Lista de obras - Rachel C. Chambers - Dominio Público Uruguay

A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis

artículo científico publicado en 2019

Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis

scientific journal article

Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia.

artículo científico publicado en 2009

Activation of fibroblast procollagen alpha 1(I) transcription by mechanical strain is transforming growth factor-beta-dependent and involves increased binding of CCAAT-binding factor (CBF/NF-Y) at the proximal promoter

scientific journal article

Activation of proteinase-activated receptor-2 in mesothelial cells induces pleural inflammation.

artículo científico publicado en 2004

Acute Respiratory Distress Syndrome

artículo científico publicado en 2017

Altered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lung fibrosis

artículo científico publicado en 2014

Angiotensin II and the fibroproliferative response to acute lung injury.

artículo científico publicado en 2003

Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

scientific article published on 11 September 2020

BARD1 mediates TGF-β signaling in pulmonary fibrosis.

artículo científico publicado en 2015

Bleomycin revisited: towards a more representative model of IPF?

artículo científico publicado en 2010

Cadmium inhibits proteoglycan and procollagen production by cultured human lung fibroblasts

artículo científico publicado en 1998

Characterization of a new mouse model of empyema and the mechanisms of pleural invasion by Streptococcus pneumoniae ⬇️

artículo científico publicado en 2011

Coagulation Cascade Proteinases in Lung Injury and Fibrosis

artículo científico publicado el 1 de julio de 2012

Coagulation and coagulation signalling in fibrosis.

artículo científico

Coagulation signalling following tissue injury: focus on the role of factor Xa.

artículo científico publicado en 2008

Collagen synthesis by mesenchymal stem cells and aortic valve interstitial cells in response to mechanical stretch.

artículo científico publicado en 2006

Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions

scientific article published on 21 January 2019

Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.

artículo científico publicado en 2012

Diminished prostaglandin E2 contributes to the apoptosis paradox in idiopathic pulmonary fibrosis

artículo científico publicado en 2010

Enhanced inflammation in aged mice following infection with Streptococcus pneumoniae is associated with decreased IL-10 and augmented chemokine production.

artículo científico publicado en 2015

Escape from the matrix: multiple mechanisms for fibroblast activation in pulmonary fibrosis

artículo científico publicado en 2008

Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease

artículo científico publicado en 2013

Evidence for chemokine synergy during neutrophil migration in ARDS

artículo científico publicado en 2016

Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation

artículo científico publicado en 2013

Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF

artículo científico publicado en 2016

Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome

artículo científico publicado en 2017

Factor Xa stimulates fibroblast procollagen production, proliferation, and calcium signaling via PAR1 activation

artículo científico publicado en 2004

From clot to collagen: coagulation peptides in interstitial lung disease ⬇️

artículo científico publicado el 1 de mayo de 1998

Genome-Wide Posttranscriptional Dysregulation by MicroRNAs in Human Asthma as Revealed by Frac-seq

scientific article published on 16 May 2018

Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching

artículo científico publicado en 2003

Human SARS-CoV-2 challenge uncovers local and systemic response dynamics

artículo científico publicado en 2024

Identification of an active metabolite of PAR-1 antagonist RWJ-58259 and synthesis of analogues to enhance its metabolic stability

artículo científico publicado en 2016

Impact of a functional polymorphism in the PAR-1 gene promoter in COPD and COPD exacerbations

artículo científico publicado en 2014

Increased endothelin-1 and its localization during the development of bleomycin-induced pulmonary fibrosis in rats

artículo científico publicado en 1998

Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury.

artículo científico publicado en 2009

Innate Immunity in Lung Fibrosis: A Therapeutic Role for Surfactant Protein D? ⬇️

artículo científico publicado el 1 de marzo de 2012

Innate immune signaling and stem cell renewal in idiopathic pulmonary fibrosis

artículo científico publicado en 2016

International registry for idiopathic pulmonary fibrosis

article published in 2008

Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis

artículo científico publicado en 2014

JAK inhibitors in COVID-19: need for vigilance regarding increased inherent thrombotic risk

artículo científico publicado en 2020

Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

artículo científico publicado en 2006

Mechanisms of alveolar epithelial injury, repair, and fibrosis

artículo científico publicado en 2015

Mechanistic overlap between chronic lung injury and cancer: ERS Lung Science Conference 2017 report.

artículo científico publicado en 2017

Molecular targets in pulmonary fibrosis: the myofibroblast in focus.

artículo científico publicado en 2007

Neutrophils and tissue damage: is hypoxia the key to excessive degranulation?

artículo científico publicado en 2016

New tale for an old fox in IPF?

artículo científico publicado en 2013

Novel therapeutic approaches for pulmonary fibrosis

artículo científico publicado en 2011

PAR-1-dependent and PAR-independent pro-inflammatory signaling in human lung fibroblasts exposed to thrombin.

artículo científico publicado en 2012

Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo.

artículo científico publicado en 2008

Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages

scientific article published on 27 January 2014

Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation

artículo científico publicado en 2014

Proteinase-activated receptors in fibroproliferative lung disease.

artículo científico publicado en 2013

Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis

artículo científico publicado en 2008

Pulmonary venous hypertension and mechanical strain stimulate monocyte chemoattractant protein-1 release and structural remodelling of the lung in human and rodent chronic heart failure models

artículo científico publicado en 2014

Regulation of neutrophilic inflammation by proteinase-activated receptor 1 during bacterial pulmonary infection ⬇️

artículo científico publicado en 2015

Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post–COVID-19 Study

artículo científico publicado en 2023

Role of a functional polymorphism in the F2R gene promoter in sarcoidosis

artículo científico publicado en 2015

Role of serine proteases in the regulation of interleukin-877 during the development of bronchopulmonary dysplasia in preterm ventilated infants

artículo científico publicado en 2014

Role of thrombin in pulmonary fibrosis

scientific article published on 01 October 1995

Signaling pathways involved in proteinase-activated receptor1-induced proinflammatory and profibrotic mediator release following lung injury.

artículo científico publicado en 2007

Surface modification of a POSS-nanocomposite material to enhance cellular integration of a synthetic bioscaffold.

artículo científico publicado en 2016

Synthesis of novel and potent vorapaxar analogues

artículo científico publicado en 2016

TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells

artículo científico publicado en 2016

Targeting coagulation activation in severe COVID-19 pneumonia: lessons from bacterial pneumonia and sepsis

scientific article published on 01 September 2020

The RNA binding proteins ZFP36L1 and ZFP36L2 modulate transcriptional and post-transcriptional genome-wide effects of glucocorticoids

artículo científico publicado en 2022

The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection.

artículo científico publicado en 2015

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

artículo científico publicado en 2019

The mercurial nature of neutrophils: still an enigma in ARDS?

artículo científico

The pathogenesis of pulmonary fibrosis: a moving target

artículo científico publicado en 2012

The promise of mTOR as a therapeutic target pathway in idiopathic pulmonary fibrosis

artículo científico publicado en 2020

The rapamycin analogue SDZ RAD attenuates bleomycin-induced pulmonary fibrosis in rats.

artículo científico publicado en 2002

Thrombin

artículo científico publicado en 1998

Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways

artículo científico

Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1.

artículo científico publicado en 2000

Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis

artículo científico publicado en 2020

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

scientific article published on 16 September 2020

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis

artículo científico publicado en 2019

Lista de obras de Rachel C. Chambers

A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis

Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis

Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia.

Activation of fibroblast procollagen alpha 1(I) transcription by mechanical strain is transforming growth factor-beta-dependent and involves increased binding of CCAAT-binding factor (CBF/NF-Y) at the proximal promoter

Activation of proteinase-activated receptor-2 in mesothelial cells induces pleural inflammation.

Acute Respiratory Distress Syndrome

Altered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lung fibrosis

Angiotensin II and the fibroproliferative response to acute lung injury.

Author Correction: The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

BARD1 mediates TGF-β signaling in pulmonary fibrosis.

Bleomycin revisited: towards a more representative model of IPF?

Cadmium inhibits proteoglycan and procollagen production by cultured human lung fibroblasts

Characterization of a new mouse model of empyema and the mechanisms of pleural invasion by Streptococcus pneumoniae ⬇️

Coagulation Cascade Proteinases in Lung Injury and Fibrosis

Coagulation and coagulation signalling in fibrosis.

Coagulation signalling following tissue injury: focus on the role of factor Xa.

Collagen synthesis by mesenchymal stem cells and aortic valve interstitial cells in response to mechanical stretch.

Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions

Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.

Diminished prostaglandin E2 contributes to the apoptosis paradox in idiopathic pulmonary fibrosis

Enhanced inflammation in aged mice following infection with Streptococcus pneumoniae is associated with decreased IL-10 and augmented chemokine production.

Escape from the matrix: multiple mechanisms for fibroblast activation in pulmonary fibrosis

Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease

Evidence for chemokine synergy during neutrophil migration in ARDS

Ex vivo micro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation

Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF

Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome

Factor Xa stimulates fibroblast procollagen production, proliferation, and calcium signaling via PAR1 activation

From clot to collagen: coagulation peptides in interstitial lung disease ⬇️

Genome-Wide Posttranscriptional Dysregulation by MicroRNAs in Human Asthma as Revealed by Frac-seq

Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching

Human SARS-CoV-2 challenge uncovers local and systemic response dynamics

Identification of an active metabolite of PAR-1 antagonist RWJ-58259 and synthesis of analogues to enhance its metabolic stability

Impact of a functional polymorphism in the PAR-1 gene promoter in COPD and COPD exacerbations

Increased endothelin-1 and its localization during the development of bleomycin-induced pulmonary fibrosis in rats

Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury.

Innate Immunity in Lung Fibrosis: A Therapeutic Role for Surfactant Protein D? ⬇️

Innate immune signaling and stem cell renewal in idiopathic pulmonary fibrosis

International registry for idiopathic pulmonary fibrosis

Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis

JAK inhibitors in COVID-19: need for vigilance regarding increased inherent thrombotic risk

Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

Mechanisms of alveolar epithelial injury, repair, and fibrosis

Mechanistic overlap between chronic lung injury and cancer: ERS Lung Science Conference 2017 report.

Molecular targets in pulmonary fibrosis: the myofibroblast in focus.

Neutrophils and tissue damage: is hypoxia the key to excessive degranulation?

New tale for an old fox in IPF?

Novel therapeutic approaches for pulmonary fibrosis

PAR-1-dependent and PAR-independent pro-inflammatory signaling in human lung fibroblasts exposed to thrombin.

Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo.

Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages

Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation

Proteinase-activated receptors in fibroproliferative lung disease.

Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis

Pulmonary venous hypertension and mechanical strain stimulate monocyte chemoattractant protein-1 release and structural remodelling of the lung in human and rodent chronic heart failure models

Regulation of neutrophilic inflammation by proteinase-activated receptor 1 during bacterial pulmonary infection ⬇️

Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post–COVID-19 Study

Role of a functional polymorphism in the F2R gene promoter in sarcoidosis

Role of serine proteases in the regulation of interleukin-877 during the development of bronchopulmonary dysplasia in preterm ventilated infants

Role of thrombin in pulmonary fibrosis

Signaling pathways involved in proteinase-activated receptor1-induced proinflammatory and profibrotic mediator release following lung injury.

Surface modification of a POSS-nanocomposite material to enhance cellular integration of a synthetic bioscaffold.

Synthesis of novel and potent vorapaxar analogues

TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells

Targeting coagulation activation in severe COVID-19 pneumonia: lessons from bacterial pneumonia and sepsis

The RNA binding proteins ZFP36L1 and ZFP36L2 modulate transcriptional and post-transcriptional genome-wide effects of glucocorticoids

The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection.

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis

The mercurial nature of neutrophils: still an enigma in ARDS?

The pathogenesis of pulmonary fibrosis: a moving target

The promise of mTOR as a therapeutic target pathway in idiopathic pulmonary fibrosis

The rapamycin analogue SDZ RAD attenuates bleomycin-induced pulmonary fibrosis in rats.

Thrombin

Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho kinase signaling pathways

Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1.

Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis