Lista de obras - Consuelo Gajate - Dominio Público Uruguay

Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy

artículo científico publicado en 2016

Antitumor activity of Lepidium latifolium and identification of the epithionitrile 1-cyano-2,3-epithiopropane as its major active component.

artículo científico publicado en 2017

Antitumor alkyl ether lipid edelfosine: tissue distribution and pharmacokinetic behavior in healthy and tumor-bearing immunosuppressed mice.

artículo científico publicado en 2009

Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum.

artículo científico publicado en 2011

Apoptotic mechanisms are involved in the death of Strongyloides venezuelensis after triggering of nitric oxide.

artículo científico publicado en 2012

Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH(3) (edelfosine), a proapoptotic agent in tumor cells

artículo científico publicado en 2002

C-Fos is not essential for apoptosis.

artículo científico publicado en 1996

Cytochrome b co-fractionates with gelatinase-containing granules in human neutrophils

scientific article published on 01 June 1991

Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy

artículo científico publicado en 2005

Cytotoxicity of an Anti-cancer Lysophospholipid through Selective Modification of Lipid Raft Composition

artículo científico publicado en 2005

DNA and non-DNA targets in the mechanism of action of the antitumor drug trabectedin.

artículo científico publicado en 2005

Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.

artículo científico publicado en 2016

Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards macrophages versus granulocytes.

artículo científico publicado en 1993

Differential Targets and Subcellular Localization of Antitumor Alkyl-lysophospholipid in LeukemicVersusSolid Tumor Cells

artículo científico publicado en 2006

Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis.

artículo científico publicado en 2002

Dissociation of the effects of the antitumour ether lipid ET‐18‐OCH3 on cytosolic calcium and on apoptosis ⬇️

artículo científico publicado el 1 de agosto de 1997

Drug Uptake, Lipid Rafts, and Vesicle Trafficking Modulate Resistance to an Anticancer Lysophosphatidylcholine Analogue in Yeast ⬇️

artículo científico publicado el 18 de enero de 2013

Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.

artículo científico publicado en 2006

Effects of the anti-neoplastic agent ET-18-OCH3 and some analogs on the biophysical properties of model membranes.

artículo científico publicado en 2006

Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells.

artículo científico publicado en 2007

Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy.

artículo científico publicado en 2006

Fluorescent Phenylpolyene Analogues of the Ether Phospholipid Edelfosine for the Selective Labeling of Cancer Cells

artículo científico publicado en 2004

Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.

artículo científico publicado en 2005

In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts

artículo científico publicado en 2010

Induction of apoptosis in human mitogen-activated peripheral blood T-lymphocytes by the ether phospholipid ET-18-OCH3: involvement of the Fas receptor/ligand system.

artículo científico publicado en 1999

Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions.

artículo científico publicado en 2009

Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells.

artículo científico publicado en 2011

Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells

artículo científico publicado en 2009

Isolation of Lipid Rafts Through Discontinuous Sucrose Gradient Centrifugation and Fas/CD95 Death Receptor Localization in Raft Fractions.

artículo científico publicado en 2017

Lipid raft connection between extrinsic and intrinsic apoptotic pathways.

artículo científico publicado en 2009

Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma ⬇️

artículo científico publicado el 31 de mayo de 2013

Lipid raft-mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implications

artículo científico publicado en 2015

Lipid raft-targeted therapy in multiple myeloma.

artículo científico publicado en 2010

Lipid rafts and Fas/CD95 signaling in cancer chemotherapy.

artículo científico publicado en 2011

Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy.

artículo científico publicado en 2010

Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling.

artículo científico publicado en 2015

Lipid rafts as major platforms for signaling regulation in cancer

artículo científico publicado en 2014

Lipid rafts, death receptors and CASMERs: new insights for cancer therapy

artículo científico publicado en 2010

Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine.

artículo científico

Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils.

artículo científico publicado en 1993

Major co-localization of the extracellular-matrix degradative enzymes heparanase and gelatinase in tertiary granules of human neutrophils ⬇️

artículo científico publicado el 1 de noviembre de 1997

Microtubules, microtubule-interfering agents and apoptosis.

artículo científico publicado en 2003

Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.

artículo científico publicado en 2017

Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis.

artículo científico publicado en 2009

Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy

scientific article published on 24 September 2007

Synthesis and biological evaluation of new selective cytotoxic cyclolignans derived from podophyllotoxin.

artículo científico publicado en 2004

The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death.

artículo científico publicado en 2016

The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells ⬇️

artículo científico publicado el 15 de diciembre de 2001

Triggers and signaling cross-talk controlling cell death commitment

artículo científico publicado en 2015

Lista de obras de Consuelo Gajate

Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy

Antitumor activity of Lepidium latifolium and identification of the epithionitrile 1-cyano-2,3-epithiopropane as its major active component.

Antitumor alkyl ether lipid edelfosine: tissue distribution and pharmacokinetic behavior in healthy and tumor-bearing immunosuppressed mice.

Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum.

Apoptotic mechanisms are involved in the death of Strongyloides venezuelensis after triggering of nitric oxide.

Biological activities, mechanisms of action and biomedical prospect of the antitumor ether phospholipid ET-18-OCH(3) (edelfosine), a proapoptotic agent in tumor cells

C-Fos is not essential for apoptosis.

Cytochrome b co-fractionates with gelatinase-containing granules in human neutrophils

Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy

Cytotoxicity of an Anti-cancer Lysophospholipid through Selective Modification of Lipid Raft Composition

DNA and non-DNA targets in the mechanism of action of the antitumor drug trabectedin.

Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.

Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards macrophages versus granulocytes.

Differential Targets and Subcellular Localization of Antitumor Alkyl-lysophospholipid in LeukemicVersusSolid Tumor Cells

Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis.

Dissociation of the effects of the antitumour ether lipid ET‐18‐OCH3 on cytosolic calcium and on apoptosis ⬇️

Drug Uptake, Lipid Rafts, and Vesicle Trafficking Modulate Resistance to an Anticancer Lysophosphatidylcholine Analogue in Yeast ⬇️

Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts.

Effects of the anti-neoplastic agent ET-18-OCH3 and some analogs on the biophysical properties of model membranes.

Endoplasmic reticulum stress in the proapoptotic action of edelfosine in solid tumor cells.

Fas/CD95 death receptor and lipid rafts: new targets for apoptosis-directed cancer therapy.

Fluorescent Phenylpolyene Analogues of the Ether Phospholipid Edelfosine for the Selective Labeling of Cancer Cells

Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.

In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts

Induction of apoptosis in human mitogen-activated peripheral blood T-lymphocytes by the ether phospholipid ET-18-OCH3: involvement of the Fas receptor/ligand system.

Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions.

Involvement of mitochondrial and B-RAF/ERK signaling pathways in berberine-induced apoptosis in human melanoma cells.

Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells

Isolation of Lipid Rafts Through Discontinuous Sucrose Gradient Centrifugation and Fas/CD95 Death Receptor Localization in Raft Fractions.

Lipid raft connection between extrinsic and intrinsic apoptotic pathways.

Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma ⬇️

Lipid raft-mediated Fas/CD95 apoptotic signaling in leukemic cells and normal leukocytes and therapeutic implications

Lipid raft-targeted therapy in multiple myeloma.

Lipid rafts and Fas/CD95 signaling in cancer chemotherapy.

Lipid rafts and clusters of apoptotic signaling molecule-enriched rafts in cancer therapy.

Lipid rafts and raft-mediated supramolecular entities in the regulation of CD95 death receptor apoptotic signaling.

Lipid rafts as major platforms for signaling regulation in cancer

Lipid rafts, death receptors and CASMERs: new insights for cancer therapy

Lipid rafts, endoplasmic reticulum and mitochondria in the antitumor action of the alkylphospholipid analog edelfosine.

Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils.

Major co-localization of the extracellular-matrix degradative enzymes heparanase and gelatinase in tertiary granules of human neutrophils ⬇️

Microtubules, microtubule-interfering agents and apoptosis.

Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.

Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis.

Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy

Synthesis and biological evaluation of new selective cytotoxic cyclolignans derived from podophyllotoxin.

The alkylphospholipid edelfosine shows activity against Strongyloides venezuelensis and induces apoptosis-like cell death.

The antitumor ether lipid ET-18-OCH3 induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells ⬇️

Triggers and signaling cross-talk controlling cell death commitment