Lista de obras - Pieter Annaert - Dominio Público Uruguay

A sensitive liquid chromatography method for analysis of propofol in small volumes of neonatal blood

artículo científico publicado en 2019

Age-dependent activity of the uptake transporters Ntcp and Oatp1b2 in male rat hepatocytes: from birth till adulthood

artículo científico publicado en 2014

Albumin is the main plasma binding protein for indoxyl sulfate and p-cresyl sulfate

artículo científico publicado en 2013

Antenatal sildenafil administration to prevent pulmonary hypertension in congenital diaphragmatic hernia (SToP-PH): study protocol for a phase I/IIb placenta transfer and safety study

artículo científico publicado en 2018

Approaches to Dose Finding in Neonates, Illustrating the Variability between Neonatal Drug Development Programs

artículo científico publicado en 2020

Cell Imaging Counting as a Novel Ex Vivo Approach for Investigating Drug-Induced Hepatotoxicity in Zebrafish Larvae.

artículo científico publicado en 2017

Cholestasis Differentially Affects Liver Connexins

scientific article published on 07 September 2020

Clearance Prediction of HIV Protease Inhibitors in Man: Role of Hepatic Uptake.

artículo científico publicado en 2015

Clinical determinants of calcineurin inhibitor disposition: a mechanistic review

artículo científico publicado en 2016

Combined use of ordered mesoporous silica and precipitation inhibitors for improved oral absorption of the poorly soluble weak base itraconazole

artículo científico publicado en 2010

Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance.

artículo científico publicado en 2016

Comparison between 2-hydroxypropyl-β-cyclodextrin and 2-hydroxypropyl-γ-cyclodextrin for inclusion complex formation with danazol

Comparison of the complexation between methylprednisolone and different cyclodextrins in solution by 1H-NMR and molecular modeling studies

artículo científico publicado en 2010

Concomitant Treatment with Voriconazole and Flucloxacillin: A Combination to Avoid

scientific article published in 2021

Current insights in the complexities underlying drug-induced cholestasis

scientific article published on 01 July 2019

Determinants of the Magnitude of Interaction Between Tacrolimus and Voriconazole/Posaconazole in Solid Organ Recipients.

artículo científico publicado en 2017

Drug-induced cholestasis detection in cryopreserved rat hepatocytes in sandwich culture

article

Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes

artículo científico publicado en 2016

Effect of ABCB1 diplotype on tacrolimus disposition in renal recipients depends on CYP3A5 and CYP3A4 genotype

artículo científico publicado en 2016

Effect of Age on The Hepatocellularity Number for Wistar rats

scientific article published on 23 December 2015

Effect of the Direct Oral Anticoagulants Rivaroxaban and Apixaban on the Disposition of Calcineurin Inhibitors in Transplant Recipients.

artículo científico publicado en 2016

Effects of Drugs Formerly Proposed for COVID-19 Treatment on Connexin43 Hemichannels

artículo científico publicado en 2022

Enhanced absorption of the poorly soluble drug fenofibrate by tuning its release rate from ordered mesoporous silica

artículo científico publicado en 2010

Evaluation of fasted and fed state simulated and human intestinal fluids as solvent system in the Ussing chambers model to explore food effects on intestinal permeability.

artículo científico publicado en 2014

Evaluation of fasted state human intestinal fluid as apical solvent system in the Caco-2 absorption model and comparison with FaSSIF.

artículo científico publicado en 2014

Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption

artículo científico publicado en 2009

Excipient-Mediated Supersaturation Stabilization in Human Intestinal Fluids

artículo científico publicado en 2011

Extra collagen overlay prolongs the differentiated phenotype in sandwich-cultured rat hepatocytes.

artículo científico publicado en 2017

Fexofenadine, a Putative In Vivo P-glycoprotein Probe, Fails to Predict Clearance of the Substrate Tacrolimus in Renal Recipients.

artículo científico publicado en 2017

Formulate-ability of ten compounds with different physicochemical profiles in SMEDDS

artículo científico publicado en 2009

Hepatic Clearance Prediction of Nine Human Immunodeficiency Virus Protease Inhibitors in Rat.

artículo científico publicado en 2015

Hepatocyte-based in vitro model for assessment of drug-induced cholestasis.

artículo científico publicado en 2013

High Intrapatient Variability of Tacrolimus Concentrations Predicts Accelerated Progression of Chronic Histologic Lesions in Renal Recipients

artículo científico publicado en 2016

Higher versus standard amikacin single dose in emergency department patients with severe sepsis and shock: a randomized controlled trial

artículo científico publicado en 2017

Impact of hypoalbuminemia on voriconazole pharmacokinetics in critically ill adult patients

artículo científico publicado en 2014

In situ perfusion in rodents to explore intestinal drug absorption: challenges and opportunities.

artículo científico publicado en 2014

In vitro and in vivo investigation of the gastrointestinal behavior of simvastatin

scientific article published on 20 June 2016

In vitro disposition profiling of heterocyclic compounds

artículo científico publicado en 2015

In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor

artículo científico publicado en 2014

Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica

artículo científico publicado en 2008

Influence of drug transport proteins on the pharmacokinetics and drug interactions of HIV protease inhibitors.

artículo científico publicado en 2011

Influence of formulation composition and process on the characteristics and in vitro release from PLGA-based sustained release injectables

artículo científico publicado en 2014

Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study

scientific article published on 01 July 1999

Integration and validation of the ex vivo human placenta perfusion model.

artículo científico publicado en 2017

Inter-Subject Variability in OCT1 Activity in 27 Batches of Cryopreserved Human Hepatocytes and Association with OCT1 mRNA Expression and Genotype.

artículo científico publicado en 2017

Intestinal behavior of the ester prodrug tenofovir DF in humans

artículo científico publicado en 2015

Investigation of Saliva as an Alternative to Plasma Monitoring of Voriconazole.

artículo científico publicado en 2015

Lipophilic nalmefene prodrugs to achieve a one-month sustained release.

artículo científico publicado en 2016

MRP2 Inhibition by HIV Protease Inhibitors in Rat and Human Hepatocytes: A Quantitative Confocal Microscopy Study.

artículo científico publicado en 2018

Meropenem Target Attainment and Population Pharmacokinetics in Critically Ill Septic Patients with Preserved or Increased Renal Function

artículo científico publicado en 2022

Modeling the Time Course of the Tissue Responses to Intramuscular Long-acting Paliperidone Palmitate Nano-/Microcrystals and Polystyrene Microspheres in the Rat.

artículo científico publicado en 2015

Multimodal non-linear optical imaging for the investigation of drug nano-/microcrystal-cell interactions

artículo científico publicado en 2015

Ontogeny of Hepatic Transporters and Drug-Metabolizing Enzymes in Humans and in Nonclinical Species

artículo científico publicado en 2021

Ordered mesoporous silica induces pH-independent supersaturation of the basic low solubility compound itraconazole resulting in enhanced transepithelial transport

artículo científico publicado en 2008

Ordered mesoporous silica material SBA-15: a broad-spectrum formulation platform for poorly soluble drugs

artículo científico publicado en 2009

PK/PD of single-dose amikacin in emergency department patients with severe sepsis/shock: should we apply the ICU-based higher loading dose?

artículo científico publicado en 2015

Pharmacokinetics of Posaconazole Oral Suspension in Children Dosed According to Body Surface Area.

artículo científico publicado en 2015

Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.

artículo científico publicado en 2015

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.

artículo científico publicado en 2014

Posaconazole plasma exposure correlated to intestinal mucositis in allogeneic stem cell transplant patients.

artículo científico publicado en 2016

Postprandial changes in solubilizing capacity of human intestinal fluids for BCS class II drugs.

artículo científico publicado en 2009

Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation.

artículo científico publicado en 2017

Preventing release in the acidic environment of the stomach via occlusion in ordered mesoporous silica enhances the absorption of poorly soluble weakly acidic drugs

scientific article published on 15 July 2011

Primary Hepatocytes in Sandwich Culture.

artículo científico publicado en 2015

Rapid conversion of the ester prodrug abiraterone acetate results in intestinal supersaturation and enhanced absorption of abiraterone: In vitro, rat in situ and human in vivo studies

artículo científico publicado en 2015

Response to: 'Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'.

artículo científico publicado en 2017

Role of the OATP Transporter Family and a Benzbromarone-SensitiveEfflux Transporter in the Hepatocellular Disposition of Vincristine.

artículo científico publicado en 2017

SLC22A1/OCT1 Genotype Affects O-desmethyltramadol Exposure in Newborn Infants

artículo científico publicado en 2016

Safety Assessment of Compounds after In Vitro Metabolic Conversion Using Zebrafish Eleuthero Embryos ⬇️

artículo científico

Sodium fluorescein is a probe substrate for hepatic drug transport mediated by OATP1B1 and OATP1B3.

artículo científico publicado en 2011

Stability of therapeutic albumin solutions used for molecular adsorbent recirculating system-based liver dialysis.

artículo científico

Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro-In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound.

artículo científico publicado en 2016

Supersaturation in human gastric fluids

artículo científico publicado en 2012

Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study

artículo científico publicado en 2016

The Effect of Food on the Intraluminal Behavior of Abiraterone Acetate in Man.

artículo científico publicado en 2016

The FXR agonist obeticholic acid prevents gut barrier dysfunction and bacterial translocation in cholestatic rats.

artículo científico publicado en 2015

The Neonatal and Juvenile Pig in Pediatric Drug Discovery and Development

artículo científico publicado en 2020

The conflict between in vitro release studies in human biorelevant media and the in vivo exposure in rats of the lipophilic compound fenofibrate

artículo científico publicado en 2011

The effect of macrophage and angiogenesis inhibition on the drug release and absorption from an intramuscular sustained-release paliperidone palmitate suspension.

artículo científico publicado en 2016

The ontogeny of drug metabolizing enzymes and transporters in the rat

scientific journal article

Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: role of glycine conjugates

artículo científico publicado en 2013

Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2)

artículo científico publicado en 1997

Transport-Metabolism Interplay of Atazanavir in Rat Hepatocytes.

artículo científico publicado en 2015

Unbound Ritonavir Concentrations in Rat and Human Hepatocytes

scientific article published on 18 May 2015

Verapamil hepatic clearance in four preclinical rat models: towards activity-based scaling

artículo científico publicado en 2015

Lista de obras de Pieter Annaert

A sensitive liquid chromatography method for analysis of propofol in small volumes of neonatal blood

Age-dependent activity of the uptake transporters Ntcp and Oatp1b2 in male rat hepatocytes: from birth till adulthood

Albumin is the main plasma binding protein for indoxyl sulfate and p-cresyl sulfate

Antenatal sildenafil administration to prevent pulmonary hypertension in congenital diaphragmatic hernia (SToP-PH): study protocol for a phase I/IIb placenta transfer and safety study

Approaches to Dose Finding in Neonates, Illustrating the Variability between Neonatal Drug Development Programs

Cell Imaging Counting as a Novel Ex Vivo Approach for Investigating Drug-Induced Hepatotoxicity in Zebrafish Larvae.

Cholestasis Differentially Affects Liver Connexins

Clearance Prediction of HIV Protease Inhibitors in Man: Role of Hepatic Uptake.

Clinical determinants of calcineurin inhibitor disposition: a mechanistic review

Combined use of ordered mesoporous silica and precipitation inhibitors for improved oral absorption of the poorly soluble weak base itraconazole

Comparative performance of oral midazolam clearance and plasma 4β-hydroxycholesterol to explain interindividual variability in tacrolimus clearance.

Comparison between 2-hydroxypropyl-β-cyclodextrin and 2-hydroxypropyl-γ-cyclodextrin for inclusion complex formation with danazol

Comparison of the complexation between methylprednisolone and different cyclodextrins in solution by 1H-NMR and molecular modeling studies

Concomitant Treatment with Voriconazole and Flucloxacillin: A Combination to Avoid

Current insights in the complexities underlying drug-induced cholestasis

Determinants of the Magnitude of Interaction Between Tacrolimus and Voriconazole/Posaconazole in Solid Organ Recipients.

Drug-induced cholestasis detection in cryopreserved rat hepatocytes in sandwich culture

Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes

Effect of ABCB1 diplotype on tacrolimus disposition in renal recipients depends on CYP3A5 and CYP3A4 genotype

Effect of Age on The Hepatocellularity Number for Wistar rats

Effect of the Direct Oral Anticoagulants Rivaroxaban and Apixaban on the Disposition of Calcineurin Inhibitors in Transplant Recipients.

Effects of Drugs Formerly Proposed for COVID-19 Treatment on Connexin43 Hemichannels

Enhanced absorption of the poorly soluble drug fenofibrate by tuning its release rate from ordered mesoporous silica

Evaluation of fasted and fed state simulated and human intestinal fluids as solvent system in the Ussing chambers model to explore food effects on intestinal permeability.

Evaluation of fasted state human intestinal fluid as apical solvent system in the Caco-2 absorption model and comparison with FaSSIF.

Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption

Excipient-Mediated Supersaturation Stabilization in Human Intestinal Fluids

Extra collagen overlay prolongs the differentiated phenotype in sandwich-cultured rat hepatocytes.

Fexofenadine, a Putative In Vivo P-glycoprotein Probe, Fails to Predict Clearance of the Substrate Tacrolimus in Renal Recipients.

Formulate-ability of ten compounds with different physicochemical profiles in SMEDDS

Hepatic Clearance Prediction of Nine Human Immunodeficiency Virus Protease Inhibitors in Rat.

Hepatocyte-based in vitro model for assessment of drug-induced cholestasis.

High Intrapatient Variability of Tacrolimus Concentrations Predicts Accelerated Progression of Chronic Histologic Lesions in Renal Recipients

Higher versus standard amikacin single dose in emergency department patients with severe sepsis and shock: a randomized controlled trial

Impact of hypoalbuminemia on voriconazole pharmacokinetics in critically ill adult patients

In situ perfusion in rodents to explore intestinal drug absorption: challenges and opportunities.

In vitro and in vivo investigation of the gastrointestinal behavior of simvastatin

In vitro disposition profiling of heterocyclic compounds

In vivo evaluation of different formulation strategies for sustained release injectables of a poorly soluble HIV protease inhibitor

Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica

Influence of drug transport proteins on the pharmacokinetics and drug interactions of HIV protease inhibitors.

Influence of formulation composition and process on the characteristics and in vitro release from PLGA-based sustained release injectables

Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study

Integration and validation of the ex vivo human placenta perfusion model.

Inter-Subject Variability in OCT1 Activity in 27 Batches of Cryopreserved Human Hepatocytes and Association with OCT1 mRNA Expression and Genotype.

Intestinal behavior of the ester prodrug tenofovir DF in humans

Investigation of Saliva as an Alternative to Plasma Monitoring of Voriconazole.

Lipophilic nalmefene prodrugs to achieve a one-month sustained release.

MRP2 Inhibition by HIV Protease Inhibitors in Rat and Human Hepatocytes: A Quantitative Confocal Microscopy Study.

Meropenem Target Attainment and Population Pharmacokinetics in Critically Ill Septic Patients with Preserved or Increased Renal Function

Modeling the Time Course of the Tissue Responses to Intramuscular Long-acting Paliperidone Palmitate Nano-/Microcrystals and Polystyrene Microspheres in the Rat.

Multimodal non-linear optical imaging for the investigation of drug nano-/microcrystal-cell interactions

Ontogeny of Hepatic Transporters and Drug-Metabolizing Enzymes in Humans and in Nonclinical Species

Ordered mesoporous silica induces pH-independent supersaturation of the basic low solubility compound itraconazole resulting in enhanced transepithelial transport

Ordered mesoporous silica material SBA-15: a broad-spectrum formulation platform for poorly soluble drugs

PK/PD of single-dose amikacin in emergency department patients with severe sepsis/shock: should we apply the ICU-based higher loading dose?

Pharmacokinetics of Posaconazole Oral Suspension in Children Dosed According to Body Surface Area.

Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.

Posaconazole plasma exposure correlated to intestinal mucositis in allogeneic stem cell transplant patients.

Postprandial changes in solubilizing capacity of human intestinal fluids for BCS class II drugs.

Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation.

Preventing release in the acidic environment of the stomach via occlusion in ordered mesoporous silica enhances the absorption of poorly soluble weakly acidic drugs

Primary Hepatocytes in Sandwich Culture.

Rapid conversion of the ester prodrug abiraterone acetate results in intestinal supersaturation and enhanced absorption of abiraterone: In vitro, rat in situ and human in vivo studies

Response to: 'Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'.

Role of the OATP Transporter Family and a Benzbromarone-SensitiveEfflux Transporter in the Hepatocellular Disposition of Vincristine.

SLC22A1/OCT1 Genotype Affects O-desmethyltramadol Exposure in Newborn Infants

Safety Assessment of Compounds after In Vitro Metabolic Conversion Using Zebrafish Eleuthero Embryos ⬇️

Sodium fluorescein is a probe substrate for hepatic drug transport mediated by OATP1B1 and OATP1B3.

Stability of therapeutic albumin solutions used for molecular adsorbent recirculating system-based liver dialysis.

Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro-In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound.

Supersaturation in human gastric fluids

Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study

The Effect of Food on the Intraluminal Behavior of Abiraterone Acetate in Man.

The FXR agonist obeticholic acid prevents gut barrier dysfunction and bacterial translocation in cholestatic rats.

The Neonatal and Juvenile Pig in Pediatric Drug Discovery and Development

The conflict between in vitro release studies in human biorelevant media and the in vivo exposure in rats of the lipophilic compound fenofibrate

The effect of macrophage and angiogenesis inhibition on the drug release and absorption from an intramuscular sustained-release paliperidone palmitate suspension.