Lista de obras - Anna E. King - Dominio Público Uruguay

AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo.

artículo científico publicado en 2016

AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization

artículo científico publicado en 2018

ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1

scientific article published on 14 September 2015

Accurate and Unbiased Quantitation of Amyloid-β Fluorescence Images Using ImageSURF

artículo científico publicado en 2019

Age Moderates the Effects of Traumatic Brain Injury on Beta-Amyloid Plaque Load in APP/PS1 Mice

scientific article published on 06 March 2019

Age is no barrier: predictors of academic success in older learners

scientific article published on 15 November 2017

Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection.

artículo científico publicado en 2005

Alterations in neurofilaments and the transformation of the cytoskeleton in axons may provide insight into the aberrant neuronal changes of Alzheimer's disease.

artículo científico publicado en 2016

Alzheimer's Disease and NQO1: Is there a Link?

artículo científico publicado en 2017

Amyloid β accumulation and inner retinal degenerative changes in Alzheimer's disease transgenic mouse.

artículo científico publicado en 2016

Association Between Components of Cognitive Reserve and Serum BDNF in Healthy Older Adults

Axon pathology and repair

artículo científico publicado en 2016

Axonal degeneration, distal collateral branching and neuromuscular junction architecture alterations occur prior to symptom onset in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

artículo científico publicado en 2016

Axonal shearing in mature cortical neurons induces attempted regeneration and the reestablishment of neurite polarity

artículo científico publicado en 2009

Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system.

artículo científico publicado en 2009

C9ORF72 expression and cellular localization over mouse development.

artículo científico publicado en 2015

C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking

artículo científico publicado en 2014

C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking

artículo científico publicado en 2017

CRISPR/Cas-Mediated Knock-in of Genetically Encoded Fluorescent Biosensors into the AAVS1 Locus of Human-Induced Pluripotent Stem Cells

Calretinin and Neuropeptide Y interneurons are differentially altered in the motor cortex of the SOD1G93A mouse model of ALS.

artículo científico publicado en 2017

Changes in TDP-43 expression in development, aging, and in the neurofilament light protein knockout mouse.

artículo científico publicado en 2014

Chronic excitotoxin-induced axon degeneration in a compartmented neuronal culture model

artículo científico publicado en 2012

Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net

Combination treatment with leptin and pioglitazone in a mouse model of Alzheimer's disease

artículo científico publicado en 2016

Connectivity of Pathology: The Olfactory System as a Model for Network-Driven Mechanisms of Alzheimer's Disease Pathogenesis

artículo científico publicado en 2015

Cortical murine neurons lacking the neurofilament light chain protein have an attenuated response to injury in vitro.

artículo científico publicado en 2013

Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease

artículo científico publicado en 2008

Cytoskeletal changes during development and aging in the cortex of neurofilament light protein knockout mice

artículo científico publicado en 2013

Defining the earliest pathological changes of Alzheimer's disease

artículo científico publicado en 2016

Degeneration of axons in spinal white matter in G93A mSOD1 mouse characterized by NFL and α-internexin immunoreactivity

artículo científico publicado en 2012

Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments.

artículo científico publicado en 2014

Disruption of leptin signalling in a mouse model of Alzheimer's disease.

artículo científico publicado en 2018

Effects of TDP-43 overexpression on neuron proteome and morphology in vitro

Enhanced Anti-Amyloid Effect of Combined Leptin and Pioglitazone in APP/PS1 Transgenic Mice

Enhanced anti-amyloid effect of combined leptin and pioglitazone in APP/PS1 transgenic mice

Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer's model.

artículo científico publicado en 2017

Erratum: C9ORF72 expression and cellular localization over mouse development

artículo científico publicado en 2016

Excitotoxicity and Axon Degeneration

Excitotoxicity in ALS: Overstimulation, or overreaction?

artículo científico publicado en 2015

Excitotoxicity mediated by non-NMDA receptors causes distal axonopathy in long-term cultured spinal motor neurons.

artículo científico publicado en 2007

Excitotoxin-induced caspase-3 activation and microtubule disintegration in axons is inhibited by taxol.

artículo científico publicado en 2013

Focal damage to the adult rat neocortex induces wound healing accompanied by axonal sprouting and dendritic structural plasticity

artículo científico publicado en 2010

Glutamate induces rapid loss of axonal neurofilament proteins from cortical neurons in vitro

artículo científico publicado en 2005

Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis - vulnerability of lower motor neurons to proximal excitotoxicity

artículo científico publicado en 2015

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

scientific article published on 13 April 2020

Image-Based Quantitation of Kainic Acid-Induced Excitotoxicity as a Model of Neurodegeneration in Human iPSC-Derived Neurons

ImageSURF: An ImageJ Plugin for Batch Pixel-Based Image Segmentation Using Random Forests

artículo científico publicado en 2017

Iron is increased in the brains of ageing mice lacking the neurofilament light gene

artículo científico publicado en 2019

Island Study Linking Aging and Neurodegenerative Disease (ISLAND) Targeting Dementia Risk Reduction: Protocol for a Prospective Web-Based Cohort Study

Island Study Linking Aging and Neurodegenerative Disease (ISLAND) Targeting Dementia Risk Reduction: Protocol for a Prospective Web-Based Cohort Study (Preprint)

Late-life environmental enrichment preserves short-term memory and may attenuate microglia in male APP/PS1 mice

scientific article published on 16 April 2019

Localization of glutamate receptors in developing cortical neurons in culture and relationship to susceptibility to excitotoxicity.

artículo científico publicado en 2006

Lysosomal alterations and decreased electrophysiological activity in CLN3 disease patient-derived cortical neurons

Methods for In Vivo CRISPR/Cas Editing of the Adult Murine Retina.

artículo científico publicado en 2018

Microfluidic Device for Studying Traumatic Brain Injury

Microfluidic culture platform for studying neuronal response to mild to very mild axonal stretch injury.

artículo científico publicado en 2014

Microfluidic primary culture model of the lower motor neuron-neuromuscular junction circuit

artículo científico publicado en 2013

Microglia Demonstrate Local Mixed Inflammation and a Defined Morphological Shift in an APP/PS1 Mouse Model

artículo científico publicado en 2020

Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase

artículo científico publicado en 2014

Microtubule-dependent processes precede pathological calcium influx in excitotoxin-induced axon degeneration

scientific article published on 05 December 2019

Mid-life environmental enrichment increases synaptic density in CA1 in a mouse model of Aβ-associated pathology and positively influences synaptic and cognitive health in healthy ageing.

artículo científico publicado en 2016

Mild and repetitive very mild axonal stretch injury triggers cystoskeletal mislocalization and growth cone collapse

artículo científico publicado en 2017

Neurofilament light gene deletion exacerbates amyloid, dystrophic neurite, and synaptic pathology in the APP/PS1 transgenic model of Alzheimer's disease.

artículo científico publicado en 2015

Neuroprotective upregulation of endogenous α-synuclein precedes ubiquitination in cultured dopaminergic neurons.

artículo científico publicado en 2010

Pathological Links between Traumatic Brain Injury and Dementia: Australian Pre-Clinical Research

scientific article published on 01 March 2020

Peripheral treatment with enoxaparin exacerbates amyloid plaque pathology in Tg2576 mice.

artículo científico publicado en 2016

Poor oral hygiene, oral microorganisms and aspiration pneumonia risk in older people in residential aged care: a systematic review

artículo científico publicado en 2020

Rab1-dependent ER-Golgi transport dysfunction is a common pathogenic mechanism in SOD1, TDP-43 and FUS-associated ALS.

artículo científico publicado en 2015

Regional differences in beta amyloid plaque deposition and variable response to midlife environmental enrichment in the cortex of APP/PS1 mice

artículo científico publicado en 2020

Retinal ganglion cell axons regenerate in the presence of intact sensory fibres.

artículo científico publicado en 2006

Rod microglia and their role in neurological diseases

artículo científico publicado en 2019

Sex-Specific Protective Effects of Cognitive Reserve on Age-Related Cognitive Decline

Stainless steel pinholes for fast fabrication of high-performance microchip electrophoresis devices by CO2 laser ablation

artículo científico publicado en 2013

TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy

scientific article published on 06 January 2021

The HDAC6 Inhibitor Trichostatin A Acetylates Microtubules and Protects Axons From Excitotoxin-Induced Degeneration in a Compartmented Culture Model

article

The Influence of Genetic Factors and Cognitive Reserve on Structural and Functional Resting-State Brain Networks in Aging and Alzheimer's Disease

artículo científico publicado en 2019

The TAS Test project: a prospective longitudinal validation of new online motor-cognitive tests to detect preclinical Alzheimer’s disease and estimate 5-year risks of cognitive decline and dementia

The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease.

artículo científico publicado en 2015

The impact of metallothionein-II on microglial response to tumor necrosis factor-alpha (TNFα) and downstream effects on neuronal regeneration.

artículo científico publicado en 2018

The potential roles of genetic factors in predicting ageing-related cognitive change and Alzheimer’s disease

Utility of Self-Destructing CRISPR/Cas Constructs for Targeted Gene Editing in the Retina

artículo científico publicado en 2019

α-Synuclein protects neurons from apoptosis downstream of free-radical production through modulation of the MAPK signalling pathway.

artículo científico publicado en 2012

Lista de obras de Anna E. King

AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo.

AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization

ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1

Accurate and Unbiased Quantitation of Amyloid-β Fluorescence Images Using ImageSURF

Age Moderates the Effects of Traumatic Brain Injury on Beta-Amyloid Plaque Load in APP/PS1 Mice

Age is no barrier: predictors of academic success in older learners

Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection.

Alterations in neurofilaments and the transformation of the cytoskeleton in axons may provide insight into the aberrant neuronal changes of Alzheimer's disease.

Alzheimer's Disease and NQO1: Is there a Link?

Amyloid β accumulation and inner retinal degenerative changes in Alzheimer's disease transgenic mouse.

Association Between Components of Cognitive Reserve and Serum BDNF in Healthy Older Adults

Axon pathology and repair

Axonal degeneration, distal collateral branching and neuromuscular junction architecture alterations occur prior to symptom onset in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Axonal shearing in mature cortical neurons induces attempted regeneration and the reestablishment of neurite polarity

Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system.

C9ORF72 expression and cellular localization over mouse development.

C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking

C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking

CRISPR/Cas-Mediated Knock-in of Genetically Encoded Fluorescent Biosensors into the AAVS1 Locus of Human-Induced Pluripotent Stem Cells

Calretinin and Neuropeptide Y interneurons are differentially altered in the motor cortex of the SOD1G93A mouse model of ALS.

Changes in TDP-43 expression in development, aging, and in the neurofilament light protein knockout mouse.

Chronic excitotoxin-induced axon degeneration in a compartmented neuronal culture model

Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net

Combination treatment with leptin and pioglitazone in a mouse model of Alzheimer's disease

Connectivity of Pathology: The Olfactory System as a Model for Network-Driven Mechanisms of Alzheimer's Disease Pathogenesis

Cortical murine neurons lacking the neurofilament light chain protein have an attenuated response to injury in vitro.

Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease

Cytoskeletal changes during development and aging in the cortex of neurofilament light protein knockout mice

Defining the earliest pathological changes of Alzheimer's disease

Degeneration of axons in spinal white matter in G93A mSOD1 mouse characterized by NFL and α-internexin immunoreactivity

Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments.

Disruption of leptin signalling in a mouse model of Alzheimer's disease.

Effects of TDP-43 overexpression on neuron proteome and morphology in vitro

Enhanced Anti-Amyloid Effect of Combined Leptin and Pioglitazone in APP/PS1 Transgenic Mice

Enhanced anti-amyloid effect of combined leptin and pioglitazone in APP/PS1 transgenic mice

Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer's model.

Erratum: C9ORF72 expression and cellular localization over mouse development

Excitotoxicity and Axon Degeneration

Excitotoxicity in ALS: Overstimulation, or overreaction?

Excitotoxicity mediated by non-NMDA receptors causes distal axonopathy in long-term cultured spinal motor neurons.

Excitotoxin-induced caspase-3 activation and microtubule disintegration in axons is inhibited by taxol.

Focal damage to the adult rat neocortex induces wound healing accompanied by axonal sprouting and dendritic structural plasticity

Glutamate induces rapid loss of axonal neurofilament proteins from cortical neurons in vitro

Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis - vulnerability of lower motor neurons to proximal excitotoxicity

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

Image-Based Quantitation of Kainic Acid-Induced Excitotoxicity as a Model of Neurodegeneration in Human iPSC-Derived Neurons

ImageSURF: An ImageJ Plugin for Batch Pixel-Based Image Segmentation Using Random Forests

Iron is increased in the brains of ageing mice lacking the neurofilament light gene

Island Study Linking Aging and Neurodegenerative Disease (ISLAND) Targeting Dementia Risk Reduction: Protocol for a Prospective Web-Based Cohort Study

Island Study Linking Aging and Neurodegenerative Disease (ISLAND) Targeting Dementia Risk Reduction: Protocol for a Prospective Web-Based Cohort Study (Preprint)

Late-life environmental enrichment preserves short-term memory and may attenuate microglia in male APP/PS1 mice

Localization of glutamate receptors in developing cortical neurons in culture and relationship to susceptibility to excitotoxicity.

Lysosomal alterations and decreased electrophysiological activity in CLN3 disease patient-derived cortical neurons

Methods for In Vivo CRISPR/Cas Editing of the Adult Murine Retina.

Microfluidic Device for Studying Traumatic Brain Injury

Microfluidic culture platform for studying neuronal response to mild to very mild axonal stretch injury.

Microfluidic primary culture model of the lower motor neuron-neuromuscular junction circuit

Microglia Demonstrate Local Mixed Inflammation and a Defined Morphological Shift in an APP/PS1 Mouse Model

Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase

Microtubule-dependent processes precede pathological calcium influx in excitotoxin-induced axon degeneration

Mid-life environmental enrichment increases synaptic density in CA1 in a mouse model of Aβ-associated pathology and positively influences synaptic and cognitive health in healthy ageing.

Mild and repetitive very mild axonal stretch injury triggers cystoskeletal mislocalization and growth cone collapse

Neurofilament light gene deletion exacerbates amyloid, dystrophic neurite, and synaptic pathology in the APP/PS1 transgenic model of Alzheimer's disease.

Neuroprotective upregulation of endogenous α-synuclein precedes ubiquitination in cultured dopaminergic neurons.

Pathological Links between Traumatic Brain Injury and Dementia: Australian Pre-Clinical Research

Peripheral treatment with enoxaparin exacerbates amyloid plaque pathology in Tg2576 mice.

Poor oral hygiene, oral microorganisms and aspiration pneumonia risk in older people in residential aged care: a systematic review

Rab1-dependent ER-Golgi transport dysfunction is a common pathogenic mechanism in SOD1, TDP-43 and FUS-associated ALS.

Regional differences in beta amyloid plaque deposition and variable response to midlife environmental enrichment in the cortex of APP/PS1 mice

Retinal ganglion cell axons regenerate in the presence of intact sensory fibres.

Rod microglia and their role in neurological diseases

Sex-Specific Protective Effects of Cognitive Reserve on Age-Related Cognitive Decline

Stainless steel pinholes for fast fabrication of high-performance microchip electrophoresis devices by CO2 laser ablation

TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy

The HDAC6 Inhibitor Trichostatin A Acetylates Microtubules and Protects Axons From Excitotoxin-Induced Degeneration in a Compartmented Culture Model

The Influence of Genetic Factors and Cognitive Reserve on Structural and Functional Resting-State Brain Networks in Aging and Alzheimer's Disease

The TAS Test project: a prospective longitudinal validation of new online motor-cognitive tests to detect preclinical Alzheimer’s disease and estimate 5-year risks of cognitive decline and dementia

The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease.

The impact of metallothionein-II on microglial response to tumor necrosis factor-alpha (TNFα) and downstream effects on neuronal regeneration.