Lista de obras - Zhude Tu - Dominio Público Uruguay

2-(2-Piperidyl)- and 2-(2-pyrrolidyl)chromans as nicotine agonists: synthesis and preliminary pharmacological characterization.

artículo científico publicado en 2001

4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies

artículo científico publicado en 2016

A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression.

artículo científico publicado en 2015

A practical process for the preparation of [(32)P]S1P and binding assay for S1P receptor ligands

artículo científico publicado en 2015

A promising carbon-11-labeled sphingosine-1-phosphate receptor 1-specific PET tracer for imaging vascular injury.

artículo científico publicado en 2016

Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small Molecules

scientific article published on 16 May 2018

Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM).

artículo científico publicado en 2014

Binding of the radioligand SIL23 to α-synuclein fibrils in Parkinson disease brain tissue establishes feasibility and screening approaches for developing a Parkinson disease imaging agent

artículo científico publicado en 2013

C-11 radiochemistry in cancer imaging applications.

artículo científico publicado en 2010

Carbon-11 labeled papaverine as a PET tracer for imaging PDE10A: radiosynthesis, in vitro and in vivo evaluation.

artículo científico publicado en 2010

Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide.

artículo científico publicado en 2011

Chiral resolution of serial potent and selective σ1 ligands and biological evaluation of (-)-[18F]TZ3108 in rodent and the nonhuman primate brain

artículo científico publicado en 2017

Chromaproline and Chromaperidine, nicotine agonists, and Donepezil, cholinesterase inhibitor, enhance performance of memory tasks in ovariectomized rats.

artículo científico publicado en 2002

Comparison of [(11)C]TZ1964B and [(18)F]MNI659 for PET imaging brain PDE10A in nonhuman primates

artículo científico publicado en 2016

Design and synthesis of pyrazolopyridine derivatives as sphingosine 1-phosphate receptor 2 ligands.

artículo científico publicado en 2017

Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils.

artículo científico publicado en 2015

Design, Synthesis, and In Vitro and In Vivo Evaluation of an (18)F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P1) PET Tracer.

artículo científico publicado en 2016

Endogenous dopamine (DA) competes with the binding of a radiolabeled D₃ receptor partial agonist in vivo: a positron emission tomography study

artículo científico publicado en 2011

Exploration of Sulfur-Containing Analogues for Imaging Vesicular Acetylcholine Transporter in the Brain

artículo científico publicado en 2018

Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomography.

artículo científico publicado en 2007

Functional assays to define agonists and antagonists of the sigma-2 receptor.

artículo científico publicado en 2013

Glycan array analysis of the antigen repertoire targeted by tumor-binding antibodies

artículo científico publicado en 2012

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site.

artículo científico publicado en 2011

In vitro and ex vivo characterization of (-)-TZ659 as a ligand for imaging the vesicular acetylcholine transporter

artículo científico publicado en 2015

In vitro and in vivo characterization of two C-11-labeled pet tracers for vesicular acetylcholine transporter.

artículo científico publicado en 2014

Kinetics modeling and occupancy studies of a novel C-11 PET tracer for VAChT in nonhuman primates

artículo científico publicado en 2015

N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.

artículo científico publicado en 2005

Neuroprotective effects of high affinity Σ1 receptor selective compounds.

artículo científico publicado en 2011

PET Imaging Study of S1PR1 Expression in a Rat Model of Multiple Sclerosis

artículo científico publicado en 2016

PET Study of Sphingosine-1-Phosphate Receptor 1 Expression in Response to Vascular Inflammation in a Rat Model of Carotid Injury.

artículo científico publicado en 2017

Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response

artículo científico publicado en 2017

Preclinical evaluation of a promising C-11 labeled PET tracer for imaging phosphodiesterase 10A in the brain of living subject

artículo científico publicado en 2015

Preclinical evaluation of the novel monoclonal antibody H6-11 for prostate cancer imaging.

artículo científico publicado en 2013

Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate

artículo científico publicado en 2014

Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain

artículo científico publicado en 2011

Sigma-2 ligands induce tumour cell death by multiple signalling pathways.

artículo científico publicado en 2012

Syntheses and radiosyntheses of two carbon-11 labeled potent and selective radioligands for imaging vesicular acetylcholine transporter

artículo científico publicado en 2014

Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter

artículo científico publicado en 2015

Synthesis and biological characterization of stable and radioiodinated (+/-)-trans-2-hydroxy-3-P[4-(3-iodophenyl)piperidyl]-1,2,3,4-tetrahydronaphthalene (3'-IBVM).

artículo científico publicado en 2000

Synthesis and characterization of selective dopamine D2 receptor antagonists.

artículo científico publicado en 2005

Synthesis and evaluation of 15-(4-(2-[¹⁸F]Fluoroethoxy)phenyl)pentadecanoic acid: a potential PET tracer for studying myocardial fatty acid metabolism.

artículo científico publicado en 2010

Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups.

artículo científico publicado en 2012

Synthesis and in vitro and in vivo evaluation of 18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter

artículo científico publicado en 2009

Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands.

artículo científico publicado en 2005

Synthesis and in vitro biological evaluation of carbonyl group-containing analogues for σ1 receptors.

artículo científico publicado en 2011

Synthesis and in vitro biological evaluation of pyrazole group-containing analogues for PDE10A.

artículo científico publicado en 2013

Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease

artículo científico publicado en 2017

Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors.

artículo científico publicado en 2014

Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A.

artículo científico publicado en 2011

Synthesis and in vitro evaluation of α-synuclein ligands.

artículo científico publicado en 2012

Synthesis and in vitro pharmacological evaluation of indolyl carboxylic amide analogues as D3 dopamine receptor selective ligands

artículo científico publicado en 2013

Synthesis and pharmacological evaluation of fluorine-containing D₃ dopamine receptor ligands.

artículo científico publicado en 2011

Synthesis and structure-activity relationship studies of conformationally flexible tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands.

artículo científico publicado en 2014

Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.

artículo científico publicado en 2012

Synthesis, resolution, and in vitro evaluation of three vesicular acetylcholine transporter ligands and evaluation of the lead fluorine-18 radioligand in a nonhuman primate

artículo científico publicado en 2017

The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine. ⬇️

artículo científico publicado en 2010

Upregulated Sphingosine 1-Phosphate Receptor 1 Expression in Human and Murine Atherosclerotic Plaques.

artículo científico publicado en 2017

Lista de obras de Zhude Tu

2-(2-Piperidyl)- and 2-(2-pyrrolidyl)chromans as nicotine agonists: synthesis and preliminary pharmacological characterization.

4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies

A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression.

A practical process for the preparation of [(32)P]S1P and binding assay for S1P receptor ligands

A promising carbon-11-labeled sphingosine-1-phosphate receptor 1-specific PET tracer for imaging vascular injury.

Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small Molecules

Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM).

Binding of the radioligand SIL23 to α-synuclein fibrils in Parkinson disease brain tissue establishes feasibility and screening approaches for developing a Parkinson disease imaging agent

C-11 radiochemistry in cancer imaging applications.

Carbon-11 labeled papaverine as a PET tracer for imaging PDE10A: radiosynthesis, in vitro and in vivo evaluation.

Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide.

Chiral resolution of serial potent and selective σ1 ligands and biological evaluation of (-)-[18F]TZ3108 in rodent and the nonhuman primate brain

Chromaproline and Chromaperidine, nicotine agonists, and Donepezil, cholinesterase inhibitor, enhance performance of memory tasks in ovariectomized rats.

Comparison of [(11)C]TZ1964B and [(18)F]MNI659 for PET imaging brain PDE10A in nonhuman primates

Design and synthesis of pyrazolopyridine derivatives as sphingosine 1-phosphate receptor 2 ligands.

Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils.

Design, Synthesis, and In Vitro and In Vivo Evaluation of an (18)F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P1) PET Tracer.

Endogenous dopamine (DA) competes with the binding of a radiolabeled D₃ receptor partial agonist in vivo: a positron emission tomography study

Exploration of Sulfur-Containing Analogues for Imaging Vesicular Acetylcholine Transporter in the Brain

Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomography.

Functional assays to define agonists and antagonists of the sigma-2 receptor.

Glycan array analysis of the antigen repertoire targeted by tumor-binding antibodies

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site.

In vitro and ex vivo characterization of (-)-TZ659 as a ligand for imaging the vesicular acetylcholine transporter

In vitro and in vivo characterization of two C-11-labeled pet tracers for vesicular acetylcholine transporter.

Kinetics modeling and occupancy studies of a novel C-11 PET tracer for VAChT in nonhuman primates

N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.

Neuroprotective effects of high affinity Σ1 receptor selective compounds.

PET Imaging Study of S1PR1 Expression in a Rat Model of Multiple Sclerosis

PET Study of Sphingosine-1-Phosphate Receptor 1 Expression in Response to Vascular Inflammation in a Rat Model of Carotid Injury.

Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response

Preclinical evaluation of a promising C-11 labeled PET tracer for imaging phosphodiesterase 10A in the brain of living subject

Preclinical evaluation of the novel monoclonal antibody H6-11 for prostate cancer imaging.

Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate

Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain

Sigma-2 ligands induce tumour cell death by multiple signalling pathways.

Syntheses and radiosyntheses of two carbon-11 labeled potent and selective radioligands for imaging vesicular acetylcholine transporter

Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter

Synthesis and biological characterization of stable and radioiodinated (+/-)-trans-2-hydroxy-3-P[4-(3-iodophenyl)piperidyl]-1,2,3,4-tetrahydronaphthalene (3'-IBVM).

Synthesis and characterization of selective dopamine D2 receptor antagonists.

Synthesis and evaluation of 15-(4-(2-[¹⁸F]Fluoroethoxy)phenyl)pentadecanoic acid: a potential PET tracer for studying myocardial fatty acid metabolism.

Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups.

Synthesis and in vitro and in vivo evaluation of 18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter

Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands.

Synthesis and in vitro biological evaluation of carbonyl group-containing analogues for σ1 receptors.

Synthesis and in vitro biological evaluation of pyrazole group-containing analogues for PDE10A.

Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease

Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors.

Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A.

Synthesis and in vitro evaluation of α-synuclein ligands.

Synthesis and in vitro pharmacological evaluation of indolyl carboxylic amide analogues as D3 dopamine receptor selective ligands

Synthesis and pharmacological evaluation of fluorine-containing D₃ dopamine receptor ligands.

Synthesis and structure-activity relationship studies of conformationally flexible tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands.

Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.

Synthesis, resolution, and in vitro evaluation of three vesicular acetylcholine transporter ligands and evaluation of the lead fluorine-18 radioligand in a nonhuman primate

The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine. ⬇️

Upregulated Sphingosine 1-Phosphate Receptor 1 Expression in Human and Murine Atherosclerotic Plaques.