Lista de obras - Victor Mangas-Sanjuan - Dominio Público Uruguay

A multilevel object-oriented modelling methodology for physiologically-based pharmacokinetics (PBPK): Evaluation with a semi-mechanistic pharmacokinetic model

scientific article published on 09 January 2020

A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability.

artículo científico publicado en 2014

Agitation Rate and Time for Complete Dissolution in BCS Biowaivers Based on Investigation of a BCS Biowaiver for Dexketoprofen Tablets.

artículo científico publicado en 2015

Assessment of the Inter-Batch Variability of Microstructure Parameters in Topical Semisolids and Impact on the Demonstration of Equivalence

scientific article published on 01 October 2019

Assessment of the Regulatory Methods for the Comparison of Highly Variable Dissolution Profiles.

artículo científico publicado en 2016

Commentary on the MID3 Good Practices Paper

artículo científico publicado en 2017

Comparison of free software platforms for the calculation of the 90% confidence interval of f2 similarity factor by bootstrap analysis

artículo científico publicado en 2020

Computer simulations for bioequivalence trials: Selection of analyte in BCS class II and IV drugs with first-pass metabolism, two metabolic pathways and intestinal efflux transporter

artículo científico publicado en 2018

Cyclometalated Iminophosphorane Gold(III) and Platinum(II) Complexes. A Highly Permeable Cationic Platinum(II) Compound with Promising Anticancer Properties

artículo científico publicado en 2015

Defining level A IVIVC dissolution specifications based on individual in vitro dissolution profiles of a controlled release formulation.

artículo científico publicado en 2018

Drug gastrointestinal absorption in rat: Strain and gender differences

artículo científico publicado en 2015

Enhancing Oral Absorption of β-Lapachone: Progress Till Date.

artículo científico publicado en 2016

IVIVC approach based on carbamazepine bioequivalence studies combination

artículo científico publicado en 2017

In Silico Prediction of Caco-2 Cell Permeability by a Classification QSAR Approach

artículo científico publicado en 2011

In vitro-in situ permeability and dissolution of fexofenadine with kinetic modeling in the presence of sodium dodecyl sulfate

scientific article published on 11 August 2011

In vitro-in vivo correlations: general concepts, methodologies and regulatory applications

artículo científico

Intestinal Permeability of β-Lapachone and Its Cyclodextrin Complexes and Physical Mixtures

artículo científico publicado en 2015

Investigating the Discriminatory Power of BCS-Biowaiver in Vitro Methodology to Detect Bioavailability Differences between Immediate Release Products Containing a Class I Drug.

artículo científico publicado en 2015

Ion-pair strategy for enabling amifostine oral absorption: rat in situ and in vivo experiments.

artículo científico publicado en 2013

Modified nonsink equation for permeability estimation in cell monolayers: comparison with standard methods.

artículo científico publicado en 2014

Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration

artículo científico publicado en 2019

Population pharmacokinetic model of lithium and drug compliance assessment

artículo científico publicado en 2016

Population pharmacokinetic/pharmacodynamic modelling of the effects of axomadol and its O-demethyl metabolite on pupil diameter and nociception in healthy subjects

artículo científico publicado en 2016

Semi-mechanistic Pharmacokinetic/Pharmacodynamic model of three pegylated rHuEPO and ior®EPOCIM in New Zealand rabbits.

artículo científico publicado en 2018

Semi-physiologic model validation and bioequivalence trials simulation to select the best analyte for acetylsalicylic acid.

artículo científico publicado en 2015

Semimechanistic cell-cycle type-based pharmacokinetic/pharmacodynamic model of chemotherapy-induced neutropenic effects of diflomotecan under different dosing schedules.

artículo científico publicado en 2015

Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9-substituted camptothecin derivatives.

artículo científico publicado en 2013

Systematic modelling and design evaluation of unperturbed tumour dynamics in xenografts.

artículo científico publicado en 2018

Target-Site Investigation for the Plasma Prolactin Response: Mechanism-Based Pharmacokinetic-Pharmacodynamic Analysis of Risperidone and Paliperidone in the Rat.

artículo científico publicado en 2016

Topiramate pharmacokinetics in neonates undergoing therapeutic hypothermia and proposal of an optimised dosing schedule

scientific article published on 22 August 2019

Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors.

artículo científico publicado en 2014

Validation of a semi-physiological model for caffeine in healthy subjects and cirrhotic patients.

artículo científico publicado en 2015

Variability of permeability estimation from different protocols of subculture and transport experiments in cell monolayers.

artículo científico publicado en 2014

Lista de obras de Victor Mangas-Sanjuan

A multilevel object-oriented modelling methodology for physiologically-based pharmacokinetics (PBPK): Evaluation with a semi-mechanistic pharmacokinetic model

A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability.

Agitation Rate and Time for Complete Dissolution in BCS Biowaivers Based on Investigation of a BCS Biowaiver for Dexketoprofen Tablets.

Assessment of the Inter-Batch Variability of Microstructure Parameters in Topical Semisolids and Impact on the Demonstration of Equivalence

Assessment of the Regulatory Methods for the Comparison of Highly Variable Dissolution Profiles.

Commentary on the MID3 Good Practices Paper

Comparison of free software platforms for the calculation of the 90% confidence interval of f2 similarity factor by bootstrap analysis

Computer simulations for bioequivalence trials: Selection of analyte in BCS class II and IV drugs with first-pass metabolism, two metabolic pathways and intestinal efflux transporter

Cyclometalated Iminophosphorane Gold(III) and Platinum(II) Complexes. A Highly Permeable Cationic Platinum(II) Compound with Promising Anticancer Properties

Defining level A IVIVC dissolution specifications based on individual in vitro dissolution profiles of a controlled release formulation.

Drug gastrointestinal absorption in rat: Strain and gender differences

Enhancing Oral Absorption of β-Lapachone: Progress Till Date.

IVIVC approach based on carbamazepine bioequivalence studies combination

In Silico Prediction of Caco-2 Cell Permeability by a Classification QSAR Approach

In vitro-in situ permeability and dissolution of fexofenadine with kinetic modeling in the presence of sodium dodecyl sulfate

In vitro-in vivo correlations: general concepts, methodologies and regulatory applications

Intestinal Permeability of β-Lapachone and Its Cyclodextrin Complexes and Physical Mixtures

Investigating the Discriminatory Power of BCS-Biowaiver in Vitro Methodology to Detect Bioavailability Differences between Immediate Release Products Containing a Class I Drug.

Ion-pair strategy for enabling amifostine oral absorption: rat in situ and in vivo experiments.

Modified nonsink equation for permeability estimation in cell monolayers: comparison with standard methods.

Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration

Population pharmacokinetic model of lithium and drug compliance assessment

Population pharmacokinetic/pharmacodynamic modelling of the effects of axomadol and its O-demethyl metabolite on pupil diameter and nociception in healthy subjects

Semi-mechanistic Pharmacokinetic/Pharmacodynamic model of three pegylated rHuEPO and ior®EPOCIM in New Zealand rabbits.

Semi-physiologic model validation and bioequivalence trials simulation to select the best analyte for acetylsalicylic acid.

Semimechanistic cell-cycle type-based pharmacokinetic/pharmacodynamic model of chemotherapy-induced neutropenic effects of diflomotecan under different dosing schedules.

Semisynthesis, cytotoxic activity, and oral availability of new lipophilic 9-substituted camptothecin derivatives.

Systematic modelling and design evaluation of unperturbed tumour dynamics in xenografts.

Target-Site Investigation for the Plasma Prolactin Response: Mechanism-Based Pharmacokinetic-Pharmacodynamic Analysis of Risperidone and Paliperidone in the Rat.

Topiramate pharmacokinetics in neonates undergoing therapeutic hypothermia and proposal of an optimised dosing schedule

Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors.

Validation of a semi-physiological model for caffeine in healthy subjects and cirrhotic patients.

Variability of permeability estimation from different protocols of subculture and transport experiments in cell monolayers.