Lista de obras - Daniel Mertens - Dominio Público Uruguay

A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia

artículo científico publicado en 2009

Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer

B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions

artículo científico publicado en 2001

BCL10 is not the gene inactivated by mutation in the 1p22 deletion region in mantle cell lymphoma

scientific article published on 01 August 2000

BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like.

artículo científico publicado en 2000

Biological diversity and risk-adapted treatment of chronic lymphocytic leukemia ⬇️

artículo científico publicado el 1 de septiembre de 2010

Blocking distinct interactions between Glioblastoma cells and their tissue microenvironment: A novel multi-targeted therapeutic approach

artículo científico publicado en 2018

CLL and deletion 13q14: merely the miRs?

artículo científico publicado en 2012

Chronic lymphocytic leukemia - genomics lead the way ⬇️

artículo científico publicado el 1 de octubre de 2011

Chronic lymphocytic leukemia and 13q14: miRs and more

artículo científico publicado en 2009

Circulating microRNAs in hematological diseases: principles, challenges, and perspectives

artículo científico publicado en 2013

Comprehensive microRNA expression profiling in cerebrospinal fluid distinguishes between neurological disease classes

artículo científico publicado en 2018

DNA damage-induced transcriptional program in CLL: biological and diagnostic implications for functional p53 testing

artículo científico publicado en 2010

DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia

artículo científico publicado en 2016

DNA methylation of chronic lymphocytic leukemia with differential response to chemotherapy

artículo científico publicado en 2020

Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial.

artículo científico publicado en 2009

Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes

artículo científico publicado en 2005

Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB.

artículo científico publicado en 2013

Evidence for distinct pathomechanisms in genetic subgroups of chronic lymphocytic leukemia revealed by quantitative expression analysis of cell cycle, activation, and apoptosis-associated genes

artículo científico publicado en 2005

Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays.

artículo científico publicado en 2006

FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL

scientific article published on 03 December 2018

Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas

artículo científico publicado en 2006

From pathogenesis to treatment of chronic lymphocytic leukaemia

artículo científico publicado en 2009

Genetics of Chronic Lymphocytic Leukemia ⬇️

artículo científico publicado el 17 de noviembre de 2011

Germline allele-specific expression of DAPK1 in chronic lymphocytic leukemia

artículo científico publicado en 2013

High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations

Ibrutinib-resistant CLL: unwanted and unwonted!

artículo científico publicado en 2017

Immune modulatory agents in hematopoietic malignancies ⬇️

artículo científico publicado el 8 de junio de 2011

Impact of serum storage conditions on microRNA stability

artículo científico publicado en 2012

Importance of genetics in chronic lymphocytic leukemia ⬇️

artículo científico publicado el 23 de marzo de 2011

In vivo processing assay based on a dual-luciferase reporter system to evaluate DROSHA enzymatic activity.

artículo científico publicado en 2014

In-vivo quantification of primary microRNA processing by Drosha with a luciferase based system

artículo científico publicado en 2011

Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks

artículo científico publicado en 2019

Loss of cooperativity of secreted CD40L and increased dose-response to IL4 on CLL cell viability correlates with enhanced activation of NF-kB and STAT6

scientific article published on 27 May 2014

Missing the notch in NOTCH1

artículo científico publicado en 2013

Moving from prognostic to predictive factors in chronic lymphocytic leukaemia (CLL).

artículo científico publicado en 2010

Mutations driving CLL and their evolution in progression and relapse

artículo científico publicado en 2015

NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG.

artículo científico publicado en 2013

Non-malignant B cells and chronic lymphocytic leukemia cells induce a pro-survival phenotype in CD14+ cells from peripheral blood

artículo científico publicado en 2011

Nurse-like cells show deregulated expression of genes involved in immunocompetence

artículo científico publicado en 2011

Off-target effects of siRNA specific for GFP

artículo científico publicado en 2008

Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL

scientific article published on 12 July 2019

Prognostic and predictive factors in patients with chronic lymphocytic leukemia: relevant in the era of novel treatment approaches?

artículo científico publicado en 2014

Programmed death-1 and its ligand are novel immunotolerant molecules expressed on leukemic B cells in chronic lymphocytic leukemia

artículo científico publicado en 2012

Quantitative DNA methylation analysis identifies a single CpG dinucleotide important for ZAP-70 expression and predictive of prognosis in chronic lymphocytic leukemia

artículo científico publicado en 2012

Rapid detection of ATM/p53 function with p27Kip FACS analysis: a novel diagnostic tool for chronic lympocytic leukemia?

artículo científico publicado en 2016

Reduced expression of CAMTA1 correlates with adverse outcome in neuroblastoma patients

artículo científico publicado en 2006

SYK carries no activating point mutations in patients with chronic lymphocytic leukaemia (CLL).

artículo científico publicado en 2010

TCL1A and ATM are co-expressed in chronic lymphocytic leukemia cells without deletion of 11q ⬇️

artículo científico publicado el 8 de agosto de 2012

Targeting inhibitor of apoptosis proteins by Smac mimetic elicits cell death in poor prognostic subgroups of chronic lymphocytic leukemia

artículo científico publicado en 2015

Telomere length in mantle cell lymphoma

artículo científico publicado en 2012

The candidate immunotherapeutical target, the receptor for hyaluronic acid-mediated motility, is associated with proliferation and shows prognostic value in B-cell chronic lymphocytic leukemia.

artículo científico publicado en 2008

Toward chemotherapy-free treatment of CLL

scientific article published on 01 September 2011

miR-34a as part of the resistance network in chronic lymphocytic leukemia

artículo científico publicado en 2008

Lista de obras de Daniel Mertens

A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia

Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer

B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions

BCL10 is not the gene inactivated by mutation in the 1p22 deletion region in mantle cell lymphoma

BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like.

Biological diversity and risk-adapted treatment of chronic lymphocytic leukemia ⬇️

Blocking distinct interactions between Glioblastoma cells and their tissue microenvironment: A novel multi-targeted therapeutic approach

CLL and deletion 13q14: merely the miRs?

Chronic lymphocytic leukemia - genomics lead the way ⬇️

Chronic lymphocytic leukemia and 13q14: miRs and more

Circulating microRNAs in hematological diseases: principles, challenges, and perspectives

Comprehensive microRNA expression profiling in cerebrospinal fluid distinguishes between neurological disease classes

DNA damage-induced transcriptional program in CLL: biological and diagnostic implications for functional p53 testing

DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia

DNA methylation of chronic lymphocytic leukemia with differential response to chemotherapy

Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial.

Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes

Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB.

Evidence for distinct pathomechanisms in genetic subgroups of chronic lymphocytic leukemia revealed by quantitative expression analysis of cell cycle, activation, and apoptosis-associated genes

Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays.

FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL

Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas

From pathogenesis to treatment of chronic lymphocytic leukaemia

Genetics of Chronic Lymphocytic Leukemia ⬇️

Germline allele-specific expression of DAPK1 in chronic lymphocytic leukemia

High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations

Ibrutinib-resistant CLL: unwanted and unwonted!

Immune modulatory agents in hematopoietic malignancies ⬇️

Impact of serum storage conditions on microRNA stability

Importance of genetics in chronic lymphocytic leukemia ⬇️

In vivo processing assay based on a dual-luciferase reporter system to evaluate DROSHA enzymatic activity.

In-vivo quantification of primary microRNA processing by Drosha with a luciferase based system

Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks

Loss of cooperativity of secreted CD40L and increased dose-response to IL4 on CLL cell viability correlates with enhanced activation of NF-kB and STAT6

Missing the notch in NOTCH1

Moving from prognostic to predictive factors in chronic lymphocytic leukaemia (CLL).

Mutations driving CLL and their evolution in progression and relapse

NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG.

Non-malignant B cells and chronic lymphocytic leukemia cells induce a pro-survival phenotype in CD14+ cells from peripheral blood

Nurse-like cells show deregulated expression of genes involved in immunocompetence

Off-target effects of siRNA specific for GFP

Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL

Prognostic and predictive factors in patients with chronic lymphocytic leukemia: relevant in the era of novel treatment approaches?

Programmed death-1 and its ligand are novel immunotolerant molecules expressed on leukemic B cells in chronic lymphocytic leukemia

Quantitative DNA methylation analysis identifies a single CpG dinucleotide important for ZAP-70 expression and predictive of prognosis in chronic lymphocytic leukemia

Rapid detection of ATM/p53 function with p27Kip FACS analysis: a novel diagnostic tool for chronic lympocytic leukemia?

Reduced expression of CAMTA1 correlates with adverse outcome in neuroblastoma patients

SYK carries no activating point mutations in patients with chronic lymphocytic leukaemia (CLL).

TCL1A and ATM are co-expressed in chronic lymphocytic leukemia cells without deletion of 11q ⬇️

Targeting inhibitor of apoptosis proteins by Smac mimetic elicits cell death in poor prognostic subgroups of chronic lymphocytic leukemia

Telomere length in mantle cell lymphoma

The candidate immunotherapeutical target, the receptor for hyaluronic acid-mediated motility, is associated with proliferation and shows prognostic value in B-cell chronic lymphocytic leukemia.

Toward chemotherapy-free treatment of CLL

miR-34a as part of the resistance network in chronic lymphocytic leukemia