Lista de obras - Ian E. Alexander - Dominio Público Uruguay

A genome-wide map of adeno-associated virus-mediated human gene targeting

artículo científico publicado en 2014

A novel intronic splice site deletion of the IL-2 receptor common gamma chain results in expression of a dysfunctional protein and T-cell-positive X-linked Severe combined immunodeficiency.

artículo científico publicado en 2014

AAV vectors encoding malarial antigens stimulate antigen-specific immunity but do not protect from parasite infection.

artículo científico publicado en 2006

AAV-Mediated Gene Delivery to the Mouse Liver

artículo científico publicado en 2019

AAV-encoded OTC activity persisting to adulthood following delivery to newborn spf(ash) mice is insufficient to prevent shRNA-induced hyperammonaemia.

artículo científico publicado en 2013

AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization

artículo científico publicado en 2018

ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice

artículo científico publicado en 2015

Accepting risk in clinical research: is the gene therapy field becoming too risk-averse?

artículo científico publicado en 2009

Adeno-associated virus and lentivirus vectors mediate efficient and sustained transduction of cultured mouse and human dorsal root ganglia sensory neurons.

artículo científico publicado en 2001

Adeno-associated virus serotypes for gene therapeutics.

artículo científico

Adeno-associated virus vectors preferentially transduce cells in S phase.

artículo científico publicado en 1994

Adeno-associated virus vectors show variable dependence on divalent cations for thermostability: implications for purification and handling.

artículo científico publicado en 2000

Adeno-associated virus vectors transduce primary cells much less efficiently than immortalized cells.

artículo científico publicado en 1995

Adeno-associated virus vectors: immunobiology and potential use for immune modulation.

artículo científico

Adeno-associated virus-mediated rescue of neonatal lethality in argininosuccinate synthetase-deficient mice

artículo científico publicado en 2013

Age-Related Seroprevalence of Antibodies Against AAV-LK03 in a UK Population Cohort

artículo científico publicado en 2018

Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses

artículo científico publicado en 2014

Australasian Gene Therapy Society kicks off.

artículo científico publicado en 2002

Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity.

artículo científico publicado en 2017

Blockade of HMGB1 Attenuates Diabetic Nephropathy in Mice.

artículo científico publicado en 2018

C2C12 co-culture on a fibroblast substratum enables sustained survival of contractile, highly differentiated myotubes with peripheral nuclei and adult fast myosin expression.

artículo científico publicado en 2004

CD4 expression on EL4 cells as an epiphenomenon of retroviral transduction and selection

artículo científico publicado en 2004

Cardiac Gene Therapy: Therapeutic Potential and Current Progress ⬇️

artículo científico publicado el 1 de octubre de 2003

Characterisation of a P140K mutant O6-methylguanine-DNA-methyltransferase (MGMT)-expressing transgenic mouse line with drug-selectable bone marrow

artículo científico publicado en 2006

Clinical Trial of MGMT(P140K) gene therapy in the treatment of paediatric patients with brain tumours.

artículo científico publicado en 2018

Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality

scientific article published on 01 November 2018

Coherence analysis discriminates between retroviral integration patterns in CD34(+) cells transduced under differing clinical trial conditions

artículo científico publicado en 2015

Comparison of gene transfer to the murine liver following intraperitoneal and intraportal delivery of hepatotropic AAV pseudo-serotypes.

artículo científico publicado en 2012

DNA-damaging agents greatly increase the transduction of nondividing cells by adeno-associated virus vectors.

artículo científico publicado en 1994

Delivering efficient liver-directed AAV-mediated gene therapy

artículo científico publicado en 2017

Developing strategies for detection of gene doping.

artículo científico publicado en 2008

Differential subcellular localization of CD86 in human PBMC-derived macrophages and DCs, and ultrastructural characterization by immuno-electron microscopy.

artículo científico publicado en 2004

Directed Evolution of Adeno-Associated Virus Vectors in Human Cardiomyocytes for Cardiac Gene Therapy

article

Dystrophinopathy carrier determination and detection of protein deficiencies in muscular dystrophy using lentiviral MyoD-forced myogenesis.

artículo científico publicado en 2007

Exploiting the unique regenerative capacity of the liver to underpin cell and gene therapy strategies for genetic and acquired liver disease.

artículo científico publicado en 2014

Expression and regulation of retinoic acid receptors in human breast cancer cells ⬇️

artículo científico publicado el 15 de abril de 1992

Fetal brain disruption sequence in sisters ⬇️

artículo científico publicado el 1 de agosto de 1995

Fibroblasts can be genetically modified to produce excitable cells capable of electrical coupling.

artículo científico publicado en 2005

Fibroblasts modulate cardiomyocyte excitability: implications for cardiac gene therapy.

artículo científico publicado en 2006

Gene therapy clinical trials worldwide to 2012 - an update.

artículo científico

Gene therapy clinical trials worldwide to 2017: An update

artículo científico publicado en 2018

Gene therapy for metabolic disorders: an overview with a focus on urea cycle disorders.

artículo científico publicado en 2012

Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects.

artículo científico publicado en 2017

Gene therapy in sport

artículo científico publicado en 2006

Gene therapy in transplantation

scientific article published on 09 May 2009

Gene therapy: applications and progress towards the clinic.

artículo científico publicado en 2004

Gene therapy: progress in childhood disease.

artículo científico

Gene therapy: therapeutic applications and relevance to pathology

artículo científico

Genetic instability and the development of steroid hormone insensitivity in cultured T 47D human breast cancer cells

artículo científico publicado en 1988

Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus

artículo científico publicado en 2016

HeLa cells cocultured with peripheral blood lymphocytes acquire an immuno-inhibitory phenotype through up-regulation of indoleamine 2,3-dioxygenase activity.

artículo científico publicado en 2002

Human Connexin40 Mutations Slow Conduction and Increase Propensity for Atrial Fibrillation.

artículo científico publicado en 2017

Human PBMC-derived dendritic cells transduced with an adenovirus vectorinduce cytotoxic T-lymphocyte responses against a vector-encoded antigen in vitro.

artículo científico publicado en 1999

Human fibroblasts transduced with CD80 or CD86 efficiently trans-costimulate CD4+ and CD8+ T lymphocytes in HLA-restricted reactions: implications for immune augmentation cancer therapy and autoimmunity.

artículo científico publicado en 1999

Human induced pluripotent stem cells derived under feeder-free conditions display unique cell cycle and DNA replication gene profiles

artículo científico

Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome.

artículo científico publicado en 2017

Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence.

artículo científico publicado en 2014

In vivo assessment of mutations in OTC for dominant-negative effects following rAAV2/8-mediated gene delivery to the mouse liver.

artículo científico publicado en 2009

Induction and prevention of severe hyperammonemia in the spfash mouse model of ornithine transcarbamylase deficiency using shRNA and rAAV-mediated gene delivery

artículo científico publicado en 2011

Intrahepatic activation of naive CD4+ T cells by liver-resident phagocytic cells

artículo científico publicado en 2014

Inverse relationship between estrogen receptor and epidermal growth factor receptor mRNA levels in human breast cancer cell lines

artículo científico publicado en 1990

Isling: A Tool for Detecting Integration of Wild-Type Viruses and Clinical Vectors

artículo científico publicado en 2022

Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency

artículo científico publicado en 2016

Liver-directed gene expression using recombinant AAV 2/8 vectors--a tolerogenic strategy for gene delivery?

artículo científico publicado en 2010

Lymphoid regeneration from gene-corrected SCID-X1 subject-derived iPSCs.

artículo científico publicado en 2015

Lymphomagenesis in SCID-X1 mice following lentivirus-mediated phenotype correction independent of insertional mutagenesis and gammac overexpression

artículo científico publicado en 2010

Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle.

artículo científico publicado en 2009

Mitochondrial respiratory chain hepatopathies: role of liver transplantation. A case series of five patients.

artículo científico publicado en 2011

Modeling correction of severe urea cycle defects in the growing murine liver using a hybrid recombinant adeno-associated virus/piggyBac transposase gene delivery system

artículo científico publicado en 2015

Overexpression of indoleamine dioxygenase in rat liver allografts using a high-efficiency adeno-associated virus vector does not prevent acute rejection.

artículo científico publicado en 2009

PARTIAL PANCREATIC TRANSDIFFERENTIATION OF PRIMARY HUMAN HEPATOCYTES IN THE LIVERS OF A HUMANISED MOUSE MODEL.

artículo científico publicado en 2018

Potential use of gene transfer in athletic performance enhancement.

artículo científico publicado en 2007

Progestin inhibition of progesterone receptor gene expression in human breast cancer cells

artículo científico publicado en 1989

Promoter interference mediated by the U3 region in early-generation HIV-1-derived lentivirus vectors can influence detection of transgene expression in a cell-type and species-specific manner.

artículo científico publicado en 2003

Restoring the natural tropism of AAV2 vectors for human liver

scientific article published on 01 September 2020

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model

artículo científico publicado en 2013

Sexually dimorphic patterns of episomal rAAV genome persistence in the adult mouse liver and correlation with hepatocellular proliferation

artículo científico publicado en 2009

Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia

article by Caroline Michot et al published 6 April 2012 in Journal of Inherited Metabolic Disease

Synthetic certified DNA reference material for analysis of human erythropoietin transgene and transcript in gene doping and gene therapy.

artículo científico publicado en 2016

The Molecular Bases of Phenylketonuria (PKU) in New South Wales, Australia: Mutation Profile and Correlation with Tetrahydrobiopterin (BH4) Responsiveness.

artículo científico publicado en 2013

The adenovirus E4 ORF6 and E1b 55 kDa proteins cooperate in a p53-independent manner to enhance transduction by recombinant adeno-associated virus vectors.

artículo científico publicado en 2000

The ethics of gene therapy: balancing the risks.

artículo científico publicado en 2010

The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak.

artículo científico publicado en 2013

Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration.

artículo científico publicado en 1997

Transfer of Contaminants in Adeno-Associated Virus Vector Stocks Can Mimic Transduction and Lead to Artifactual Results ⬇️

artículo científico publicado el 1 de noviembre de 1997

Transient suppression of hepatocellular replication in the mouse liver following transduction with recombinant adeno-associated virus.

artículo científico publicado en 2015

Ub-ISAP: a streamlined UNIX pipeline for mining unique viral vector integration sites from next generation sequencing data.

artículo científico publicado en 2017

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

artículo científico publicado en 2007

Lista de obras de Ian E. Alexander

A genome-wide map of adeno-associated virus-mediated human gene targeting

A novel intronic splice site deletion of the IL-2 receptor common gamma chain results in expression of a dysfunctional protein and T-cell-positive X-linked Severe combined immunodeficiency.

AAV vectors encoding malarial antigens stimulate antigen-specific immunity but do not protect from parasite infection.

AAV-Mediated Gene Delivery to the Mouse Liver

AAV-encoded OTC activity persisting to adulthood following delivery to newborn spf(ash) mice is insufficient to prevent shRNA-induced hyperammonaemia.

AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization

ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice

Accepting risk in clinical research: is the gene therapy field becoming too risk-averse?

Adeno-associated virus and lentivirus vectors mediate efficient and sustained transduction of cultured mouse and human dorsal root ganglia sensory neurons.

Adeno-associated virus serotypes for gene therapeutics.

Adeno-associated virus vectors preferentially transduce cells in S phase.

Adeno-associated virus vectors show variable dependence on divalent cations for thermostability: implications for purification and handling.

Adeno-associated virus vectors transduce primary cells much less efficiently than immortalized cells.

Adeno-associated virus vectors: immunobiology and potential use for immune modulation.

Adeno-associated virus-mediated rescue of neonatal lethality in argininosuccinate synthetase-deficient mice

Age-Related Seroprevalence of Antibodies Against AAV-LK03 in a UK Population Cohort

Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses

Australasian Gene Therapy Society kicks off.

Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity.

Blockade of HMGB1 Attenuates Diabetic Nephropathy in Mice.

C2C12 co-culture on a fibroblast substratum enables sustained survival of contractile, highly differentiated myotubes with peripheral nuclei and adult fast myosin expression.

CD4 expression on EL4 cells as an epiphenomenon of retroviral transduction and selection

Cardiac Gene Therapy: Therapeutic Potential and Current Progress ⬇️

Characterisation of a P140K mutant O6-methylguanine-DNA-methyltransferase (MGMT)-expressing transgenic mouse line with drug-selectable bone marrow

Clinical Trial of MGMT(P140K) gene therapy in the treatment of paediatric patients with brain tumours.

Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality

Coherence analysis discriminates between retroviral integration patterns in CD34(+) cells transduced under differing clinical trial conditions

Comparison of gene transfer to the murine liver following intraperitoneal and intraportal delivery of hepatotropic AAV pseudo-serotypes.

DNA-damaging agents greatly increase the transduction of nondividing cells by adeno-associated virus vectors.

Delivering efficient liver-directed AAV-mediated gene therapy

Developing strategies for detection of gene doping.

Differential subcellular localization of CD86 in human PBMC-derived macrophages and DCs, and ultrastructural characterization by immuno-electron microscopy.

Directed Evolution of Adeno-Associated Virus Vectors in Human Cardiomyocytes for Cardiac Gene Therapy

Dystrophinopathy carrier determination and detection of protein deficiencies in muscular dystrophy using lentiviral MyoD-forced myogenesis.

Exploiting the unique regenerative capacity of the liver to underpin cell and gene therapy strategies for genetic and acquired liver disease.

Expression and regulation of retinoic acid receptors in human breast cancer cells ⬇️

Fetal brain disruption sequence in sisters ⬇️

Fibroblasts can be genetically modified to produce excitable cells capable of electrical coupling.

Fibroblasts modulate cardiomyocyte excitability: implications for cardiac gene therapy.

Gene therapy clinical trials worldwide to 2012 - an update.

Gene therapy clinical trials worldwide to 2017: An update

Gene therapy for metabolic disorders: an overview with a focus on urea cycle disorders.

Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects.

Gene therapy in sport

Gene therapy in transplantation

Gene therapy: applications and progress towards the clinic.

Gene therapy: progress in childhood disease.

Gene therapy: therapeutic applications and relevance to pathology

Genetic instability and the development of steroid hormone insensitivity in cultured T 47D human breast cancer cells

Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus

HeLa cells cocultured with peripheral blood lymphocytes acquire an immuno-inhibitory phenotype through up-regulation of indoleamine 2,3-dioxygenase activity.

Human Connexin40 Mutations Slow Conduction and Increase Propensity for Atrial Fibrillation.

Human PBMC-derived dendritic cells transduced with an adenovirus vectorinduce cytotoxic T-lymphocyte responses against a vector-encoded antigen in vitro.

Human fibroblasts transduced with CD80 or CD86 efficiently trans-costimulate CD4+ and CD8+ T lymphocytes in HLA-restricted reactions: implications for immune augmentation cancer therapy and autoimmunity.

Human induced pluripotent stem cells derived under feeder-free conditions display unique cell cycle and DNA replication gene profiles

Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome.

Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence.

In vivo assessment of mutations in OTC for dominant-negative effects following rAAV2/8-mediated gene delivery to the mouse liver.

Induction and prevention of severe hyperammonemia in the spfash mouse model of ornithine transcarbamylase deficiency using shRNA and rAAV-mediated gene delivery

Intrahepatic activation of naive CD4+ T cells by liver-resident phagocytic cells

Inverse relationship between estrogen receptor and epidermal growth factor receptor mRNA levels in human breast cancer cell lines

Isling: A Tool for Detecting Integration of Wild-Type Viruses and Clinical Vectors

Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency

Liver-directed gene expression using recombinant AAV 2/8 vectors--a tolerogenic strategy for gene delivery?

Lymphoid regeneration from gene-corrected SCID-X1 subject-derived iPSCs.

Lymphomagenesis in SCID-X1 mice following lentivirus-mediated phenotype correction independent of insertional mutagenesis and gammac overexpression

Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle.

Mitochondrial respiratory chain hepatopathies: role of liver transplantation. A case series of five patients.

Modeling correction of severe urea cycle defects in the growing murine liver using a hybrid recombinant adeno-associated virus/piggyBac transposase gene delivery system

Overexpression of indoleamine dioxygenase in rat liver allografts using a high-efficiency adeno-associated virus vector does not prevent acute rejection.

PARTIAL PANCREATIC TRANSDIFFERENTIATION OF PRIMARY HUMAN HEPATOCYTES IN THE LIVERS OF A HUMANISED MOUSE MODEL.

Potential use of gene transfer in athletic performance enhancement.

Progestin inhibition of progesterone receptor gene expression in human breast cancer cells

Promoter interference mediated by the U3 region in early-generation HIV-1-derived lentivirus vectors can influence detection of transgene expression in a cell-type and species-specific manner.

Restoring the natural tropism of AAV2 vectors for human liver

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model

Sexually dimorphic patterns of episomal rAAV genome persistence in the adult mouse liver and correlation with hepatocellular proliferation

Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia

Synthetic certified DNA reference material for analysis of human erythropoietin transgene and transcript in gene doping and gene therapy.