Lista de obras - Michael Hubank - Dominio Público Uruguay

A genomic atlas of human adrenal and gonad development

artículo científico publicado en 2017

A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.

artículo científico publicado en 2005

Accurate Sample Assignment in a Multiplexed, Ultrasensitive, High-Throughput Sequencing Assay for Minimal Residual Disease

artículo científico

Astrovirus VA1/HMO-C: an increasingly recognized neurotropic pathogen in immunocompromised patients

artículo científico publicado en 2015

Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression.

artículo científico publicado en 2010

Cardioprotection mediated by urocortin is dependent on PKCepsilon activation.

artículo científico publicado en 2005

Cardiovascular GO annotation initiative year 1 report: why cardiovascular GO?

artículo científico

Cell cycle status in AML blast cells from peripheral blood, bone marrow aspirates and trephines and implications for biological studies and treatment.

artículo científico publicado en 2016

ChIP-on-chip analysis reveals angiopoietin 2 (Ang2, ANGPT2) as a novel target of steroidogenic factor-1 (SF-1, NR5A1) in the human adrenal gland.

artículo científico publicado en 2010

Circulating tumour DNA is a potential biomarker for disease progression and response to targeted therapy in advanced thyroid cancer

scientific article published on 22 September 2018

Comprehensive molecular characterisation of epilepsy-associated glioneuronal tumours.

artículo científico publicado en 2017

Cord blood transplantation recapitulates fetal ontogeny with a distinct molecular signature that supports CD4 T-cell reconstitution

scientific article published on 02 November 2017

Correction of scaling mismatches in oligonucleotide microarray data.

artículo científico publicado en 2006

Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis.

artículo científico publicado en 2016

Development of a targeted sequencing approach to identify prognostic, predictive and diagnostic markers in paediatric solid tumours

artículo científico publicado en 2017

Differential gene expression in the hippocampus of the Df1/+ mice: a model for 22q11.2 deletion syndrome and schizophrenia.

artículo científico publicado en 2007

Discovery of genes with highly restricted expression patterns in the Drosophila wing disc using DNA oligonucleotide microarrays

artículo científico publicado en 2003

Down-regulation of the dopamine receptor D2 in mice lacking ataxin 1.

artículo científico publicado en 2007

Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression.

artículo científico publicado en 2011

Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA.

artículo científico publicado en 2005

Exome sequencing for the differential diagnosis of ciliary chondrodysplasias: Example of a WDR35 mutation case and review of the literature.

artículo científico publicado en 2017

Eye on the B-ALL: B-cell receptor repertoires reveal persistence of numerous B-lymphoblastic leukemia subclones from diagnosis to relapse.

artículo científico publicado en 2016

From the top down: towards a predictive biology of signalling networks

artículo científico publicado en 2003

Gene expression profiling and its application in studies of haematological malignancy.

artículo científico publicado en 2004

Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype.

artículo científico publicado en 2010

Genome-wide analysis of alternative splicing in medulloblastoma identifies splicing patterns characteristic of normal cerebellar development.

artículo científico publicado en 2011

Global analysis of gene expression in NGF-deprived sympathetic neurons identifies molecular pathways associated with cell death ⬇️

artículo científico publicado el 8 de noviembre de 2011

High throughput sequencing in acute lymphoblastic leukemia reveals clonal architecture of central nervous system and bone marrow compartments.

artículo científico publicado en 2017

Human Coronavirus OC43 Associated with Fatal Encephalitis

artículo científico publicado en 2016

Human IFNAR2 deficiency: Lessons for antiviral immunity

scientific journal article

Inactivating NF1 Mutations Are Enriched in Advanced Breast Cancer and Contribute to Endocrine Therapy Resistance

artículo científico publicado en 2019

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

scientific article published on 01 April 2020

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

artículo científico publicado en 2008

Isolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-Derived Cone Photoreceptor Cells

artículo científico publicado en 2017

K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect.

artículo científico publicado en 2002

Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial.

artículo científico publicado en 2018

Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome

article

Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses.

artículo científico publicado en 2003

Microarray interrogation of human metanephric mesenchymal cells highlights potentially important molecules in vivo.

artículo científico publicado en 2006

Mitochondrial and oxidative stress genes are differentially expressed in neutrophils of sJIA patients treated with tocilizumab: a pilot microarray study

artículo científico publicado en 2016

New targets of urocortin-mediated cardioprotection

artículo científico publicado en 2010

OP11ESTABLISHING A DIAGNOSTIC PIPELINE FOR METHYLOME ANALYSIS OF PAEDIATRIC AND ADULT BRAIN TUMOURS IN THE UK USING THE HEIDELBERG CLASSIFIER.

artículo científico publicado en 2015

Optimised ARID1A immunohistochemistry is an accurate predictor of ARID1A mutational status in gynaecological cancers.

artículo científico publicado en 2018

Prox1 maintains muscle structure and growth in the developing heart

scientific journal article

Radiation-induced delayed cell death in a hypomorphic Artemis cell line.

artículo científico publicado en 2006

Robustness of the p53 network and biological hackers

artículo científico publicado en 2005

Scalable and Resilient SARS-CoV-2 testing in an Academic Centre

artículo científico publicado en 2020

Specific gene expression profiles in systemic juvenile idiopathic arthritis

article

Sterol O-acyltransferase 1 (SOAT1, ACAT) is a novel target of steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) in the human adrenal

artículo científico publicado en 2011

Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor.

artículo científico publicado en 2010

Targeting acute myeloid leukemia by drug-induced c-MYB degradation

artículo científico publicado en 2017

Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson‐Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform

artículo científico publicado en 2019

The E2A-HLF oncogenic fusion protein acts through Lmo2 and Bcl-2 to immortalize hematopoietic progenitors

scientific article published on 12 November 2010

Tnfaip8 is an essential gene for the regulation of glucocorticoid-mediated apoptosis of thymocytes

artículo científico publicado en 2009

Triplet therapy with palbociclib, taselisib and fulvestrant in PIK3CA mutant breast cancer and doublet palbociclib and taselisib in pathway mutant solid cancers

scientific article published on 21 September 2020

Ultra-sensitive mutation detection and genome-wide DNA copy number reconstruction by error corrected circulating tumour DNA sequencing

Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium-insensitive phospholipase A2 gene expression

scientific journal article

rHVDM: an R package to predict the activity and targets of a transcription factor

artículo científico publicado en 2008

Lista de obras de Michael Hubank

A genomic atlas of human adrenal and gonad development

A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.

Accurate Sample Assignment in a Multiplexed, Ultrasensitive, High-Throughput Sequencing Assay for Minimal Residual Disease

Astrovirus VA1/HMO-C: an increasingly recognized neurotropic pathogen in immunocompromised patients

Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression.

Cardioprotection mediated by urocortin is dependent on PKCepsilon activation.

Cardiovascular GO annotation initiative year 1 report: why cardiovascular GO?

Cell cycle status in AML blast cells from peripheral blood, bone marrow aspirates and trephines and implications for biological studies and treatment.

ChIP-on-chip analysis reveals angiopoietin 2 (Ang2, ANGPT2) as a novel target of steroidogenic factor-1 (SF-1, NR5A1) in the human adrenal gland.

Circulating tumour DNA is a potential biomarker for disease progression and response to targeted therapy in advanced thyroid cancer

Comprehensive molecular characterisation of epilepsy-associated glioneuronal tumours.

Cord blood transplantation recapitulates fetal ontogeny with a distinct molecular signature that supports CD4 T-cell reconstitution

Correction of scaling mismatches in oligonucleotide microarray data.

Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis.

Development of a targeted sequencing approach to identify prognostic, predictive and diagnostic markers in paediatric solid tumours

Differential gene expression in the hippocampus of the Df1/+ mice: a model for 22q11.2 deletion syndrome and schizophrenia.

Discovery of genes with highly restricted expression patterns in the Drosophila wing disc using DNA oligonucleotide microarrays

Down-regulation of the dopamine receptor D2 in mice lacking ataxin 1.

Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression.

Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA.

Exome sequencing for the differential diagnosis of ciliary chondrodysplasias: Example of a WDR35 mutation case and review of the literature.

Eye on the B-ALL: B-cell receptor repertoires reveal persistence of numerous B-lymphoblastic leukemia subclones from diagnosis to relapse.

From the top down: towards a predictive biology of signalling networks

Gene expression profiling and its application in studies of haematological malignancy.

Generation of novel pharmacogenomic candidates in response to methotrexate in juvenile idiopathic arthritis: correlation between gene expression and genotype.

Genome-wide analysis of alternative splicing in medulloblastoma identifies splicing patterns characteristic of normal cerebellar development.

Global analysis of gene expression in NGF-deprived sympathetic neurons identifies molecular pathways associated with cell death ⬇️

High throughput sequencing in acute lymphoblastic leukemia reveals clonal architecture of central nervous system and bone marrow compartments.

Human Coronavirus OC43 Associated with Fatal Encephalitis

Human IFNAR2 deficiency: Lessons for antiviral immunity

Inactivating NF1 Mutations Are Enriched in Advanced Breast Cancer and Contribute to Endocrine Therapy Resistance

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

Isolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-Derived Cone Photoreceptor Cells

K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect.

Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial.

Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome

Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses.

Microarray interrogation of human metanephric mesenchymal cells highlights potentially important molecules in vivo.

Mitochondrial and oxidative stress genes are differentially expressed in neutrophils of sJIA patients treated with tocilizumab: a pilot microarray study

New targets of urocortin-mediated cardioprotection

OP11ESTABLISHING A DIAGNOSTIC PIPELINE FOR METHYLOME ANALYSIS OF PAEDIATRIC AND ADULT BRAIN TUMOURS IN THE UK USING THE HEIDELBERG CLASSIFIER.

Optimised ARID1A immunohistochemistry is an accurate predictor of ARID1A mutational status in gynaecological cancers.

Prox1 maintains muscle structure and growth in the developing heart

Radiation-induced delayed cell death in a hypomorphic Artemis cell line.

Robustness of the p53 network and biological hackers

Scalable and Resilient SARS-CoV-2 testing in an Academic Centre

Specific gene expression profiles in systemic juvenile idiopathic arthritis

Sterol O-acyltransferase 1 (SOAT1, ACAT) is a novel target of steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) in the human adrenal

Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor.

Targeting acute myeloid leukemia by drug-induced c-MYB degradation

Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson‐Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform

The E2A-HLF oncogenic fusion protein acts through Lmo2 and Bcl-2 to immortalize hematopoietic progenitors

Tnfaip8 is an essential gene for the regulation of glucocorticoid-mediated apoptosis of thymocytes

Triplet therapy with palbociclib, taselisib and fulvestrant in PIK3CA mutant breast cancer and doublet palbociclib and taselisib in pathway mutant solid cancers

Ultra-sensitive mutation detection and genome-wide DNA copy number reconstruction by error corrected circulating tumour DNA sequencing

Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium-insensitive phospholipase A2 gene expression

rHVDM: an R package to predict the activity and targets of a transcription factor