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Lista de obras de Gutkind JS

1 Alpha,25-dihydroxyvitamin D3 and its TX527 analog inhibit the growth of endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein-coupled receptor in vitro and in vivo.

artículo científico publicado en 2009

4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer

scientific article published on 20 March 2019

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

article

A common requirement for the catalytic activity and both SH2 domains of SHP-2 in mitogen-activated protein (MAP) kinase activation by the ErbB family of receptors. A specific role for SHP-2 in map, but not c-Jun amino-terminal kinase activation

artículo científico publicado en 1998

A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.

artículo científico publicado en 2012

A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha

artículo científico publicado en 1997

A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells

artículo científico publicado en 1993

A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5.

artículo científico publicado en 1999

A new G(q)-initiated MAPK signaling pathway in the heart.

artículo científico publicado en 2009

A new twist for the tumour suppressor hamartin

artículo científico publicado en 2000

A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans

artículo científico publicado en 2006

A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes ⬇️

artículo científico publicado el 1 de marzo de 1991

A novel functional splice variant of AKT3 defined by analysis of alternative splice expression in HPV-positive oropharyngeal cancers

artículo científico publicado en 2017

A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity

A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer

artículo científico publicado en 2008

A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation.

artículo científico publicado en 2010

A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability.

artículo científico publicado en 2009

A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis

artículo científico publicado en 2013

A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells

artículo científico publicado en 2011

A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers

artículo científico publicado en 2016

A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes.

artículo científico publicado en 2014

Accelerated wound healing by mTOR activation in genetically defined mouse models.

artículo científico publicado en 2010

Accumulation of dephosphorylated 4EBP after mTOR inhibition with rapamycin is sufficient to disrupt paracrine transformation by the KSHV vGPCR oncogene.

artículo científico publicado en 2013

Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling ⬇️

artículo científico publicado el 6 de diciembre de 2011

Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells ⬇️

artículo científico publicado el 1 de diciembre de 1991

Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma.

artículo científico publicado en 1998

Activation of GPCR-Gαi signaling increases keratinocyte proliferation and reduces differentiation, leading to epidermal hyperplasia

scientific article published on 07 November 2019

Activation of Ras and Rho GTPases and MAP Kinases by G-protein-coupled receptors.

artículo científico publicado en 2010

Activation of adenylyl cyclases, regulation of insulin status, and cell survival by G(alpha)olf in pancreatic beta-cells.

artículo científico publicado en 2002

Activation of the mTOR pathway in primary medullary thyroid carcinoma and lymph node metastases.

artículo científico publicado en 2012

Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer.

artículo científico publicado en 2016

Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex

artículo científico publicado en 1999

Activation of transforming G protein-coupled receptors induces rapid tyrosine phosphorylation of cellular proteins, including p125FAK and the p130 v-src substrate

artículo científico publicado el 15 de octubre de 1992

Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.

artículo científico publicado en 2013

An NF-kappaB gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia.

artículo científico publicado en 2007

An essential role for Rac1 in endothelial cell function and vascular development.

artículo científico publicado en 2008

An interplay between the p38 MAPK pathway and AUBPs regulates c-fos mRNA stability during mitogenic stimulation

artículo científico publicado en 2015

Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.

artículo científico publicado en 2008

Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling

artículo científico publicado en 2020

Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1).

artículo científico publicado en 2002

Arrestins as rheostats of GPCR signalling

artículo científico publicado en 2018

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

artículo científico publicado en 2018

Assembly and patterning of the vascular network of the vertebrate hindbrain

artículo científico publicado en 2011

Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment

artículo científico publicado en 2007

Augmented Wnt signaling in a mammalian model of accelerated aging

scientific journal article

Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12.

artículo científico publicado en 2005

Beyond Synthetic Lethality: Charting the Landscape of Pairwise Gene Expression States Associated with Survival in Cancer

artículo científico publicado en 2019

Binding-induced folding of a natively unstructured transcription factor.

artículo científico publicado en 2008

Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling.

artículo científico publicado en 1994

Biology of advanced uveal melanoma and next steps for clinical therapeutics

artículo científico publicado en 2014

Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis

artículo científico publicado en 2014

CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis.

artículo científico publicado en 2012

CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila.

artículo científico publicado en 2002

Carboxyl-terminal Domain of p27Kip1 Activates CDC2 ⬇️

artículo científico publicado el 29 de agosto de 1997

Cardiovascular effects of alpha-adrenergic drugs: differences between clonidine and guanabenz.

artículo científico publicado en 1986

Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.

artículo científico publicado en 1997

Cell growth control by G protein-coupled receptors: from signal transduction to signal integration

artículo científico publicado en 1998

Cellular Systems for Studying Human Oral Squamous Cell Carcinomas ⬇️

artículo científico publicado el 1 de enero de 2011

Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action

artículo científico publicado en 1998

Characterization of beta-adrenergic receptors in sections from human blood lymphocyte pellets by quantitative autoradiography

artículo científico publicado en 1988

Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter

artículo científico publicado el 1 de mayo de 1992

Chemical carcinogenesis models for evaluating molecular-targeted prevention and treatment of oral cancer.

artículo científico publicado en 2009

Chemopreventive and chemotherapeutic actions of mTOR inhibitor in genetically defined head and neck squamous cell carcinoma mouse model.

artículo científico publicado en 2012

Chimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13.

artículo científico publicado en 2004

Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in mice

artículo científico publicado en 2014

Circulating Fibroblast Growth Factor-2, HIV-Tat, and Vascular Endothelial Cell Growth Factor-A in HIV-Infected Children with Renal Disease Activate Rho-A and Src in Cultured Renal Endothelial Cells.

artículo científico publicado en 2016

Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B.

artículo científico publicado en 2004

Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects.

artículo científico publicado en 2010

Combination chemotherapy and radiation of human squamous cell carcinoma of the head and neck augments CTL-mediated lysis.

artículo científico publicado en 2006

Combined image guided monitoring the pharmacokinetics of rapamycin loaded human serum albumin nanoparticles with a split luciferase reporter

artículo científico publicado en 2016

Combining portable Raman probes with nanotubes for theranostic applications

artículo científico publicado en 2011

Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

artículo científico publicado en 1993

Complementary roles of intracellular and pericellular collagen degradation pathways in vivo.

artículo científico publicado en 2007

Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis.

artículo científico publicado en 2004

Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3.

artículo científico publicado en 2010

Control of the epithelial stem cell epigenome: the shaping of epithelial stem cell identity.

artículo científico

Correction to: mTOR co-targeting strategies for head and neck cancer therapy

artículo científico publicado en 2019

Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma.

artículo científico publicado en 2014

Cross-desensitization and cointernalization of H1 and H2 histamine receptors reveal new insights into histamine signal integration.

artículo científico publicado en 2013

Cryo-electron microscopy structure and analysis of the P-Rex1-Gβγ signaling scaffold

scientific article published on 16 October 2019

Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection.

artículo científico publicado en 2006

DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays

artículo científico publicado en 2012

Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer

artículo científico publicado en 2011

Deletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cells

artículo científico publicado en 2000

Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways ⬇️

artículo científico publicado el 1 de enero de 1991

Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation

artículo científico publicado en 2005

Dermatomyositis paraneoplastic syndrome before symptomatic tonsillar squamous cell carcinoma: a case report

artículo científico publicado en 2014

Detecting cancer metastasis and accompanying protein biomarkers at single cell levels using a 3D-printed microfluidic immunoarray

artículo científico publicado en 2020

Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography

artículo científico publicado en 2004

Development of a yeast-based system to identify new hBRAFV600E functional interactors

scientific article published on 20 September 2018

Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor

artículo científico publicado en 2004

Direct targeting of Gαq and Gα11 oncoproteins in cancer cells

artículo científico publicado en 2019

Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative.

artículo científico publicado en 2007

Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays

artículo científico publicado en 2000

Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice

artículo científico publicado en 2010

Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades. Evidence for a role of paxillin in c-Jun NH(2)-terminal kinase activation

artículo científico publicado en 1999

Diverse activation states of RhoA in human lung cancer cells: contribution of G protein coupled receptors.

artículo científico publicado en 2007

Diverse biologic properties imparted by the c-fgr proto-oncogene ⬇️

artículo científico publicado el 15 de febrero de 1992

Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's sarcomagenesis?

artículo científico publicado en 2004

Down-regulation of CXCL5 inhibits squamous carcinogenesis.

artículo científico publicado en 2006

Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibition

artículo científico publicado en 1995

E-cadherin and Hakai: signalling, remodeling or destruction?

artículo científico publicado en 2002

E1a is an exogenous in vivo tumour suppressor.

artículo científico publicado en 2017

EPS8 upregulates FOXM1 expression, enhancing cell growth and motility

artículo científico publicado en 2010

Effect of activating and inactivating mutations of Gs- and Gi2-alpha protein subunits on growth and differentiation of 3T3-L1 preadipocytes.

artículo científico publicado en 1997

Effect of chronic administration of the converting enzyme inhibitor enalapril (MK 421) on brain atrial natriuretic peptide receptors in Wistar-Kyoto and spontaneously hypertensive rats

artículo científico publicado en 1988

Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation ⬇️

artículo científico publicado el 27 de agosto de 1998

Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance

scientific article published on 01 May 2019

Electrochemical Immunosensors for Interleukin-6. Comparison of Carbon Nanotube Forest and Gold Nanoparticle platforms.

artículo científico publicado en 2009

Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis

scientific article published on 12 August 2019

Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes

scientific article published on 01 January 2003

Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6.

artículo científico publicado en 2010

Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes

artículo científico publicado en 2017

Epigenetics, noncoding RNAs, and cell signaling--crossroads in the regulation of cell fate decisions

artículo científico publicado en 2013

Erlotinib and the Risk of Oral Cancer: The Erlotinib Prevention of Oral Cancer (EPOC) Randomized Clinical Trial.

artículo científico publicado en 2015

Establishment of a novel cancer cell line derived from vulvar carcinoma associated with lichen sclerosus exhibiting a fibroblast-dependent tumorigenic potential

scientific article published on 23 October 2019

Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters

scientific journal article

Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing ⬇️

artículo científico publicado el 4 de febrero de 2013

Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets

artículo científico publicado en 2013

Expression of an active Gαs mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance.

artículo científico publicado en 2017

Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data.

artículo científico publicado en 2012

Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis

artículo científico publicado en 1998

Fluorescent, bioactive protein nanoparticles (prodots) for rapid, improved cellular uptake.

artículo científico publicado en 2015

Functional roles of Akt signaling in mouse skin tumorigenesis.

artículo científico publicado en 2002

Further evidence of interaction between vasodilator beta 2- and vasoconstrictor alpha 2-adrenoceptor-mediated responses in maintaining vascular tone in anesthetized rats.

artículo científico publicado en 1989

Future directions and treatment strategies for head and neck squamous cell carcinomas

artículo científico publicado en 2012

G Protein Coupled Receptors and Heterotrimeric G Proteins as Cancer Drivers

scientific article published on 03 December 2020

G-protein-coupled receptors and cancer.

artículo científico publicado en 2007

G-protein-coupled receptors and signaling networks: emerging paradigms.

artículo científico publicado en 2001

GENIPAC: A Genomic Information Portal for Head and Neck Cancer Cell Systems

artículo científico publicado en 2018

GNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling

artículo científico publicado en 2018

Gene discovery in oral squamous cell carcinoma through the Head and Neck Cancer Genome Anatomy Project: confirmation by microarray analysis.

artículo científico publicado en 2003

Gene expression changes in a patient presenting nonleukaemic nasal granulocytic sarcoma to acute myelogenous leukaemia using 40 K cDNA microarray

artículo científico publicado en 2006

Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure.

artículo científico publicado en 2009

Gene expression profiles in squamous cell carcinomas of the oral cavity: use of laser capture microdissection for the construction and analysis of stage-specific cDNA libraries.

artículo científico publicado en 2000

Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma

artículo científico publicado en 2015

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK.

artículo científico publicado en 2017

Genetic variants affecting equivalent protein family positions reflect human diversity.

artículo científico publicado en 2017

Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies.

artículo científico publicado en 2016

Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

artículo científico publicado en 2019

Germline genetic variation modulates tumor progression and metastasis in a mouse model of neuroendocrine prostate carcinoma.

artículo científico publicado en 2013

Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays.

artículo científico publicado en 2004

Global gene expression profiles of human head and neck squamous carcinoma cell lines.

artículo científico publicado en 2004

Growth factor-sensitive molecular targets identified in primary and metastatic head and neck squamous cell carcinoma using microarray analysis.

artículo científico publicado en 2005

Gα12 Requires Acylation for Its Transforming Activity ⬇️

artículo científico publicado el 3 de marzo de 1998

Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins

artículo científico publicado en 2018

HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers

artículo científico publicado en 2020

HPV16 E5 Mediates Resistance to PD-L1 Blockade and Can Be Targeted with Rimantadine in Head and Neck Cancer

scientific article published on 17 December 2019

Head and Neck Cancer in the New Era of Precision Medicine

artículo científico publicado en 2018

Heparin inhibits angiotensin II-induced vasoconstriction on isolated mouse mesenteric resistance arteries through Rho-A- and PKA-dependent pathways

artículo científico publicado en 2012

Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis.

artículo científico publicado en 2014

Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.

artículo científico publicado en 2014

Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential

artículo científico publicado en 2004

How mitogen-activated protein kinases recognize and phosphorylate their targets: A QM/MM study.

artículo científico publicado en 2009

Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor

artículo científico publicado en 1999

Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma.

artículo científico publicado en 2008

IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells ⬇️

artículo científico publicado el 1 de diciembre de 1992

Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase

scientific journal article

Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes.

artículo científico publicado en 2003

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

artículo científico publicado en 2010

Illuminating G-Protein-Coupling Selectivity of GPCRs

artículo científico publicado en 2019

Illuminating the Onco-GPCRome: Novel G protein-coupled receptor-driven oncocrine networks and targets for cancer immunotherapy

artículo científico publicado en 2019

Imaging the distribution of individual platinum-based anticancer drug molecules attached to single-wall carbon nanotubes

artículo científico publicado en 2009

Immune Modulation of Head and Neck Squamous Cell Carcinoma and the Tumor Microenvironment by Conventional Therapeutics

scientific article published on 27 February 2019

Immunolocalization of c-Fos and c-Jun in human oral mucosa and in oral squamous cell carcinoma.

artículo científico publicado en 2002

Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice

artículo científico publicado en 2013

Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition.

artículo científico publicado en 2013

Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells.

artículo científico publicado en 2015

Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis.

artículo científico publicado en 2015

Increased angiotensin II receptors in brain nuclei of DOCA-salt hypertensive rats ⬇️

artículo científico publicado el 1 de septiembre de 1988

Increased concentration of angiotensin II binding sites in selected brain areas of spontaneously hypertensive rats ⬇️

artículo científico publicado el 1 de enero de 1988

Induction of apoptosis in head-and-neck squamous carcinoma cells by gamma-irradiation and bleomycin is p53-independent

scientific article published on 01 December 2000

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system

artículo científico publicado en 2002

Inhibition of Mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions.

artículo científico publicado en 2008

Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons

artículo científico publicado en 2007

Inhibition of basic leucine zipper transcription is a major mediator of atrial dilatation

artículo científico publicado en 2006

Inhibition of mTOR Signaling and Clinical Activity of Rapamycin in Head and Neck Cancer in a Window of Opportunity Trial

scientific article published on 12 November 2018

Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes

artículo científico publicado en 2021

Insights into β2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3.

artículo científico publicado en 2014

Insulin-like Growth Factor-I Inhibits the Stress-activated Protein Kinase/c-Jun N-terminal Kinase ⬇️

artículo científico publicado el 2 de octubre de 1998

Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC

artículo científico publicado en 2017

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules

artículo científico publicado en 1995

Integrin αβ1, αvβ, α6β effectors p130Cas, Src and talin regulate carcinoma invasion and chemoresistance

artículo científico publicado en 2011

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors

artículo científico publicado en 1996

Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer.

artículo científico publicado en 2017

Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer.

artículo científico publicado en 2011

Interleukin-21 expression and its association with proinflammatory cytokines in untreated chronic periodontitis patients.

artículo científico publicado en 2011

Interpretation of cancer mutations using a multiscale map of protein systems

artículo científico publicado en 2021

Investigation of the catalytic mechanism of farnesyl pyrophosphate synthase by computer simulation

artículo científico publicado en 2006

Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway.

artículo científico publicado en 2014

Kaposi's sarcoma virally encoded, G-protein-coupled receptor: a paradigm for paracrine transformation.

artículo científico publicado en 2009

Keeping the epidermal stem cell niche in shape

artículo científico publicado en 2010

LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma.

artículo científico publicado en 2016

LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes

artículo científico publicado en 2014

Laminin-gamma2 overexpression in head-and-neck squamous cell carcinoma.

artículo científico publicado en 2002

Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma

artículo científico publicado en 2003

Levels of sirolimus in saliva and blood following mouthwash application

scientific article published on 24 March 2014

Levels of sirolimus in saliva and blood following oral topical sustained-release varnish delivery system application

artículo científico publicado en 2015

Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma

scientific article published on 01 January 1997

Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo

scientific article published on 11 July 2016

Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor rapamycin.

artículo científico publicado en 2012

Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation.

artículo científico publicado en 2011

Lower number of atrial natriuretic peptide receptors in thymocytes and spleen cells of spontaneously hypertensive rats.

artículo científico publicado en 1987

MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements.

artículo científico publicado en 2010

MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D.

artículo científico publicado en 2007

Massively parallel sequencing reveals an accumulation of de novo mutations and an activating mutation of LPAR1 in a patient with metastatic neuroblastoma

artículo científico publicado en 2013

Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature

artículo científico publicado en 2007

Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer

artículo científico publicado en 2010

Meeting report--the NIDCR 2(nd) Salivary Gland Tumor Meeting, November 2008

artículo científico publicado en 2009

Melanoma cell lysate induces CCR7 expression and in vivo migration to draining lymph nodes of therapeutic human dendritic cells.

artículo científico publicado en 2014

Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway.

artículo científico publicado en 2003

Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells

scientific article published on 10 July 2019

Metformin Is Associated With Reduced Odds for Colorectal Cancer Among Persons With Diabetes

artículo científico publicado en 2019

Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions

artículo científico publicado en 2012

Microfluidic electrochemical immunoarray for ultrasensitive detection of two cancer biomarker proteins in serum

artículo científico publicado en 2011

Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.

artículo científico publicado en 2010

Modular architecture and novel protein-protein interactions regulating the RGS-containing Rho guanine nucleotide exchange factors.

artículo científico publicado en 2004

Modulation of canonical Wnt signaling by the extracellular matrix component biglycan

artículo científico publicado en 2011

Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma

artículo científico publicado en 2006

Molecular mechanisms deployed by virally encoded G protein-coupled receptors in human diseases

artículo científico publicado en 2012

Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6.

artículo científico publicado en 2007

Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

artículo científico publicado en 2000

Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis

artículo científico publicado en 2020

Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells ⬇️

artículo científico publicado el 1 de octubre de 1992

NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell.

artículo científico publicado en 2016

Nano delivers big: designing molecular missiles for cancer therapeutics

artículo científico publicado en 2011

Nanostructured immunosensor for attomolar detection of cancer biomarker interleukin-8 using massively labeled superparamagnetic particles

artículo científico publicado en 2011

Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1.

artículo científico publicado en 2006

Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis

artículo científico publicado en 2014

Novel 1-Phenylcycloalkanecarboxylic Acid Derivatives Are Potent and Selective .sigma.1 Ligands

artículo científico publicado en 1994

Novel Molecular Mediators in the Pathway Connecting G-protein-coupled Receptors to MAP Kinase Cascades

scientific article published on 01 May 1999

Novel insights into G protein and G protein-coupled receptor signaling in cancer

artículo científico publicado en 2014

Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas.

artículo científico publicado en 2012

Nuclear mapping of nanodrug delivery systems in dynamic cellular environments

artículo científico publicado en 2012

Onco-GPCR signaling and dysregulated expression of microRNAs in human cancer.

artículo científico publicado en 2016

Oncotargeting G proteins: The Hippo in the room.

artículo científico publicado en 2014

Oral Cancer: Integration of Studies for Diagnostic and Therapeutic Precision

scientific article published on 01 November 2019

Oral and Pharyngeal Epithelial Keratinocyte Culture ⬇️

artículo científico publicado el 1 de enero de 2013

Overexpression of mammalian protein kinase C-zeta does not affect the growth characteristics of NIH 3T3 cells.

artículo científico publicado en 1995

P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.

artículo científico publicado en 2004

P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration

artículo científico publicado en 2007

PD-1 blockade attenuates immunosuppressive myeloid cells due to inhibition of CD47/SIRPα axis in HPV negative head and neck squamous cell carcinoma

artículo científico publicado en 2015

PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets.

artículo científico publicado en 2010

PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation

artículo científico publicado en 2013

PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells

artículo científico publicado en 2016

PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis.

artículo científico publicado en 2011

PLC-γ activation is required for PDGF-βR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells

scientific article published on 01 July 1997

PRECOG: PREdicting COupling probabilities of G-protein coupled receptors

scientific article published on 01 July 2019

PTEN deficiency contributes to the development and progression of head and neck cancer.

artículo científico publicado en 2013

Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis.

artículo científico publicado en 2010

Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion.

artículo científico publicado en 2007

Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01.

artículo científico publicado en 2004

Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents

artículo científico publicado en 2008

Phase 1 dose-finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer

artículo científico publicado en 2019

Phase II trial of everolimus in patients with previously treated recurrent or metastatic head and neck squamous cell carcinoma.

artículo científico publicado en 2016

Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein

artículo científico publicado en 2011

Phosphoinositide 3-kinase gamma is a mediator of Gbetagamma-dependent Jun kinase activation

artículo científico publicado en 1998

Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light.

artículo científico publicado en 2005

Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor.

artículo científico publicado en 2003

Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF

artículo científico publicado en 2002

Plexin B1 is downregulated in renal cell carcinomas and modulates cell growth.

artículo científico publicado en 2008

Plexin-B1 utilizes RhoA and Rho kinase to promote the integrin-dependent activation of Akt and ERK and endothelial cell motility

artículo científico publicado en 2007

Polymeric Nanovehicle Regulated Spatiotemporal Real-Time Imaging of the Differentiation Dynamics of Transplanted Neural Stem Cells after Traumatic Brain Injury

artículo científico publicado en 2015

Potent activation of RhoA by Galpha q and Gq-coupled receptors.

artículo científico publicado en 2002

Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands.

artículo científico publicado en 2016

Prevention of tumor growth driven by PIK3CA and HPV oncogenes by targeting mTOR signaling with metformin in oral squamous carcinomas expressing OCT3.

artículo científico publicado en 2015

Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis

artículo científico publicado en 2013

Profiling EGFR activity in head and neck squamous cell carcinoma by using a novel layered membrane Western blot technology.

artículo científico publicado en 2005

Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway.

scientific article published on 07 July 2009

Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.

artículo científico publicado en 2005

Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells

artículo científico publicado en 1996

Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry.

artículo científico publicado en 2005

Proteomic analysis of laser-captured paraffin-embedded tissues: a molecular portrait of head and neck cancer progression.

artículo científico publicado en 2008

Proteomic profiling of the cancer microenvironment by antibody arrays ⬇️

artículo científico publicado el 1 de octubre de 2001

RCAS/SCL-TVA animal model allows targeted delivery of polyoma middle T oncogene to vascular endothelial progenitors in vivo and results in hemangioma development.

artículo científico publicado en 2008

RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?

artículo científico publicado en 2001

Rab25 regulates invasion and metastasis in head and neck cancer.

artículo científico publicado en 2013

Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk

artículo científico publicado en 2006

Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB

artículo científico publicado en 2002

Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice.

artículo científico publicado en 2010

Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model.

artículo científico publicado en 2009

Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter

artículo científico publicado en 2006

Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm

artículo científico publicado en 2019

Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

artículo científico publicado en 1994

Receptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation

artículo científico publicado en 2012

Reciprocal negative regulation between S100A7/psoriasin and beta-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity.

artículo científico publicado en 2008

Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation

artículo científico publicado en 2012

Reducing the burden of oral and pharyngeal cancers.

artículo científico publicado en 1998

Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase

artículo científico publicado en 2002

Regulation of c-myc expression by PDGF through Rho GTPases.

artículo científico publicado en 2001

Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.

artículo científico publicado en 2001

Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors.

artículo científico publicado en 2000

Regulation of p73 by c-Abl through the p38 MAP kinase pathway.

artículo científico publicado en 2002

Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.

artículo científico publicado en 1996

Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1.

artículo científico publicado en 2005

Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor.

artículo científico publicado en 2010

Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells

artículo científico publicado en 2007

Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF

scientific article published on 01 March 1997

RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.

artículo científico publicado en 2015

Robo4 signaling in endothelial cells implies attraction guidance mechanisms.

artículo científico publicado en 2006

Role for EPS8 in squamous carcinogenesis.

artículo científico publicado en 2008

Role of GRB2‐associated binder 1 in epidermal growth factor receptor‐induced signaling in head and neck squamous cell carcinoma ⬇️

artículo científico publicado el 28 de agosto de 2012

Role of mitogen-activated protein kinases and c-Jun/AP-1 trans-activating activity in the regulation of protease mRNAs and the malignant phenotype in NIH 3T3 fibroblasts.

artículo científico publicado en 1999

SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis

artículo científico publicado en 2014

SET overexpression decreases cell detoxification efficiency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates.

artículo científico publicado en 2012

SOX2 Epidermal Overexpression Promotes Cutaneous Wound Healing via Activation of EGFR/MEK/ERK Signaling Mediated by EGFR Ligands

scientific article published on 14 February 2019

Scaffold proteins dictate Rho GTPase-signaling specificity

artículo científico publicado en 2005

Scientific progress in understanding oral and pharyngeal cancers ⬇️

artículo científico publicado el 1 de junio de 1998

Selective effects of activation of protein kinase C isozymes on cyclic AMP accumulation ⬇️

artículo científico publicado el 1 de febrero de 1991

Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras.

artículo científico publicado en 2010

Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis.

artículo científico publicado en 2006

Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer

artículo científico publicado en 2011

Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer

artículo científico publicado en 2012

Signaling circuitries controlling stem cell fate: to be or not to be ⬇️

artículo científico publicado el 29 de agosto de 2011

Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation.

artículo científico publicado en 2000

Signaling from G protein-coupled receptors to the c-jun promoter involves the MEF2 transcription factor. Evidence for a novel c-jun amino-terminal kinase-independent pathway.

artículo científico publicado en 1997

Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret.

artículo científico publicado en 1998

Signals and Receptors

artículo científico publicado en 2016

Single-wall carbon nanotube forest arrays for immunoelectrochemical measurement of four protein biomarkers for prostate cancer

artículo científico publicado en 2009

Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes

artículo científico publicado en 2008

Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation

artículo científico publicado en 2014

Sonic Hedgehog in SCLC.

artículo científico publicado en 2015

Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models

scientific article published on 20 February 2014

Structural and Biochemical Basis for Ubiquitin Ligase Recruitment by Arrestin-related Domain-containing Protein-3 (ARRDC3)

artículo científico publicado en 2014

Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential

artículo científico publicado en 2019

Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4

scientific article published on 05 December 2019

TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma.

artículo científico publicado en 2007

TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation.

artículo científico publicado en 2008

TRAIL induces apoptosis in oral squamous carcinoma cells--a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5.

scientific article published on February 2013

Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery.

artículo científico publicado en 2009

Targeted therapeutic nanotubes influence the viscoelasticity of cancer cells to overcome drug resistance

artículo científico publicado en 2014

Targeting mTOR in Head and Neck Cancer-Response

artículo científico publicado en 2019

Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis.

artículo científico publicado en 2016

The Constitutively Active Mutant Gα13Transforms Mouse Fibroblast Cells Deficient in Insulin-like Growth Factor-I Receptor ⬇️

artículo científico publicado el 21 de noviembre de 1997

The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4.

artículo científico publicado en 2006

The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma.

artículo científico publicado en 2006

The NOTCH4-HEY1 pathway induces epithelial mesenchymal transition in head and neck squamous cell carcinoma

artículo científico publicado en 2017

The Next Frontier: Head and Neck Cancer Immunoprevention.

artículo científico publicado en 2017

The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.

artículo científico publicado en 2004

The PH domain of Ras-GAP is sufficient for in vitro binding to beta gamma subunits of heterotrimeric G proteins.

artículo científico publicado en 1996

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades ⬇️

artículo científico publicado el 23 de enero de 1998

The basic domain of HIV-tat transactivating protein is essential for its targeting to lipid rafts and regulating fibroblast growth factor-2 signaling in podocytes isolated from children with HIV-1-associated nephropathy

artículo científico publicado en 2014

The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation.

artículo científico publicado en 2009

The biology of tobacco and nicotine: bench to bedside.

artículo científico publicado en 2005

The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.

artículo científico publicado en 2013

The expression of sphingosine kinase-1 in head and neck carcinoma

artículo científico publicado en 2010

The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies

artículo científico publicado en 2014

The homozygous CX3CR1-M280 mutation impairs human monocyte survival.

artículo científico publicado en 2018

The p53 tumor suppressor targets a novel regulator of G protein signaling ⬇️

artículo científico publicado el 22 de julio de 1997

The pathway connecting muscarinic acetylcholine receptors to the nucleus involves small GTP-binding proteins

artículo científico publicado el 1 de enero de 1998

The platelet-derived growth factor controls c-myc expression through a JNK- and AP-1-dependent signaling pathway.

artículo científico publicado en 2003

The ras-related GTPase rac1 regulates a proliferative pathway selectively utilized by G-protein coupled receptors ⬇️

artículo científico publicado el 24 de septiembre de 1998

The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG

artículo científico publicado en 2002

The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation.

artículo científico publicado en 1997

The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis.

artículo científico publicado en 2004

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

artículo científico publicado en 1995

Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation.

artículo científico publicado en 2003

Transcriptional signature primes human oral mucosa for rapid wound healing.

artículo científico publicado en 2018

Transforming G protein-coupled receptors potently activate JNK (SAPK). Evidence for a divergence from the tyrosine kinase signaling pathway.

artículo científico publicado en 1995

Translocation of the FGR protein-tyrosine kinase as a consequence of neutrophil activation.

artículo científico publicado en 1989

Treatment with clorgyline and pargyline differentially decreases clonidine-induced hypotension and bradycardia.

artículo científico publicado en 1984

Tyrosine kinases of the Src family participate in signaling to MAP kinase from both Gq and Gi-coupled receptors

scientific article published on 01 March 1998

Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release ⬇️

artículo científico publicado el 1 de julio de 1990

Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway

scientific journal article

Ultrasensitive detection of cancer biomarkers in the clinic by use of a nanostructured microfluidic array

artículo científico publicado en 2012

Ultrasensitive electrochemical immunosensor for oral cancer biomarker IL-6 using carbon nanotube forest electrodes and multilabel amplification.

artículo científico publicado en 2010

Ultrasensitive immunosensor for cancer biomarker proteins using gold nanoparticle film electrodes and multienzyme-particle amplification.

artículo científico publicado en 2009

Uncoupling of epidermal growth factor-dependent proliferation and invasion in a model of squamous carcinoma progression.

artículo científico publicado en 2005

Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection

artículo científico publicado en 2016

Using Heterologous COS-7 Cells to Identify Semaphorin-Signaling Components.

artículo científico publicado en 2017

VE-cadherin and claudin-5: it takes two to tango.

artículo científico publicado en 2008

VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin

scientific journal article

Viral hijacking of G-protein-coupled-receptor signalling networks.

artículo científico publicado en 2004

Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling

artículo científico publicado en 2015

WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13.

artículo científico publicado en 2016

[VE-cadherin takes a walk on the wild side]

artículo científico publicado en 2007

c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase

artículo científico publicado en 2011

cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits.

artículo científico publicado en 2018

mTOR Inhibitors and its Role in the Treatment of Head and Neck Squamous Cell Carcinoma ⬇️

artículo científico publicado el 1 de marzo de 2012

mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas

artículo científico publicado en 2012

mTOR co-targeting in cetuximab resistance in head and neck cancers harboring PIK3CA and RAS mutations

artículo científico publicado en 2014

mTOR co-targeting strategies for head and neck cancer therapy

artículo científico publicado en 2017

mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

artículo científico publicado en 2012

mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model.

artículo científico publicado en 2016

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

artículo científico publicado en 2009

mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family

artículo científico publicado en 2002

p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model.

artículo científico publicado en 2012

p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in ne

artículo científico publicado en 2004

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