Lista de obras - Chris Abell - Dominio Público Uruguay

A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry

artículo científico publicado en 2009

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase

artículo científico publicado en 2009

Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121

artículo científico publicado en 2012

Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes

artículo científico publicado en 2010

Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change, and cooperativity

artículo científico publicado en 2007

Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases

artículo científico publicado en 2007

Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51

artículo científico publicado en 2016

From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo‐Like Kinase 1 ⬇️

artículo científico publicado el 29 de marzo de 2011

Hierarchical Self-Assembly of Cellulose Nanocrystals in a Confined Geometry

artículo científico publicado en 2016

High‐Throughput Interrogation of Ligand Binding Mode Using a Fluorescence‐Based Assay ⬇️

artículo científico publicado el 22 de junio de 2012

Inhibition ofMycobacterium tuberculosisPantothenate Synthetase by Analogues of the Reaction Intermediate

artículo científico publicado en 2008

Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

artículo científico publicado en 2013

Optimization of the Interligand Overhauser Effect for Fragment Linking: Application to Inhibitor Discovery against Mycobacterium tuberculosis Pantothenate Synthetase

artículo científico publicado en 2010

Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series TargetingMycobacterium tuberculosisCYP121

artículo científico publicado en 2013

Structural constraints on protein self-processing in L-aspartate- -decarboxylase

artículo científico publicado en 2003

Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis

artículo científico publicado en 2011

Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites

artículo científico publicado en 2003

Structure ofEscherichia coliaspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation

artículo científico publicado en 2012

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

artículo científico publicado en 2013

The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor

artículo científico publicado en 2002

Threonine 57 is required for the post-translational activation ofEscherichia coliaspartate α-decarboxylase ⬇️

artículo científico publicado en 2014

Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1

artículo científico publicado en 2012

Using a Fragment-Based Approach To Target Protein-Protein Interactions

artículo científico publicado en 2013

Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically

artículo científico publicado en 2014

pH-tuneable binding of 2′-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study

artículo científico publicado en 2007

Lista de obras de Chris Abell

A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase

Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121

Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes

Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change, and cooperativity

Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases

Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51

From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo‐Like Kinase 1 ⬇️

Hierarchical Self-Assembly of Cellulose Nanocrystals in a Confined Geometry

High‐Throughput Interrogation of Ligand Binding Mode Using a Fluorescence‐Based Assay ⬇️

Inhibition ofMycobacterium tuberculosisPantothenate Synthetase by Analogues of the Reaction Intermediate

Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

Optimization of the Interligand Overhauser Effect for Fragment Linking: Application to Inhibitor Discovery against Mycobacterium tuberculosis Pantothenate Synthetase

Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series TargetingMycobacterium tuberculosisCYP121

Structural constraints on protein self-processing in L-aspartate- -decarboxylase

Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis

Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites

Structure ofEscherichia coliaspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor

Threonine 57 is required for the post-translational activation ofEscherichia coliaspartate α-decarboxylase ⬇️

Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1

Using a Fragment-Based Approach To Target Protein-Protein Interactions

Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically

pH-tuneable binding of 2′-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study