Lista de obras - Gijsbertus van der Horst

A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue

artículo científico publicado en 2002

A baculovirus photolyase with DNA repair activity and circadian clock regulatory function.

artículo científico publicado en 2012

A day and night difference in the response of the hepatic transcriptome to cyclophosphamide treatment

artículo científico publicado en 2014

Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.

artículo científico publicado en 2011

Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction

scientific article published on 22 August 2005

Age-Related Neuronal Degeneration: Complementary Roles of Nucleotide Excision Repair and Transcription-Coupled Repair in Preventing Neuropathology ⬇️

artículo científico publicado el 8 de diciembre de 2011

Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy mice

artículo científico publicado en 2012

Altered phase-relationship between peripheral oscillators and environmental time in Cry1 or Cry2 deficient mouse models for early and late chronotypes

artículo científico publicado en 2013

An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.

artículo científico publicado en 2008

An observational study on disturbed peripheral circadian rhythms in hemodialysis patients

artículo científico publicado en 2015

Assembling a clock for all seasons: are there M and E oscillators in the genes?

artículo científico publicado en 2001

Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression.

artículo científico publicado en 2003

Biochemical and biological characterization of wild-type and ATPase-deficient Cockayne syndrome B repair protein.

artículo científico publicado en 1998

Biomarkers for circadian rhythm disruption independent of time of day

artículo científico publicado en 2015

Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice

artículo científico publicado en 2011

CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock

artículo científico publicado en 2015

Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice

scientific journal article

Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency

artículo científico publicado en 2014

Cell-free translation of human lysosomal alpha-glucosidase: evidence for reduced precursor synthesis in an adult patient with glycogenosis type II

scientific article published on 01 November 1987

Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.

artículo científico publicado en 2008

Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice.

artículo científico publicado en 2015

Circadian Variation in Human Milk Composition, a Systematic Review

scientific article published on 04 August 2020

Circadian behavioral rhythms in Cry1/Cry2 double-deficient mice induced by methamphetamine.

artículo científico publicado en 2008

Circadian clock genes directly regulate expression of the Na(+)/H(+) exchanger NHE3 in the kidney

scientific journal article

Circadian variation in tamoxifen pharmacokinetics in mice and breast cancer patients.

artículo científico publicado en 2015

Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice.

artículo científico publicado en 2015

Cockayne syndrome: defective repair of transcription? ⬇️

artículo científico publicado el 16 de julio de 1997

Colorectal liver metastases with a disrupted circadian rhythm phase shift the peripheral clock in liver and kidney.

artículo científico publicado en 2014

Critical cholangiocarcinogenesis control by cryptochrome clock genes

artículo científico publicado en 2017

DNA damage and ageing: new-age ideas for an age-old problem

artículo científico publicado en 2008

Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition

scientific journal article

Degradation of gangliosides by the lysosomal sialidase requires an activator protein

artículo científico publicado en 1992

Delayed and accelerated aging share common longevity assurance mechanisms

artículo científico publicado en 2008

Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage

scientific journal article

Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis

scientific journal article

Differential ultraviolet-B-induced immunomodulation in XPA, XPC, and CSB DNA repair-deficient mice

artículo científico publicado en 2001

Disruption of clock gene expression in human colorectal liver metastases.

artículo científico publicado en 2016

Disruption of the Cockayne syndrome B gene impairs spontaneous tumorigenesis in cancer-predisposed Ink4a/ARF knockout mice

artículo científico publicado en 2001

Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance in photolyase transgenic mice.

artículo científico publicado en 2002

Expression of cDNA encoding the human "protective protein" associated with lysosomal beta-galactosidase and neuraminidase: homology to yeast proteases

artículo científico publicado en 1988

Flexible phase adjustment of circadian albumin D site-binding protein (DBP) gene expression by CRYPTOCHROME1

artículo científico publicado en 2010

Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance.

artículo científico publicado en 2006

Functionality of cryopreserved juvenile ovaries from mutant mice in different genetic background strains after allotransplantation.

artículo científico publicado en 2009

Genome instability and accelerated aging: The relevance for normal aging and life span extension

High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice

scientific journal article

Human papillomavirus mediated inhibition of DNA damage sensing and repair drives skin carcinogenesis.

artículo científico publicado en 2015

Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

scientific journal article

Identification of Cyclobutane Pyrimidine Dimer-Responsive Genes Using UVB-Irradiated Human Keratinocytes Transfected with In Vitro-Synthesized Photolyase mRNA.

artículo científico publicado en 2015

Impact of the circadian clock on in vitro genotoxic risk assessment assays.

artículo científico publicado en 2009

Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice

artículo científico publicado en 2006

Initiation of transcription in yeast mitochondria: analysis of origins of replication and of genes coding for a messenger RNA and a transfer RNA ⬇️

artículo científico publicado el 24 de febrero de 1984

Interacting molecular loops in the mammalian circadian clock

artículo científico publicado en 2000

Isolation and characterization of nuclear genes coding for subunits of the yeast ubiquinol-cytochrome c reductase complex

scientific article published on 01 December 1982

Mammalian cryptochromes impinge on cell cycle progression in a circadian clock-independent manner

scientific article published on 01 November 2011

Measurement of internal body time by blood metabolomics.

scholarly article

Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B.

artículo científico publicado en 2002

Morquio B syndrome: a primary defect in beta-galactosidase

artículo científico publicado en 1983

Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice.

artículo científico publicado en 2016

New aspects on mechanisms of chemical carcinogenesis: emphasis on species and gender/sex differences and developmental/aging determinants

artículo científico publicado en 2008

Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

artículo científico publicado en 2002

Nucleocytoplasmic shuttling and phosphorylation of BMAL1 are regulated by circadian clock in cultured fibroblasts.

artículo científico publicado en 2003

Optimization of irinotecan chronotherapy with P-glycoprotein inhibition.

artículo científico publicado en 2013

Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle.

artículo científico publicado en 2014

Phase responses to light pulses in mice lacking functional per or cry genes.

artículo científico publicado en 2004

Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock

artículo científico publicado en 1999

Photoaffinity labeling of the lysosomal neuraminidase from bovine testis

scientific article published on 01 December 1990

Powerful skin cancer protection by a CPD-photolyase transgene.

artículo científico publicado en 2005

Relationship Between Sunitinib Pharmacokinetics and Administration Time: Preclinical and Clinical Evidence.

artículo científico publicado en 2015

Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex.

artículo científico publicado en 2004

Repair characteristics and differentiation propensity of long-term cultures of epidermal keratinocytes derived from normal and NER-deficient mice

artículo científico publicado en 2005

Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for Cockayne syndrome

scientific journal article

SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities.

artículo científico publicado en 2013

The BMAL1 C terminus regulates the circadian transcription feedback loop.

artículo científico publicado en 2006

The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genes.

artículo científico publicado en 2001

The Potorous CPD Photolyase Rescues a Cryptochrome-Deficient Mammalian Circadian Clock ⬇️

artículo científico publicado el 16 de agosto de 2011

The circadian clock components CRY1 and CRY2 are necessary to sustain sex dimorphism in mouse liver metabolism.

artículo científico publicado en 2009

The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis.

artículo científico publicado en 2014

The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation

artículo científico publicado en 2010

The cross talk between pathways in the repair of 8-oxo-7,8-dihydroguanine in mouse and human cells.

artículo científico publicado en 2012

The cryptochromes: blue light photoreceptors in plants and animals.

artículo científico publicado en 2011

The nucleotide excision repair protein XPC is essential for bulky DNA adducts to promote interleukin-6 expression via the activation of p38-SAPK.

artículo científico publicado en 2015

Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging

artículo científico publicado en 2016

Transfection of pseudouridine-modified mRNA encoding CPD-photolyase leads to repair of DNA damage in human keratinocytes: a new approach with future therapeutic potential

artículo científico publicado en 2013

UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice.

artículo científico publicado en 2002

Vagal regulation of respiratory clocks in mice.

artículo científico publicado en 2007

Lista de obras de Gijsbertus van der Horst

A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue

A baculovirus photolyase with DNA repair activity and circadian clock regulatory function.

A day and night difference in the response of the hepatic transcriptome to cyclophosphamide treatment

Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.

Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction

Age-Related Neuronal Degeneration: Complementary Roles of Nucleotide Excision Repair and Transcription-Coupled Repair in Preventing Neuropathology ⬇️

Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy mice

Altered phase-relationship between peripheral oscillators and environmental time in Cry1 or Cry2 deficient mouse models for early and late chronotypes

An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.

An observational study on disturbed peripheral circadian rhythms in hemodialysis patients

Assembling a clock for all seasons: are there M and E oscillators in the genes?

Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression.

Biochemical and biological characterization of wild-type and ATPase-deficient Cockayne syndrome B repair protein.

Biomarkers for circadian rhythm disruption independent of time of day

Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice

CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock

Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice

Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency

Cell-free translation of human lysosomal alpha-glucosidase: evidence for reduced precursor synthesis in an adult patient with glycogenosis type II

Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.

Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice.

Circadian Variation in Human Milk Composition, a Systematic Review

Circadian behavioral rhythms in Cry1/Cry2 double-deficient mice induced by methamphetamine.

Circadian clock genes directly regulate expression of the Na(+)/H(+) exchanger NHE3 in the kidney

Circadian variation in tamoxifen pharmacokinetics in mice and breast cancer patients.

Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice.

Cockayne syndrome: defective repair of transcription? ⬇️

Colorectal liver metastases with a disrupted circadian rhythm phase shift the peripheral clock in liver and kidney.

Critical cholangiocarcinogenesis control by cryptochrome clock genes

DNA damage and ageing: new-age ideas for an age-old problem

Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition

Degradation of gangliosides by the lysosomal sialidase requires an activator protein

Delayed and accelerated aging share common longevity assurance mechanisms

Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage

Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis

Differential ultraviolet-B-induced immunomodulation in XPA, XPC, and CSB DNA repair-deficient mice

Disruption of clock gene expression in human colorectal liver metastases.

Disruption of the Cockayne syndrome B gene impairs spontaneous tumorigenesis in cancer-predisposed Ink4a/ARF knockout mice

Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance in photolyase transgenic mice.

Expression of cDNA encoding the human "protective protein" associated with lysosomal beta-galactosidase and neuraminidase: homology to yeast proteases

Flexible phase adjustment of circadian albumin D site-binding protein (DBP) gene expression by CRYPTOCHROME1

Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance.

Functionality of cryopreserved juvenile ovaries from mutant mice in different genetic background strains after allotransplantation.

Genome instability and accelerated aging: The relevance for normal aging and life span extension

High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice

Human papillomavirus mediated inhibition of DNA damage sensing and repair drives skin carcinogenesis.

Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

Identification of Cyclobutane Pyrimidine Dimer-Responsive Genes Using UVB-Irradiated Human Keratinocytes Transfected with In Vitro-Synthesized Photolyase mRNA.

Impact of the circadian clock on in vitro genotoxic risk assessment assays.

Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice

Initiation of transcription in yeast mitochondria: analysis of origins of replication and of genes coding for a messenger RNA and a transfer RNA ⬇️

Interacting molecular loops in the mammalian circadian clock

Isolation and characterization of nuclear genes coding for subunits of the yeast ubiquinol-cytochrome c reductase complex

Mammalian cryptochromes impinge on cell cycle progression in a circadian clock-independent manner

Measurement of internal body time by blood metabolomics.

Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B.

Morquio B syndrome: a primary defect in beta-galactosidase

Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice.

New aspects on mechanisms of chemical carcinogenesis: emphasis on species and gender/sex differences and developmental/aging determinants

Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

Nucleocytoplasmic shuttling and phosphorylation of BMAL1 are regulated by circadian clock in cultured fibroblasts.

Optimization of irinotecan chronotherapy with P-glycoprotein inhibition.

Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle.

Phase responses to light pulses in mice lacking functional per or cry genes.

Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock

Photoaffinity labeling of the lysosomal neuraminidase from bovine testis

Powerful skin cancer protection by a CPD-photolyase transgene.

Relationship Between Sunitinib Pharmacokinetics and Administration Time: Preclinical and Clinical Evidence.

Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex.

Repair characteristics and differentiation propensity of long-term cultures of epidermal keratinocytes derived from normal and NER-deficient mice

Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for Cockayne syndrome

SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities.

The BMAL1 C terminus regulates the circadian transcription feedback loop.

The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genes.

The Potorous CPD Photolyase Rescues a Cryptochrome-Deficient Mammalian Circadian Clock ⬇️

The circadian clock components CRY1 and CRY2 are necessary to sustain sex dimorphism in mouse liver metabolism.

The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis.

The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation

The cross talk between pathways in the repair of 8-oxo-7,8-dihydroguanine in mouse and human cells.