Lista de obras - Paul P Geurink - Dominio Público Uruguay

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase

artículo científico publicado en 2017

A MALDI-TOF Approach to Ubiquitin Ligase Activity

artículo científico publicado en 2018

A Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos

artículo científico publicado en 2020

A cleavable linker based on the levulinoyl ester for activity-based protein profiling

artículo científico publicado en 2010

A general chemical ligation approach towards isopeptide-linked ubiquitin and ubiquitin-like assay reagents

artículo científico publicado en 2011

A peptide hydroxamate library for enrichment of metalloproteinases: towards an affinity-based metalloproteinase profiling protocol

artículo científico publicado en 2008

Activity-Based Profiling of 2-Oxoglutarate Oxygenases

scientific article published on 01 May 2011

Activity-Dependent Photoaffinity Labeling of Metalloproteases

artículo científico publicado en 2017

Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t

artículo científico publicado en 2010

Catching a DUB in the act: novel ubiquitin-based active site directed probes

artículo científico publicado en 2014

Design of Peptide Hydroxamate-Based Photoreactive Activity-Based Probes of Zinc-Dependent Metalloproteases

Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis

scientific article published on 19 December 2019

Development of Diubiquitin-Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes

artículo científico publicado en 2016

Development of Inhibitors, Probes, and PROTAC Provides a Complete Toolbox to Study PARK7 in the Living Cell

artículo científico publicado en 2024

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

artículo científico publicado en 2016

Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection

artículo científico publicado en 2021

Functional Proteomics on Zinc-Dependent Metalloproteinases using Inhibitor Probes

artículo científico publicado en 2009

Identification and characterization of diverse OTU deubiquitinases in bacteria

scientific article published on 22 June 2020

Identification and isolation of lantibiotics from culture: a bioorthogonal chemistry approach

article

Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites

artículo científico publicado en 2013

Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites

artículo científico publicado en 2010

Inhibition of papain-like protease PLpro blocks SARS-CoV-2 spread and promotes anti-viral immunity

artículo científico publicado en 2020

Inhibition of the Deubiquitinase Usp14 Diminishes Direct MHC Class I Antigen Presentation

artículo científico publicado en 2017

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

artículo científico publicado en 2018

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

artículo científico publicado en 2019

Manno-epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors

scientific article published on 30 June 2020

Mechanism and inhibition of SARS-CoV-2 PLpro

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

scientific article published on 26 August 2020

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

artículo científico publicado en 2016

Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15

scientific journal article

Native chemical ligation at methionine bioisostere norleucine allows for N-terminal chemical protein ligation

scientific article published on 01 August 2018

Nature of pharmacophore influences active site specificity of proteasome inhibitors

artículo científico publicado en 2010

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

artículo científico publicado en 2016

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

artículo científico publicado en 2013

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

artículo científico publicado en 2013

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

artículo científico publicado en 2020

Photoaffinity labeling in activity-based protein profiling

artículo científico publicado en 2012

Poly(ethylene glycol)-based stable isotope labeling reagents for the quantitative analysis of low molecular weight metabolites by LC-MS.

artículo científico publicado en 2008

Probing the proteasome cavity in three steps: bio-orthogonal photo-reactive suicide substrates

artículo científico publicado en 2010

Profiling DUBs and Ubl-specific proteases with activity-based probes

artículo científico publicado en 2019

Proteasome selectivity towards Michael acceptor containing oligopeptide-based inhibitors

artículo científico publicado en 2010

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

artículo científico publicado en 2019

Solid-Phase Synthesis of Succinylhydroxamate Peptides: Functionalized Matrix Metalloproteinase Inhibitors

scientific article published in 2006

Structural basis of the specificity of USP18 toward ISG15.

artículo científico publicado en 2017

The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types

artículo científico publicado en 2011

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases

scientific article published on 13 July 2016

The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells

artículo científico publicado en 2015

The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells

artículo científico publicado en 2015

Total chemical synthesis of murine ISG15 and an activity-based probe with physiological binding properties

artículo científico publicado en 2019

Lista de obras de Paul P Geurink

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase

A MALDI-TOF Approach to Ubiquitin Ligase Activity

A Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos

A cleavable linker based on the levulinoyl ester for activity-based protein profiling

A general chemical ligation approach towards isopeptide-linked ubiquitin and ubiquitin-like assay reagents

A peptide hydroxamate library for enrichment of metalloproteinases: towards an affinity-based metalloproteinase profiling protocol

Activity-Based Profiling of 2-Oxoglutarate Oxygenases

Activity-Dependent Photoaffinity Labeling of Metalloproteases

Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t

Catching a DUB in the act: novel ubiquitin-based active site directed probes

Design of Peptide Hydroxamate-Based Photoreactive Activity-Based Probes of Zinc-Dependent Metalloproteases

Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis

Development of Diubiquitin-Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes

Development of Inhibitors, Probes, and PROTAC Provides a Complete Toolbox to Study PARK7 in the Living Cell

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition

Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection

Functional Proteomics on Zinc-Dependent Metalloproteinases using Inhibitor Probes

Identification and characterization of diverse OTU deubiquitinases in bacteria

Identification and isolation of lantibiotics from culture: a bioorthogonal chemistry approach

Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites

Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites

Inhibition of papain-like protease PLpro blocks SARS-CoV-2 spread and promotes anti-viral immunity

Inhibition of the Deubiquitinase Usp14 Diminishes Direct MHC Class I Antigen Presentation

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies

Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity

Manno-epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors

Mechanism and inhibition of SARS-CoV-2 PLpro

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne

Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15

Native chemical ligation at methionine bioisostere norleucine allows for N-terminal chemical protein ligation

Nature of pharmacophore influences active site specificity of proteasome inhibitors

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis

On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

Photoaffinity labeling in activity-based protein profiling

Poly(ethylene glycol)-based stable isotope labeling reagents for the quantitative analysis of low molecular weight metabolites by LC-MS.

Probing the proteasome cavity in three steps: bio-orthogonal photo-reactive suicide substrates

Profiling DUBs and Ubl-specific proteases with activity-based probes

Proteasome selectivity towards Michael acceptor containing oligopeptide-based inhibitors

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

Solid-Phase Synthesis of Succinylhydroxamate Peptides: Functionalized Matrix Metalloproteinase Inhibitors

Structural basis of the specificity of USP18 toward ISG15.

The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases

The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells

The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells

Total chemical synthesis of murine ISG15 and an activity-based probe with physiological binding properties