Lista de obras - Nick Holford - Dominio Público Uruguay

A Pharmacokinetic Standard for Babies and Adults ⬇️

artículo científico publicado el 6 de mayo de 2013

A Time to Event Tutorial for Pharmacometricians ⬇️

artículo científico publicado el 15 de mayo de 2013

A combined pharmacokinetic model for the hypoxia-targeted prodrug PR-104A in humans, dogs, rats and mice predicts species differences in clearance and toxicity.

artículo científico publicado en 2010

A comparison of bootstrap approaches for estimating uncertainty of parameters in linear mixed-effects models.

artículo científico publicado en 2013

A hemodynamic model to guide blood pressure control during deliberate hypotension with sodium nitroprusside in children.

artículo científico publicado en 2015

A pharmacodynamic model for the time course of tumor shrinkage by gemcitabine + carboplatin in non-small cell lung cancer patients.

artículo científico publicado en 2008

A procedure for generating bootstrap samples for the validation of nonlinear mixed-effects population models.

artículo científico publicado en 1999

A review of mixed-effects models of tumor growth and effects of anticancer drug treatment used in population analysis.

artículo científico publicado en 2014

A size standard for pharmacokinetics.

artículo científico publicado en 1996

Acetaminophen analgesia in children: placebo effect and pain resolution after tonsillectomy.

artículo científico publicado en 2001

Adrenal venography and ultrasound in the investigation of the adrenal gland: an analysis of 58 cases

scientific article published on 01 June 1975

Allometric size: The scientific theory and extension to normal fat mass

artículo científico publicado en 2017

Analysis of population pharmacokinetic data using NONMEM and WinBUGS.

artículo científico publicado en 2005

Antagonism of some spasmogens of the rat seminal vesicle.

artículo científico publicado en 1972

Application of clinical trial simulation to compare proof-of-concept study designs for drugs with a slow onset of effect; an example in Alzheimer's disease

artículo científico publicado en 2006

Aspects of theophylline clearance in children.

artículo científico publicado en 1997

Authors' response to Marras and Oakes, ‘piecing together the puzzle of progression and mortality in Parkinson's disease’ ⬇️

artículo científico publicado el 1 de mayo de 2013

Behavioural tolerance to morphine analgesia is supraspinally mediated: a quantitative analysis of dose-response relationships

artículo científico publicado en 1989

Benzodiazepine receptors in the human cerebellar cortex: a quantitative autoradiographic and pharmacological study demonstrating the predominance of type I receptors

artículo científico publicado en 1987

Busulfan in infant to adult hematopoietic cell transplant recipients: a population pharmacokinetic model for initial and Bayesian dose personalization.

artículo científico publicado en 2013

Caffeine overdose in a premature infant: clinical course and pharmacokinetics

artículo científico publicado en 1999

Clinical pharmacokinetics and pharmacodynamics of warfarin. Understanding the dose-effect relationship.

artículo científico publicado en 1986

Clinical pharmacology = disease progression + drug action ⬇️

artículo científico publicado el 1 de enero de 2015

Clinical pharmacology: principles and practice of drug therapy in medical education.

artículo científico publicado en 2002

Complex PK/PD models--an alcoholic experience

artículo científico publicado el 1 de octubre de 1997

Concepts and usefulness of pharmacokinetic-pharmacodynamic modelling.

artículo científico publicado en 1990

DRUGMODEL.

artículo científico publicado en 1981

Determination of maximum effect

artículo científico publicado en 2002

Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children.

artículo científico publicado en 2004

Dexmedetomidine pharmacokinetics in the obese

artículo científico publicado en 2015

Disease progression and neuroscience.

artículo científico

Disease progression and pharmacodynamics in Parkinson disease - evidence for functional protection with levodopa and other treatments

artículo científico publicado en 2006

Disposition of total and unbound prednisolone in renal transplant patients receiving anticonvulsants

scientific article published on 01 January 1984

Divergence in pharmacokinetic parameters of quinidine obtained by specific and nonspecific assay methods

artículo científico publicado en 1979

Does saturable formation of gemcitabine triphosphate occur in patients?

artículo científico publicado en 2008

Dose-dependent elimination of propranolol and its major metabolites in humans

scientific article published on 01 July 1983

Dosing in children

artículo científico publicado en 2010

Drug concentration, binding, and effect in vivo

artículo científico publicado en 1984

Drug treatment effects on disease progression.

artículo científico publicado en 2001

Effects of antiarrhythmic drugs on atrioventricular conduction in patients with acute myocardial infarction.

artículo científico publicado en 1980

Erratum to: does saturable formation of gemcitabine triphosphate occur in patients?

scientific article published on 01 March 2015

Evaluation of a morphine maturation model for the prediction of morphine clearance in children.

artículo científico publicado en 2011

Evaluation of bootstrap methods for estimating uncertainty of parameters in nonlinear mixed-effects models: a simulation study in population pharmacokinetics.

artículo científico publicado en 2013

External Evaluation of Population Pharmacokinetic Models of Vancomycin in Neonates: The transferability of published models to different clinical settings.

artículo científico publicado en 2013

Features and toxicokinetics of clozapine in overdose.

artículo científico publicado en 1998

Gastrointestinal absorption of quinidine from some solutions and commercial tablets

scientific article published on 01 June 1980

Getting the dose right for obese children.

artículo científico publicado en 2016

Holford NHG and Sheiner LB "Understanding the Dose-Effect Relationship-Clinical Application of Pharmacokinetic-Pharmacodynamic Models", Clin Pharmacokin 6:429-453 (1981)-The Backstory.

artículo científico publicado en 2011

Importance of hematocrit for a tacrolimus target concentration strategy.

scientific article published on 27 September 2013

Improved liquid-chromatographic assay of quinidine and its metabolites in biological fluids

artículo científico publicado en 1982

Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling

artículo científico publicado en 2014

Induction of quinidine metabolism and plasma protein binding by phenobarbital in dogs

artículo científico publicado en 1984

Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model.

artículo científico publicado en 2010

Input from the deep south compartment. A personal viewpoint

scientific article published on 01 September 1995

Interpreting the results of Parkinson's disease clinical trials: Time for a change ⬇️

artículo científico publicado el 2 de marzo de 2011

Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics.

artículo científico publicado en 2007

Leaving no stone unturned, or extracting blood from stone?

scientific article published on 23 November 2009

Levodopa slows progression of Parkinson's disease: external validation by clinical trial simulation

artículo científico publicado en 2007

Limited predictability of amikacin clearance in extreme premature neonates at birth

artículo científico publicado en 2006

Mechanisms of enhancement of the antitumour activity of melphalan by the tumour-blood-flow inhibitor 5,6-dimethylxanthenone-4-acetic acid

artículo científico publicado en 1997

Methodologic aspects of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine.

scientific article published on December 1992

Mixed linear and non-linear disposition of lazabemide, a reversible and selective inhibitor of monoamine oxidase B

artículo científico publicado en 1994

Modeling helps in understanding antidepressants.

artículo científico publicado en 2012

Models for describing absorption rate and estimating extent of bioavailability: application to cefetamet pivoxil

artículo científico publicado en 1992

More on heparin lock

artículo científico publicado en 1977

Negligible excretion of unchanged ketoprofen, naproxen, and probenecid in urine

scientific article published on 01 November 1980

Negligible impact of birth on renal function and drug metabolism

scientific article published on 10 October 2018

Opiate receptor binding-effect relationship: sufentanil and etorphine produce analgesia at the mu-site with low fractional receptor occupancy.

artículo científico publicado en 1984

PKPD model of interleukin-21 effects on thermoregulation in monkeys--application and evaluation of stochastic differential equations.

artículo científico publicado en 2006

Paracetamol and metabolite pharmacokinetics in infants.

artículo científico publicado en 2003

Paracetamol plasma and cerebrospinal fluid pharmacokinetics in children ⬇️

artículo científico publicado el 1 de septiembre de 1998

Pharmacodynamics of lazabemide, a reversible and selective inhibitor of monoamine oxidase B

artículo científico publicado en 1994

Pharmacokinetic-pharmacodynamic analysis of unbound disopyramide directly measured in serial plasma samples in man

artículo científico publicado en 1984

Pharmacokinetics and pharmacodynamics of 1,25-dihydroxyvitamin D3 in the chick

scientific article published on 01 September 1982

Pharmacokinetics and pharmacodynamics of quinidine and its metabolite, quinidine-N-oxide, in beagle dogs

artículo científico publicado en 1984

Pharmacokinetics of prednisolone and endogenous hydrocortisone levels in cushingoid and non-cushingoid patients

artículo científico publicado en 1981

Pharmacokinetics of quinidine and three of its metabolites in man.

artículo científico publicado en 1984

Pharmacometrics: opportunity for reducing disease burden in the developing world: the case of Africa

artículo científico publicado en 2013

Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics

artículo científico publicado en 2006

Plasma nitrate clearance in mice: modeling of the systemic production of nitrate following the induction of nitric oxide synthesis

scientific article published on 01 January 1995

Population PKPD modelling of the long-term hypoglycaemic effect of gliclazide given as a once-a-day modified release (MR) formulation.

artículo científico publicado en 2003

Population clinical pharmacology of children: general principles.

artículo científico publicado en 2006

Population clinical pharmacology of children: modelling covariate effects.

artículo científico publicado en 2006

Population pharmacokinetic and adverse event analysis of topotecan in patients with solid tumors.

artículo científico publicado en 2002

Population pharmacokinetics of humanized monoclonal antibody HuCC49deltaCH2 and murine antibody CC49 in colorectal cancer patients

artículo científico publicado en 2007

Postoperative analgesia using diclofenac and acetaminophen in children.

artículo científico publicado en 2014

Predicting concentrations in children presenting with acetaminophen overdose

artículo científico publicado en 1999

Predicting weight using postmenstrual age--neonates to adults.

artículo científico publicado en 2011

Prediction of Fat-Free Mass in Children

artículo científico publicado en 2015

Prediction of morphine dose in humans.

artículo científico publicado en 2011

Prediction of the outcome of a phase 3 clinical trial of an antischizophrenic agent (quetiapine fumarate) by simulation with a population pharmacokinetic and pharmacodynamic model.

artículo científico publicado en 2000

Prednisolone pharmacodynamics assessed by inhibition of the mixed lymphocyte reaction

artículo científico publicado en 1982

Prednisone and prednisolone bioavailability in renal transplant patients

artículo científico publicado en 1982

Progression of motor and nonmotor features of Parkinson's disease and their response to treatment ⬇️

artículo científico publicado el 1 de agosto de 2012

Quantitative analysis of the disopyramide concentration-effect relationship

artículo científico publicado en 1980

Quantitative justification for target concentration intervention--parameter variability and predictive performance using population pharmacokinetic models for aminoglycosides.

artículo científico publicado en 2004

Quinidine pharmacokinetics in man: choice of a disposition model and absolute bioavailability studies

scientific article published on 01 August 1979

Quinidine-digoxin interaction

artículo científico publicado en 1980

Rectal acetaminophen pharmacokinetics

artículo científico publicado en 1998

Rectal paracetamol dosing regimens: determination by computer simulation.

artículo científico publicado en 1997

Relationship of metabolism of 2'-, 3'- and 5'-adenine nucleotides to presynaptic inhibition of transmitter release in rat vas deferens

artículo científico publicado en 1986

Relationship of muscle strength to potassium concentration in a hypokalaemic infant

artículo científico publicado en 1997

Relative bioavailability of chlorthalidone in humans: adverse influence of polyethylene glycol

artículo científico publicado en 1982

Relevance of pharmacodynamic principles in therapeutics.

artículo científico publicado en 1991

Response to Diaz and de Leon "the mathematics of drug dose individualization should be built with random effects linear models".

artículo científico publicado en 2013

Results and validation of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine ⬇️

artículo científico publicado el 1 de diciembre de 1992

Review: efficient rehabilitation trial designs using disease progress modeling: a pediatric traumatic brain injury example

scientific article published on 03 December 2009

Safe and effective variability-a criterion for dose individualization

artículo científico publicado en 2012

Simulation of correlated continuous and categorical variables using a single multivariate distribution

artículo científico publicado en 2006

Size, myths and the clinical pharmacokinetics of analgesia in paediatric patients.

artículo científico publicado en 1997

Slow release theophylline (Theo-24)

scientific article published on 01 March 1986

Slow-release theophylline (THEO-24)

artículo científico publicado en 1986

Stereoselective disposition and glucuronidation of propranolol in humans

artículo científico publicado en 1982

TDM is dead. Long live TCI!

artículo científico publicado en 2020

Tacrolimus pharmacokinetics after kidney transplantation--Influence of changes in haematocrit and steroid dose

artículo científico publicado en 2015

Target concentration intervention: beyond Y2K

artículo científico publicado en 1999

The Absence of Effect of Azathioprine on Prednisolone Pharmacokinetics Following Maintenance Prednisone Doses in Kidney Transplant Patients ⬇️

artículo científico publicado el 1 de mayo de 1984

The Effect of Size, Maturation, Global Asphyxia, Cerebral Ischemia, and Therapeutic Hypothermia on the Pharmacokinetics of High-Dose Recombinant Erythropoietin in Fetal Sheep

artículo científico publicado en 2020

The Pharmacokinetics of Remifentanil in Patients Undergoing Coronary Artery Bypass Grafting with Cardiopulmonary Bypass ⬇️

artículo científico publicado el 1 de noviembre de 2001

The SLCO1B1 rs4149032 polymorphism is highly prevalent in South Africans and is associated with reduced rifampin concentrations: dosing implications.

artículo científico publicado en 2011

The digoxin concentration: before and after the fact

artículo científico publicado el 1 de octubre de 1977

The effect of quinidine and its metabolites on the electrocardiogram and systolic time intervals: concentration--effect relationships.

artículo científico publicado en 1981

The effect of tacrine and lecithin in Alzheimer's disease. A population pharmacodynamic analysis of five clinical trials.

artículo científico publicado en 1994

The ghosts of departed quantities: approaches to dealing with observations below the limit of quantitation.

artículo científico publicado en 2012

The population pharmacokinetics of allopurinol and oxypurinol in patients with gout

artículo científico publicado en 2013

The quinidine-digoxin interaction

artículo científico publicado en 1980

The response to levodopa in Parkinson's disease: imposing pharmacological law and order

artículo científico publicado en 1996

The target concentration approach to clinical drug development.

artículo científico publicado en 1995

The use of model-based tumor-size metrics to predict survival.

artículo científico publicado en 2014

Theophylline target concentration in severe airways obstruction - 10 or 20 mg/L? A randomised concentration-controlled trial

scientific article published on 01 December 1993

Time and theophylline concentration help explain the recovery of peak flow following acute airways obstruction. Population analysis of a randomised concentration controlled trial

artículo científico publicado en 1993

Time for quantitative clinical pharmacology: a proposal for a pharmacometrics curriculum.

artículo científico publicado en 2007

Tips and traps analyzing pediatric PK data.

artículo científico publicado en 2011

Understanding dosing: children are small adults, neonates are immature children.

artículo científico publicado en 2013

Unit dose calendar packaging and elderly patient compliance

artículo científico publicado el 27 de noviembre de 1991

Unit dose dispensing

artículo científico publicado en 1991

Variability of concentrations after rectal paracetamol

artículo científico publicado el 1 de enero de 1998

Volume shifts and protein binding estimates using equilibrium dialysis: application to prednisolone binding in humans

artículo científico publicado en 1983

Vz, the terminal phase volume: time for its terminal phase?

artículo científico publicado en 2001

What is the best size predictor for dose in the obese child?

artículo científico publicado en 2017

beta-blockers vs calcium channel blockers vs ACE inhibitors

artículo científico publicado en 1992

Farmacocinética del paracetamol rectal después de una cirugía mayor en niños.

artículo científico publicado en 1995

Lista de obras de Nick Holford

A Pharmacokinetic Standard for Babies and Adults ⬇️

A Time to Event Tutorial for Pharmacometricians ⬇️

A combined pharmacokinetic model for the hypoxia-targeted prodrug PR-104A in humans, dogs, rats and mice predicts species differences in clearance and toxicity.

A comparison of bootstrap approaches for estimating uncertainty of parameters in linear mixed-effects models.

A hemodynamic model to guide blood pressure control during deliberate hypotension with sodium nitroprusside in children.

A pharmacodynamic model for the time course of tumor shrinkage by gemcitabine + carboplatin in non-small cell lung cancer patients.

A procedure for generating bootstrap samples for the validation of nonlinear mixed-effects population models.

A review of mixed-effects models of tumor growth and effects of anticancer drug treatment used in population analysis.

A size standard for pharmacokinetics.

Acetaminophen analgesia in children: placebo effect and pain resolution after tonsillectomy.

Adrenal venography and ultrasound in the investigation of the adrenal gland: an analysis of 58 cases

Allometric size: The scientific theory and extension to normal fat mass

Analysis of population pharmacokinetic data using NONMEM and WinBUGS.

Antagonism of some spasmogens of the rat seminal vesicle.

Application of clinical trial simulation to compare proof-of-concept study designs for drugs with a slow onset of effect; an example in Alzheimer's disease

Aspects of theophylline clearance in children.

Authors' response to Marras and Oakes, ‘piecing together the puzzle of progression and mortality in Parkinson's disease’ ⬇️

Behavioural tolerance to morphine analgesia is supraspinally mediated: a quantitative analysis of dose-response relationships

Benzodiazepine receptors in the human cerebellar cortex: a quantitative autoradiographic and pharmacological study demonstrating the predominance of type I receptors

Busulfan in infant to adult hematopoietic cell transplant recipients: a population pharmacokinetic model for initial and Bayesian dose personalization.

Caffeine overdose in a premature infant: clinical course and pharmacokinetics

Clinical pharmacokinetics and pharmacodynamics of warfarin. Understanding the dose-effect relationship.

Clinical pharmacology = disease progression + drug action ⬇️

Clinical pharmacology: principles and practice of drug therapy in medical education.

Complex PK/PD models--an alcoholic experience

Concepts and usefulness of pharmacokinetic-pharmacodynamic modelling.

DRUGMODEL.

Determination of maximum effect

Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children.

Dexmedetomidine pharmacokinetics in the obese

Disease progression and neuroscience.

Disease progression and pharmacodynamics in Parkinson disease - evidence for functional protection with levodopa and other treatments

Disposition of total and unbound prednisolone in renal transplant patients receiving anticonvulsants

Divergence in pharmacokinetic parameters of quinidine obtained by specific and nonspecific assay methods

Does saturable formation of gemcitabine triphosphate occur in patients?

Dose-dependent elimination of propranolol and its major metabolites in humans

Dosing in children

Drug concentration, binding, and effect in vivo

Drug treatment effects on disease progression.

Effects of antiarrhythmic drugs on atrioventricular conduction in patients with acute myocardial infarction.

Erratum to: does saturable formation of gemcitabine triphosphate occur in patients?

Evaluation of a morphine maturation model for the prediction of morphine clearance in children.

Evaluation of bootstrap methods for estimating uncertainty of parameters in nonlinear mixed-effects models: a simulation study in population pharmacokinetics.

External Evaluation of Population Pharmacokinetic Models of Vancomycin in Neonates: The transferability of published models to different clinical settings.

Features and toxicokinetics of clozapine in overdose.

Gastrointestinal absorption of quinidine from some solutions and commercial tablets

Getting the dose right for obese children.

Holford NHG and Sheiner LB "Understanding the Dose-Effect Relationship-Clinical Application of Pharmacokinetic-Pharmacodynamic Models", Clin Pharmacokin 6:429-453 (1981)-The Backstory.

Importance of hematocrit for a tacrolimus target concentration strategy.

Improved liquid-chromatographic assay of quinidine and its metabolites in biological fluids

Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling

Induction of quinidine metabolism and plasma protein binding by phenobarbital in dogs

Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model.

Input from the deep south compartment. A personal viewpoint

Interpreting the results of Parkinson's disease clinical trials: Time for a change ⬇️

Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics.

Leaving no stone unturned, or extracting blood from stone?

Levodopa slows progression of Parkinson's disease: external validation by clinical trial simulation

Limited predictability of amikacin clearance in extreme premature neonates at birth

Mechanisms of enhancement of the antitumour activity of melphalan by the tumour-blood-flow inhibitor 5,6-dimethylxanthenone-4-acetic acid

Methodologic aspects of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine.

Mixed linear and non-linear disposition of lazabemide, a reversible and selective inhibitor of monoamine oxidase B

Modeling helps in understanding antidepressants.

Models for describing absorption rate and estimating extent of bioavailability: application to cefetamet pivoxil

More on heparin lock

Negligible excretion of unchanged ketoprofen, naproxen, and probenecid in urine

Negligible impact of birth on renal function and drug metabolism

Opiate receptor binding-effect relationship: sufentanil and etorphine produce analgesia at the mu-site with low fractional receptor occupancy.

PKPD model of interleukin-21 effects on thermoregulation in monkeys--application and evaluation of stochastic differential equations.

Paracetamol and metabolite pharmacokinetics in infants.

Paracetamol plasma and cerebrospinal fluid pharmacokinetics in children ⬇️

Pharmacodynamics of lazabemide, a reversible and selective inhibitor of monoamine oxidase B

Pharmacokinetic-pharmacodynamic analysis of unbound disopyramide directly measured in serial plasma samples in man

Pharmacokinetics and pharmacodynamics of 1,25-dihydroxyvitamin D3 in the chick

Pharmacokinetics and pharmacodynamics of quinidine and its metabolite, quinidine-N-oxide, in beagle dogs

Pharmacokinetics of prednisolone and endogenous hydrocortisone levels in cushingoid and non-cushingoid patients

Pharmacokinetics of quinidine and three of its metabolites in man.

Pharmacometrics: opportunity for reducing disease burden in the developing world: the case of Africa

Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics