Lista de obras - Jonathan Harris - Dominio Público Uruguay

An androgen receptor mutation in the MDA-MB-453 cell line model of molecular apocrine breast cancer compromises receptor activity

artículo científico publicado en 2012

Characterization of ENU-induced Mutations in Red Blood Cell Structural Proteins

artículo científico publicado en 2013

Characterization of the retinoid orphan-related receptor-alpha coactivator binding interface: a structural basis for ligand-independent transcription

artículo científico publicado en 2002

Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1

scientific article published on 04 April 2019

Decreased androgen receptor levels and receptor function in breast cancer contribute to the failure of response to medroxyprogesterone acetate.

artículo científico publicado en 2005

Decreased expression of the glutathione S-transferases alpha and pi genes in human renal cell carcinoma

scientific article published on 01 December 1990

Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics

artículo científico publicado en 2016

Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition.

artículo científico publicado en 2015

Epitope map for a growth hormone receptor agonist monoclonal antibody, MAb 263.

artículo científico publicado en 2003

Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors

artículo científico publicado en 2016

Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype.

artículo científico publicado en 2009

Hormone status selects for spontaneous somatic androgen receptor variants that demonstrate specific ligand and cofactor dependent activities in autochthonous prostate cancer.

artículo científico publicado en 2000

Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits

artículo científico publicado en 1996

Improving the Selectivity of Engineered Protease Inhibitors: Optimizing the P2 Prime Residue Using a Versatile Cyclic Peptide Library

artículo científico publicado en 2015

Inhibitory GH receptor extracellular domain monoclonal antibodies: three-dimensional epitope mapping

artículo científico publicado en 2011

Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs

artículo científico publicado en 2017

Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network

artículo científico publicado en 2011

Mechanism-based selection of a potent kallikrein-related peptidase 7 inhibitor from a versatile library based on the sunflower trypsin inhibitor SFTI-1

artículo científico publicado en 2013

Molecular and structural basis of androgen receptor responses to dihydrotestosterone, medroxyprogesterone acetate and Δ(4)-tibolone.

artículo científico publicado en 2013

Mutation of the androgen receptor causes oncogenic transformation of the prostate

artículo científico publicado en 2005

Natural and engineered plasmin inhibitors: applications and design strategies.

artículo científico

Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14.

artículo científico publicado en 2012

PSA/KLK3 AREI promoter polymorphism alters androgen receptor binding and is associated with prostate cancer susceptibility

artículo científico publicado en 2006

Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment

artículo científico publicado en 2013

Plasmin substrate binding site cooperativity guides the design of potent peptide aldehyde inhibitors.

artículo científico publicado en 2011

Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif

scientific article published in PLoS ONE

Probing the Specificity of Binding to the Major Nuclear Localization Sequence-binding Site of Importin- Using Oriented Peptide Library Screening

artículo científico publicado en 2010

Proteases and proteomics: cutting to the core of human skin pathologies

artículo científico

Proteases: common culprits in human skin disorders

artículo científico

Quinazolinone derivatives as inhibitors of homologous recombinase RAD51.

artículo científico publicado en 2017

Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum

artículo científico publicado en 2016

Selective cleavage of human sex hormone-binding globulin by kallikrein-related peptidases and effects on androgen action in LNCaP prostate cancer cells

artículo científico publicado en 2012

Structural and functional consequences of glutamine tract variation in the androgen receptor.

artículo científico publicado en 2004

Structure-function analysis of the Rev-erbA and RVR ligand-binding domains reveals a large hydrophobic surface that mediates corepressor binding and a ligand cavity occupied by side chains

scientific article published on 01 May 2000

Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target

scientific article published on 01 April 1999

Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold

artículo científico publicado en 2016

Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4.

artículo científico publicado en 2009

The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine

scientific journal article

The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment

artículo científico publicado en 2002

The isolation and characterization of the major glutathione S-transferase from the squid Loligo vulgaris

artículo científico publicado en 1991

The temperature activated HtrA protease from pathogen Chlamydia trachomatis acts as both a chaperone and protease at 37 degrees C.

artículo científico publicado en 2007

Whole-genome landscape of pancreatic neuroendocrine tumours.

artículo científico publicado en 2017

Lista de obras de Jonathan Harris

An androgen receptor mutation in the MDA-MB-453 cell line model of molecular apocrine breast cancer compromises receptor activity

Characterization of ENU-induced Mutations in Red Blood Cell Structural Proteins

Characterization of the retinoid orphan-related receptor-alpha coactivator binding interface: a structural basis for ligand-independent transcription

Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1

Decreased androgen receptor levels and receptor function in breast cancer contribute to the failure of response to medroxyprogesterone acetate.

Decreased expression of the glutathione S-transferases alpha and pi genes in human renal cell carcinoma

Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics

Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition.

Epitope map for a growth hormone receptor agonist monoclonal antibody, MAb 263.

Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors

Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype.

Hormone status selects for spontaneous somatic androgen receptor variants that demonstrate specific ligand and cofactor dependent activities in autochthonous prostate cancer.

Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits

Improving the Selectivity of Engineered Protease Inhibitors: Optimizing the P2 Prime Residue Using a Versatile Cyclic Peptide Library

Inhibitory GH receptor extracellular domain monoclonal antibodies: three-dimensional epitope mapping

Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs

Mastering the canonical loop of serine protease inhibitors: enhancing potency by optimising the internal hydrogen bond network

Mechanism-based selection of a potent kallikrein-related peptidase 7 inhibitor from a versatile library based on the sunflower trypsin inhibitor SFTI-1

Molecular and structural basis of androgen receptor responses to dihydrotestosterone, medroxyprogesterone acetate and Δ(4)-tibolone.

Mutation of the androgen receptor causes oncogenic transformation of the prostate

Natural and engineered plasmin inhibitors: applications and design strategies.

Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14.

PSA/KLK3 AREI promoter polymorphism alters androgen receptor binding and is associated with prostate cancer susceptibility

Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment

Plasmin substrate binding site cooperativity guides the design of potent peptide aldehyde inhibitors.

Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif

Probing the Specificity of Binding to the Major Nuclear Localization Sequence-binding Site of Importin- Using Oriented Peptide Library Screening

Proteases and proteomics: cutting to the core of human skin pathologies

Proteases: common culprits in human skin disorders

Quinazolinone derivatives as inhibitors of homologous recombinase RAD51.

Selective Substrates and Inhibitors for Kallikrein-Related Peptidase 7 (KLK7) Shed Light on KLK Proteolytic Activity in the Stratum Corneum

Selective cleavage of human sex hormone-binding globulin by kallikrein-related peptidases and effects on androgen action in LNCaP prostate cancer cells

Structural and functional consequences of glutamine tract variation in the androgen receptor.

Structure-function analysis of the Rev-erbA and RVR ligand-binding domains reveals a large hydrophobic surface that mediates corepressor binding and a ligand cavity occupied by side chains

Structure/function analysis of a dUTPase: catalytic mechanism of a potential chemotherapeutic target

Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold

Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4.

The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine

The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment

The isolation and characterization of the major glutathione S-transferase from the squid Loligo vulgaris

The temperature activated HtrA protease from pathogen Chlamydia trachomatis acts as both a chaperone and protease at 37 degrees C.

Whole-genome landscape of pancreatic neuroendocrine tumours.