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Lista de obras de Pierre Hainaut

(18)F-FDG PET-CT for Surveillance of Brazilian Patients with Li-Fraumeni Syndrome

artículo científico publicado en 2015

20 years into the Gambia Hepatitis Intervention Study: assessment of initial hypotheses and prospects for evaluation of protective effectiveness against liver cancer.

artículo científico publicado en 2008

20-years of population-based cancer registration in hepatitis B and liver cancer prevention in the Gambia, West Africa

artículo científico publicado en 2013

249(ser) TP53 mutation in plasma DNA, hepatitis B viral infection, and risk of hepatocellular carcinoma.

artículo científico publicado en 2005

4-Aminobiphenyl-hemoglobin adducts and risk of smoking-related disease in never smokers and former smokers in the European Prospective Investigation into Cancer and Nutrition prospective study

artículo científico publicado en 2005

A TP53 founder mutation, p.R337H, is associated with phyllodes breast tumors in Brazil

article

A common molecular mechanism underlies two phenotypically distinct 17p13.1 microdeletion syndromes

artículo científico publicado en 2010

A global view of hepatocellular carcinoma: trends, risk, prevention and management

artículo científico publicado en 2019

A meta-analysis of cancer risk associated with the TP53 intron 3 duplication polymorphism (rs17878362): geographic and tumor-specific effects.

artículo científico publicado en 2013

A sample storage management system for biobanks.

artículo científico publicado en 2010

A structural role for metal ions in the "wild-type" conformation of the tumor suppressor protein p53.

artículo científico publicado en 1993

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

artículo científico publicado en 2008

ALK fusion variants detection by targeted RNA-next generation sequencing and clinical responses to crizotinib in ALK-positive non-small cell lung cancer.

artículo científico publicado en 2017

Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake

artículo científico publicado en 2010

Aberrant DNA methylation links cancer susceptibility locus 15q25.1 to apoptotic regulation and lung cancer

artículo científico publicado en 2010

Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).

artículo científico publicado en 2011

Absence of association between HPV DNA, TP53 codon 72 polymorphism, and risk of oesophageal cancer in a high-risk area of China

artículo científico publicado en 2001

Abstract 1836: Distinct tumor spectrum and age of onset in a Brazilian cohort of p.R337HTP53mutation carriers

article

Abstract 4282: GermlineTP53p.R337H mutations and Li-Fraumeni syndrome: A new variant form of the disease

Abstract 5598: Germline TP53 mutation in very early onset breast cancer patients without BRCA1 and BRCA2 mutation in Brazilian population

article

Activation of p53 by the cytoprotective aminothiol WR1065: DNA-damage-independent pathway and redox-dependent modulation of p53 DNA-binding activity.

artículo científico publicado en 2003

Aetiological differences in demographical, clinical and pathological characteristics of hepatocellular carcinoma in The Gambia

artículo científico publicado en 2010

Aflatoxin exposure and viral hepatitis in the etiology of liver cirrhosis in the Gambia, West Africa

artículo científico publicado en 2008

Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand: association with tumors developing in the absence of liver cirrhosis

artículo científico publicado en 2012

Age at cancer onset in germline TP53 mutation carriers: association with polymorphisms in predicted G-quadruplex structures

artículo científico publicado en 2013

Air pollution and risk of lung cancer in a prospective study in Europe

artículo científico publicado en 2006

Amount of DNA in plasma and cancer risk: A prospective study

An apoptosis methylation prognostic signature for early lung cancer in the IFCT-0002 trial

artículo científico publicado en 2012

Analysis of p53 quaternary structure in relation to sequence-specific DNA binding

scientific article published on 01 January 1994

Analysis of p53, p16MTS, p21WAF1 and H-ras in archived bladder tumours from workers exposed to aromatic amines

artículo científico

Ancestry of the Brazilian TP53 c.1010G>A (p.Arg337His, R337H) Founder Mutation: Clues from Haplotyping of Short Tandem Repeats on Chromosome 17p.

artículo científico publicado en 2015

Anthropometry, Silhouette Trajectory, and Risk of Breast Cancer in Mexican Women

Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus

artículo científico publicado en 2008

Arrayed primer extension resequencing of mutations in the TP53 tumor suppressor gene: comparison with denaturing HPLC and direct sequencing

artículo científico publicado en 2005

Assessment of genetic damage in healthy and diseased tissue.

artículo científico

Assessment of transformed properties in vitro and of tumorigenicity in vivo in primary keratinocytes cultured for epidermal sheet transplantation.

artículo científico publicado en 2010

Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand

artículo científico publicado en 2012

Association between TP53 R249S mutation and polymorphisms in TP53 intron 1 in hepatocellular carcinoma

artículo científico publicado en 2013

Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study

artículo científico publicado en 2010

Association of prediagnostic physical activity with survival following breast cancer diagnosis: influence of TP53 mutation status

artículo científico publicado en 2013

BTG gene expression in the p53-dependent and -independent cellular response to DNA damage

scientific article published on 01 February 2000

Biobanking in a fast moving world: an international perspective

artículo científico publicado en 2011

Biological functions of p53 isoforms through evolution: lessons from animal and cellular models.

artículo científico publicado en 2011

Biomarkers Predict p53 Gene Therapy Efficacy in Recurrent Squamous Cell Carcinoma of the Head and Neck

artículo científico publicado en 2009

Biomarkers in cancer research and treatment: promises and challenges

Biospecimen Reporting for Improved Study Quality

artículo científico publicado en 2011

Biospecimen reporting for improved study quality (BRISQ)

artículo científico publicado en 2011

Biospecimen reporting for improved study quality (BRISQ)

Breast cancer in Latin America: global burden, patterns, and risk factors

artículo científico publicado en 2014

Breast cancer in pre-menopausal women in West Africa: analysis of temporal trends and evaluation of risk factors associated with reproductive life.

artículo científico publicado en 2013

Breast-cancer stromal cells with TP53 mutations

scientific article published on 01 April 2008

CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression

artículo científico publicado en 2011

Cancer Diagnostic and Predictive Biomarkers 2015.

artículo científico publicado en 2015

Cancer Diagnostic and Predictive Biomarkers 2016.

artículo científico publicado en 2017

Cancer as a metabolic disease

Cancer diagnostic and predictive biomarkers

artículo científico publicado en 2014

Cancer prevention and control: hepatocellular carcinoma

scientific article published on 25 July 2019

Cancers of the upper gastro-intestinal tract: a review of somatic mutation distributions.

artículo científico

Changes in the pattern of breast cancer burden among African American women: evidence based on 29 states and District of Columbia during 1998 to 2010.

artículo científico publicado en 2014

Characterisation of human fibroblasts as keratinocyte feeder layer using p63 isoforms status

artículo científico publicado en 2009

Circulating Osteopontin and Prediction of Hepatocellular Carcinoma Development in a Large European Population

artículo científico publicado en 2016

Circulating free DNA in plasma or serum as biomarker of carcinogenesis: practical aspects and biological significance

artículo científico publicado en 2007

Clinical implications of p53 tumor suppressor gene mutation and protein expression in esophageal adenocarcinomas: results of a ten-year prospective study.

artículo científico publicado en 2003

Combination of AKT inhibitor ARQ 092 and sorafenib potentiates inhibition of tumor progression in cirrhotic rat model of hepatocellular carcinoma.

artículo científico publicado en 2018

Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma

artículo científico publicado en 2008

Computational approaches for predicting the biological effect of p53 missense mutations: a comparison of three sequence analysis based methods

artículo científico publicado en 2006

Control of hepatocellular carcinoma through hepatitis B vaccination in areas of high endemicity: perspectives for global liver cancer prevention

artículo científico publicado en 2009

Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer

artículo científico publicado en 2016

Correction: Protein Profiling in Hepatocellular Carcinoma by Label-Free Quantitative Proteomics in Two West African Populations.

artículo científico publicado en 2013

Cost-effectiveness of early cancer surveillance for patients with Li-Fraumeni syndrome

artículo científico publicado en 2019

Cross-Validation Study for Epidermal Growth Factor Receptor and KRAS Mutation Detection in 74 Blinded Non-small Cell Lung Carcinoma Samples: A Total of 5550 Exons Sequenced by 15 Molecular French Laboratories (Evaluation of the EGFR Mutation Status f

article

Cross-talks between cyclooxygenase-2 and tumor suppressor protein p53: Balancing life and death during inflammatory stress and carcinogenesis

artículo científico publicado en 2007

Curbing the liver cancer epidemic in Africa.

artículo científico publicado en 2008

Cytokeratin expression in adenocarcinomas of the esophagogastric junction: a comparative study of adenocarcinomas of the distal esophagus and of the proximal stomach

scientific article published on 01 September 2002

DNA adducts and lung cancer risk: a prospective study

artículo científico publicado en 2005

DNA methylation changes associated with risk factors in tumors of the upper aerodigestive tract

artículo científico publicado en 2012

DNA methylation of hepatitis B virus (HBV) genome associated with the development of hepatocellular carcinoma and occult HBV infection

artículo científico publicado en 2010

Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects

artículo científico publicado en 1997

DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53.

artículo científico publicado en 2002

Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study

artículo científico publicado en 2011

Detailed haplotype analysis at the TP53 locus in p.R337H mutation carriers in the population of Southern Brazil: evidence for a founder effect.

artículo científico publicado en 2010

Detection of R337H, a germline TP53 mutation predisposing to multiple cancers, in asymptomatic women participating in a breast cancer screening program in Southern Brazil

article

Detection of p53 codon 249 mutation in Nigerian patients with hepatocellular carcinoma using a novel evaluation of cell-free DNA.

artículo científico publicado en 2008

Dietary Carbohydrate, Glycemic Index, Glycemic Load, and Breast Cancer Risk Among Mexican Women

artículo científico publicado en 2015

Distinct pattern of TP53 mutations in squamous cell carcinoma of the esophagus in Iran

artículo científico publicado en 2001

Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture

artículo científico publicado en 2007

Downregulation of transcription factor E4F1 in hepatocarcinoma cells: HBV-dependent effects on autophagy, proliferation and metabolism.

artículo científico

Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation

artículo científico publicado en 2012

EUELC project: a multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration

artículo científico publicado en 2009

Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers

artículo científico publicado en 2013

Editorial foreword special issue "hepatocellular carcinoma--a worldwide translational approach"

artículo científico publicado en 2009

Editorial: from cancer genotypes to phenotypes: a never-ending complexity.

artículo científico publicado en 2016

Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma

artículo científico publicado en 2004

Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein.

artículo científico publicado en 2010

Effects of tobacco smoke and benzo[a]pyrene on human endothelial cell and monocyte stress responses.

artículo científico publicado en 2001

Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53.

artículo científico publicado en 2013

Efficient hepatitis C antigen immunohistological staining in sections of normal, cirrhotic and tumoral liver using a new monoclonal antibody directed against serum-derived HCV E2 glycoproteins

artículo científico

Environmental tobacco smoke and risk of respiratory cancer and chronic obstructive pulmonary disease in former smokers and never smokers in the EPIC prospective study

artículo científico publicado en 2005

Epidermal growth factor receptor (EGFR) mutations and expression in squamous cell carcinoma of the esophagus in central Asia

artículo científico publicado en 2012

Epigenetic silencing of sFRP1 activates the canonical Wnt pathway and contributes to increased cell growth and proliferation in hepatocellular carcinoma.

artículo científico publicado en 2012

Esophageal cancer: cases and causes (part I)

artículo científico publicado en 2007

Estrogen levels act as a rheostat on p53 levels and modulate p53-dependent responses in breast cancer cell lines

artículo científico publicado en 2010

Evaluating the arrayed primer extension resequencing assay of TP53 tumor suppressor gene

artículo científico publicado en 2002

Evaluation of tumorigenic risk of tissue-engineered oral mucosal epithelial cells by using combinational examinations

scientific article published on 14 June 2010

Exposure to hazardous substances in a standard molecular biology laboratory environment: evaluation of exposures in IARC laboratories.

artículo científico publicado en 2009

Extremely high Tp53 mutation load in esophageal squamous cell carcinoma in Golestan Province, Iran

artículo científico publicado en 2011

First International p53 Isoforms Meeting: 'p53 isoforms through evolution: from identification to biological function'

artículo científico publicado en 2010

Frequent occurrence of gastric cancer in Asian kindreds with Li-Fraumeni syndrome.

artículo científico publicado en 2014

Future perspectives on molecular epidemiology ⬇️

artículo científico

G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms

artículo científico publicado en 2010

Genetic alterations in esophageal cancer and their relevance to etiology and pathogenesis: a review

artículo científico publicado en 1996

Genetic and epigenetic alterations as biomarkers for cancer detection, diagnosis and prognosis

artículo científico publicado en 2007

Genetics of lung-cancer susceptibility

artículo científico publicado en 2010

Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia

artículo científico publicado en 2011

Hepatitis B surface antigenaemia and alpha-foetoprotein detection from dried blood spots: applications to field-based studies and to clinical care in hepatitis B virus endemic areas.

artículo científico publicado en 2005

Hepatitis B viral load and risk for liver cirrhosis and hepatocellular carcinoma in The Gambia, West Africa

artículo científico publicado en 2009

Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells.

artículo científico publicado en 2011

Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity

artículo científico publicado en 2005

Hepatocellular carcinoma: from gene to public health.

artículo científico publicado en 1997

Higher-than-expected population prevalence of potentially pathogenic germline TP53 variants in individuals unselected for cancer history.

artículo científico

Highly prevalent TP53 mutation predisposing to many cancers in the Brazilian population: a case for newborn screening?

artículo científico publicado en 2009

Hormonal therapy and risk of breast cancer in mexican women

artículo científico publicado en 2013

Human papillomavirus infection among 100 oesophageal cancer cases in the People's Republic of China

article

Human papillomavirus type 16 and TP53 mutation in oral cancer: matched analysis of the IARC multicenter study

artículo científico publicado en 2004

Human tissue biobanks as instruments for drug discovery and development: impact on personalized medicine

article

IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools

artículo científico publicado en 1998

IARC p53 mutation database: a relational database to compile and analyze p53 mutations in human tumors and cell lines. International Agency for Research on Cancer

artículo científico publicado en 1999

Identification of osteopontin as a novel marker for early hepatocellular carcinoma

artículo científico publicado en 2011

Impact of G-quadruplex structures and intronic polymorphisms rs17878362 and rs1642785 on basal and ionizing radiation-induced expression of alternative p53 transcripts

artículo científico publicado en 2014

Impact of delay to cryopreservation on RNA integrity and genome-wide expression profiles in resected tumor samples

artículo científico publicado en 2013

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

artículo científico publicado en 2007

In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249.

artículo científico publicado en 2007

In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure.

artículo científico publicado en 2009

Inactivation of the p53 protein in cell lines derived from human esophageal cancers

artículo científico publicado en 1997

Increase in female liver cancer in the Gambia, West Africa: evidence from 19 years of population-based cancer registration (1988-2006)

artículo científico publicado en 2011

Increased oxidative damage in carriers of the germline TP53 p.R337H mutation

artículo científico publicado en 2012

Increased salt concentration reversibly destabilizes p53 quaternary structure and sequence-specific DNA binding.

artículo científico publicado en 1994

Independent prognostic value of somatic TP53 gene mutations in 1794 breast cancer patients.

artículo científico publicado en 2005

Inducible nitric oxide synthase, nitrotyrosine and p53 mutations in the molecular pathogenesis of Barrett's esophagus and esophageal adenocarcinoma

artículo científico publicado en 2008

Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European Prospective Investigation into Cancer and Nutrition (EPIC).

artículo científico publicado en 2010

Initiation of human astrocytoma by clonal evolution of cells with progressive loss of p53 functions in a patient with a 283H TP53 germ-line mutation: evidence for a precursor lesion.

artículo científico publicado en 2002

Integrating mutation data and structural analysis of the TP53 tumor-suppressor protein

artículo científico publicado en 2002

Interaction of heat-shock protein 70 with p53 translated in vitro: evidence for interaction with dimeric p53 and for a role in the regulation of p53 conformation ⬇️

artículo científico publicado el 1 de octubre de 1992

Interactions between hepatitis B virus and aflatoxin B(1): effects on p53 induction in HepaRG cells

artículo científico publicado en 2011

Interferon-inducible guanylate binding protein (GBP)-2: a novel p53-regulated tumor marker in esophageal squamous cell carcinomas

artículo científico publicado en 2009

International efforts to develop biospecimen best practices.

artículo científico publicado en 2010

Intraepithelial p63-dependent expression of distinct components of cell adhesion complexes in normal esophageal mucosa and squamous cell carcinoma

artículo científico publicado en 2010

KRAS mutation status in primary nonsmall cell lung cancer and matched metastases.

artículo científico publicado en 2010

Lessons from TP53 mutations in breast cancers: from carcinogen fingerprints to clinical correlates

artículo científico publicado en 2000

Li-Fraumeni and Li-Fraumeni-like syndrome among children diagnosed with pediatric cancer in Southern Brazil

artículo científico publicado en 2013

Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype

artículo científico publicado en 2003

Li-Fraumeni syndrome in a Malaysian kindred

artículo científico publicado en 2008

Li-Fraumeni syndrome: report of a clinical research workshop and creation of a research consortium

artículo científico publicado en 2012

Long-term protection against HBV chronic carriage of Gambian adolescents vaccinated in infancy and immune response in HBV booster trial in adolescence

artículo científico publicado en 2007

Loss of TP53-DNA interaction induced by p.C135R in lung cancer.

artículo científico publicado en 2007

Low Prevalence of TP53 Mutations and MDM2 Amplifications in Pediatric Rhabdomyosarcoma

artículo científico publicado en 2012

Low frequency of p16/CDKN2 gene mutations in esophageal carcinomas

artículo científico publicado en 1996

Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity.

artículo científico publicado en 2014

Lung tumor KRAS and TP53 mutations in nonsmokers reflect exposure to PAH-rich coal combustion emissions.

artículo científico publicado en 2001

Massively regulated genes: the example of TP53.

artículo científico publicado en 2010

Metal ions as regulators of the conformation and function of the tumour suppressor protein p53: implications for carcinogenesis.

artículo científico publicado en 1999

Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells

scientific article published on 01 November 2000

Methodology of laboratory measurements in prospective studies on gene-environment interactions: the experience of GenAir

artículo científico publicado en 2005

Methylation patterns in sentinel genes in peripheral blood cells of heavy smokers: Influence of cruciferous vegetables in an intervention study

artículo científico publicado en 2011

MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma

artículo científico publicado en 2010

Modulation by copper of p53 conformation and sequence-specific DNA binding: role for Cu(II)/Cu(I) redox mechanism

artículo científico publicado en 1995

Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc.

artículo científico publicado en 1998

Molecular and clinical differences between adenocarcinomas of the esophagus and of the gastric cardia

artículo científico publicado en 2001

Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali

artículo científico publicado en 2015

Molecular detection of early-stage laryngopharyngeal squamous cell carcinomas

artículo científico publicado en 2005

Molecular epidemiology: linking molecular scale insights to population impacts ⬇️

artículo científico

Molecular etiopathogenesis of esophageal cancers

artículo científico publicado en 1996

More chinks in the armor of cancer: potential for new therapies.

artículo científico publicado en 2016

Mutant p53 protein, master regulator of human malignancies: a report on the Fifth Mutant p53 Workshop

artículo científico publicado en 2011

Mutant p53 rescue and modulation of p53 redox state.

artículo científico publicado en 2009

Mutant p53 targeting by the low molecular weight compound STIMA-1

artículo científico publicado en 2008

Mutant p53 targeting by the low molecular weight compound STIMA-1.

artículo científico publicado en 2017

Mutation of TP53 and alteration of p14(arf) expression in EGFR- and KRAS-mutated lung adenocarcinomas

artículo científico publicado en 2013

Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand

artículo científico publicado en 2011

Mésothéliome : les dispositifs en place en France « le réseau mésothéliome » 1998–2013

article

Natural variations of copper and sulfur stable isotopes in blood of hepatocellular carcinoma patients

artículo científico publicado en 2015

Next-generation sequencing: emerging lessons on the origins of human cancer

artículo científico publicado en 2011

Nitric oxide induces conformational and functional modifications of wild-type p53 tumor suppressor protein.

artículo científico publicado en 1997

Nitric oxide nitrates tyrosine residues of tumor-suppressor p53 protein in MCF-7 cells

scientific article published on 01 January 2000

Nitric oxide prevents gamma-radiation-induced cell cycle arrest by impairing p53 function in MCF-7 cells.

artículo científico publicado en 2001

Obesity, inflammatory markers, and endometrial cancer risk: a prospective case-control study

artículo científico publicado en 2010

On the origin of G --> T transversions in lung cancer

artículo científico publicado en 2003

Osteopontin and latent-TGF β binding-protein 2 as potential diagnostic markers for HBV-related hepatocellular carcinoma

artículo científico publicado en 2014

Overweight, obesity and risk of premenopausal breast cancer according to ethnicity: a systematic review and dose-response meta-analysis

artículo científico publicado en 2013

P53 at the atomic scale: the multiple faces of a crystal

artículo científico publicado el 1 de julio de 1997

PD-L1 protein expression assessed by immunohistochemistry is neither prognostic nor predictive of benefit from adjuvant chemotherapy in resected non-small cell lung cancer.

artículo científico publicado en 2017

PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

artículo científico publicado en 2009

PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines

artículo científico publicado en 2014

Papillomavirus infection in the conjunctiva of individuals with and without AIDS: an autopsy series from Uganda

artículo científico publicado en 2005

Pathology as the cornerstone of human tissue banking: European consensus expert group report

artículo científico

Patterns of Benign and Malignant Lesions of the Thyroid in Two Wilayahs of Northeastern Algeria.

artículo científico publicado en 2015

Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history

scientific article published on 01 June 2007

Pharmacological rescue of p53 in cancer cells: the soloist meets the PRIMA donna

artículo científico publicado en 2011

Plasma Circulating Tumor DNA Levels for the Monitoring of Melanoma Patients: Landscape of Available Technologies and Clinical Applications.

artículo científico publicado en 2017

Polycyclic aromatic hydrocarbon exposure in oesophageal tissue and risk of oesophageal squamous cell carcinoma in north-eastern Iran

artículo científico publicado en 2010

Pooled Analysis of the Prognostic and Predictive Effects of TP53 Comutation Status Combined With KRAS or EGFR Mutation in Early-Stage Resected Non-Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy

artículo científico publicado en 2017

Pooled analysis of the prognostic and predictive effects of KRAS mutation status and KRAS mutation subtype in early-stage resected non-small-cell lung cancer in four trials of adjuvant chemotherapy

artículo científico publicado en 2013

Poor intercellular transport and absence of enhanced antiproliferative activity after non-viral gene transfer of VP22-P53 or P53-VP22 fusions into p53 null cell lines in vitro or in vivo

scientific article published on 01 July 2005

Population-based breast (female) and cervix cancer rates in the Gambia: evidence of ethnicity-related variations

artículo científico publicado en 2010

Predicting the transactivation activity of p53 missense mutants using a four-body potential score derived from Delaunay tessellations

artículo científico publicado en 2006

Premalignant lesions of the esophagogastric mucosa.

artículo científico publicado en 2004

Prevalence of the TP53 p.R337H mutation in breast cancer patients in Brazil

artículo científico publicado en 2014

Prognostic and Predictive Effect of TP53 Mutations in Patients with Non-Small Cell Lung Cancer from Adjuvant Cisplatin-Based Therapy Randomized Trials: A LACE-Bio Pooled Analysis

artículo científico publicado en 2016

Prognostic and predictive value of TP53 mutations in node-positive breast cancer patients treated with anthracycline- or anthracycline/taxane-based adjuvant therapy: results from the BIG 02-98 phase III trial

artículo científico publicado en 2012

Prognostic value ofTP53,KRASandEGFRmutations in nonsmall cell lung cancer: the EUELC cohort

article

Properties of the six isoforms of p63: p53-like regulation in response to genotoxic stress and cross talk with DeltaNp73.

artículo científico publicado en 2007

Protein profiling in hepatocellular carcinoma by label-free quantitative proteomics in two west African populations

artículo científico publicado en 2013

Proteomics beyond proteomics: toward clinical applications

scientific article published on January 2011

Pulmonary embolism findings on chest radiographs and multislice spiral CT.

artículo científico publicado en 2004

Quantitation of p53 nuclear relocation in response to stress using a yeast functional assay: effects of irradiation and modulation by heavy metal ions.

artículo científico publicado en 2005

Quantitative analysis of DNA methylation after whole bisulfitome amplification of a minute amount of DNA from body fluids.

artículo científico publicado en 2009

Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors

artículo científico publicado en 2009

Quantitative analysis of plasma TP53 249Ser-mutated DNA by electrospray ionization mass spectrometry.

artículo científico publicado en 2005

Rare germline variant (rs78378222) in the TP53 3' UTR: Evidence for a new mechanism of cancer predisposition in Li-Fraumeni syndrome

artículo científico publicado en 2016

Recent advances in p53 research: an interdisciplinary perspective.

artículo científico publicado en 2008

Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice

artículo científico publicado en 2017

Redox control and interplay between p53 isoforms: roles in the regulation of basal p53 levels, cell fate, and senescence

artículo científico publicado en 2011

Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

artículo científico publicado en 1993

Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper.

artículo científico publicado en 1997

Relationships between lung adenocarcinoma and gender, age, smoking and occupational risk factors: A case-case study

artículo científico publicado en 2009

Response to “Germline TP53 R337H mutation is not sufficient to establish Li-Fraumeni or Li-Fraumeni-like syndrome”, by Ribeiro et al

Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1.

artículo científico publicado en 2002

Revisiting tumor patterns and penetrance in germline TP53 mutation carriers: temporal phases of Li-Fraumeni syndrome.

artículo científico publicado en 2017

Role of obesity in the risk of breast cancer: lessons from anthropometry

artículo científico publicado en 2013

Role of p53 in the induction of cyclooxygenase-2 by cisplatin or paclitaxel in non-small cell lung cancer cell lines.

artículo científico publicado en 2009

Sarcomas in TP53 germline mutation carriers: a review of the IARC TP53 database

artículo científico publicado en 2011

Screening for germline BRCA1, BRCA2, TP53 and CHEK2 mutations in families at-risk for hereditary breast cancer identified in a population-based study from Southern Brazil

artículo científico publicado en 2016

Seasonal variation in TP53 R249S-mutated serum DNA with aflatoxin exposure and hepatitis B virus infection

artículo científico publicado en 2011

Ser-249 TP53 and CTNNB1 mutations in circulating free DNA of Egyptian patients with hepatocellular carcinoma versus chronic liver diseases.

artículo científico publicado en 2008

Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia

artículo científico publicado en 2000

Ser-249TP53 mutation in tumour and plasma DNA of hepatocellular carcinoma patients from a high incidence area in the Gambia, West Africa

artículo científico publicado en 2004

Significance of TP53 mutations as predictive markers of adjuvant cisplatin-based chemotherapy in completely resected non-small-cell lung cancer.

artículo científico publicado en 2014

Skin human papillomavirus type 38 alters p53 functions by accumulation of deltaNp73.

artículo científico publicado en 2006

Smoky coal exposure, NBS1 polymorphisms, p53 protein accumulation, and lung cancer risk in Xuan Wei, China

artículo científico publicado en 2005

Somatic TP53 Mutations in the Era of Genome Sequencing.

artículo científico publicado en 2016

Somatic mutation databases as tools for molecular epidemiology and molecular pathology of cancer: proposed guidelines for improving data collection, distribution, and integration

artículo científico publicado en 2009

Sources of bias in the detection and reporting of p53 mutations in human cancer: analysis of the IARC p53 mutation database

scientific article published on 01 February 1999

Sources of pre-analytical variations in yield of DNA extracted from blood samples: analysis of 50,000 DNA samples in EPIC.

artículo científico publicado en 2012

Surface functionalization of gold nanoclusters with arginine: a trade-off between microtumor uptake and radiotherapy enhancement

scientific article published on 01 April 2020

Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms.

artículo científico publicado en 2018

TP53 Mutations and HBX Status Analysis in Hepatocellular Carcinomas from Iran: Evidence for Lack of Association between HBV Genotype D and TP53 R249S Mutations

artículo científico publicado en 2011

TP53 PIN3 and MDM2 SNP309 polymorphisms as genetic modifiers in the Li-Fraumeni syndrome: impact on age at first diagnosis.

artículo científico publicado en 2009

TP53 PIN3 and PEX4 polymorphisms and infertility associated with endometriosis or with post-in vitro fertilization implantation failure.

artículo científico publicado en 2012

TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia

artículo científico publicado en 2012

TP53 R249S mutations, exposure to aflatoxin, and occurrence of hepatocellular carcinoma in a cohort of chronic hepatitis B virus carriers from Qidong, China

artículo científico publicado en 2009

TP53 and EGFR mutations in combination with lifestyle risk factors in tumours of the upper aerodigestive tract from South America

artículo científico publicado en 2009

TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: distinct patterns in never, former, and current smokers

artículo científico publicado en 2005

TP53 and long-term prognosis in colorectal cancer: mutations in the L3 zinc-binding domain predict poor survival

artículo científico publicado en 1998

TP53 mutation p.R337H in gastric cancer tissues of a 12-year-old male child: evidence for chimerism involving a common mutant founder haplotype: case report

artículo científico publicado en 2011

TP53 mutation patterns in breast cancers: searching for clues of environmental carcinogenesis.

artículo científico publicado en 2001

TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer

artículo científico publicado en 2004

TP53 mutation spectrum in lung cancers and mutagenic signature of components of tobacco smoke: lessons from the IARC TP53 mutation database

artículo científico publicado en 2001

TP53 mutations and MDM2 gene amplification in squamous-cell carcinomas of the esophagus in south Thailand

scientific article published on 01 October 2000

TP53 mutations as biomarkers for cancer epidemiology in Latin America: current knowledge and perspectives

artículo científico publicado en 2005

TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes

artículo científico publicado en 2007

TP53 mutations in human cancers: origins, consequences, and clinical use

artículo científico publicado en 2010

TP53 mutations in squamous-cell carcinomas of the conjunctiva: evidence for UV-induced mutagenesis

artículo científico publicado en 2004

TP53 mutations, amplification of P63 and expression of cell cycle proteins in squamous cell carcinoma of the oesophagus from a low incidence area in Western Europe

artículo científico publicado en 2001

TP53 mutations, human papilloma virus DNA and inflammation markers in esophageal squamous cell carcinoma from the Rift Valley, a high-incidence area in Kenya

artículo científico publicado en 2011

TP53 p.R337H is a conditional cancer-predisposing mutation: further evidence from a homozygous patient

artículo científico publicado en 2013

TP53 polymorphism, HPV infection, and risk of cervical cancer.

artículo científico publicado en 2001

TP53, EGFR, and KRAS mutations in relation to VHL inactivation and lifestyle risk factors in renal-cell carcinoma from central and eastern Europe

TP53: a key gene in human cancer.

artículo científico publicado en 2002

TP53andKRAS2Mutations in Plasma DNA of Healthy Subjects and Subsequent Cancer Occurrence: A Prospective Study

article by Emmanuelle Gormally et al published 1 July 2006 in Cancer Research

TP63 P2 promoter functional analysis identifies β-catenin as a key regulator of ΔNp63 expression

artículo científico publicado en 2011

Targeted deep sequencing of plasma circulating cell-free DNA reveals Vimentin and Fibulin 1 as potential epigenetic biomarkers for hepatocellular carcinoma

artículo científico publicado en 2017

Targeting the hallmarks of cancer: towards a rational approach to next-generation cancer therapy

artículo científico publicado en 2013

Temperature sensitivity for conformation is an intrinsic property of wild-type p53.

artículo científico publicado en 1995

The European Prospective Investigation into Cancer and Nutrition biobank

artículo científico publicado en 2011

The Evolution of Tumors in Mice and Humans with Germline p53 Mutations

artículo científico publicado en 2015

The Gambia Liver Cancer Study: Infection with hepatitis B and C and the risk of hepatocellular carcinoma in West Africa

artículo científico publicado en 2004

The IARC TP53 database: new online mutation analysis and recommendations to users

artículo científico publicado en 2002

The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation

artículo científico publicado en 2016

The TP53 fertility network

artículo científico publicado en 2012

The TP53 mutation, R337H, is associated with Li-Fraumeni and Li-Fraumeni-like syndromes in Brazilian families.

artículo científico publicado en 2006

The aflatoxin-induced TP53 mutation at codon 249 (R249S): biomarker of exposure, early detection and target for therapy

artículo científico publicado en 2009

The associations of sequence variants in DNA-repair and cell-cycle genes with cancer risk: genotype-phenotype correlations.

artículo científico publicado en 2009

The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer

artículo científico publicado en 2006

The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway.

artículo científico publicado en 2000

The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase.

artículo científico publicado en 2003

The expression of TA and DeltaNp63 are regulated by different mechanisms in liver cells.

artículo científico publicado en 2005

The genetic–metabolic duality of cancer

The profile and contribution of rare germline copy number variants to cancer risk in Li-Fraumeni patients negative for TP53 mutations.

artículo científico publicado en 2014

The role of the pathologist in tissue banking: European Consensus Expert Group Report

artículo científico publicado en 2010

The tumor suppressor gene TP53: implications for cancer management and therapy

artículo científico publicado en 2004

The tumor suppressor protein p53: a receptor to genotoxic stress that controls cell growth and survival

artículo científico publicado el 1 de enero de 1995

The use of biomarkers to study pathogenesis and mechanisms of cancer: oesophagus and skin cancer as models

artículo científico publicado el 1 de enero de 1997

Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers

artículo científico publicado en 2002

Toward a roadmap in global biobanking for health

artículo científico publicado en 2012

Training the Next Generation of Biobankers: A Two-Year Master's Course in the Management of Biobanks.

artículo científico publicado en 2017

Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis.

artículo científico publicado en 2010

Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB.

artículo científico

Transcriptional regulation of thymine DNA glycosylase (TDG) by the tumor suppressor protein p53

artículo científico publicado en 2012

Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk: the EPIC study

artículo científico publicado en 2011

Tumor protein 53 mutations and inherited cancer: beyond Li-Fraumeni syndrome.

artículo científico publicado en 2010

Tumor-cell-derived microvesicles as carriers of molecular information in cancer

artículo científico publicado en 2013

Tumor-specific mutations in p53: the acid test

scientific article published on 01 January 2002

Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies

artículo científico publicado en 2010

Variable population prevalence estimates of germline TP53 variants: A gnomAD-based analysis

article

WITHDRAWN: Expression of p53, p63, and p73 isoforms in squamous cell carcinoma and adenocarcinoma of esophagus☆,☆☆

artículo científico publicado en 2005

Whole-genome sequencing analysis of phenotypic heterogeneity and anticipation in Li-Fraumeni cancer predisposition syndrome

artículo científico publicado en 2014

Wnt/beta-catenin signaling pathway in hepatocellular carcinomas cases from Colombia

artículo científico publicado en 2015

Worldwide genetic diversity of HBV genotypes and risk of hepatocellular carcinoma

artículo científico publicado en 2009

Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging.

artículo científico publicado en 2017

Zinc binding and redox control of p53 structure and function.

artículo científico publicado en 2001

[Epidemiology, prevention, screening and diagnosis of hepatocellular carcinoma]

artículo científico publicado en 2009

[TP53 tumor suppressor gene: 20 years (and ten thousand mutations) later]

scientific article published on 01 January 2000

p16 expression in Barrett's esophagus and esophageal adenocarcinoma: association with genetic and epigenetic alterations.

artículo científico publicado en 2005

p53 Protocols: the Original Soundtrack of 25 Years of p53 Research. Methods in Molecular Biology. Vol. 234.

artículo científico publicado en 2004

p53 and human cancer: the first ten thousand mutations.

artículo científico publicado en 2000

p53 as a sensor of carcinogenic exposures: mechanisms of p53 protein induction and lessons from p53 gene mutations.

artículo científico publicado en 1997

p53 in metabolism, aging and cancer

artículo científico

p53 regulates the transcription of its Delta133p53 isoform through specific response elements contained within the TP53 P2 internal promoter

artículo científico publicado en 2010

p53 status influences response to tamoxifen but not to fulvestrant in breast cancer cell lines

artículo científico publicado en 2011

p53, stem cell biology and childhood blastomas

scientific article published on 01 March 2019

p53-Dependent repression of focal adhesion kinase in response to estradiol in breast cancer cell-lines

artículo científico publicado en 2010

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