Lista de obras - Rosemary O'Connor - Dominio Público Uruguay

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

artículo científico publicado en 2019

A case report of spontaneous mutation (C33>U) in the iron-responsive element of L-ferritin causing hyperferritinemia-cataract syndrome.

artículo científico publicado en 2009

A cell viability assay based on monitoring respiration by optical oxygen sensing

artículo científico publicado en 2000

Bile acids destabilise HIF-1α and promote anti-tumour phenotypes in cancer cell models

artículo científico publicado en 2016

Comparative bioenergetic assessment of transformed cells using a cell energy budget platform

artículo científico publicado en 2011

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

artículo científico publicado en 2013

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

scientific journal article

Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription

artículo científico publicado en 2011

Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR.

artículo científico publicado en 2007

EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion.

artículo científico publicado en 2004

Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-X(L).

artículo científico publicado en 2002

Essential function for PDLIM2 in cell polarization in three-dimensional cultures by feedback regulation of the β1-integrin-RhoA signaling axis.

artículo científico publicado en 2014

FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion

artículo científico publicado en 2018

Fluorescence-based cell viability screening assays using water-soluble oxygen probes

artículo científico publicado en 2003

HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H(+) ATPase.

artículo científico publicado en 2013

Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking.

artículo científico publicado en 2009

IGF-1 Receptor and Adhesion Signaling: An Important Axis in Determining Cancer Cell Phenotype and Therapy Resistance

artículo científico publicado en 2015

IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β-Nrf2-BNIP3 Pathway

scientific article published on 08 January 2020

IGF-1 receptor activity in the Golgi of migratory cancer cells depends on adhesion-dependent phosphorylation of Tyr1250 and Tyr1251

scientific article published on 26 May 2020

IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin

artículo científico publicado en 2016

Identification of an IGF-1R kinase regulatory phosphatase using the fission yeast Schizosaccharomyces pombe and a GFP tagged IGF-1R in mammalian cells.

artículo científico publicado en 2002

Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis

artículo científico publicado en 2012

Induction of apoptosis by the Bcl-2 homologue Bak

artículo científico publicado en 1995

Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells.

artículo científico publicado en 2017

Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration

artículo científico publicado en 2006

Interleukin 4 inhibits IL-2-induced proliferation of a human T-leukemia cell line without interfering with p56-LCK kinase activation

artículo científico publicado en 1992

Itm2a silencing rescues lamin A mediated inhibition of 3T3-L1 adipocyte differentiation.

artículo científico publicado en 2017

Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels.

artículo científico publicado en 2008

Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level

artículo científico publicado en 2008

Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells

artículo científico publicado en 2010

Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth

artículo científico publicado en 2005

PDLIM2 Is a Marker of Adhesion and β-Catenin Activity in Triple-Negative Breast Cancer

artículo científico publicado en 2019

PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D.

artículo científico publicado en 2013

PDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome.

artículo científico publicado en 2013

Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase

artículo científico publicado en 2009

Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction.

artículo científico publicado en 2011

Production and characterization of a monoclonal antibody to a myeloid specific differentiation antigen

artículo científico publicado en 1987

RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.

artículo científico publicado en 2013

RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells

artículo científico publicado en 2016

RACK1 to the future--a historical perspective

artículo científico publicado en 2013

Regulation of IGF-I receptor signaling in tumor cells.

artículo científico publicado en 2003

Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts

artículo científico publicado en 2002

Rethinking the bile acid/gut microbiome axis in cancer

artículo científico publicado en 2017

Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.

artículo científico publicado en 2010

Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-kappaB.

artículo científico publicado en 2008

Serine phosphorylation of the insulin-like growth factor I (IGF-1) receptor C-terminal tail restrains kinase activity and cell growth

artículo científico publicado en 2012

Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1

artículo científico publicado en 2013

Survival factors and apoptosis ⬇️

artículo científico publicado el 1 de enero de 1998

The insulin-like growth factor-I receptor is regulated by CD28 and protects activated T cells from apoptosis

artículo científico publicado en 2000

The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth

artículo científico publicado en 2007

Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway ⬇️

artículo científico publicado el 5 de abril de 2011

Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration

artículo científico publicado en 2008

Lista de obras de Rosemary O'Connor

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

A case report of spontaneous mutation (C33>U) in the iron-responsive element of L-ferritin causing hyperferritinemia-cataract syndrome.

A cell viability assay based on monitoring respiration by optical oxygen sensing

Bile acids destabilise HIF-1α and promote anti-tumour phenotypes in cancer cell models

Comparative bioenergetic assessment of transformed cells using a cell energy budget platform

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription

Effects of RACK1 on cell migration and IGF-I signalling in cardiomyoctes are not dependent on an association with the IGF-IR.

EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion.

Erythrocyte survival is promoted by plasma and suppressed by a Bak-derived BH3 peptide that interacts with membrane-associated Bcl-X(L).

Essential function for PDLIM2 in cell polarization in three-dimensional cultures by feedback regulation of the β1-integrin-RhoA signaling axis.

FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion

Fluorescence-based cell viability screening assays using water-soluble oxygen probes

HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H(+) ATPase.

Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking.

IGF-1 Receptor and Adhesion Signaling: An Important Axis in Determining Cancer Cell Phenotype and Therapy Resistance

IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β-Nrf2-BNIP3 Pathway

IGF-1 receptor activity in the Golgi of migratory cancer cells depends on adhesion-dependent phosphorylation of Tyr1250 and Tyr1251

IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin

Identification of an IGF-1R kinase regulatory phosphatase using the fission yeast Schizosaccharomyces pombe and a GFP tagged IGF-1R in mammalian cells.

Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis

Induction of apoptosis by the Bcl-2 homologue Bak

Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells.

Insulin-like growth factor I controls a mutually exclusive association of RACK1 with protein phosphatase 2A and beta1 integrin to promote cell migration

Interleukin 4 inhibits IL-2-induced proliferation of a human T-leukemia cell line without interfering with p56-LCK kinase activation

Itm2a silencing rescues lamin A mediated inhibition of 3T3-L1 adipocyte differentiation.

Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels.

Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level

Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells

Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth

PDLIM2 Is a Marker of Adhesion and β-Catenin Activity in Triple-Negative Breast Cancer

PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D.

PDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome.

Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase

Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction.

Production and characterization of a monoclonal antibody to a myeloid specific differentiation antigen

RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.

RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells

RACK1 to the future--a historical perspective

Regulation of IGF-I receptor signaling in tumor cells.

Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts

Rethinking the bile acid/gut microbiome axis in cancer

Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.

Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-kappaB.

Serine phosphorylation of the insulin-like growth factor I (IGF-1) receptor C-terminal tail restrains kinase activity and cell growth

Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1

Survival factors and apoptosis ⬇️

The insulin-like growth factor-I receptor is regulated by CD28 and protects activated T cells from apoptosis

The insulin-like growth factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth

Tim-4 inhibition of T-cell activation and T helper type 17 differentiation requires both the immunoglobulin V and mucin domains and occurs via the mitogen-activated protein kinase pathway ⬇️

Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration