Lista de obras - Paul M. Loadman - Dominio Público Uruguay

5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study ⬇️

artículo científico publicado el 22 de abril de 2003

A Novel Theranostic Strategy for MMP-14-Expressing Glioblastomas Impacts Survival.

artículo científico publicado en 2017

A liquid chromatography-tandem mass spectrometry method to measure fatty acids in biological samples ⬇️

artículo científico publicado en 2017

A preclinical pharmacokinetic study of the bioreductive drug AQ4N

artículo científico publicado en 2001

A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota ⬇️

artículo científico publicado en 2017

A randomized controlled trial of eicosapentaenoic acid and/or aspirin for colorectal adenoma prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme (The seAFOod Polyp Prevention Trial): study protocol for a randomize

artículo científico publicado en 2013

A study of inter-individual variability in the Phase II metabolism of xenobiotics in human skin

artículo científico publicado en 2018

An optimised assay for quantitative, high-throughput analysis of polysialyltransferase activity

scientific article published on 12 August 2016

Analysis of the imidazoacridinone C1311 by high-performance liquid chromatography

artículo científico publicado en 1997

Angiogenesis in the hollow fiber tumor model influences drug delivery to tumor cells: implications for anticancer drug screening programs

artículo científico publicado en 1998

Anticancer Drug Development

Anticolorectal cancer activity of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid

artículo científico

Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.

artículo científico publicado en 2012

Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1 targeted tripartite quinone drug delivery system.

artículo científico publicado en 2007

Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins

artículo científico publicado en 2013

Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma

artículo científico publicado en 2000

Comet assay and flow cytometry analysis of DNA repair in normal and cancer cells treated with known mutagens with different mechanisms of action.

artículo científico publicado en 2003

Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development

scientific article published on 01 June 2003

Detergent addition to tryptic digests and ion mobility separation prior to MS/MS improves peptide yield and protein identification for in situ proteomic investigation of frozen and formalin-fixed paraffin-embedded adenocarcinoma tissue sections

artículo científico publicado en 2009

Development of a Novel Tumor-Targeted Vascular Disrupting Agent Activated by Membrane-Type Matrix Metalloproteinases ⬇️

artículo científico publicado el 27 de julio de 2010

Development of novel tumor-targeted theranostic nanoparticles activated by membrane-type matrix metalloproteinases for combined cancer magnetic resonance imaging and therapy

artículo científico publicado en 2013

Drug delivery in a tumour cord model: a computational simulation ⬇️

artículo científico publicado en 2017

Effect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signaling in human colorectal cancer cells

artículo científico publicado en 2010

Effects of routes of administration of TCNU on its plasma, tissue and tumour concentrations

artículo científico publicado en 1988

Eicosapentaenoic acid and/or aspirin for preventing colorectal adenomas during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme: the seAFOod RCT

Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota

artículo científico publicado en 2014

Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours.

artículo científico publicado en 1998

Evaluation of the safety of C-1311 (SYMADEX) administered in a phase 1 dose escalation trial as a weekly infusion for 3 consecutive weeks in patients with advanced solid tumours

scientific article published on 22 December 2009

Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry

artículo científico publicado en 2007

Experimental anti-tumor effects of flavone acetic acid (LM975)

artículo científico publicado en 1988

Expression of matrix metalloproteinase-10 in human bladder transitional cell carcinoma.

artículo científico

Extraction of the synthetic lytic peptide, cecropin B, from biological fluid and analysis using reversed-phase high-performance liquid chromatography.

artículo científico publicado en 1995

FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms

artículo científico publicado en 2012

Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid).

artículo científico publicado en 1987

Gas chromatographic analysis of triethylenethiophosphoramide and triethylenephosphoramide in biological specimens

scientific article published on 01 March 1985

High-performance liquid chromatographic analysis of AQ4N, an alkylaminoanthraquinone N-oxide.

artículo científico publicado en 2000

How can the potential of the duocarmycins be unlocked for cancer therapy?

artículo científico publicado en 2020

Identification of stage-specific breast markers using quantitative proteomics

artículo científico publicado en 2013

Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy.

artículo científico

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog

artículo científico publicado en 2014

In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts.

artículo científico publicado en 2009

In vivo metabolism of the antitumor imidazoacridinone C1311 in the mouse and in vitro comparison with humans.

artículo científico publicado en 1999

Inactivation of apaziquone by haematuria: implications for the design of phase III clinical trials against non-muscle invasive bladder cancer

artículo científico publicado en 2019

Influence of the tissue distribution of ThioTEPA and its metabolite, TEPA, on the response of murine colon tumours

scientific article published on 01 January 1987

MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas.

artículo científico publicado en 2004

Mathematical and computational models of drug transport in tumours.

artículo científico

Measurement of red blood cell eicosapentaenoic acid (EPA) levels in a randomised trial of EPA in patients with colorectal cancer liver metastases ⬇️

artículo científico publicado en 2016

Membrane type matrix metalloproteinases (MMPs) show differential expression in non-small cell lung cancer (NSCLC) compared to normal lung: correlation of MMP-14 mRNA expression and proteolytic activity.

artículo científico publicado en 2007

Method development for protein profiling in biological tissues by matrix-assisted laser desorption/ionisation mass spectrometry imaging

scientific article published on 01 May 2008

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity

artículo científico publicado en 2011

Mucosal biomarkers of colorectal cancer risk do not increase at 6 months following sleeve gastrectomy, unlike gastric bypass

artículo científico publicado en 2014

NAD(P)H:Quinone oxidoreductase-1 C609T polymorphism analysis in human superficial bladder cancers: relationship of genotype status to NQO1 phenotype and clinical response to Mitomycin C.

artículo científico publicado en 2004

Pharmacokinetic drug interactions with anticancer drugs.

artículo científico publicado en 1994

Pharmacokinetics and anti-tumour activity of B.4152, a reactive molecular combination of 5-fluorouracil and N-(2-chloroethyl)-N-nitrosourea, and its uracil analogue

artículo científico publicado en 1996

Pharmacokinetics and cytotoxicity of B.3839, a molecular combination of 5-fluorouracil and N-(2-chloroethyl)-N-nitrosourea, in a mouse model

scientific article published on 01 August 1992

Pharmacokinetics and tissue distribution of the imidazoacridinone C1311 in tumour-bearing mice

artículo científico publicado en 1998

Pharmacological approach towards the development of indolequinone bioreductive drugs based on the clinically inactive agent EO9.

artículo científico publicado en 2002

Pharmacological inhibition of polysialyltransferase ST8SiaII modulates tumour cell migration

artículo científico publicado en 2013

Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice

scientific article published on 01 April 2000

Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment

artículo científico publicado en 2016

Potentiation of EO9 anti-tumour activity by hydralazine

artículo científico publicado en 1993

Preclinical pharmacology of the pyrrolobenzodiazepine (PBD) monomer DRH-417 (NSC 709119).

artículo científico publicado en 2007

Predicting tumor responses to mitomycin C on the basis of DT-diaphorase activity or drug metabolism by tumor homogenates: implications for enzyme-directed bioreductive drug development

scientific article published on 01 November 2000

Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent.

artículo científico publicado en 2004

Proteases in cancer drug delivery.

artículo científico publicado en 2016

Rationalized Computer-Aided Design of Matrix-Metalloprotease-Selective Prodrugs

artículo científico publicado en 2017

Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.

artículo científico publicado en 2013

Reduction of tumor blood flow by flavone acetic acid: a possible component of therapy

artículo científico publicado en 1989

Separation methods for anthraquinone related anti-cancer drugs.

artículo científico publicado en 2001

Structural properties governing drug-plasma protein binding determined by high-performance liquid chromatography method

artículo científico publicado en 2017

Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties

artículo científico publicado en 2012

Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation.

artículo científico publicado en 2012

The relationship between the in vitro chemosensitivity of tumor cells and tumor response in vivo in an experimental tumor model

scientific article published on 01 March 1991

Thin-layer chromatography/matrix-assisted laser desorption/ionisation mass spectrometry and matrix-assisted laser desorption/ionisation mass spectrometry imaging for the analysis of phospholipids in LS174T colorectal adenocarcinoma xenografts treate

artículo científico publicado en 2015

ThioTEPA pharmacokinetics during intravesical chemotherapy and the influence of Tween 80

scientific article published on 01 January 1990

ThioTEPA pharmacokinetics during intravesical chemotherapy: the influence of dose and volume of instillate on systemic uptake and dose rate to the tumour

artículo científico publicado en 1996

Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.

artículo científico publicado en 2011

Tumor-targeted prodrug ICT2588 demonstrates therapeutic activity against solid tumors and reduced potential for cardiovascular toxicity

artículo científico publicado en 2014

Unique chemosensitivity of MAC 16 tumours to flavone acetic acid (LM975, NSC 347512).

artículo científico publicado en 1988

Use of matrix-assisted laser desorption/ionisation mass spectrometry in cancer research.

artículo científico publicado en 2011

Lista de obras de Paul M. Loadman

5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study ⬇️

A Novel Theranostic Strategy for MMP-14-Expressing Glioblastomas Impacts Survival.

A liquid chromatography-tandem mass spectrometry method to measure fatty acids in biological samples ⬇️

A preclinical pharmacokinetic study of the bioreductive drug AQ4N

A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota ⬇️

A randomized controlled trial of eicosapentaenoic acid and/or aspirin for colorectal adenoma prevention during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme (The seAFOod Polyp Prevention Trial): study protocol for a randomize

A study of inter-individual variability in the Phase II metabolism of xenobiotics in human skin

An optimised assay for quantitative, high-throughput analysis of polysialyltransferase activity

Analysis of the imidazoacridinone C1311 by high-performance liquid chromatography

Angiogenesis in the hollow fiber tumor model influences drug delivery to tumor cells: implications for anticancer drug screening programs

Anticancer Drug Development

Anticolorectal cancer activity of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid

Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.

Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1 targeted tripartite quinone drug delivery system.

Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins

Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma

Comet assay and flow cytometry analysis of DNA repair in normal and cancer cells treated with known mutagens with different mechanisms of action.

Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development

Detergent addition to tryptic digests and ion mobility separation prior to MS/MS improves peptide yield and protein identification for in situ proteomic investigation of frozen and formalin-fixed paraffin-embedded adenocarcinoma tissue sections

Development of a Novel Tumor-Targeted Vascular Disrupting Agent Activated by Membrane-Type Matrix Metalloproteinases ⬇️

Development of novel tumor-targeted theranostic nanoparticles activated by membrane-type matrix metalloproteinases for combined cancer magnetic resonance imaging and therapy

Drug delivery in a tumour cord model: a computational simulation ⬇️

Effect of eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signaling in human colorectal cancer cells

Effects of routes of administration of TCNU on its plasma, tissue and tumour concentrations

Eicosapentaenoic acid and/or aspirin for preventing colorectal adenomas during colonoscopic surveillance in the NHS Bowel Cancer Screening Programme: the seAFOod RCT

Eicosapentaenoic acid free fatty acid prevents and suppresses colonic neoplasia in colitis-associated colorectal cancer acting on Notch signaling and gut microbiota

Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours.

Evaluation of the safety of C-1311 (SYMADEX) administered in a phase 1 dose escalation trial as a weekly infusion for 3 consecutive weeks in patients with advanced solid tumours

Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry

Experimental anti-tumor effects of flavone acetic acid (LM975)

Expression of matrix metalloproteinase-10 in human bladder transitional cell carcinoma.

Extraction of the synthetic lytic peptide, cecropin B, from biological fluid and analysis using reversed-phase high-performance liquid chromatography.

FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms

Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid).

Gas chromatographic analysis of triethylenethiophosphoramide and triethylenephosphoramide in biological specimens

High-performance liquid chromatographic analysis of AQ4N, an alkylaminoanthraquinone N-oxide.

How can the potential of the duocarmycins be unlocked for cancer therapy?

Identification of stage-specific breast markers using quantitative proteomics

Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy.

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog

In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts.

In vivo metabolism of the antitumor imidazoacridinone C1311 in the mouse and in vitro comparison with humans.

Inactivation of apaziquone by haematuria: implications for the design of phase III clinical trials against non-muscle invasive bladder cancer

Influence of the tissue distribution of ThioTEPA and its metabolite, TEPA, on the response of murine colon tumours

MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas.

Mathematical and computational models of drug transport in tumours.

Measurement of red blood cell eicosapentaenoic acid (EPA) levels in a randomised trial of EPA in patients with colorectal cancer liver metastases ⬇️

Membrane type matrix metalloproteinases (MMPs) show differential expression in non-small cell lung cancer (NSCLC) compared to normal lung: correlation of MMP-14 mRNA expression and proteolytic activity.

Method development for protein profiling in biological tissues by matrix-assisted laser desorption/ionisation mass spectrometry imaging

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity

Mucosal biomarkers of colorectal cancer risk do not increase at 6 months following sleeve gastrectomy, unlike gastric bypass

NAD(P)H:Quinone oxidoreductase-1 C609T polymorphism analysis in human superficial bladder cancers: relationship of genotype status to NQO1 phenotype and clinical response to Mitomycin C.

Pharmacokinetic drug interactions with anticancer drugs.

Pharmacokinetics and anti-tumour activity of B.4152, a reactive molecular combination of 5-fluorouracil and N-(2-chloroethyl)-N-nitrosourea, and its uracil analogue

Pharmacokinetics and cytotoxicity of B.3839, a molecular combination of 5-fluorouracil and N-(2-chloroethyl)-N-nitrosourea, in a mouse model

Pharmacokinetics and tissue distribution of the imidazoacridinone C1311 in tumour-bearing mice

Pharmacological approach towards the development of indolequinone bioreductive drugs based on the clinically inactive agent EO9.

Pharmacological inhibition of polysialyltransferase ST8SiaII modulates tumour cell migration

Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice

Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment

Potentiation of EO9 anti-tumour activity by hydralazine

Preclinical pharmacology of the pyrrolobenzodiazepine (PBD) monomer DRH-417 (NSC 709119).

Predicting tumor responses to mitomycin C on the basis of DT-diaphorase activity or drug metabolism by tumor homogenates: implications for enzyme-directed bioreductive drug development

Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent.

Proteases in cancer drug delivery.

Rationalized Computer-Aided Design of Matrix-Metalloprotease-Selective Prodrugs

Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.

Reduction of tumor blood flow by flavone acetic acid: a possible component of therapy

Separation methods for anthraquinone related anti-cancer drugs.

Structural properties governing drug-plasma protein binding determined by high-performance liquid chromatography method

Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties

Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation.

The relationship between the in vitro chemosensitivity of tumor cells and tumor response in vivo in an experimental tumor model

Thin-layer chromatography/matrix-assisted laser desorption/ionisation mass spectrometry and matrix-assisted laser desorption/ionisation mass spectrometry imaging for the analysis of phospholipids in LS174T colorectal adenocarcinoma xenografts treate

ThioTEPA pharmacokinetics during intravesical chemotherapy and the influence of Tween 80

ThioTEPA pharmacokinetics during intravesical chemotherapy: the influence of dose and volume of instillate on systemic uptake and dose rate to the tumour

Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.

Tumor-targeted prodrug ICT2588 demonstrates therapeutic activity against solid tumors and reduced potential for cardiovascular toxicity

Unique chemosensitivity of MAC 16 tumours to flavone acetic acid (LM975, NSC 347512).