Lista de obras - Lachlan D. Rash - Dominio Público Uruguay

A dynamic pharmacophore drives the interaction between Psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a

artículo científico publicado en 2011

ASIC3: first the heartache, now a migraine!

scientific article published on 01 September 2013

Acid-Sensing Ion Channel Pharmacology, Past, Present, and Future ….

artículo científico publicado en 2017

Acid-sensing ion channel (ASIC) structure and function: Insights from spider, snake and sea anemone venoms.

artículo científico publicado en 2017

Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3.

artículo científico publicado en 2009

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

artículo científico publicado en 2014

Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3

artículo científico publicado en 2012

D. russelii Venom Mediates Vasodilatation of Resistance Like Arteries via Activation of Kv and KCa Channels

artículo científico publicado en 2019

De novo sequencing of peptides from the parotid secretion of the cane toad, Bufo marinus (Rhinella marina).

artículo científico publicado en 2010

Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1.

artículo científico publicado en 2017

Erratum: Corrigendum: Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

article

Evidence that histamine is the principal pharmacological component of venom from an Australian wolf spider (Lycosa godeffroyi) ⬇️

artículo científico publicado el 1 de febrero de 1998

Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3.

artículo científico publicado en 2012

Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain.

artículo científico publicado en 2017

Inhibition of voltage-gated Na(+) currents in sensory neurones by the sea anemone toxin APETx2.

artículo científico publicado en 2012

Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels

artículo científico publicado en 2014

Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.

artículo científico publicado en 2015

Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

artículo científico publicado en 2014

NaV1.7 as a pain target - From gene to pharmacology.

artículo científico publicado en 2016

Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity

artículo científico publicado en 2006

Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels

scientific article published on 24 April 2019

PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a.

artículo científico publicado en 2015

Pharmacology and biochemistry of spider venoms.

artículo científico publicado en 2002

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.

artículo científico publicado en 2017

Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli.

artículo científico publicado en 2013

Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury

artículo científico publicado en 2016

Sex differences in the pharmacological activity of venom from the white-tailed spider (Lampona cylindrata).

artículo científico publicado en 2000

Spider-venom peptides as therapeutics.

artículo científico publicado en 2010

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells

artículo científico publicado en 2017

The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a

artículo científico publicado en 2006

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.

artículo científico publicado en 2017

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

artículo científico publicado en 2017

Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula

artículo científico publicado en 2015

Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores

artículo científico publicado en 2014

Venomics: a new paradigm for natural products-based drug discovery.

scientific article published on 24 February 2010

Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels.

artículo científico publicado en 2015

Lista de obras de Lachlan D. Rash

A dynamic pharmacophore drives the interaction between Psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a

ASIC3: first the heartache, now a migraine!

Acid-Sensing Ion Channel Pharmacology, Past, Present, and Future ….

Acid-sensing ion channel (ASIC) structure and function: Insights from spider, snake and sea anemone venoms.

Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3.

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3

D. russelii Venom Mediates Vasodilatation of Resistance Like Arteries via Activation of Kv and KCa Channels

De novo sequencing of peptides from the parotid secretion of the cane toad, Bufo marinus (Rhinella marina).

Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1.

Erratum: Corrigendum: Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

Evidence that histamine is the principal pharmacological component of venom from an Australian wolf spider (Lycosa godeffroyi) ⬇️

Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3.

Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain.

Inhibition of voltage-gated Na(+) currents in sensory neurones by the sea anemone toxin APETx2.

Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels

Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.

Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

NaV1.7 as a pain target - From gene to pharmacology.

Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity

Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels

PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a.

Pharmacology and biochemistry of spider venoms.

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.

Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli.

Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury

Sex differences in the pharmacological activity of venom from the white-tailed spider (Lampona cylindrata).

Spider-venom peptides as therapeutics.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells

The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula

Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores

Venomics: a new paradigm for natural products-based drug discovery.

Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels.