Lista de obras - Christian Gaiddon - Dominio Público Uruguay

A balancing act: using small molecules for therapeutic intervention of the p53 pathway in cancer

scientific article published on 01 September 2020

A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53

artículo científico publicado en 2018

A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin.

artículo científico publicado en 2016

A ruthenium-containing organometallic compound reduces tumor growth through induction of the endoplasmic reticulum stress gene CHOP.

artículo científico publicado en 2009

Alteration of the Bcl-x/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis: evidence for the implication of the p53 signaling pathway

artículo científico publicado en 2000

Apoptosis-independent organoruthenium anticancer complexes that overcome multidrug resistance: self-assembly and phenotypic screening strategies

Bifunctional ligand design for modulating mutant p53 aggregation in cancer

artículo científico publicado en 2019

Brain-derived neurotrophic factor stimulates AP-1 and cyclic AMP-responsive element dependent transcriptional activity in central nervous system neurons.

artículo científico publicado en 1996

Ca2+/calmodulin kinase types II and IV regulate c-fos transcription in the AtT20 corticotroph cell line.

artículo científico publicado en 1996

Cancer cell cytotoxicity of cyclometalated compounds obtained with osmium(II) complexes.

artículo científico publicado en 2013

Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons

artículo científico publicado en 2011

Could a Feeding Jejunostomy be Integrated into a Standardized Preoperative Management of Oeso-gastric Junction Adenocarcinoma?

artículo científico publicado en 2017

Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73.

artículo científico publicado en 2003

Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2.

artículo científico publicado en 2009

DNA binding to an anticancer organo-ruthenium complex

article

Flavaglines as potent anticancer and cytoprotective agents

artículo científico publicado en 2012

Gold-phosphine-porphyrin as potential metal-based theranostics

artículo científico publicado en 2014

HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway

scientific article published on 07 November 2019

Holographic Traction Force Microscopy

artículo científico publicado en 2018

Impact of cyclometalated ruthenium(II) complexes on lactate dehydrogenase activity and cytotoxicity in gastric and colon cancer cells

artículo científico publicado en 2016

Library of second-generation cycloruthenated compounds and evaluation of their biological properties as potential anticancer drugs: passing the nanomolar barrier.

artículo científico publicado en 2011

Monomeric Ti(iv)-based complexes incorporating luminescent nitrogen ligands: synthesis, structural characterization, emission spectroscopy and cytotoxic activities

artículo científico

Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis

artículo científico publicado en 2007

Novel flavaglines displaying improved cytotoxicity.

artículo científico publicado en 2010

Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.

artículo científico publicado en 2005

Pituitary adenylate cyclase-activating polypeptide transduces through cAMP/PKA and PKC pathways and stimulates proopiomelanocortin gene transcription in mouse melanotropes

artículo científico publicado en 1996

Preferential Response of Basal-Like Head and Neck Squamous Cell Carcinoma Cell Lines to EGFR-Targeted Therapy Depending on EREG-Driven Oncogenic Addiction

artículo científico publicado en 2019

Reactivity of Cu(ii)-, Zn(ii)- and Fe(ii)-thiosemicarbazone complexes with glutathione and metallothionein: from stability to dissociation to transmetallation

scientific article published on 01 May 2019

Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo.

artículo científico publicado en 1999

Regulation of a Notch3-Hes1 pathway and protective effect by a tocopherol-omega alkanol chain derivative in muscle atrophy.

artículo científico publicado en 2014

Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action

artículo científico publicado en 2018

Ruthenium (II)-derived organometallic compounds induce cytostatic and cytotoxic effects on mammalian cancer cell lines through p53-dependent and p53-independent mechanisms.

artículo científico publicado en 2005

Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival.

artículo científico publicado en 2007

Structural Determinants of p53-Independence in Anticancer Ruthenium-Arene Schiff-Base Complexes.

artículo científico publicado en 2016

Subcellular localization and transport kinetics of ruthenium organometallic anticancer compounds in living cells: a dose-dependent role for amino acid and iron transporters

artículo científico publicado en 2014

The retinoblastoma susceptibility gene product/Sp1 signalling pathway is modulated by Ca2+/calmodulin kinases II and IV activity

artículo científico publicado en 1999

The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton.

artículo científico publicado en 2016

The Champagne sign.

artículo científico publicado en 2018

Tissue specificity and regulation of the N-terminal diversity of reticulon 3

artículo científico publicado en 2005

Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63.

artículo científico publicado en 2016

Transcriptional effects in GH3 cells of Gs alpha mutants associated with human pituitary tumors: stimulation of adenosine 3',5'-monophosphate response element-binding protein-mediated transcription and of prolactin and growth hormone promoter activi

artículo científico publicado en 1995

Use of a case-mix approach to study the trends in the incidence of second primary cancers.

artículo científico publicado en 2018

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

artículo científico publicado en 1999

Lista de obras de Christian Gaiddon

A balancing act: using small molecules for therapeutic intervention of the p53 pathway in cancer

A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53

A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin.

A ruthenium-containing organometallic compound reduces tumor growth through induction of the endoplasmic reticulum stress gene CHOP.

Alteration of the Bcl-x/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis: evidence for the implication of the p53 signaling pathway

Apoptosis-independent organoruthenium anticancer complexes that overcome multidrug resistance: self-assembly and phenotypic screening strategies

Bifunctional ligand design for modulating mutant p53 aggregation in cancer

Brain-derived neurotrophic factor stimulates AP-1 and cyclic AMP-responsive element dependent transcriptional activity in central nervous system neurons.

Ca2+/calmodulin kinase types II and IV regulate c-fos transcription in the AtT20 corticotroph cell line.

Cancer cell cytotoxicity of cyclometalated compounds obtained with osmium(II) complexes.

Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons

Could a Feeding Jejunostomy be Integrated into a Standardized Preoperative Management of Oeso-gastric Junction Adenocarcinoma?

Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73.

Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2.

DNA binding to an anticancer organo-ruthenium complex

Flavaglines as potent anticancer and cytoprotective agents

Gold-phosphine-porphyrin as potential metal-based theranostics

HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway

Holographic Traction Force Microscopy

Impact of cyclometalated ruthenium(II) complexes on lactate dehydrogenase activity and cytotoxicity in gastric and colon cancer cells

Library of second-generation cycloruthenated compounds and evaluation of their biological properties as potential anticancer drugs: passing the nanomolar barrier.

Monomeric Ti(iv)-based complexes incorporating luminescent nitrogen ligands: synthesis, structural characterization, emission spectroscopy and cytotoxic activities

Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis

Novel flavaglines displaying improved cytotoxicity.

Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.

Pituitary adenylate cyclase-activating polypeptide transduces through cAMP/PKA and PKC pathways and stimulates proopiomelanocortin gene transcription in mouse melanotropes

Preferential Response of Basal-Like Head and Neck Squamous Cell Carcinoma Cell Lines to EGFR-Targeted Therapy Depending on EREG-Driven Oncogenic Addiction

Reactivity of Cu(ii)-, Zn(ii)- and Fe(ii)-thiosemicarbazone complexes with glutathione and metallothionein: from stability to dissociation to transmetallation

Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo.

Regulation of a Notch3-Hes1 pathway and protective effect by a tocopherol-omega alkanol chain derivative in muscle atrophy.

Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action

Ruthenium (II)-derived organometallic compounds induce cytostatic and cytotoxic effects on mammalian cancer cell lines through p53-dependent and p53-independent mechanisms.

Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival.

Structural Determinants of p53-Independence in Anticancer Ruthenium-Arene Schiff-Base Complexes.

Subcellular localization and transport kinetics of ruthenium organometallic anticancer compounds in living cells: a dose-dependent role for amino acid and iron transporters

The retinoblastoma susceptibility gene product/Sp1 signalling pathway is modulated by Ca2+/calmodulin kinases II and IV activity

The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton.

The Champagne sign.

Tissue specificity and regulation of the N-terminal diversity of reticulon 3

Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63.

Transcriptional effects in GH3 cells of Gs alpha mutants associated with human pituitary tumors: stimulation of adenosine 3',5'-monophosphate response element-binding protein-mediated transcription and of prolactin and growth hormone promoter activi

Use of a case-mix approach to study the trends in the incidence of second primary cancers.

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.