Lista de obras - Saïd Yous - Dominio Público Uruguay

Antagonists of the adenosine A2A receptor based on a 2-arylbenzoxazole scaffold: Investigation of the C5- and C7-positions to enhance affinity

artículo científico publicado en 2017

Antioxidant activity of benzoxazolinonic and benzothiazolinonic derivatives in the LDL oxidation model.

artículo científico publicado en 2009

Antioxidant activity of melatonin and a pinoline derivative on linoleate model system.

artículo científico publicado en 2005

Antioxydant activity of β-carboline derivatives in the LDL oxidation model

scientific article published on 30 March 2011

Bitopic fluorescent antagonists of the A2A adenosine receptor based on pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine functionalized congeners

artículo científico publicado en 2017

Carbazole scaffolds in cancer therapy: a review from 2012 to 2018

scientific article published on 01 December 2019

Comparison of 3D structures and AT(1) binding properties of pyrazolidine-3,5-diones and tetrahydropyridazine-3,6-diones with parent antihypertensive drug irbesartan.

artículo científico publicado en 2002

Design and synthesis of 3-phenyltetrahydronaphthalenic derivatives as new selective MT2 melatoninergic ligands. Part II.

artículo científico publicado en 2009

Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3.

artículo científico publicado en 2008

Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines

artículo científico publicado en 2015

Design and synthesis of naphthalenic derivatives as new ligands at the melatonin binding site MT3

scientific article published on 15 February 2011

Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands

artículo científico publicado en 2003

Design of experiments for enantiomeric separation in supercritical fluid chromatography.

artículo científico publicado en 2015

Design, synthesis and evaluation of 2-aryl benzoxazoles as promising hit for the A2A receptor.

artículo científico publicado en 2017

Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I).

artículo científico publicado en 2012

Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands

artículo científico publicado en 2010

Dual CD system in capillary electrophoresis for direct separation of the four stereoisomers of agonist and antagonist melatoninergic ligands.

artículo científico publicado en 2010

Enantiomeric resolution of new aromatase inhibitors by liquid chromatography on cellulose chiral stationary phases.

artículo científico publicado en 2005

Enantioseparation and thermodynamic study of naphthalene derivatives, new melatoninergic agonists, on coated amylose [tris(S)-1-phenylethylcarbamate] stationary phase. Transposition to preparative scale.

artículo científico publicado en 2014

Enhanced detection for determination of enantiomeric purity of novel agomelatine analogs by EKC using single and dual cyclodextrin systems

artículo científico publicado en 2014

Exposure to glycol ethers in a population of French men evaluated by measurement of urinary alkoxycarboxylic acids.

artículo científico publicado en 2004

Homology modeling of MT1 and MT2 receptors

artículo científico publicado en 2007

Homology modelling of the serotoninergic 5-HT2c receptor.

artículo científico publicado en 2006

Increased susceptibility of low-density lipoprotein to ex vivo oxidation in mice transgenic for human apolipoprotein B treated with 1 melatonin-related compound is not associated with atherosclerosis progression

artículo científico publicado en 2005

Interactions of bexarotene (LGD1069, Targretin) with the coagulation system

artículo científico publicado en 2011

Investigations of new lead structures for the design of novel cyclooxygenase-2 inhibitors

artículo científico publicado en 2002

Lipid-lowering properties of 6-benzoyl-2(3H)-benzothiazolone and structurally related compounds

artículo científico publicado en 2005

Melatonergic ligands: Design, synthesis and pharmacological evaluation of novel series of naphthofuranic derivatives

artículo científico publicado en 2015

New melatonin (MT1/MT2) ligands: design and synthesis of (8,9-dihydro-7H-furo[3,2-f]chromen-1-yl) derivatives

artículo científico publicado en 2014

New naphthalenic ligands of melatoninergic receptors

artículo científico publicado en 1992

New phenylaniline derivatives as modulators of amyloid protein precursor metabolism

scholarly article by Marion Gay published in May 2018

New quinolinic derivatives as melatonergic ligands: Synthesis and pharmacological evaluation

artículo científico publicado en 2017

New substrate analogues of human serotonin N-acetyltransferase produce in situ specific and potent inhibitors

artículo científico publicado en 2004

Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARgamma agonists

artículo científico

Novel conformationally constrained analogues of agomelatine as new melatoninergic ligands.

artículo científico publicado en 2012

Novel naphthalenic ligands with high affinity for the melatonin receptor

artículo científico publicado el 17 de abril de 1992

Old and new inhibitors of quinone reductase 2.

artículo científico

Preparation and pharmacological evaluation of a novel series of 2-(phenylthio)benzo[b]thiophenes as selective MT2 receptor ligands

artículo científico publicado en 2011

Preparative HPLC separation of methoxytetralins, ligands for melatonin receptors, containing two chiral centers with polysaccharide chiral stationary phases. Determination of enantiomeric purity.

artículo científico publicado en 2005

Quantification of the water/lipid affinity of melatonin and a pinoline derivative in lipid models

artículo científico publicado en 2007

Quantitative structure-activity relationships studies of antioxidant hexahydropyridoindoles and flavonoid derivatives.

artículo científico publicado en 2007

Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver

artículo científico publicado en 2009

Structural basis of ligand recognition at the human MT1 melatonin receptor

scientific article published on 24 April 2019

Synthesis and biological evaluation of new naphtho- and quinolinocyclopentane derivatives as potent melatoninergic (MT1/MT2) and serotoninergic (5-HT2C) dual ligands

artículo científico publicado en 2017

Synthesis and evaluation of benzoxazolinonic imidazoles and derivatives as non-steroidal aromatase inhibitors.

artículo científico publicado en 2004

Synthesis and pharmacological evaluation of a series of the agomelatine analogues as melatonin MT1 /MT2 agonist and 5-HT2C antagonist

artículo científico publicado en 2013

Synthesis and pharmacological evaluation of analgesic 6-substituted 2(3H)-benzothiazolones

artículo científico publicado en 2001

Synthesis and pharmacological evaluation of dual ligands for melatonin (MT1/MT2) and serotonin 5-HT2C receptor subtypes (II).

artículo científico publicado en 2014

Synthesis of 3-phenylnaphthalenic derivatives as new selective MT(2) melatoninergic ligands.

artículo científico publicado en 2008

Synthesis of nitroindole derivatives with high affinity and selectivity for melatoninergic binding sites MT(3).

artículo científico publicado en 2002

Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.

artículo científico

The RXR Agonist Bexarotene Improves Cholesterol Homeostasis and Inhibits Atherosclerosis Progression in a Mouse Model of Mixed Dyslipidemia

article

Three-Dimensional Quantitative Structure–Activity Relationship ofMT3 Melatonin Binding Site Ligands: A Comparative Molecular Field Analysis

Three-dimensional quantitative structure-activity relationships of cyclo-oxygenase-2 (COX-2) inhibitors: a comparative molecular field analysis.

artículo científico publicado en 2001

XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity

scientific article published on 24 April 2019

Lista de obras de Saïd Yous

Antagonists of the adenosine A2A receptor based on a 2-arylbenzoxazole scaffold: Investigation of the C5- and C7-positions to enhance affinity

Antioxidant activity of benzoxazolinonic and benzothiazolinonic derivatives in the LDL oxidation model.

Antioxidant activity of melatonin and a pinoline derivative on linoleate model system.

Antioxydant activity of β-carboline derivatives in the LDL oxidation model

Bitopic fluorescent antagonists of the A2A adenosine receptor based on pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine functionalized congeners

Carbazole scaffolds in cancer therapy: a review from 2012 to 2018

Comparison of 3D structures and AT(1) binding properties of pyrazolidine-3,5-diones and tetrahydropyridazine-3,6-diones with parent antihypertensive drug irbesartan.

Design and synthesis of 3-phenyltetrahydronaphthalenic derivatives as new selective MT2 melatoninergic ligands. Part II.

Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3.

Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines

Design and synthesis of naphthalenic derivatives as new ligands at the melatonin binding site MT3

Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands

Design of experiments for enantiomeric separation in supercritical fluid chromatography.

Design, synthesis and evaluation of 2-aryl benzoxazoles as promising hit for the A2A receptor.

Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I).

Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands

Dual CD system in capillary electrophoresis for direct separation of the four stereoisomers of agonist and antagonist melatoninergic ligands.

Enantiomeric resolution of new aromatase inhibitors by liquid chromatography on cellulose chiral stationary phases.

Enantioseparation and thermodynamic study of naphthalene derivatives, new melatoninergic agonists, on coated amylose [tris(S)-1-phenylethylcarbamate] stationary phase. Transposition to preparative scale.

Enhanced detection for determination of enantiomeric purity of novel agomelatine analogs by EKC using single and dual cyclodextrin systems

Exposure to glycol ethers in a population of French men evaluated by measurement of urinary alkoxycarboxylic acids.

Homology modeling of MT1 and MT2 receptors

Homology modelling of the serotoninergic 5-HT2c receptor.

Increased susceptibility of low-density lipoprotein to ex vivo oxidation in mice transgenic for human apolipoprotein B treated with 1 melatonin-related compound is not associated with atherosclerosis progression

Interactions of bexarotene (LGD1069, Targretin) with the coagulation system

Investigations of new lead structures for the design of novel cyclooxygenase-2 inhibitors

Lipid-lowering properties of 6-benzoyl-2(3H)-benzothiazolone and structurally related compounds

Melatonergic ligands: Design, synthesis and pharmacological evaluation of novel series of naphthofuranic derivatives

New melatonin (MT1/MT2) ligands: design and synthesis of (8,9-dihydro-7H-furo[3,2-f]chromen-1-yl) derivatives

New naphthalenic ligands of melatoninergic receptors

New phenylaniline derivatives as modulators of amyloid protein precursor metabolism

New quinolinic derivatives as melatonergic ligands: Synthesis and pharmacological evaluation

New substrate analogues of human serotonin N-acetyltransferase produce in situ specific and potent inhibitors

Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARgamma agonists

Novel conformationally constrained analogues of agomelatine as new melatoninergic ligands.

Novel naphthalenic ligands with high affinity for the melatonin receptor

Old and new inhibitors of quinone reductase 2.

Preparation and pharmacological evaluation of a novel series of 2-(phenylthio)benzo[b]thiophenes as selective MT2 receptor ligands

Preparative HPLC separation of methoxytetralins, ligands for melatonin receptors, containing two chiral centers with polysaccharide chiral stationary phases. Determination of enantiomeric purity.

Quantification of the water/lipid affinity of melatonin and a pinoline derivative in lipid models

Quantitative structure-activity relationships studies of antioxidant hexahydropyridoindoles and flavonoid derivatives.

Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver

Structural basis of ligand recognition at the human MT1 melatonin receptor

Synthesis and biological evaluation of new naphtho- and quinolinocyclopentane derivatives as potent melatoninergic (MT1/MT2) and serotoninergic (5-HT2C) dual ligands

Synthesis and evaluation of benzoxazolinonic imidazoles and derivatives as non-steroidal aromatase inhibitors.

Synthesis and pharmacological evaluation of a series of the agomelatine analogues as melatonin MT1 /MT2 agonist and 5-HT2C antagonist

Synthesis and pharmacological evaluation of analgesic 6-substituted 2(3H)-benzothiazolones

Synthesis and pharmacological evaluation of dual ligands for melatonin (MT1/MT2) and serotonin 5-HT2C receptor subtypes (II).

Synthesis of 3-phenylnaphthalenic derivatives as new selective MT(2) melatoninergic ligands.

Synthesis of nitroindole derivatives with high affinity and selectivity for melatoninergic binding sites MT(3).

Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.

The RXR Agonist Bexarotene Improves Cholesterol Homeostasis and Inhibits Atherosclerosis Progression in a Mouse Model of Mixed Dyslipidemia

Three-Dimensional Quantitative Structure–Activity Relationship ofMT3 Melatonin Binding Site Ligands: A Comparative Molecular Field Analysis

Three-dimensional quantitative structure-activity relationships of cyclo-oxygenase-2 (COX-2) inhibitors: a comparative molecular field analysis.

XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity