Lista de obras - Manfred Gessler - Dominio Público Uruguay

1q gain is a frequent finding in preoperatively treated Wilms tumors, but of limited prognostic value for risk stratification in the SIOP2001/GPOH trial

article

A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1

artículo científico publicado en 1999

A Sequence-Ready 3-Mb PAC Contig Covering 16 Breakpoints of the Wilms Tumor/Anirida Region of Human Chromosome 11p13 ⬇️

artículo científico publicado el 15 de octubre de 1998

A WAGR region gene between PAX-6 and FSHB expressed in fetal brain

artículo científico publicado en 1994

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

scientific journal article

All-trans retinoic acid treatment of Wilms tumor cells reverses expression of genes associated with high risk and relapse in vivo

artículo científico publicado en 2005

An Ordered NotI Fragment Map of Human Chromosome Band 11p15

scientific article published on 01 September 1994

An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation

artículo científico publicado en 2016

An integrated YAC clone contig for the WAGR region on human chromosome 11p13-p14.1.

artículo científico publicado en 1995

Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos

scientific journal article

Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information

artículo científico publicado en 2018

Author Correction: The landscape of genomic alterations across childhood cancers

artículo científico publicado en 2018

Autoantibody signature differentiates Wilms tumor patients from neuroblastoma patients

artículo científico publicado en 2011

COUP-TFII orchestrates venous and lymphatic endothelial identity by homo- or hetero-dimerisation with PROX1.

artículo científico publicado en 2013

Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites

scientific article published on 20 February 2019

Characterization of hey bHLH genes in teleost fish

article

Characterization of primary Wilms tumor cultures as an in vitro model

artículo científico publicado en 2011

Characterization of the chromosomal translocation t(10;17)(q22;p13) in clear cell sarcoma of kidney

artículo científico publicado en 2012

Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family

artículo científico publicado en 2000

Chibby, a novel antagonist of the Wnt pathway, is not involved in Wilms tumor development.

artículo científico publicado en 2005

Cloning and expression analysis of the mouse stroma marker Snep encoding a novel nidogen domain protein

artículo científico publicado en 2004

Cloning of breakpoints of a chromosome translocation identifies the AN2 locus

artículo científico publicado en 1989

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition

scientific journal article

Combining miRNA and mRNA Expression Profiles in Wilms Tumor Subtypes

artículo científico publicado en 2016

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

artículo científico publicado en 2013

Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

artículo científico publicado en 2000

Confirmation of the localization of the human recombination activating gene 1 (RAG1) to chromosome 11p13

scientific article published on 01 February 1994

CpG island clones for chromosome 11p--a resource for mapping and gene identification

artículo científico publicado en 1995

Defective autophagy through epg5 mutation results in failure to reduce germ plasm and mitochondria

artículo científico publicado en 2015

Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt)

Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors

artículo científico publicado en 2007

Developmental expression and biochemical characterization of Emu family members

scientific journal article

Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family.

artículo científico publicado en 1998

Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors

artículo científico publicado en 2006

Differential expression of the cellular oncogenes c-src and c-yes in embryonal and adult chicken tissues ⬇️

artículo científico publicado el 1 de septiembre de 1984

Distinct molecular origins for Denys-Drash and Frasier syndromes

artículo científico publicado en 1993

Dll1 and Dll4: similar, but not the same

DrugTargetInspector: An assistance tool for patient treatment stratification

artículo científico publicado en 2015

ETV6-NTRK3 in congenital mesoblastic nephroma: A report of the SIOP/GPOH nephroblastoma study.

artículo científico publicado en 2017

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

artículo científico publicado en 2010

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development

artículo científico publicado en 2003

Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila

artículo científico publicado en 2005

Expression patterns of the mouse Spir-2 actin nucleator

artículo científico publicado en 2010

Expression profiling of Wilms tumors reveals new candidate genes for different clinical parameters

artículo científico publicado en 2006

Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a putative secreted protein expressed in restricted domains of the developing and adult brain

scientific journal article

Fjx1: a notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain

scientific journal article

Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms.

artículo científico publicado en 1998

Further evidence that imbalance of WT1 isoforms may be involved in Denys – Drash syndrome

article

GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development.

artículo científico publicado en 2014

GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families

scientific article published in Nature

Gain of 1q is associated with adverse outcome in favorable histology Wilms' tumors

artículo científico publicado en 2001

Gene expression profiles of brain endothelial cells during embryonic development at bulk and single-cell levels.

artículo científico

Hey bHLH Factors in Cardiovascular Development

article

Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus

artículo científico publicado en 2015

Hey bHLH factors in cardiovascular development.

artículo científico publicado en 2002

Hey bHLH transcription factors

artículo científico

Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts

artículo científico publicado en 2005

Hey genes in cardiovascular development

artículo científico publicado en 2003

Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis

artículo científico publicado en 1999

Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti

scientific journal article

High-risk blastemal Wilms tumor can be modeled by 3D spheroid cultures in vitro

artículo científico publicado en 2019

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

artículo científico publicado en 1990

Homozygous inactivation of WT1 in a Wilms' tumor associated with the WAGR syndrome

artículo científico publicado en 1993

Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines

artículo científico publicado en 1992

Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate

artículo científico publicado en 2006

Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration

scientific article published on 07 November 2019

Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse

scientific journal article

Identification of limited regions of genetic aberrations in patients affected with Wilms' tumor using a tiling-path chromosome 22 array

Identification of the human homolog of the imprinted mouse Air non-coding RNA.

artículo científico publicado en 2008

Infrequent mutation of theWT1 gene in 77 Wilms' tumors

article

Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways

artículo científico publicado en 2008

Isolation and characterization of a cosmid contig for the GCPS gene region

Less may be more for stage I epithelial Wilms tumors

artículo científico publicado en 2020

Loss of 11q and 16q in Wilms tumors is associated with anaplasia, tumor recurrence, and poor prognosis

artículo científico publicado en 2007

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease

artículo científico publicado en 2008

Loss of heterozygosity at 2q37 in sporadic Wilms' tumor: putative role for miR-562.

artículo científico publicado en 2009

Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation

artículo científico publicado en 2018

MYCN and MAX alterations in Wilms tumor and identification of novel N-MYC interaction partners as biomarker candidates

artículo científico publicado en 2021

Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes

artículo científico publicado en 2014

Molecular analysis of E-cadherin and cadherin-11 in Wilms' tumours

artículo científico publicado en 2000

Mosaic variegated aneuploidy in mouse BubR1 deficient embryos and pregnancy loss in human

artículo científico publicado en 2014

Mouse gridlock

artículo científico publicado en 2002

Multi-omics enrichment analysis using the GeneTrail2 web service

artículo científico publicado en 2016

Multicenter study identified molecular blood-born protein signatures for Wilms Tumor

artículo científico publicado en 2011

Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors

artículo científico publicado en 2015

Mutually exclusive BCOR internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney: not the full story

artículo científico publicado en 2016

New prognostic markers revealed by evaluation of genes correlated with clinical parameters in Wilms tumors.

artículo científico publicado en 2008

Nierentumoren

Novel familial WT1 read-through mutation associated with Wilms tumor and slow progressive nephropathy

artículo científico publicado en 2005

Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers

artículo científico publicado en 2009

Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors

scientific journal article

Overlapping expression pattern of the actin organizers Spir-1 and formin-2 in the developing mouse nervous system and the adult brain

artículo científico publicado en 2004

Pericentric intrachromosomal insertion responsible for recurrence of del(11)(p13p14) in a family

artículo científico publicado en 1993

Phenotypic variability in Hey2 -/- mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome

artículo científico publicado en 2004

Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1

artículo científico publicado en 2012

Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo

scientific journal article

Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol

artículo científico publicado en 2017

Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations.

artículo científico publicado en 2018

Publisher Correction: The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol

artículo científico publicado en 2019

REGGAE: a novel approach for the identification of key transcriptional regulators

artículo científico publicado en 2018

Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants.

artículo científico publicado en 2018

Retinoic acid pathway activity in Wilms tumors and characterization of biological responses in vitro

artículo científico publicado en 2011

Sarcoma classification by DNA methylation profiling

artículo científico publicado en 2021

Sequence of the WT1 upstream region including the Wit-1 gene.

artículo científico publicado en 1993

Six new polymorphic microsatellite markers used for the integration of genetic and physical maps of human chromosome 7

scientific article published on 01 June 1996

Structure, use, and risks of biomaterial repositories of embryonal tumors

artículo científico publicado en 2006

Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor.

artículo científico publicado en 2010

Survival in patients with high-risk prostate cancer is predicted by miR-221, which regulates proliferation, apoptosis, and invasion of prostate cancer cells by inhibiting IRF2 and SOCS3.

artículo científico publicado en 2014

TP53 alterations in Wilms tumour represent progression events with strong intratumour heterogeneity that are closely linked but not limited to anaplasia

artículo científico publicado en 2017

TRIM28 haploinsufficiency predisposes to Wilms tumor

scientific article published on 14 February 2019

Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors

scientific journal article

Target genes of the WNT/beta-catenin pathway in Wilms tumors

artículo científico publicado en 2006

The Notch pathway inhibits TGFβ signaling in breast cancer through HEYL-mediated crosstalk

artículo científico publicado en 2014

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

scientific journal article

The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol

scholarly article by Gordan M. Vujanić published in October 2018

The gene encoding the GPI-anchored membrane protein p137GPI (M11S1) maps to human chromosome 11p13 and is highly conserved in the mouse

artículo científico publicado en 1996

The genomic organization and expression of the WT1 gene

artículo científico publicado el 1 de abril de 1992

The landscape of genomic alterations across childhood cancers

artículo científico publicado en 2018

The potassium channel gene HK1 maps to human chromosome 11p14.1, close to the FSHB gene

artículo científico publicado en 1992

The rodent Four-jointed ortholog Fjx1 regulates dendrite extension

The role of TCF3 as potential master regulator in blastemal Wilms tumors

The transcription factor Hey and nuclear lamins specify and maintain cell identity

artículo científico publicado en 2019

The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation

artículo científico publicado en 2016

Transcript map of a 900-kb genomic region in Xp22.1-p22.2: identification of 12 novel genes.

artículo científico publicado en 1998

Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals

artículo científico publicado en 2005

Treatment-independent miRNA signature in blood of Wilms tumor patients

artículo científico publicado en 2012

Upregulation of Soluble Vascular Endothelial Growth Factor Receptor 1 Contributes to Angiogenesis Defects in the Placenta of α 2B -Adrenoceptor–Deficient Mice

article published in 2007

Very-KIND is a novel nervous system specific guanine nucleotide exchange factor for Ras GTPases

artículo científico publicado en 2005

WTX inactivation is a frequent, but late event in Wilms tumors without apparent clinical impact

artículo científico publicado en 2009

cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region.

artículo científico publicado en 1995

her7 and hey1, but not lunatic fringe show dynamic expression during somitogenesis in medaka (Oryzias latipes).

artículo científico publicado en 2004

Lista de obras de Manfred Gessler

1q gain is a frequent finding in preoperatively treated Wilms tumors, but of limited prognostic value for risk stratification in the SIOP2001/GPOH trial

A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1

A Sequence-Ready 3-Mb PAC Contig Covering 16 Breakpoints of the Wilms Tumor/Anirida Region of Human Chromosome 11p13 ⬇️

A WAGR region gene between PAX-6 and FSHB expressed in fetal brain

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

All-trans retinoic acid treatment of Wilms tumor cells reverses expression of genes associated with high risk and relapse in vivo

An Ordered NotI Fragment Map of Human Chromosome Band 11p15

An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation

An integrated YAC clone contig for the WAGR region on human chromosome 11p13-p14.1.

Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos

Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information

Author Correction: The landscape of genomic alterations across childhood cancers

Autoantibody signature differentiates Wilms tumor patients from neuroblastoma patients

COUP-TFII orchestrates venous and lymphatic endothelial identity by homo- or hetero-dimerisation with PROX1.

Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites

Characterization of hey bHLH genes in teleost fish

Characterization of primary Wilms tumor cultures as an in vitro model

Characterization of the chromosomal translocation t(10;17)(q22;p13) in clear cell sarcoma of kidney

Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family

Chibby, a novel antagonist of the Wnt pathway, is not involved in Wilms tumor development.

Cloning and expression analysis of the mouse stroma marker Snep encoding a novel nidogen domain protein

Cloning of breakpoints of a chromosome translocation identifies the AN2 locus

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition

Combining miRNA and mRNA Expression Profiles in Wilms Tumor Subtypes

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

Confirmation of the localization of the human recombination activating gene 1 (RAG1) to chromosome 11p13

CpG island clones for chromosome 11p--a resource for mapping and gene identification

Defective autophagy through epg5 mutation results in failure to reduce germ plasm and mitochondria

Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt)

Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors

Developmental expression and biochemical characterization of Emu family members

Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family.

Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors

Differential expression of the cellular oncogenes c-src and c-yes in embryonal and adult chicken tissues ⬇️

Distinct molecular origins for Denys-Drash and Frasier syndromes

Dll1 and Dll4: similar, but not the same

DrugTargetInspector: An assistance tool for patient treatment stratification

ETV6-NTRK3 in congenital mesoblastic nephroma: A report of the SIOP/GPOH nephroblastoma study.

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development

Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila

Expression patterns of the mouse Spir-2 actin nucleator

Expression profiling of Wilms tumors reveals new candidate genes for different clinical parameters

Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a putative secreted protein expressed in restricted domains of the developing and adult brain

Fjx1: a notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain

Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms.

Further evidence that imbalance of WT1 isoforms may be involved in Denys – Drash syndrome

GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development.

GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families

Gain of 1q is associated with adverse outcome in favorable histology Wilms' tumors

Gene expression profiles of brain endothelial cells during embryonic development at bulk and single-cell levels.

Hey bHLH Factors in Cardiovascular Development

Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus

Hey bHLH factors in cardiovascular development.

Hey bHLH transcription factors

Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts

Hey genes in cardiovascular development

Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis

Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti

High-risk blastemal Wilms tumor can be modeled by 3D spheroid cultures in vitro

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

Homozygous inactivation of WT1 in a Wilms' tumor associated with the WAGR syndrome

Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines

Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate

Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration

Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse

Identification of limited regions of genetic aberrations in patients affected with Wilms' tumor using a tiling-path chromosome 22 array

Identification of the human homolog of the imprinted mouse Air non-coding RNA.

Infrequent mutation of theWT1 gene in 77 Wilms' tumors

Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways

Isolation and characterization of a cosmid contig for the GCPS gene region

Less may be more for stage I epithelial Wilms tumors

Loss of 11q and 16q in Wilms tumors is associated with anaplasia, tumor recurrence, and poor prognosis

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease

Loss of heterozygosity at 2q37 in sporadic Wilms' tumor: putative role for miR-562.

Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation

MYCN and MAX alterations in Wilms tumor and identification of novel N-MYC interaction partners as biomarker candidates

Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes