Lista de obras - Juergen Bulitta - Dominio Público Uruguay

ABT-773: pharmacokinetics and interactions with ranitidine and sucralfate

artículo científico publicado en 2003

Alterations in Pharmacokinetics of Gemcitabine and Erlotinib by Concurrent Administration of Hyangsayukgunja-Tang, a Gastroprotective Herbal Medicine.

artículo científico publicado en 2017

Aminoglycoside Concentrations Required for Synergy with Carbapenems against Pseudomonas aeruginosa Determined via Mechanistic Studies and Modeling

artículo científico publicado en 2017

Aminoglycosides against carbapenem-resistant Enterobacteriaceae in the critically ill: the pitfalls of aminoglycoside susceptibility

artículo científico publicado en 2017

Application of pharmacokinetic-pharmacodynamic modeling and the justification of a novel fusidic acid dosing regimen: raising Lazarus from the dead.

scientific article published on June 2011

Assessment of bisphenol A exposure in Korean pregnant women by physiologically based pharmacokinetic modeling.

artículo científico publicado en 2010

Attenuation of colistin bactericidal activity by high inoculum of Pseudomonas aeruginosa characterized by a new mechanism-based population pharmacodynamic model

artículo científico publicado en 2010

Bone penetration of amoxicillin and clavulanic acid evaluated by population pharmacokinetics and Monte Carlo simulation

artículo científico publicado en 2009

Characterization of Hypermutator Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis in Australia

scientific article published on 27 March 2019

Characterizing the time-course of antihypertensive activity and optimal dose range of fimasartan via mechanism-based population modeling

artículo científico publicado en 2017

Clinical Regimens of Favipiravir Inhibit Zika Virus Replication in the Hollow-Fiber Infection Model

article

Clinical population pharmacokinetics and toxicodynamics of linezolid

artículo científico publicado en 2014

Clinically relevant plasma concentrations of colistin in combination with imipenem enhance pharmacodynamic activity against multidrug-resistant Pseudomonas aeruginosa at multiple inocula

artículo científico publicado en 2011

Colistin and Polymyxin B Dosage Regimens against Acinetobacter baumannii: Differences in Activity and the Emergence of Resistance

artículo científico publicado en 2016

Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance

artículo científico publicado en 2015

Combating carbapenem-resistant Acinetobacter baumannii by an optimized imipenem plus tobramycin dosage regimen - prospective validation via hollow fiber infection and mathematical modeling

artículo científico publicado en 2018

Combination therapy for carbapenem-resistant Gram-negative bacteria

artículo científico publicado en 2013

Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii

artículo científico publicado en 2016

Comparable Bioavailability and Disposition of Pefloxacin in Patients with Cystic Fibrosis and Healthy Volunteers Assessed via Population Pharmacokinetics

scientific article published on 10 July 2019

Comparable Efficacy and Better Safety of Double β-Lactam Combination Therapy versus β‑Lactam plus Aminoglycoside in Gram-Negative Bacteria in Randomized, Controlled Trials

artículo científico publicado en 2019

Comparison of the pharmacokinetics and pharmacodynamic profile of carumonam in cystic fibrosis patients and healthy volunteers

artículo científico publicado en 2009

Competitive inhibition of renal tubular secretion of ciprofloxacin and metabolite by probenecid

artículo científico publicado en 2010

Competitive inhibition of renal tubular secretion of gemifloxacin by probenecid

artículo científico publicado en 2009

Conjugation of 10 kDa Linear PEG onto Trastuzumab Fab' Is Sufficient to Significantly Enhance Lymphatic Exposure while Preserving in Vitro Biological Activity

artículo científico publicado en 2016

Controlling antibiotic release from mesoporous silica nano drug carriers via self-assembled polyelectrolyte coating

artículo científico publicado en 2015

Correction to: Lessons learned in the development of sustained release penicillin drug delivery systems for the prophylactic treatment of rheumatic heart disease (RHD)

scientific article published on 01 June 2018

Defining the Active Fraction of Daptomycin against Methicillin-Resistant Staphylococcus aureus (MRSA) Using a Pharmacokinetic and Pharmacodynamic Approach

artículo científico publicado en 2016

Determination of the small RNA GcvB regulon in the Gram-negative bacterial pathogen Pasteurella multocida and identification of the GcvB seed binding region.

artículo científico publicado en 2018

Development and qualification of a pharmacodynamic model for the pronounced inoculum effect of ceftazidime against Pseudomonas aeruginosa

artículo científico publicado en 2008

Development and validation of a liquid chromatography-mass spectrometry assay for polymyxin B in bacterial growth media.

artículo científico publicado en 2014

Development of a Physiologically Relevant Population Pharmacokinetic in Vitro-in Vivo Correlation Approach for Designing Extended-Release Oral Dosage Formulation

artículo científico publicado en 2016

Development of an Enantioselective and Biomarker-Informed Translational Population Pharmacokinetic/Pharmacodynamic Model for Etodolac

artículo científico publicado en 2017

Differences in suppression of regrowth and resistance despite similar initial bacterial killing for meropenem and piperacillin/tazobactam against Pseudomonas aeruginosa and Escherichia coli.

artículo científico publicado en 2018

Disposition, oral bioavailability, and tissue distribution of zearalenone in rats at various dose levels.

artículo científico publicado en 2009

Distinguishing Antimicrobial Models with Different Resistance Mechanisms via Population Pharmacodynamic Modeling

artículo científico publicado en 2016

Doripenem population pharmacokinetics and dosing requirements for critically ill patients receiving continuous venovenous haemodiafiltration

artículo científico publicado en 2014

Effect of Sipjeondaebo-Tang on the Pharmacokinetics of S-1, an Anticancer Agent, in Rats Evaluated by Population Pharmacokinetic Modeling

artículo científico publicado en 2017

Effect of different renal function on antibacterial effects of piperacillin against Pseudomonas aeruginosa evaluated via the hollow-fibre infection model and mechanism-based modelling.

artículo científico publicado en 2016

Effect of half-life on the pharmacodynamic index of zanamivir against influenza virus delineated by a mathematical model

artículo científico publicado en 2011

Effects of grapefruit juice on the pharmacokinetics of sildenafil

artículo científico publicado en 2002

Emergence of polymyxin B resistance influences pathogenicity in Pseudomonas aeruginosa mutators

artículo científico publicado en 2015

Establishing a predictive ivivc for a drug with strongly pH dependent dissolution kinetics via population pharmacokinetic modeling

scholarly article by Tae Hwan Kim et al published January 2017 in Drug Metabolism and Pharmacokinetics

Evaluation by monte carlo simulation of the pharmacokinetics of two doses of meropenem administered intermittently or as a continuous infusion in healthy volunteers.

artículo científico publicado en 2005

Evaluation of Pharmacokinetic/Pharmacodynamic Model-Based Optimized Combination Regimens against Multidrug-Resistant Pseudomonas aeruginosa in a Murine Thigh Infection Model by Using Humanized Dosing Schemes

artículo científico publicado en 2017

Evaluation of Tobramycin and Ciprofloxacin as a Synergistic Combination Against Hypermutable Pseudomonas Aeruginosa Strains via Mechanism-Based Modelling

scientific article published on 12 September 2019

Evaluation of enrofloxacin use in koalas (Phascolarctos cinereus) via population pharmacokinetics and Monte Carlo simulation.

artículo científico publicado en 2013

Evaluation of once-daily vancomycin against methicillin-resistant Staphylococcus aureus in a hollow-fiber infection model

artículo científico publicado en 2011

Evaluation of the pharmacokinetics–pharmacodynamics of fusidic acid against Staphylococcus aureus and Streptococcus pyogenes using in vitro infection models: implications for dose selection ⬇️

artículo científico publicado el 1 de mayo de 2011

FDA Public Workshop Summary: Advancing Animal Models for Antibacterial Drug Development

artículo científico publicado en 2020

First Penicillin-Binding Protein Occupancy Patterns of β-Lactams and β-Lactamase Inhibitors in Klebsiella pneumoniae

scientific article published on 25 May 2018

First penicillin-binding protein occupancy patterns for 15 β-lactams and β-lactamase inhibitors in Mycobacterium abscessus

artículo científico publicado en 2020

Four Decades of β-Lactam Antibiotic Pharmacokinetics in Cystic Fibrosis

artículo científico publicado en 2019

Front-loaded linezolid regimens result in increased killing and suppression of the accessory gene regulator system of Staphylococcus aureus. ⬇️

artículo científico publicado en 2012

Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans

scientific article published on 25 April 2019

High-Dose Ampicillin-Sulbactam Combinations Combat Polymyxin-Resistant Acinetobacter baumannii in a Hollow-Fiber Infection Model

artículo científico publicado en 2017

High-intensity meropenem combinations with polymyxin B: new strategies to overcome carbapenem resistance in Acinetobacter baumannii

artículo científico publicado en 2016

Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin

artículo científico publicado en 2017

Inhibition of flucloxacillin tubular renal secretion by piperacillin

artículo científico publicado en 2008

Interaction of pefloxacin and enoxacin with the human cytochrome P450 enzyme CYP1A2

artículo científico publicado en 1999

Lessons learned in the development of sustained release penicillin drug delivery systems for the prophylactic treatment of rheumatic heart disease (RHD).

artículo científico publicado en 2018

Mechanism-based model of parasite growth and dihydroartemisinin pharmacodynamics in murine malaria

artículo científico publicado en 2012

Mechanistic population pharmacokinetics of total and unbound paclitaxel for a new nanodroplet formulation versus Taxol in cancer patients

artículo científico publicado en 2008

Meropenem-Tobramycin Combination Regimens Combat Carbapenem-Resistant Pseudomonas aeruginosa in the Hollow-Fiber Infection Model Simulating Augmented Renal Clearance in Critically Ill Patients

artículo científico publicado en 2019

Modeling the autoinhibition of clarithromycin metabolism during repeated oral administration

scientific article published on 04 May 2009

Multiple-pool cell lifespan models for neutropenia to assess the population pharmacodynamics of unbound paclitaxel from two formulations in cancer patients

artículo científico publicado en 2008

Natural history of Acinetobacter baumannii infection in mice

scientific article published on 18 July 2019

New dosing strategies for an old antibiotic: pharmacodynamics of front-loaded regimens of colistin at simulated pharmacokinetics in patients with kidney or liver disease

artículo científico publicado en 2013

Nonlinear pharmacokinetics of piperacillin in healthy volunteers--implications for optimal dosage regimens

artículo científico publicado en 2010

Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter cloacae

articulo cientifico

Novel Population Pharmacokinetic Approach to Explain the Differences between Cystic Fibrosis Patients and Healthy Volunteers via Protein Binding

scientific article published on 18 June 2019

Novel approach to optimize synergistic carbapenem-aminoglycoside combinations against carbapenem-resistant Acinetobacter baumannii

artículo científico publicado en 2015

Novel rate-area-shape modeling approach to quantify bacterial killing and regrowth for in vitro static time-kill studies

artículo científico publicado en 2014

Optimization and evaluation of piperacillin plus tobramycin combination dosage regimens against Pseudomonas aeruginosa for patients with altered pharmacokinetics via the hollow-fiber infection model and mechanism-based modeling

artículo científico publicado en 2018

Optimization of Polymyxin B in Combination with Doripenem To Combat Mutator Pseudomonas aeruginosa

artículo científico publicado en 2016

Optimization of Synergistic Combination Regimens against Carbapenem- and Aminoglycoside-Resistant Clinical Pseudomonas aeruginosa Isolates via Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling

artículo científico publicado en 2016

Optimization of a meropenem plus tobramycin combination dosage regimen against hypermutable and non-hypermutable Pseudomonas aeruginosa via mechanism-based modeling and the hollow-fiber infection model.

artículo científico publicado en 2018

Optimization of voriconazole therapy for the treatment of invasive fungal infections in adults

artículo científico publicado en 2018

Optimizing Polymyxin Combinations Against Resistant Gram-Negative Bacteria

artículo científico publicado en 2015

PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin

artículo científico publicado en 2013

PEGylation does not significantly change the initial intravenous or subcutaneous pharmacokinetics or lymphatic exposure of trastuzumab in rats but increases plasma clearance after subcutaneous administration.

artículo científico publicado en 2015

Paradoxical Effect of Polymyxin B: High Drug Exposure Amplifies Resistance in Acinetobacter baumannii

scientific article published on 11 April 2016

Penetration of antibacterials into bone: pharmacokinetic, pharmacodynamic and bioanalytical considerations

artículo científico publicado en 2009

Penetration of moxifloxacin into bone evaluated by Monte Carlo simulation

artículo científico publicado en 2009

Performance and robustness of the Monte Carlo importance sampling algorithm using parallelized S-ADAPT for basic and complex mechanistic models.

artículo científico publicado en 2011

Pharmacodynamics of dose-escalated 'front-loading' polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli

artículo científico publicado en 2017

Pharmacodynamics of early, high-dose linezolid against vancomycin-resistant enterococci with elevated MICs and pre-existing genetic mutations

artículo científico publicado en 2012

Pharmacodynamics of vancomycin at simulated epithelial lining fluid concentrations against methicillin-resistant Staphylococcus aureus (MRSA): implications for dosing in MRSA pneumonia

artículo científico publicado en 2009

Pharmacokinetic-pharmacodynamic rationale for cefepime dosing regimens in intensive care units.

artículo científico publicado en 2006

Pharmacokinetics and metabolite profiling of fimasartan, a novel antihypertensive agent, in rats

Pharmacokinetics and pharmacodynamics of antibiotics in intensive care

artículo científico publicado en 2016

Pharmacokinetics of 1,4-butanediol in rats: bioactivation to gamma-hydroxybutyric acid, interaction with ethanol, and oral bioavailability.

artículo científico publicado en 2008

Pharmacokinetics of ertapenem in colorectal tissue.

artículo científico

Pharmakokinetik und Pharmakodynamik der β-Lactame: Was wir über β-Lactame wissen und was wir wissen möchten

scientific article published on 01 January 2006

Phase 2, randomized, double-blind, dose-ranging study evaluating the safety, tolerability, population pharmacokinetics, and efficacy of oral torezolid phosphate in patients with complicated skin and skin structure infections.

artículo científico publicado en 2010

Physiologically based pharmacokinetics of zearalenone

artículo científico publicado en 2009

Placental transfer and mammary excretion of a novel angiotensin receptor blocker fimasartan in rats

artículo científico publicado en 2016

Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies

artículo científico publicado en 2016

Polymyxin Combinations Combat Escherichia coli Harboring mcr-1 and blaNDM-5: Preparation for a Postantibiotic Era.

artículo científico publicado en 2017

Polymyxin Resistance in Acinetobacter baumannii: Genetic Mutations and Transcriptomic Changes in Response to Clinically Relevant Dosage Regimens.

artículo científico publicado en 2016

Polymyxin combinations: pharmacokinetics and pharmacodynamics for rationale use.

artículo científico publicado en 2015

Polymyxin-resistant, carbapenem-resistant Acinetobacter baumannii is eradicated by a triple combination of agents that lack individual activity

artículo científico publicado en 2017

Population Pharmacokinetic Modeling of the Enterohepatic Recirculation of Fimasartan in Rats, Dogs, and Humans

artículo científico publicado en 2015

Population Pharmacokinetics and Penetration into Prostatic, Seminal, and Vaginal Fluid for Ciprofloxacin, Levofloxacin, and Their Combination

artículo científico publicado en 2011

Population Pharmacokinetics and Target Attainment of Ertapenem in Plasma and Tissue Assessed via Microdialysis in Morbidly Obese Patients after Laparoscopic Visceral Surgery

scientific article published on 17 October 2016

Population Pharmacokinetics and Target Attainment of Meropenem in Plasma and Tissue of Morbidly Obese Patients after Laparoscopic Intraperitoneal Surgery

artículo científico publicado en 2015

Population Pharmacokinetics of a Novel Histone Deacetylase Inhibitor, Cyclo{(2S)-2-Amino-8-[(Aminocarbonyl)Hydrazono] Decanoyl-1- L -Tryptophyl- L -Isoleucyl-(2R)-2-Piperidinecarbonyl} (SD-2007), and Its Metabolic Conversion to Apicidin after Intrave

artículo científico publicado en 2011

Population data analysis of dissolution time profiles: Assessment of physicochemical properties of the drug, drug particles and the pharmaceutical formulation

artículo científico publicado en 2015

Population pharmacokinetics and pharmacodynamics of continuous versus short-term infusion of imipenem-cilastatin in critically ill patients in a randomized, controlled trial

artículo científico publicado en 2007

Population pharmacokinetics at two dose levels and pharmacodynamic profiling of flucloxacillin

artículo científico publicado en 2007

Population pharmacokinetics of fusidic acid: rationale for front-loaded dosing regimens due to autoinhibition of clearance

artículo científico publicado en 2012

Powder Strength Distributions for Understanding De-agglomeration of Lactose Powders

artículo científico publicado en 2012

Prediction of human pharmacokinetics and tissue distribution of apicidin, a potent histone deacetylase inhibitor, by physiologically based pharmacokinetic modeling

artículo científico publicado en 2010

Quantifying subpopulation synergy for antibiotic combinations via mechanism-based modeling and a sequential dosing design

artículo científico publicado en 2013

Quantitative Determination of Absorption and First-Pass Metabolism of Apicidin, a Potent Histone Deacetylase Inhibitor

artículo científico publicado en 2014

Resistance Emergence Mechanism and Mechanism of Resistance Suppression by Tobramycin for Cefepime for Pseudomonas aeruginosa ⬇️

artículo científico publicado el 17 de octubre de 2011

Resistance suppression by high-intensity, short-duration aminoglycoside exposure against hypermutable and non-hypermutable Pseudomonas aeruginosa

artículo científico publicado en 2016

Resurgence of colistin: a review of resistance, toxicity, pharmacodynamics, and dosing

artículo científico publicado en 2010

Shape does matter: short high-concentration exposure minimizes resistance emergence for fluoroquinolones in Pseudomonas aeruginosa

artículo científico publicado en 2014

Substantial Impact of Altered Pharmacokinetics in Critically Ill Patients on the Antibacterial Effects of Meropenem Evaluated via the Dynamic Hollow-Fiber Infection Model

artículo científico publicado en 2017

Synthesis and Structure–Activity Relationship of Thioacetamide-Triazoles against Escherichia coli

artículo científico publicado en 2022

The Lymphatic System Plays a Major Role in the Intravenous and Subcutaneous Pharmacokinetics of Trastuzumab in Rats

artículo científico publicado en 2014

The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model

artículo científico publicado en 2012

The impact of lymphatic transport on the systemic disposition of lipophilic drugs.

artículo científico publicado en 2013

The role of infection models and PK/PD modelling for optimising care of critically ill patients with severe infections

artículo científico publicado en 2017

The time course of drug effects.

artículo científico publicado en 2009

Two mechanisms of killing of Pseudomonas aeruginosa by tobramycin assessed at multiple inocula via mechanism-based modeling.

artículo científico publicado en 2015

Two new antibiotics with special qualities: the pharmacokinetics of linezolid and telithromycin

artículo científico publicado en 2004

Use of population pharmacokinetic modeling and Monte Carlo simulation to describe the pharmacodynamic profile of cefditoren in plasma and epithelial lining fluid

artículo científico publicado en 2007

Voriconazole pharmacokinetics following HSCT: results from the BMT CTN 0101 trial

artículo científico publicado en 2016

Zika virus (ZIKV) Replication is Substantially Inhibited by Novel Favipiravir and Interferon-alpha Combination Regimens

artículo científico publicado en 2017

Lista de obras de Juergen Bulitta

ABT-773: pharmacokinetics and interactions with ranitidine and sucralfate

Alterations in Pharmacokinetics of Gemcitabine and Erlotinib by Concurrent Administration of Hyangsayukgunja-Tang, a Gastroprotective Herbal Medicine.

Aminoglycoside Concentrations Required for Synergy with Carbapenems against Pseudomonas aeruginosa Determined via Mechanistic Studies and Modeling

Aminoglycosides against carbapenem-resistant Enterobacteriaceae in the critically ill: the pitfalls of aminoglycoside susceptibility

Application of pharmacokinetic-pharmacodynamic modeling and the justification of a novel fusidic acid dosing regimen: raising Lazarus from the dead.

Assessment of bisphenol A exposure in Korean pregnant women by physiologically based pharmacokinetic modeling.

Attenuation of colistin bactericidal activity by high inoculum of Pseudomonas aeruginosa characterized by a new mechanism-based population pharmacodynamic model

Bone penetration of amoxicillin and clavulanic acid evaluated by population pharmacokinetics and Monte Carlo simulation

Characterization of Hypermutator Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis in Australia

Characterizing the time-course of antihypertensive activity and optimal dose range of fimasartan via mechanism-based population modeling

Clinical Regimens of Favipiravir Inhibit Zika Virus Replication in the Hollow-Fiber Infection Model

Clinical population pharmacokinetics and toxicodynamics of linezolid

Clinically relevant plasma concentrations of colistin in combination with imipenem enhance pharmacodynamic activity against multidrug-resistant Pseudomonas aeruginosa at multiple inocula

Colistin and Polymyxin B Dosage Regimens against Acinetobacter baumannii: Differences in Activity and the Emergence of Resistance

Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance

Combating carbapenem-resistant Acinetobacter baumannii by an optimized imipenem plus tobramycin dosage regimen - prospective validation via hollow fiber infection and mathematical modeling

Combination therapy for carbapenem-resistant Gram-negative bacteria

Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii

Comparable Bioavailability and Disposition of Pefloxacin in Patients with Cystic Fibrosis and Healthy Volunteers Assessed via Population Pharmacokinetics

Comparable Efficacy and Better Safety of Double β-Lactam Combination Therapy versus β‑Lactam plus Aminoglycoside in Gram-Negative Bacteria in Randomized, Controlled Trials

Comparison of the pharmacokinetics and pharmacodynamic profile of carumonam in cystic fibrosis patients and healthy volunteers

Competitive inhibition of renal tubular secretion of ciprofloxacin and metabolite by probenecid

Competitive inhibition of renal tubular secretion of gemifloxacin by probenecid

Conjugation of 10 kDa Linear PEG onto Trastuzumab Fab' Is Sufficient to Significantly Enhance Lymphatic Exposure while Preserving in Vitro Biological Activity

Controlling antibiotic release from mesoporous silica nano drug carriers via self-assembled polyelectrolyte coating

Correction to: Lessons learned in the development of sustained release penicillin drug delivery systems for the prophylactic treatment of rheumatic heart disease (RHD)

Defining the Active Fraction of Daptomycin against Methicillin-Resistant Staphylococcus aureus (MRSA) Using a Pharmacokinetic and Pharmacodynamic Approach

Determination of the small RNA GcvB regulon in the Gram-negative bacterial pathogen Pasteurella multocida and identification of the GcvB seed binding region.

Development and qualification of a pharmacodynamic model for the pronounced inoculum effect of ceftazidime against Pseudomonas aeruginosa

Development and validation of a liquid chromatography-mass spectrometry assay for polymyxin B in bacterial growth media.

Development of a Physiologically Relevant Population Pharmacokinetic in Vitro-in Vivo Correlation Approach for Designing Extended-Release Oral Dosage Formulation

Development of an Enantioselective and Biomarker-Informed Translational Population Pharmacokinetic/Pharmacodynamic Model for Etodolac

Differences in suppression of regrowth and resistance despite similar initial bacterial killing for meropenem and piperacillin/tazobactam against Pseudomonas aeruginosa and Escherichia coli.

Disposition, oral bioavailability, and tissue distribution of zearalenone in rats at various dose levels.

Distinguishing Antimicrobial Models with Different Resistance Mechanisms via Population Pharmacodynamic Modeling

Doripenem population pharmacokinetics and dosing requirements for critically ill patients receiving continuous venovenous haemodiafiltration

Effect of Sipjeondaebo-Tang on the Pharmacokinetics of S-1, an Anticancer Agent, in Rats Evaluated by Population Pharmacokinetic Modeling

Effect of different renal function on antibacterial effects of piperacillin against Pseudomonas aeruginosa evaluated via the hollow-fibre infection model and mechanism-based modelling.

Effect of half-life on the pharmacodynamic index of zanamivir against influenza virus delineated by a mathematical model

Effects of grapefruit juice on the pharmacokinetics of sildenafil

Emergence of polymyxin B resistance influences pathogenicity in Pseudomonas aeruginosa mutators

Establishing a predictive ivivc for a drug with strongly pH dependent dissolution kinetics via population pharmacokinetic modeling

Evaluation by monte carlo simulation of the pharmacokinetics of two doses of meropenem administered intermittently or as a continuous infusion in healthy volunteers.

Evaluation of Pharmacokinetic/Pharmacodynamic Model-Based Optimized Combination Regimens against Multidrug-Resistant Pseudomonas aeruginosa in a Murine Thigh Infection Model by Using Humanized Dosing Schemes

Evaluation of Tobramycin and Ciprofloxacin as a Synergistic Combination Against Hypermutable Pseudomonas Aeruginosa Strains via Mechanism-Based Modelling

Evaluation of enrofloxacin use in koalas (Phascolarctos cinereus) via population pharmacokinetics and Monte Carlo simulation.

Evaluation of once-daily vancomycin against methicillin-resistant Staphylococcus aureus in a hollow-fiber infection model

Evaluation of the pharmacokinetics–pharmacodynamics of fusidic acid against Staphylococcus aureus and Streptococcus pyogenes using in vitro infection models: implications for dose selection ⬇️

FDA Public Workshop Summary: Advancing Animal Models for Antibacterial Drug Development

First Penicillin-Binding Protein Occupancy Patterns of β-Lactams and β-Lactamase Inhibitors in Klebsiella pneumoniae

First penicillin-binding protein occupancy patterns for 15 β-lactams and β-lactamase inhibitors in Mycobacterium abscessus

Four Decades of β-Lactam Antibiotic Pharmacokinetics in Cystic Fibrosis

Front-loaded linezolid regimens result in increased killing and suppression of the accessory gene regulator system of Staphylococcus aureus. ⬇️

Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans

High-Dose Ampicillin-Sulbactam Combinations Combat Polymyxin-Resistant Acinetobacter baumannii in a Hollow-Fiber Infection Model

High-intensity meropenem combinations with polymyxin B: new strategies to overcome carbapenem resistance in Acinetobacter baumannii

Influence of rhlR and lasR on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin

Inhibition of flucloxacillin tubular renal secretion by piperacillin

Interaction of pefloxacin and enoxacin with the human cytochrome P450 enzyme CYP1A2

Lessons learned in the development of sustained release penicillin drug delivery systems for the prophylactic treatment of rheumatic heart disease (RHD).

Mechanism-based model of parasite growth and dihydroartemisinin pharmacodynamics in murine malaria

Mechanistic population pharmacokinetics of total and unbound paclitaxel for a new nanodroplet formulation versus Taxol in cancer patients

Meropenem-Tobramycin Combination Regimens Combat Carbapenem-Resistant Pseudomonas aeruginosa in the Hollow-Fiber Infection Model Simulating Augmented Renal Clearance in Critically Ill Patients

Modeling the autoinhibition of clarithromycin metabolism during repeated oral administration

Multiple-pool cell lifespan models for neutropenia to assess the population pharmacodynamics of unbound paclitaxel from two formulations in cancer patients

Natural history of Acinetobacter baumannii infection in mice

New dosing strategies for an old antibiotic: pharmacodynamics of front-loaded regimens of colistin at simulated pharmacokinetics in patients with kidney or liver disease

Nonlinear pharmacokinetics of piperacillin in healthy volunteers--implications for optimal dosage regimens

Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter cloacae

Novel Population Pharmacokinetic Approach to Explain the Differences between Cystic Fibrosis Patients and Healthy Volunteers via Protein Binding

Novel approach to optimize synergistic carbapenem-aminoglycoside combinations against carbapenem-resistant Acinetobacter baumannii

Novel rate-area-shape modeling approach to quantify bacterial killing and regrowth for in vitro static time-kill studies

Optimization and evaluation of piperacillin plus tobramycin combination dosage regimens against Pseudomonas aeruginosa for patients with altered pharmacokinetics via the hollow-fiber infection model and mechanism-based modeling

Optimization of Polymyxin B in Combination with Doripenem To Combat Mutator Pseudomonas aeruginosa

Optimization of Synergistic Combination Regimens against Carbapenem- and Aminoglycoside-Resistant Clinical Pseudomonas aeruginosa Isolates via Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling

Optimization of a meropenem plus tobramycin combination dosage regimen against hypermutable and non-hypermutable Pseudomonas aeruginosa via mechanism-based modeling and the hollow-fiber infection model.

Optimization of voriconazole therapy for the treatment of invasive fungal infections in adults

Optimizing Polymyxin Combinations Against Resistant Gram-Negative Bacteria

PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin