Lista de obras - Robert Rottapel - Dominio Público Uruguay

3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells

artículo científico publicado en 2010

3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions

artículo científico publicado en 2011

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

scientific article published on 08 October 2013

A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling

artículo científico publicado en 2003

Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation

artículo científico publicado en 1998

Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis

artículo científico publicado en 2010

An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer.

artículo científico publicado en 2016

Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region.

artículo científico publicado en 2003

CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.

artículo científico publicado en 2007

CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway

artículo científico publicado en 2005

CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

artículo científico publicado en 2002

CaPSID: a bioinformatics platform for computational pathogen sequence identification in human genomes and transcriptomes.

artículo científico publicado en 2012

Cbl-mediated ubiquitinylation and negative regulation of Vav.

artículo científico publicado en 2003

Cell surface profiling using high-throughput flow cytometry: a platform for biomarker discovery and analysis of cellular heterogeneity

artículo científico publicado en 2014

Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages

artículo científico publicado en 2015

Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner

artículo científico publicado en 2005

Co-dependency between KRAS addiction and ARHGEF2 promotes an adaptive escape from MAPK pathway inhibition.

artículo científico publicado en 2017

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

artículo científico publicado en 2011

Expression and Signal Transduction of the FLT3 Tyrosine Kinase Receptor

article

Expression of Flt3 tyrosine kinase receptor gene in mouse hematopoietic and nervous tissues.

artículo científico publicado en 1995

Flow cytometric analysis of cytokine receptor signal transduction

artículo científico publicado en 2003

Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin-11 and interleukin-7

article

GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation.

scientific article published on October 2016

Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction

artículo científico publicado en 1998

Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response

artículo científico publicado en 2012

Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells

artículo científico publicado en 2004

Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice.

artículo científico publicado en 2007

Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.

artículo científico publicado en 2014

Interaction with the Phosphotyrosine Binding Domain/Phosphotyrosine Interacting Domain of SHC Is Required for the Transforming Activity of the FLT4/VEGFR3 Receptor Tyrosine Kinase

scientific article published in Journal of Biological Chemistry

Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer

artículo científico

Intra-articular fms-like tyrosine kinase 3 ligand expression is a driving force in induction and progression of arthritis

artículo científico publicado en 2008

Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells

scientific journal article

Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-driven and collagen-induced arthritis in mice

artículo científico publicado en 2015

Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism

artículo científico publicado en 2011

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.

artículo científico publicado en 2017

Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

artículo científico publicado en 2014

Mechanistic Insight into the Microtubule and Actin Cytoskeleton Coupling through Dynein-Dependent RhoGEF Inhibition

article published in 2012

Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1.

artículo científico publicado en 2014

Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition.

artículo científico publicado en 2012

Modulation of IL-7 thresholds by SOCS proteins in developing B lineage cells.

artículo científico publicado en 2011

Modulation of Rho guanine exchange factor Lfc activity by protein kinase A-mediated phosphorylation

artículo científico

Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes

artículo científico publicado en 2001

Phosphatidylinositol 3-kinase and Ca2+ influx dependence for ligand-stimulated internalization of the c-Kit receptor.

artículo científico publicado en 1997

Phosphatidylinositol-3' kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase

artículo científico publicado en 1996

Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts

artículo científico

Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins

artículo científico publicado en 2008

Putting the brakes on arthritis: can suppressors of cytokine signaling (SOCS) suppress rheumatoid arthritis?

artículo científico publicado en 2001

RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.

artículo científico publicado en 2017

Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.

artículo científico publicado en 2009

Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.

artículo científico publicado en 2016

Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

artículo científico publicado en 2003

Regulation of cytokine receptor signaling by SOCS1.

artículo científico publicado en 2003

Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens

artículo científico publicado en 2010

Regulation of the immune system by SOCS family adaptor proteins

artículo científico publicado en 2004

SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss

artículo científico publicado en 2014

SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain

artículo científico publicado en 1998

Signal transduction by several KIT juxtamembrane domain mutations

artículo científico publicado en 2003

Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation

artículo científico publicado en 1999

Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease

Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease

artículo científico publicado en 2011

Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes

artículo científico publicado en 2003

Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal

artículo científico publicado en 2001

Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes

artículo científico publicado en 2003

Suppressor of cytokine signaling 1 regulates an endogenous inhibitor of a mast cell protease

artículo científico publicado en 2003

Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis

artículo científico publicado en 2006

Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

artículo científico publicado en 2000

Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death

artículo científico publicado en 2004

TACC3-TSC2 maintains nuclear envelope structure and controls cell division.

artículo científico publicado en 2010

Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer

artículo científico publicado en 2017

The 3BP2 Adapter Protein Is Required for Chemoattractant-Mediated Neutrophil Activation

artículo científico publicado en 2012

The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response

artículo científico publicado en 2007

The MAGUK family protein CARD11 is essential for lymphocyte activation

scientific journal article

The Mouse W/c-kit Locus

scientific article published on 01 January 1990

The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis

artículo científico publicado en 2005

The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1

artículo científico publicado en 2014

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

artículo científico publicado en 1991

The adapter 3BP2: how it plugs into leukocyte signaling

artículo científico publicado en 2006

The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice.

artículo científico publicado en 1991

The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse

artículo científico publicado en 2004

The tumor suppressor activity of SOCS-1.

artículo científico publicado en 2002

Transcriptional Regulation of miR-31 by Oncogenic KRAS Mediates Metastatic Phenotypes by Repressing RASA1

artículo científico publicado en 2016

Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism.

artículo científico publicado en 2017

VHL: a very hip ligase

artículo científico publicado en 1999

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor ⬇️

artículo científico publicado el 1 de marzo de 1990

shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer.

artículo científico publicado en 2014

Lista de obras de Robert Rottapel

3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells

3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling

Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation

Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis

An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer.

Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region.

CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.

CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway

CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

CaPSID: a bioinformatics platform for computational pathogen sequence identification in human genomes and transcriptomes.

Cbl-mediated ubiquitinylation and negative regulation of Vav.

Cell surface profiling using high-throughput flow cytometry: a platform for biomarker discovery and analysis of cellular heterogeneity

Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages

Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner

Co-dependency between KRAS addiction and ARHGEF2 promotes an adaptive escape from MAPK pathway inhibition.

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

Expression and Signal Transduction of the FLT3 Tyrosine Kinase Receptor

Expression of Flt3 tyrosine kinase receptor gene in mouse hematopoietic and nervous tissues.

Flow cytometric analysis of cytokine receptor signal transduction

Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin-11 and interleukin-7

GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation.

Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction

Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response

Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells

Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice.

Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.

Interaction with the Phosphotyrosine Binding Domain/Phosphotyrosine Interacting Domain of SHC Is Required for the Transforming Activity of the FLT4/VEGFR3 Receptor Tyrosine Kinase

Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer

Intra-articular fms-like tyrosine kinase 3 ligand expression is a driving force in induction and progression of arthritis

Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells

Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-driven and collagen-induced arthritis in mice

Loss of Tankyrase-mediated destruction of 3BP2 is the underlying pathogenic mechanism of cherubism

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.

Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

Mechanistic Insight into the Microtubule and Actin Cytoskeleton Coupling through Dynein-Dependent RhoGEF Inhibition

Mechanistic insight into GPCR-mediated activation of the microtubule-associated RhoA exchange factor GEF-H1.

Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition.

Modulation of IL-7 thresholds by SOCS proteins in developing B lineage cells.

Modulation of Rho guanine exchange factor Lfc activity by protein kinase A-mediated phosphorylation

Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes

Phosphatidylinositol 3-kinase and Ca2+ influx dependence for ligand-stimulated internalization of the c-Kit receptor.

Phosphatidylinositol-3' kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase

Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts

Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins

Putting the brakes on arthritis: can suppressors of cytokine signaling (SOCS) suppress rheumatoid arthritis?

RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146.

Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.

Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.

Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

Regulation of cytokine receptor signaling by SOCS1.

Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens

Regulation of the immune system by SOCS family adaptor proteins

SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss

SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain

Signal transduction by several KIT juxtamembrane domain mutations

Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation

Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease

Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease

Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes

Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal

Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes

Suppressor of cytokine signaling 1 regulates an endogenous inhibitor of a mast cell protease

Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis

Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death

TACC3-TSC2 maintains nuclear envelope structure and controls cell division.

Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer

The 3BP2 Adapter Protein Is Required for Chemoattractant-Mediated Neutrophil Activation

The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response

The MAGUK family protein CARD11 is essential for lymphocyte activation

The Mouse W/c-kit Locus

The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis

The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

The adapter 3BP2: how it plugs into leukocyte signaling

The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice.

The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse