Lista de obras - Charles Brenner - Dominio Público Uruguay

31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions

artículo científico publicado en 2005

5′-Nucleotidases and their new roles in NAD+ and phosphate metabolism

article published in 2010

A cultivated taste for yeast

artículo científico publicado en 2000

A knockdown with smoke model reveals FHIT as a repressor of Heme oxygenase 1

artículo científico publicado en 2014

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

artículo científico publicado en 2018

A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction

artículo científico publicado en 2008

Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter

artículo científico publicado en 2019

Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3

artículo científico publicado en 2002

Altered specificity of Hint-W123Q supports a role for Hint inhibition by ASW in avian sex determination

artículo científico publicado en 2004

An ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probes

artículo científico publicado en 2013

Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants

artículo científico publicado en 2007

Author Correction: Senescent cells promote tissue NAD<sup>+</sup> decline during ageing via the activation of CD38<sup>+</sup> macrophages

artículo científico publicado en 2020

Biochemical, crystallographic, and mutagenic characterization of hint, the AMP-lysine hydrolase, with novel substrates and inhibitors

artículo científico publicado en 2004

Boosting NAD to spare hearing

artículo científico publicado en 2014

Calorie restriction-mediated replicative lifespan extension in yeast is non-cell autonomous

artículo científico publicado en 2015

Catalysis in the nitrilase superfamily

artículo científico publicado en 2002

Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance

artículo científico publicado en 2004

Changes in chemistry and biochemistry education: Creative responses to medical college admissions test revisions in the age of the genome ⬇️

artículo científico publicado el 1 de enero de 2013

Chemical genomics in yeast

artículo científico publicado en 2004

Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging

artículo científico publicado en 2017

Condensing the RNA world

artículo científico publicado en 2000

Control of dinucleoside polyphosphates by the FHIT-homologous HNT2 gene, adenine biosynthesis and heat shock in Saccharomyces cerevisiae

artículo científico publicado en 2002

Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1

artículo científico publicado en 2003

Coronavirus and PARP expression dysregulate the NAD Metabolome: a potentially actionable component of innate immunity

artículo científico publicado en 2020

Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers

scientific article

Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins

artículo científico publicado en 1997

Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding

artículo científico publicado en 2003

Desperately seeking Flexner: time to reemphasize basic science in medical education

artículo científico publicado en 2013

Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the α-β bridging oxygen and β phosphorus replacement ⬇️

artículo científico publicado el 1 de enero de 2001

Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans

artículo científico publicado en 2004

Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors

artículo científico publicado en 2017

Disease-associated mutations inactivate AMP-lysine hydrolase activity of Aprataxin

artículo científico publicado en 2005

Emerging Potential Benefits of Modulating NAD+ Metabolism in Cardiovascular Disease

artículo científico publicado en 2017

Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase

artículo científico publicado en 2003

Evolution of NAD Biosynthetic Enzymes

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

article by Ainslie B. Parsons et al published August 2006 in Cell

FHA-RING ubiquitin ligases in cell division cycle control

artículo científico publicado en 2008

FHIT

Feminizing chicks: a model for avian sex determination based on titration of Hint enzyme activity and the predicted structure of an Asw-Hint heterodimer

artículo científico publicado en 2003

Fhit

Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates

artículo científico publicado en 2000

Fhitness and cancer in the mouse

GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction

artículo científico publicado en 1987

Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit

artículo científico publicado en 1998

Glutamine-dependent NAD+Synthetase

artículo científico publicado en 2006

Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases ⬇️

artículo científico publicado en 2002

Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma ⬇️

artículo científico publicado en 2006

Histidine Triad (HIT) Superfamily

Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside.

artículo científico publicado en 2009

KRAS-driven miR-29b expression is required for tumor suppressor gene silencing

artículo científico publicado en 2017

Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.

artículo científico publicado en 2013

Letting off electrons to cope with metabolic stress

artículo científico publicado en 2020

Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring

scientific article published on 01 January 2019

Metabolism: Targeting a fat-accumulation gene

artículo científico publicado en 2014

Microbial NAD metabolism: lessons from comparative genomics

artículo científico publicado en 2009

Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications

artículo científico publicado en 2013

Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity

artículo científico publicado en 2001

NAD as a genotype-specific drug target

artículo científico publicado en 2013

NAD+ metabolism in health and disease

artículo científico publicado en 2006

NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity

artículo científico publicado en 2010

NNMT: A Bad Actor in Fat Makes Good in Liver.

artículo científico publicado en 2015

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

artículo científico publicado en 2016

New Tripodal, “Supercharged” Analogues of Adenosine Nucleotides: Inhibitors for the Fhit Ap3A Hydrolase

scientific article published on 01 May 1999

Nicotinamide Adenine Dinucleotide Metabolome Is Functionally Depressed in Patients Undergoing Liver Transplantation for Alcohol-Related Liver Disease

scientific article published on 31 May 2020

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

artículo científico publicado en 2018

Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk.

artículo científico publicado en 2016

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

artículo científico publicado en 2016

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy.

artículo científico publicado en 2017

Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism

artículo científico publicado en 2009

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

artículo científico publicado en 2016

Nicotinamide riboside kinase structures reveal new pathways to NAD+

artículo científico publicado en 2007

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells.

artículo científico publicado en 2017

Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.

artículo científico publicado en 2007

Nicotinamide riboside supplementation corrects deficits in oxytocin, sociability and anxiety of CD157 mutants in a mouse model of autism spectrum disorder

artículo científico publicado en 2020

Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats

artículo científico publicado en 2017

Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration

artículo científico publicado en 2017

Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition

artículo científico publicado en 2008

Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans

artículo científico publicado en 1998

Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding

artículo científico publicado en 2006

Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside

artículo científico publicado en 2012

Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin production

artículo científico publicado en 2011

On the Nonspecific Degradation of NAD+ to Nicotinamide Riboside ⬇️

artículo científico publicado el 20 de mayo de 2011

One-step site-directed mutagenesis of the Kex2 protease oxyanion hole.

artículo científico publicado en 1993

PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma

scientific article published on 22 August 2019

Pharmacological bypass of NAD salvage pathway protects neurons from chemotherapy-induced degeneration

article published in the Proceedings of the National Academy of Sciences of the United States of America

Pterostilbene raises low density lipoprotein cholesterol in people

scientific article published on 13 October 2018

Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein ⬇️

artículo científico publicado el 1 de diciembre de 1997

Quantification of protein copy number in yeast: the NAD+ metabolome

artículo científico publicado en 2014

Quantitative assessment of enzyme specificity in vivo: P2 recognition by Kex2 protease defined in a genetic system

artículo científico publicado en 1998

RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation

artículo científico publicado en 2014

RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis.

artículo científico publicado en 2013

Recent progress in the study of the intracellular functions of diadenosine polyphosphates

Rethinking Premedical and Health Professional Curricula in Light of MCAT 2015

article

Saccharomyces cerevisiae YOR071C encodes the high affinity nicotinamide riboside transporter Nrt1.

artículo científico publicado en 2008

Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

scientific article published on 05 July 2019

Scaffolding functions of arrestin-2 revealed by crystal structure and mutagenesis

artículo científico publicado en 2002

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

artículo científico publicado en 2020

Stereochemical analysis of diastereomeric 1,3-bis(adenosine-5'-O-phosphorothioyl)glycerols

artículo científico publicado en 2003

Structural and enzymatic characterization of a purified prohormone-processing enzyme: secreted, soluble Kex2 protease

artículo científico publicado en 1992

Subtleties among subtilases. The structural biology of Kex2 and furin-related prohormone convertases

artículo científico publicado en 2003

Suppression of TET1-dependent DNA demethylation is essential for KRAS-mediated transformation

artículo científico publicado en 2014

Synthetic lethal and biochemical analyses of NAD and NADH kinases in Saccharomyces cerevisiae establish separation of cellular functions

artículo científico publicado en 2006

Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans

artículo científico publicado en 2017

Targeted, LCMS-based Metabolomics for Quantitative Measurement of NAD(+) Metabolites

artículo científico publicado en 2013

The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4

artículo científico publicado en 2004

The histidine triad superfamily of nucleotide-binding proteins

artículo científico publicado en 1999

The replication focus targeting sequence (RFTS) domain is a DNA-competitive inhibitor of Dnmt1

artículo científico publicado en 2011

The reported human NADsyn2 is ammonia-dependent NAD synthetase from a pseudomonad

artículo científico publicado en 2003

Transcriptional Response of White Adipose Tissue to Withdrawal of Vitamin B3

artículo científico publicado en 2019

Two Hydrolase Resistant Analogues of Diadenosine 5',5'''-P,P-Triphosphate for Studies with FHIT, The Human Fragile Histidine Triad Protein ⬇️

artículo científico publicado el 1 de enero de 1998

Why Is Mom Stressed: Homeorhesis as the Potential Problem and Nicotinamide Riboside as the Potential Solution

artículo científico publicado en 2019

Yeast Chfr homologs retard cell cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-dependent ubiquitination

artículo científico publicado en 2007

[11] Biochemical and genetic methods for analyzing specificity and activity of a precursor-processing enzyme: Yeast Kex2 protease, kexin

article

p53 activation by knockdown technologies

artículo científico publicado en 2007

Lista de obras de Charles Brenner

31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions

5′-Nucleotidases and their new roles in NAD+ and phosphate metabolism

A cultivated taste for yeast

A knockdown with smoke model reveals FHIT as a repressor of Heme oxygenase 1

A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects

A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction

Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter

Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3

Altered specificity of Hint-W123Q supports a role for Hint inhibition by ASW in avian sex determination

An ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probes

Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants

Author Correction: Senescent cells promote tissue NAD<sup>+</sup> decline during ageing via the activation of CD38<sup>+</sup> macrophages

Biochemical, crystallographic, and mutagenic characterization of hint, the AMP-lysine hydrolase, with novel substrates and inhibitors

Boosting NAD to spare hearing

Calorie restriction-mediated replicative lifespan extension in yeast is non-cell autonomous

Catalysis in the nitrilase superfamily

Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance

Changes in chemistry and biochemistry education: Creative responses to medical college admissions test revisions in the age of the genome ⬇️

Chemical genomics in yeast

Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging

Condensing the RNA world

Control of dinucleoside polyphosphates by the FHIT-homologous HNT2 gene, adenine biosynthesis and heat shock in Saccharomyces cerevisiae

Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1

Coronavirus and PARP expression dysregulate the NAD Metabolome: a potentially actionable component of innate immunity

Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers

Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins

Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding

Desperately seeking Flexner: time to reemphasize basic science in medical education

Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the α-β bridging oxygen and β phosphorus replacement ⬇️

Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans

Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors

Disease-associated mutations inactivate AMP-lysine hydrolase activity of Aprataxin

Emerging Potential Benefits of Modulating NAD+ Metabolism in Cardiovascular Disease

Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase

Evolution of NAD Biosynthetic Enzymes

Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast

FHA-RING ubiquitin ligases in cell division cycle control

FHIT

Feminizing chicks: a model for avian sex determination based on titration of Hint enzyme activity and the predicted structure of an Asw-Hint heterodimer

Fhit

Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates

Fhitness and cancer in the mouse

GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction

Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit

Glutamine-dependent NAD+Synthetase

Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases ⬇️

Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma ⬇️

Histidine Triad (HIT) Superfamily

Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside.

KRAS-driven miR-29b expression is required for tumor suppressor gene silencing

Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.

Letting off electrons to cope with metabolic stress

Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring

Metabolism: Targeting a fat-accumulation gene

Microbial NAD metabolism: lessons from comparative genomics

Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications

Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity

NAD as a genotype-specific drug target

NAD+ metabolism in health and disease

NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity

NNMT: A Bad Actor in Fat Makes Good in Liver.

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

New Tripodal, “Supercharged” Analogues of Adenosine Nucleotides: Inhibitors for the Fhit Ap3A Hydrolase

Nicotinamide Adenine Dinucleotide Metabolome Is Functionally Depressed in Patients Undergoing Liver Transplantation for Alcohol-Related Liver Disease

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk.

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy.

Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

Nicotinamide riboside kinase structures reveal new pathways to NAD+

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells.

Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.

Nicotinamide riboside supplementation corrects deficits in oxytocin, sociability and anxiety of CD157 mutants in a mouse model of autism spectrum disorder

Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats

Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration

Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition

Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans

Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding