systems biology of multiscale, distributed biochemical network models

artículo científico publicado en 2007

The virtue of innovation: innovation through the lenses of biological evolution

artículo científico publicado en 2015

Theodor Bücher Lecture. Metabolomics, modelling and machine learning in systems biology - towards an understanding of the languages of cells. Delivered on 3 July 2005 at the 30th FEBS Congress and the 9th IUBMB conference in Budapest.

artículo científico publicado en 2006

To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?

artículo científico publicado en 2017

Towards a rational approach to the optimization of flux in microbial biotransformations

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

artículo científico publicado el 17 de agosto de 2010

Ultra-high throughput functional enrichment of large monoamine oxidase (MAO-N) libraries by fluorescence activated cell sorting

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Understanding the foundations of the structural similarities between marketed drugs and endogenous human metabolites

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Utopia documents: linking scholarly literature with research data

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VAE-Sim: A Novel Molecular Similarity Measure Based on a Variational Autoencoder

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Vacuum packing: a model system for laboratory-scale silage fermentations.

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Variable selection and multivariate methods for the identification of microorganisms by flow cytometry

artículo científico publicado en 1999

Variable selection in discriminant partial least-squares analysis.

artículo científico publicado en 1998

Very rapid flow cytometric assessment of antimicrobial susceptibility during the apparent lag phase of microbial (re)growth

scientific article published on 11 February 2019

Viability and activity in readily culturable bacteria: a review and discussion of the practical issues

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Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS)

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Visualising biological data: a semantic approach to tool and database integration

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What bio technologists knew all along...?

artículo científico publicado en 1996

What would be the observable consequences if phospholipid bilayer diffusion of drugs into cells is negligible?

artículo científico publicado en 2014

Why and when channelling can decrease pool size at constant net flux in a simple dynamic channel

artículo científico publicado en 1996

Yeast cells with impaired drug resistance accumulate glycerol and glucose.

artículo científico publicado en 2014

[40] Localized protonic coupling: Overview and critical evaluation of techniques

artículo científico publicado en 1986

biochem4j: Integrated and extensible biochemical knowledge through graph databases.

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maxdLoad2 and maxdBrowse: standards-compliant tools for microarray experimental annotation, data management and dissemination

artículo científico publicado en 2005