Lista de obras - Matthias Drosten - Dominio Público Uruguay

A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer

artículo científico publicado en 2017

A new therapeutic approach in medullary thyroid cancer treatment: inhibition of oncogenic RET signaling by adenoviral vector-mediated expression of a dominant-negative RET mutant.

artículo científico publicado en 2002

Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties.

artículo científico publicado en 2018

Antitumor capacity of a dominant-negative RET proto-oncogene mutant in a medullary thyroid carcinoma model.

artículo científico publicado en 2003

Clasp2 ensures mitotic fidelity and prevents differentiation of epidermal keratinocytes

artículo científico publicado en 2017

Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF

scientific article published on 08 April 2019

Discovery of targeting peptides for selective therapy of medullary thyroid carcinoma.

artículo científico publicado en 2005

ERF deletion rescues RAS deficiency in mouse embryonic stem cells.

artículo científico publicado en 2018

Gene therapeutic approaches for medullary thyroid carcinoma treatment.

artículo científico publicado en 2003

Genetic Validation of Cell Proliferation via Ras-Independent Activation of the Raf/Mek/Erk Pathway.

artículo científico publicado en 2017

Genetic analysis of Ras genes in epidermal development and tumorigenesis.

artículo científico publicado en 2013

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.

artículo científico publicado en 2010

Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets

scientific article published on 01 May 2018

H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences

artículo científico publicado en 2016

Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma

artículo científico publicado en 2017

K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and function

artículo científico publicado en 2010

Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway

artículo científico publicado en 2014

Mechanisms of Disease: cancer targeting and the impact of oncogenic RET for medullary thyroid carcinoma therapy.

artículo científico publicado en 2006

Modeling K-Ras-driven lung adenocarcinoma in mice: preclinical validation of therapeutic targets

artículo científico publicado en 2015

Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras

artículo científico publicado en 2011

Novel SRESPHP peptide mediates specific binding to primary medullary thyroid carcinoma after systemic injection

artículo científico publicado en 2005

Ras and p53: An unsuspected liaison.

artículo científico publicado en 2015

Ras in epidermal proliferation.

artículo científico publicado en 2014

Ras signaling is essential for skin development.

artículo científico publicado en 2013

Requirement for epithelial p38α in KRAS-driven lung tumor progression

artículo científico publicado en 2020

Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications

artículo científico publicado en 2013

Role of MEN2A-derived RET in maintenance and proliferation of medullary thyroid carcinoma.

artículo científico publicado en 2004

Targeting the MAPK Pathway in KRAS-Driven Tumors

artículo científico publicado en 2020

The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer

artículo científico publicado en 2018

The RET proto-oncogene: a potential target for molecular cancer therapy.

artículo científico publicado en 2004

Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas

scientific article published on 10 September 2020

Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.

artículo científico publicado en 2017

Using cells devoid of RAS proteins as tools for drug discovery

artículo científico publicado en 2009

c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling.

artículo científico publicado en 2018

Lista de obras de Matthias Drosten

A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer

A new therapeutic approach in medullary thyroid cancer treatment: inhibition of oncogenic RET signaling by adenoviral vector-mediated expression of a dominant-negative RET mutant.

Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties.

Antitumor capacity of a dominant-negative RET proto-oncogene mutant in a medullary thyroid carcinoma model.

Clasp2 ensures mitotic fidelity and prevents differentiation of epidermal keratinocytes

Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF

Discovery of targeting peptides for selective therapy of medullary thyroid carcinoma.

ERF deletion rescues RAS deficiency in mouse embryonic stem cells.

Gene therapeutic approaches for medullary thyroid carcinoma treatment.

Genetic Validation of Cell Proliferation via Ras-Independent Activation of the Raf/Mek/Erk Pathway.

Genetic analysis of Ras genes in epidermal development and tumorigenesis.

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.

Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets

H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences

Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma

K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and function

Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway

Mechanisms of Disease: cancer targeting and the impact of oncogenic RET for medullary thyroid carcinoma therapy.

Modeling K-Ras-driven lung adenocarcinoma in mice: preclinical validation of therapeutic targets

Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras

Novel SRESPHP peptide mediates specific binding to primary medullary thyroid carcinoma after systemic injection

Ras and p53: An unsuspected liaison.

Ras in epidermal proliferation.

Ras signaling is essential for skin development.

Requirement for epithelial p38α in KRAS-driven lung tumor progression

Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications

Role of MEN2A-derived RET in maintenance and proliferation of medullary thyroid carcinoma.

Targeting the MAPK Pathway in KRAS-Driven Tumors

The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer

The RET proto-oncogene: a potential target for molecular cancer therapy.

Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas

Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.

Using cells devoid of RAS proteins as tools for drug discovery

c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling.