Lista de obras - Galina Selivanova - Dominio Público Uruguay

915 MHz microwaves and 50 Hz magnetic field affect chromatin conformation and 53BP1 foci in human lymphocytes from hypersensitive and healthy persons

scientific article published on 01 April 2005

A novel facet of tumor suppression by p53: Induction of tumor immunogenicity.

artículo científico publicado en 2012

APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

artículo científico publicado en 2013

APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase.

artículo científico publicado en 2017

Ablation of Key Oncogenic Pathways by RITA-Reactivated p53 Is Required for Efficient Apoptosis

artículo científico publicado en 2017

Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis

artículo científico publicado en 2009

Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX ⬇️

artículo científico publicado el 6 de mayo de 2011

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

artículo científico publicado en 2002

Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin ⬇️

artículo científico publicado en 2020

Dose-response for radiation-induced apoptosis, residual 53BP1 foci and DNA-loop relaxation in human lymphocytes.

artículo científico publicado en 2005

Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells

scientific article published on 01 October 2000

Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro.

artículo científico publicado en 2013

EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins.

artículo científico publicado en 1993

Effects of PRIMA-1 on chronic lymphocytic leukaemia cells with and without hemizygous p53 deletion.

artículo científico publicado en 2004

Enterobacteria impair host p53 tumor suppressor activity through mRNA destabilization

artículo científico publicado en 2022

Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.

artículo científico publicado en 2001

Functional p53 chimeras containing the Epstein-Barr virus Gly-Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysis

artículo científico publicado en 2002

GeneXplain — Identification of Causal Biomarkers and Drug Targets in Personalized Cancer Pathways

HHV-8/KSHV during the development of Kaposi's sarcoma: evaluation by polymerase chain reaction and immunohistochemistry

scientific article published on 01 January 2005

HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating drugs nutlin-3 and RITA.

artículo científico publicado en 2009

Identification and targeting of selective vulnerability rendered by tamoxifen resistance

scientific article published on 29 July 2020

Inactivation of Myc-induced p53-dependent apoptosis in human tumors.

artículo científico publicado en 2001

Inhibition of glycolytic enzymes mediated by pharmacologically activated p53: targeting Warburg effect to fight cancer

artículo científico publicado en 2011

Inhibition of p53 activity in vitro and in living cells by a synthetic peptide derived from its core domain

artículo científico publicado en 2003

Inhibition of p53 inhibitors: progress, challenges and perspectives

artículo científico publicado en 2019

Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis

artículo científico publicado en 2014

Integrins and mutant p53 on the road to metastasis.

artículo científico publicado en 2009

Kaposi's sarcoma herpesvirus load in biopsies of cutaneous and oral Kaposi's sarcoma lesions

scientific article published on 12 July 2007

MDM2-Dependent Downregulation of p21 and hnRNP K Provides a Switch between Apoptosis and Growth Arrest Induced by Pharmacologically Activated p53

MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53

artículo científico publicado en 2009

MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts.

artículo científico publicado en 2018

Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53.

artículo científico publicado en 2014

Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

artículo científico publicado en 2002

Mutant p53: the loaded gun.

artículo científico publicado en 2001

Mutated and non-mutated TP53 as targets in the treatment of leukaemia.

artículo científico publicado en 2008

Nuclear envelope-limited chromatin sheets are part of mitotic death

artículo científico publicado en 2002

PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis.

artículo científico publicado en 2005

PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53.

artículo científico publicado en 2011

PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo

artículo científico publicado en 2011

Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2.

artículo científico publicado en 2011

Pharmacological reactivation of p53 as a strategy to treat cancer.

artículo científico

Pifithrin-α alters p53 post-translational modifications pattern and differentially inhibits p53 target genes

scientific article published on 23 January 2020

Prediction of response to anti-cancer drugs becomes robust via network integration of molecular data

scientific article published on 20 February 2019

Protein kinase Cα (PKCα) regulates p53 localization and melanoma cell survival downstream of integrin αv in three-dimensional collagen and in vivo

artículo científico publicado en 2012

Protoporphyrin IX interacts with wild-type p53 protein in vitro and induces cell death of human colon cancer cells in a p53-dependent and -independent manner

artículo científico publicado en 2006

RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism

scientific article published on 14 November 2018

RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity

artículo científico publicado en 2019

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.

scientific article published on 10 January 2014

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs

artículo científico publicado en 2017

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

artículo científico publicado en 2005

Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.

artículo científico publicado en 1999

Reactivation of mutant p53: a new strategy for cancer therapy.

artículo científico publicado en 1998

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

artículo científico publicado en 2003

Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation.

artículo científico publicado en 2010

Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA.

artículo científico publicado en 2010

Rescue of the p53 tumor suppressor by a rationally designed molecule

artículo científico publicado en 2004

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

scientific article published on 01 June 1997

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

artículo científico publicado en 2002

Robust and clinically relevant prediction of response to anti-cancer drugs via network integration of molecular profiles

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

artículo científico publicado en 2004

The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death

artículo científico publicado en 2015

The p53-mediated cytotoxicity of photodynamic therapy of cancer: recent advances.

scientific article published on 22 July 2008

The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.

artículo científico publicado en 1996

The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity

artículo científico publicado en 2006

The use of ion mobility mass spectrometry to probe modulation of the structure of p53 and of MDM2 by small molecule inhibitors

artículo científico publicado en 2015

Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia

scientific article published on 09 May 2019

Therapeutic targeting of p53 by small molecules.

artículo científico publicado en 2010

Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds

artículo científico publicado en 2020

Tumor-specific induction of apoptosis by a p53-reactivating compound.

artículo científico publicado en 2008

Wild type p53 reactivation: from lab bench to clinic.

artículo científico publicado en 2014

[Isolation and analysis of protease-deficient mutants of Bacillus amyloliquefaciens]

artículo científico publicado en 1992

p53 CRISPR Deletion Affects DNA Structure and Nuclear Architecture

artículo científico publicado en 2020

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

artículo científico publicado en 1994

p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain

artículo científico publicado en 1995

p53 induction as an indicator of DNA damage

artículo científico publicado en 2002

p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA.

artículo científico publicado en 2009

p53-induced apoptosis as a safeguard against cancer.

artículo científico publicado en 1999

p53: fighting cancer

artículo científico publicado en 2004

Lista de obras de Galina Selivanova

915 MHz microwaves and 50 Hz magnetic field affect chromatin conformation and 53BP1 foci in human lymphocytes from hypersensitive and healthy persons

A novel facet of tumor suppression by p53: Induction of tumor immunogenicity.

APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase.

Ablation of Key Oncogenic Pathways by RITA-Reactivated p53 Is Required for Efficient Apoptosis

Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis

Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX ⬇️

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin ⬇️

Dose-response for radiation-induced apoptosis, residual 53BP1 foci and DNA-loop relaxation in human lymphocytes.

Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells

Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro.

EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins.

Effects of PRIMA-1 on chronic lymphocytic leukaemia cells with and without hemizygous p53 deletion.

Enterobacteria impair host p53 tumor suppressor activity through mRNA destabilization

Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.

Functional p53 chimeras containing the Epstein-Barr virus Gly-Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysis

GeneXplain — Identification of Causal Biomarkers and Drug Targets in Personalized Cancer Pathways

HHV-8/KSHV during the development of Kaposi's sarcoma: evaluation by polymerase chain reaction and immunohistochemistry

HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating drugs nutlin-3 and RITA.

Identification and targeting of selective vulnerability rendered by tamoxifen resistance

Inactivation of Myc-induced p53-dependent apoptosis in human tumors.

Inhibition of glycolytic enzymes mediated by pharmacologically activated p53: targeting Warburg effect to fight cancer

Inhibition of p53 activity in vitro and in living cells by a synthetic peptide derived from its core domain

Inhibition of p53 inhibitors: progress, challenges and perspectives

Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis

Integrins and mutant p53 on the road to metastasis.

Kaposi's sarcoma herpesvirus load in biopsies of cutaneous and oral Kaposi's sarcoma lesions

MDM2-Dependent Downregulation of p21 and hnRNP K Provides a Switch between Apoptosis and Growth Arrest Induced by Pharmacologically Activated p53

MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53

MYC and RAS are unable to cooperate in overcoming cellular senescence and apoptosis in normal human fibroblasts.

Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53.

Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

Mutant p53: the loaded gun.

Mutated and non-mutated TP53 as targets in the treatment of leukaemia.

Nuclear envelope-limited chromatin sheets are part of mitotic death

PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis.

PRIMA-1Met/APR-246 induces apoptosis and tumor growth delay in small cell lung cancer expressing mutant p53.

PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo

Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2.

Pharmacological reactivation of p53 as a strategy to treat cancer.

Pifithrin-α alters p53 post-translational modifications pattern and differentially inhibits p53 target genes

Prediction of response to anti-cancer drugs becomes robust via network integration of molecular data

Protein kinase Cα (PKCα) regulates p53 localization and melanoma cell survival downstream of integrin αv in three-dimensional collagen and in vivo

Protoporphyrin IX interacts with wild-type p53 protein in vitro and induces cell death of human colon cancer cells in a p53-dependent and -independent manner

RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism

RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.

Reactivation of mutant p53: a new strategy for cancer therapy.

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation.

Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA.

Rescue of the p53 tumor suppressor by a rationally designed molecule

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

Robust and clinically relevant prediction of response to anti-cancer drugs via network integration of molecular profiles

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death

The p53-mediated cytotoxicity of photodynamic therapy of cancer: recent advances.

The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region.

The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity

The use of ion mobility mass spectrometry to probe modulation of the structure of p53 and of MDM2 by small molecule inhibitors

Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia

Therapeutic targeting of p53 by small molecules.

Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds

Tumor-specific induction of apoptosis by a p53-reactivating compound.

Wild type p53 reactivation: from lab bench to clinic.

[Isolation and analysis of protease-deficient mutants of Bacillus amyloliquefaciens]

p53 CRISPR Deletion Affects DNA Structure and Nuclear Architecture

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain

p53 induction as an indicator of DNA damage

p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA.

p53-induced apoptosis as a safeguard against cancer.

p53: fighting cancer