Lista de obras - Paul G Ekert - Dominio Público Uruguay

A novel Apaf-1-independent putative caspase-2 activation complex

artículo científico publicado en 2002

A prospective evaluation of whole-exome sequencing as a first-tier molecular test in infants with suspected monogenic disorders

artículo científico publicado en 2016

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations.

artículo científico publicado en 2013

Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism

artículo científico publicado en 2001

Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells.

artículo científico publicado en 1998

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

artículo científico publicado en 2004

Apoptosis and the immune system ⬇️

artículo científico publicado el 1 de enero de 1997

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

artículo científico publicado en 2002

Apoptosis, haemopoiesis and leukaemogenesis.

artículo científico publicado en 1997

Author Correction: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome

scientific article published on 01 January 2019

Autophagy and AML--food for thought.

artículo científico publicado en 2015

BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis

artículo científico publicado en 2013

Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

artículo científico publicado en 2004

Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma

artículo científico publicado en 2018

Caspase inhibitors.

artículo científico publicado en 1999

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

artículo científico publicado en 2002

Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7.

artículo científico publicado en 2005

Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis

artículo científico publicado en 2004

Chemotherapy-related cardiotoxicity: are Australian practitioners missing the point?

artículo científico publicado en 2017

Clinicopathological Correlations in Postasphyxial Organ Damage: A Donor Organ Perspective

artículo científico publicado en 1997

Clinker: visualising fusion genes detected in RNA-seq data

article

Clinker: visualizing fusion genes detected in RNA-seq data

article

Crossing paths: interactions between the cell death machinery and growth factor survival signals

artículo científico publicado en 2010

Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins

artículo científico publicado en 2016

Cytoplasmic p53 is not required for PUMA-induced apoptosis

artículo científico publicado en 2007

Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance

artículo científico publicado en 2005

Dexamethasone prevents apoptosis in a neonatal rat model of hypoxic-ischemic encephalopathy (HIE) by a reactive oxygen species-independent mechanism.

artículo científico publicado en 1997

Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP.

artículo científico publicado en 2001

Dysregulation of BCL-2 family proteins by leukemia fusion genes

artículo científico publicado en 2017

ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis.

artículo científico publicado en 2013

Efficacy of MEK inhibition in a recurrent malignant peripheral nerve sheath tumor

publication published on 12 February 2021

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1.

artículo científico publicado en 2017

Epithelial bridging on burn patients following primary excision and grafting.

artículo científico publicado en 1989

Exploring the feasibility and utility of exome-scale tumour sequencing in a clinical setting

artículo científico publicado en 2018

Exploring the utility of human DNA methylation arrays for profiling mouse genomic DNA.

artículo científico publicado en 2013

Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia

artículo científico publicado en 2016

Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML

article

Genetic determinants of anthracycline cardiotoxicity - ready for the clinic?

artículo científico publicado en 2017

Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome

artículo científico publicado en 2018

Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

artículo científico publicado en 2011

High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia

artículo científico publicado en 2013

Hoxb8 regulates expression of microRNAs to control cell death and differentiation.

artículo científico publicado en 2013

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

artículo científico publicado en 2002

Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1

artículo científico publicado en 2006

Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions

scientific article published on 21 March 2019

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

scientific journal article

Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs

artículo científico publicado en 2006

Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors

artículo científico publicado en 2009

In vitro differentiation of near-unlimited numbers of functional mouse basophils using conditional Hoxb8.

artículo científico publicado en 2013

Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors

artículo científico publicado en 1999

Insights into the pathogenesis of cerebral lesions in incontinentia pigmenti

artículo científico publicado en 2003

Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer

scientific article published on 09 October 2018

Interleukin-3-mediated regulation of β-catenin in myeloid transformation and acute myeloid leukemia

artículo científico publicado en 2014

JAFFAL: detecting fusion genes with long-read transcriptome sequencing

artículo científico publicado en 2022

Letting the breaks off MYCN.

artículo científico publicado en 2016

Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice.

artículo científico publicado en 2014

Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes.

artículo científico publicado en 2010

MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data

artículo científico publicado en 2021

MicroRNA-155 expression and function in AML: An evolving paradigm.

artículo científico publicado en 2018

Molecular basis of cytokine receptor activation

artículo científico publicado en 2010

Monolysocardiolipins accumulate in Barth syndrome but do not lead to enhanced apoptosis

artículo científico publicado en 2005

Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation.

artículo científico publicado en 2009

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

scholarly article by Behrouz Hassannia et al published 1 August 2018 in Journal of Clinical Investigation

Nerve growth factor signaling through p75 induces apoptosis in Schwann cells via a Bcl-2-independent pathway.

artículo científico publicado en 1999

Predicting the outcome of postasphyxial hypoxic-ischemic encephalopathy within 4 hours of birth

artículo científico publicado en 1997

Preterm maturation of the somatosensory evoked potential.

artículo científico publicado en 1996

Programmed anuclear cell death delimits platelet life span.

artículo científico publicado en 2007

Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival

artículo científico publicado en 2013

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.

artículo científico publicado en 2008

Quantitative proteomic analysis of EZH2 inhibition in acute myeloid leukemia reveals the targets and pathways that precede the induction of cell death

artículo científico publicado en 2017

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis

artículo científico publicado en 2014

Recurrent SPECC1L-NTRK fusions in paediatric sarcoma and brain tumours

artículo científico publicado en 2020

Role of p53 in cAMP/PKA pathway mediated apoptosis.

artículo científico publicado en 2013

Role of the β Common (βc) Family of Cytokines in Health and Disease

artículo científico publicado en 2017

SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia

artículo científico publicado en 2022

Seeking a MCL-1 inhibitor

artículo científico publicado en 2013

Sequence as well as functional similarity for DIABLO/Smac and Grim, Reaper and Hid?

artículo científico publicado en 2000

Signalling by the βc family of cytokines

artículo científico

Stuck long line syndrome.

artículo científico publicado en 2005

Targeted therapy and disease monitoring in CNTRL-FGFR1-driven leukaemia

scientific article published on 28 June 2019

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription.

artículo científico publicado en 2013

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

artículo científico publicado en 2016

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

artículo científico publicado en 2016

The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

scientific article published on 01 April 2007

The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast

artículo científico publicado en 2004

The GM-CSF receptor family: mechanism of activation and implications for disease

artículo científico publicado en 2012

The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites

artículo científico publicado en 2002

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

artículo científico publicado en 2016

The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease

artículo científico publicado en 2009

The mitochondrial death squad: hardened killers or innocent bystanders?

artículo científico publicado en 2005

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

scientific journal article

The molecular relationships between apoptosis, autophagy and necroptosis

artículo científico publicado en 2015

The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts

artículo científico publicado en 2013

The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis.

artículo científico publicado en 2002

Till death do us part.

artículo científico publicado en 2001

Triggering of apoptosis by Puma is determined by the threshold set by prosurvival Bcl-2 family proteins

artículo científico publicado en 2008

Two sisters with IMAGe syndrome: Cytomegalic adrenal histopathology, support for autosomal recessive inheritance and literature review

artículo científico publicado en 2006

Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis

artículo científico publicado en 2003

Upper cervical spinal cord injury in neonates: The use of magnetic resonance imaging

artículo científico publicado en 2001

Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer

artículo científico publicado en 2020

p53-Dependent transcriptional responses to interleukin-3 signaling

artículo científico publicado en 2012

Lista de obras de Paul G Ekert

A novel Apaf-1-independent putative caspase-2 activation complex

A prospective evaluation of whole-exome sequencing as a first-tier molecular test in infants with suspected monogenic disorders

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations.

Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism

Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells.

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

Apoptosis and the immune system ⬇️

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

Apoptosis, haemopoiesis and leukaemogenesis.

Author Correction: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome

Autophagy and AML--food for thought.

BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis

Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma

Caspase inhibitors.

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7.

Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis

Chemotherapy-related cardiotoxicity: are Australian practitioners missing the point?

Clinicopathological Correlations in Postasphyxial Organ Damage: A Donor Organ Perspective

Clinker: visualising fusion genes detected in RNA-seq data

Clinker: visualizing fusion genes detected in RNA-seq data

Crossing paths: interactions between the cell death machinery and growth factor survival signals

Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins

Cytoplasmic p53 is not required for PUMA-induced apoptosis

Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance

Dexamethasone prevents apoptosis in a neonatal rat model of hypoxic-ischemic encephalopathy (HIE) by a reactive oxygen species-independent mechanism.

Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP.

Dysregulation of BCL-2 family proteins by leukemia fusion genes

ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis.

Efficacy of MEK inhibition in a recurrent malignant peripheral nerve sheath tumor

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1.

Epithelial bridging on burn patients following primary excision and grafting.

Exploring the feasibility and utility of exome-scale tumour sequencing in a clinical setting

Exploring the utility of human DNA methylation arrays for profiling mouse genomic DNA.

Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia

Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML

Genetic determinants of anthracycline cardiotoxicity - ready for the clinic?

Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome

Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia

Hoxb8 regulates expression of microRNAs to control cell death and differentiation.

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1

Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs

Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors

In vitro differentiation of near-unlimited numbers of functional mouse basophils using conditional Hoxb8.

Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors

Insights into the pathogenesis of cerebral lesions in incontinentia pigmenti

Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer

Interleukin-3-mediated regulation of β-catenin in myeloid transformation and acute myeloid leukemia

JAFFAL: detecting fusion genes with long-read transcriptome sequencing

Letting the breaks off MYCN.

Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice.

Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes.

MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data

MicroRNA-155 expression and function in AML: An evolving paradigm.

Molecular basis of cytokine receptor activation

Monolysocardiolipins accumulate in Barth syndrome but do not lead to enhanced apoptosis

Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation.

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Nerve growth factor signaling through p75 induces apoptosis in Schwann cells via a Bcl-2-independent pathway.

Predicting the outcome of postasphyxial hypoxic-ischemic encephalopathy within 4 hours of birth

Preterm maturation of the somatosensory evoked potential.

Programmed anuclear cell death delimits platelet life span.

Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.

Quantitative proteomic analysis of EZH2 inhibition in acute myeloid leukemia reveals the targets and pathways that precede the induction of cell death

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis

Recurrent SPECC1L-NTRK fusions in paediatric sarcoma and brain tumours

Role of p53 in cAMP/PKA pathway mediated apoptosis.

Role of the β Common (βc) Family of Cytokines in Health and Disease

SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia

Seeking a MCL-1 inhibitor

Sequence as well as functional similarity for DIABLO/Smac and Grim, Reaper and Hid?

Signalling by the βc family of cytokines