Lista de obras - Thomas Kraemer - Dominio Público Uruguay

(Un)targeted hair metabolomics: first considerations and systematic evaluation on the impact of sample preparation

artículo científico publicado en 2019

A Comprehensive Multi-Analyte Method for Hair Analysis: Substance-Specific Quantification Ranges and Tool for Task-Oriented Data Evaluation

scientific article published on 27 September 2020

A machine learning approach for handling big data produced by high resolution mass spectrometry after data independent acquisition of small molecules - Proof of concept study using an artificial neural network for sample classification

artículo científico publicado en 2020

A new metabolomics-based strategy for identification of endogenous markers of urine adulteration attempts exemplified for potassium nitrite

artículo científico publicado en 2017

A novel bedtime pulsatile-release caffeine formula ameliorates sleep inertia symptoms immediately upon awakening

artículo científico publicado en 2021

A possible new oxidation marker for hair adulteration: Detection of PTeCA (1H-pyrrole-2,3,4,5-tetracarboxylic acid) in bleached hair

artículo científico publicado en 2019

Acute and Chronic Lead Exposure in Four Avian Scavenger Species in Switzerland

scientific article published on 20 September 2018

Acute death associated with Citrobacter freundii infection in an African elephant (Loxodonta africana).

artículo científico publicado en 2015

Analysis of drugs of abuse in hair: evaluation of the immunochemical method VMA-T vs. LC-MS/MS or GC-MS

scientific article published on 22 October 2011

Analytical considerations for (un)-targeted metabolomic studies with special focus on forensic applications

scientific article published on 28 November 2018

Analytical considerations for postmortem metabolomics using GC-high-resolution MS

scientific article published on 22 November 2019

Assessment of simpler calibration models in the development and validation of a fast postmortem multi-analyte LC-QTOF quantitation method in whole blood with simultaneous screening capabilities using SWATH acquisition.

artículo científico

Bioanalytical procedures for determination of drugs of abuse in blood

artículo científico publicado en 2007

Blood alcohol analysis alone versus comprehensive toxicological analysis - Systematic investigation of missed co-ingested other drugs in suspected alcohol-impaired drivers

artículo científico publicado en 2016

CYP3A4-Catalyzed Simvastatin Metabolism as a Non-Invasive Marker of Small Intestinal Health in Celiac Disease ⬇️

artículo científico publicado el 4 de junio de 2013

Cheating on forensic hair testing? Detection of potential biomarkers for cosmetically altered hair samples using untargeted hair metabolomics

artículo científico publicado en 2020

Chemistry, Pharmacology, Toxicology, and Hepatic Metabolism of Designer Drugs of the Amphetamine (Ecstasy), Piperazine, and Pyrrolidinophenone Types

article

Chiral Plasma Pharmacokinetics of 3,4-Methylenedioxymethamphetamine and its Phase I and II Metabolites following Controlled Administration to Humans.

artículo científico publicado en 2015

Chiral analysis of amphetamines in hair by liquid chromatography-tandem mass spectrometry: compliance-monitoring of attention deficit hyperactivity disorder (ADHD) patients under Elvanse® therapy and identification after controlled low-dose applicat

artículo científico publicado en 2017

Cocaine Hydroxy Metabolites in Hair: Indicators for Cocaine Use Versus External Contamination☆

artículo científico publicado en 2019

Cocaine adulteration with the anthelminthic tetramisole (levamisole/dexamisole): Long-term monitoring of its intake by chiral LC-MS/MS analysis of cocaine-positive hair samples

artículo científico publicado en 2018

Comparison of conventional liquid chromatography-tandem mass spectrometry versus microflow liquid chromatography-tandem mass spectrometry within the framework of full method validation for simultaneous quantification of 40 antidepressants and neurol

artículo científico publicado en 2015

Concentrations and ratios of amphetamine, methamphetamine, MDA, MDMA, and MDEA enantiomers determined in plasma samples from clinical toxicology and driving under the influence of drugs cases by GC-NICI-MS.

artículo científico publicado en 2003

Convenient gram-scale metabolite synthesis by engineered fission yeast strains expressing functional human P450 systems

artículo científico publicado en 2010

Cytochrome P450 dependent metabolism of the new designer drug 1-(3-trifluoromethylphenyl)piperazine (TFMPP). In vivo studies in Wistar and Dark Agouti rats as well as in vitro studies in human liver microsomes.

artículo científico publicado en 2004

Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine.

artículo científico publicado en 2004

Detection and validated quantification of 21 benzodiazepines and 3 "z-drugs" in human hair by LC-MS/MS.

artículo científico publicado en 2011

Detection and validated quantification of nine herbal phenalkylamines and methcathinone in human blood plasma by LC-MS/MS with electrospray ionization

artículo científico publicado en 2007

Detection and validated quantification of the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, tadalafil, and 2 of their metabolites in human blood plasma by LC-MS/MS--application to forensic and therapeutic drug monitoring cases.

artículo científico publicado en 2012

Detection and validated quantification of toxic alkaloids in human blood plasma--comparison of LC-APCI-MS with LC-ESI-MS/MS

artículo científico publicado en 2007

Determination of amphetamine, methamphetamine and amphetamine-derived designer drugs or medicaments in blood and urine ⬇️

artículo científico publicado el 21 de agosto de 1998

Determination of drugs of abuse in blood

artículo científico publicado en 1998

Development and validation of a dynamic range-extended LC-MS/MS multi-analyte method for 11 different postmortem matrices for redistribution studies applying solvent calibration and additional (13)C isotope monitoring.

artículo científico publicado en 2015

Development and validation of an LC-MS/MS method after chiral derivatization for the simultaneous stereoselective determination of methylenedioxy-methamphetamine (MDMA) and its phase I and II metabolites in human blood plasma

artículo científico publicado en 2014

Development and validation of an ultra-fast and sensitive microflow liquid chromatography-tandem mass spectrometry (MFLC-MS/MS) method for quantification of LSD and its metabolites in plasma and application to a controlled LSD administration study i

artículo científico publicado en 2016

Development of CT-guided biopsy sampling for time-dependent postmortem redistribution investigations in blood and alternative matrices--proof of concept and application on two cases.

artículo científico publicado en 2015

Development of a high-speed MALDI-triple quadrupole mass spectrometric method for the determination of 3,4-methylenedioxymethamphetamine (MDMA) in oral fluid

artículo científico publicado en 2015

Development of an LC-MS/MS method for the determination of endogenous cortisol in hair using (13)C3-labeled cortisol as surrogate analyte

artículo científico publicado en 2016

Discrete memory impairments in largely pure chronic users of MDMA.

artículo científico publicado en 2017

Drug testing in blood: validated negative-ion chemical ionization gas chromatographic-mass spectrometric assay for determination of amphetamine and methamphetamine enantiomers and its application to toxicology cases.

artículo científico publicado en 2002

Drug testing in blood: validated negative-ion chemical ionization gas chromatographic-mass spectrometric assay for enantioselective measurement of the designer drugs MDEA, MDMA, and MDA and its application to samples from a controlled study with MDM

artículo científico publicado en 2005

Drugs of abuse monitoring in blood for control of driving under the influence of drugs.

artículo científico publicado en 2002

Endogenous cortisol in keratinized matrices: Systematic determination of baseline cortisol levels in hair and the influence of sex, age and hair color

artículo científico publicado en 2017

Endogenous steroid hormones in hair: Investigations on different hair types, pigmentation effects and correlation to nails

scientific article published on 04 December 2019

Erratum to: Long-term monitoring of opioid, sedative and anti-inflammatory drugs in horse hair using a selective and sensitive LC-MS/MS procedure

artículo científico publicado en 2016

Evaluation of drug incorporation into hair segments and nails by enantiomeric analysis following controlled single MDMA intakes

scientific article published on 31 October 2015

Evaluation of endogenous urinary biomarkers for indirect detection of urine adulteration attempts by five different chemical adulterants in mass spectrometry methods

artículo científico publicado en 2018

Fatal poisoning involving cyclopropylfentanyl - Investigation of time-dependent postmortem redistribution

scientific article published on 16 November 2018

Feasibility of a group cessation program for co-smokers of cannabis and tobacco.

artículo científico publicado en 2015

Fenproporex N-dealkylation to amphetamine--enantioselective in vitro studies in human liver microsomes as well as enantioselective in vivo studies in Wistar and Dark Agouti rats.

artículo científico publicado en 2004

First Time View on Human Metabolome Changes after a Single Intake of 3,4-Methylenedioxymethamphetamine in Healthy Placebo-Controlled Subjects.

artículo científico

From the Cover: Zebrafish Larvae Are Insensitive to Stimulation by Cocaine: Importance of Exposure Route and Toxicokinetics

artículo científico publicado en 2016

Gadolinium Distribution in Cerebrospinal Fluid after Administration of a Gadolinium-based MR Contrast Agent in Humans

artículo científico publicado en 2018

Gas chromatographic-mass spectrometric procedures for determination of the catechol-O-methyltransferase (COMT) activity and for detection of unstable catecholic metabolites in human and rat liver preparations after COMT catalyzed in statu nascendi d

artículo científico publicado en 2000

Hair Analysis: Contamination versus Incorporation from the Circulatory System-Investigations on Single Hair Samples Using Time-of-Flight Secondary Ion Mass Spectrometry and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

scientific article published on 07 March 2019

Hair analysis for opiates: hydromorphone and hydrocodone as indicators of heroin use.

artículo científico publicado en 2016

Human Metabolome Changes after a Single Dose of 3,4-Methylenedioxymethamphetamine (MDMA) with Special Focus on Steroid Metabolism and Inflammation Processes

artículo científico publicado en 2018

Identification of cytochrome p450 enzymes involved in the metabolism of 4'-methyl-alpha-pyrrolidinopropiophenone, a novel scheduled designer drug, in human liver microsomes.

artículo científico publicado en 2003

Identification of famprofazone ingestion

scientific article published on 01 January 1998

Identification of human cytochrome P450 2D6 as major enzyme involved in the O-demethylation of the designer drug p-methoxymethamphetamine.

artículo científico publicado en 2004

Identification of new urinary gamma-hydroxybutyric acid markers applying untargeted metabolomics analysis following placebo-controlled administration to humans.

artículo científico publicado en 2018

Identification of urinary metabolites of the synthetic cannabinoid 5F-CUMYL-P7AICA in human casework

scientific article published on 13 November 2018

Impact of Cytochrome P450 2D6 Function on the Chiral Blood Plasma Pharmacokinetics of 3,4-Methylenedioxymethamphetamine (MDMA) and Its Phase I and II Metabolites in Humans.

artículo científico publicado en 2016

Impact of bispectral index monitoring on stress response and propofol consumption in patients undergoing coronary artery bypass surgery.

artículo científico publicado en 2004

Importance of Toxicokinetics to Assess the Utility of Zebrafish Larvae as Model for Psychoactive Drug Screening Using Meta-Chlorophenylpiperazine (mCPP) as Example.

artículo científico publicado en 2018

Improved and validated method for the determination of Delta(9)-tetrahydrocannabinol (THC), 11-hydroxy-THC and 11-nor-9-carboxy-THC in serum, and in human liver microsomal preparations using gas chromatography-mass spectrometry

artículo científico publicado en 2002

In situ postmortem ethanol quantification in the cerebrospinal fluid by non-water-suppressed proton MRS

scientific article published on 05 March 2019

In vitro metabolism of the synthetic cannabinoids CUMYL-PINACA, 5F-CUMYL-PINACA, CUMYL-4CN-BINACA, 5F-CUMYL-P7AICA and CUMYL-4CN-B7AICA.

artículo científico publicado en 2017

Influence of Different Sewer Biofilms on Transformation Rates of Drugs

artículo científico publicado en 2016

Inhibition potential of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites on the in vitro monoamine oxidase (MAO)-catalyzed deamination of the neurotransmitters serotonin and dopamine.

artículo científico publicado en 2015

Large scale consumption monitoring of benzodiazepines and z-drugs by hair analysis

artículo científico publicado en 2020

Liquid chromatography, in combination with a quadrupole time-of-flight instrument (LC QTOF), with sequential window acquisition of all theoretical fragment-ion spectra (SWATH) acquisition: systematic studies on its use for screenings in clinical and

artículo científico publicado en 2014

Liquid chromatography, in combination with a quadrupole time-of-flight instrument, with sequential window acquisition of all theoretical fragment-ion spectra acquisition: validated quantification of 39 antidepressants in whole blood as part of a sim

artículo científico publicado en 2015

Liquid chromatography-tandem mass spectrometry screening method using information-dependent acquisition of enhanced product ion mass spectra for synthetic cannabinoids including metabolites in urine

artículo científico publicado en 2019

Long-term monitoring of opioid, sedative and anti-inflammatory drugs in horse hair using a selective and sensitive LC-MS/MS procedure

artículo científico publicado en 2016

MALDI-MS drug analysis in biological samples: opportunities and challenges.

artículo científico publicado en 2016

Measuring the accuracy of propofol target-controlled infusion (TCI) before and after surgery with major blood loss

scientific article published on 22 January 2019

Metabolite to parent drug concentration ratios in hair for the differentiation of tramadol intake from external contamination and passive exposure

scientific article published on 03 November 2012

Metabolomic Strategies in Biomarker Research–New Approach for Indirect Identification of Drug Consumption and Sample Manipulation in Clinical and Forensic Toxicology?

scientific article published on 10 May 2019

Method development and validation for simultaneous quantification of 15 drugs of abuse and prescription drugs and 7 of their metabolites in whole blood relevant in the context of driving under the influence of drugs--usefulness of multi-analyte cali

artículo científico publicado en 2014

Negative ion chemical ionization gas chromatography-mass spectrometry and atmospheric pressure chemical ionization liquid chromatography-mass spectrometry of low-dosed and/or polar drugs in plasma.

artículo científico publicado en 2002

Negative-Ion Chemical Ionization Gas Chromatography-Mass Spectrometry Assay for Enantioselective Measurement of Amphetamines in Oral Fluid: Application to a Controlled Study with MDMA and Driving Under the Influence Cases

artículo científico publicado en 2007

Neurochemical profile of the human cervical spinal cord determined by MRS.

artículo científico publicado en 2016

Neurophysiological signature of gamma-hydroxybutyrate augmented sleep in male healthy volunteers may reflect biomimetic sleep enhancement: a randomized controlled trial

scientific article published on 08 April 2019

New evidence for old lore--urinary bladder distension on post-mortem computed tomography is related to intoxication.

artículo científico

Nocturnal Gamma-Hydroxybutyrate Reduces Cortisol-Awakening Response and Morning Kynurenine Pathway Metabolites in Healthy Volunteers

artículo científico publicado en 2019

Parameter Optimization for Feature and Hit Generation in a General Unknown Screening Method-Proof of Concept Study Using a Design of Experiment Approach for a High Resolution Mass Spectrometry Procedure after Data Independent Acquisition

artículo científico publicado en 2018

Pharmacokinetics and Pharmacodynamics of Lysergic Acid Diethylamide in Healthy Subjects

artículo científico publicado en 2017

Post-mortem whole body computed tomography of opioid (heroin and methadone) fatalities: frequent findings and comparison to autopsy

artículo científico publicado en 2014

Postmortem distribution and redistribution of MDAI and 2-MAPB in blood and alternative matrices.

artículo científico

Postmortem metabolomics: Correlating time-dependent concentration changes of xenobiotic and endogenous compounds

scientific article published on 05 May 2020

Prevalence of new psychoactive substances: A retrospective study in hair

artículo científico publicado en 2012

Prion infected meat-and-bone meal is still infectious after biodiesel production

artículo científico publicado en 2008

Purple discoloration of the colon found during autopsy: Identification of betanin, its aglycone and metabolites by liquid chromatography-high-resolution mass spectrometry.

artículo científico publicado en 2014

Retrospective monitoring of long-term recreational and dependent cocaine use in toenail clippings/scrapings as an alternative to hair

artículo científico publicado en 2014

Screening for the detection of angiotensin-converting enzyme inhibitors, their metabolites, and AT II receptor antagonists

scientific article published on 01 December 1998

Screening, library-assisted identification and validated quantification of fifteen neuroleptics and three of their metabolites in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization.

artículo científico publicado en 2003

Segmental hair analysis for differentiation of tilidine intake from external contamination using LC-ESI-MS/MS and MALDI-MS/MS imaging.

artículo científico publicado en 2014

Single Hair Cocaine Consumption Monitoring by Mass Spectrometric Imaging ⬇️

artículo científico publicado el 4 de mayo de 2011

Single hair analysis of small molecules using MALDI-triple quadrupole MS imaging and LC-MS/MS: investigations on opportunities and pitfalls.

artículo científico publicado en 2014

Social cognition and interaction in chronic users of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy").

artículo científico publicado en 2017

Steroid Profiling in Nails Using Liquid Chromatography-Tandem Mass Spectrometry

scientific article published on 05 October 2018

Structural characterization of the new synthetic cannabinoids CUMYL-PINACA, 5F-CUMYL-PINACA, CUMYL-4CN-BINACA, 5F-CUMYL-P7AICA and CUMYL-4CN-B7AICA.

artículo científico publicado en 2017

Studies on the metabolism and toxicological detection of the amphetamine-like anorectic fenproporex in human urine by gas chromatography-mass spectrometry and fluorescence polarization immunoassay

artículo científico publicado en 2000

Studies on the metabolism and toxicological detection of the amphetamine-like anorectic mefenorex in human urine by gas chromatography-mass spectrometry and fluorescence polarization immunoassay

artículo científico publicado en 1997

Studies on the metabolism of the fentanyl-derived designer drug butyrfentanyl in human in vitro liver preparations and authentic human samples using liquid chromatography-high resolution mass spectrometry (LC-HRMS).

artículo científico publicado en 2016

Suitability evaluation of new endogenous biomarkers for the identification of nitrite-based urine adulteration in mass spectrometry methods

artículo científico publicado en 2018

Systematic assessment of different solvents for the extraction of drugs of abuse and pharmaceuticals from an authentic hair pool.

artículo científico publicado en 2017

Systematic investigation of the incorporation mechanisms of zolpidem in fingernails.

artículo científico publicado en 2013

Systematic investigations of endogenous cortisol and cortisone in nails by LC-MS/MS and correlation to hair

scientific article published on 17 May 2018

The 48th annual meeting of the International Association of Forensic Toxicologists (TIAFT). Joint meeting with the Society of Toxicological and Forensic Chemistry (GTFCh). Editorial

artículo científico publicado en 2012

The antispasmodic drug mebeverine leads to positive amphetamine results by fluorescence polarization immunoassay (FPIA)--studies on the toxicological analysis of urine by FPIA and GC-MS.

artículo científico publicado en 2001

The influence of cleansing shampoos on ethyl glucuronide concentration in hair analyzed with an optimized and validated LC-MS/MS method

artículo científico publicado en 2014

Time-Dependent Postmortem Redistribution of Opioids in Blood and Alternative Matrices.

artículo científico publicado en 2018

Time-dependent postmortem redistribution of butyrfentanyl and its metabolites in blood and alternative matrices in a case of butyrfentanyl intoxication.

artículo científico publicado en 2016

Time-dependent postmortem redistribution of morphine and its metabolites in blood and alternative matrices-application of CT-guided biopsy sampling.

artículo científico publicado en 2016

Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome

artículo científico publicado en 2016

Towards Best Practice in Hair Metabolomic Studies: Systematic Investigation on the Impact of Hair Length and Color

artículo científico publicado en 2020

Toxicokinetics and analytical toxicology of amphetamine-derived designer drugs ('Ecstasy')

artículo científico publicado en 2000

Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives

artículo científico publicado en 2002

Toxicological detection of ibuprofen and its metabolites in urine using gas chromatography-mass spectrometry (GC-MS).

artículo científico publicado en 1994

Toxicological detection of selegiline and its metabolites in urine using fluorescence polarization immunoassay (FPIA) and gas chromatography-mass spectrometry (GC-MS) and differentiation by enantioselective GC-MS of the intake of selegiline from abu

artículo científico publicado el 1 de enero de 1992

Toxicology of Specific Substances

Transcriptional activation of heme oxygenase-1 and its functional significance in acetaminophen-induced hepatitis and hepatocellular injury in the rat.

artículo científico publicado en 2000

Treatment of ivermectin overdose in a miniature Shetland Pony using intravenous administration of a lipid emulsion

artículo científico publicado en 2012

Trends in drug testing in oral fluid and hair as alternative matrices.

artículo científico publicado en 2014

Untargeted metabolomics-like screening approach for chemical characterization and differentiation of canopic jar and mummy samples from Ancient Egypt using GC-high resolution MS

scholarly article by Lana Brockbals et al published 21 September 2018 in Analyst

Using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS) for investigations on single hair samples to solve the contamination versus incorporation issue of hair anal

artículo científico publicado en 2020

Validated assay for quantification of oxcarbazepine and its active dihydro metabolite 10-hydroxycarbazepine in plasma by atmospheric pressure chemical ionization liquid chromatography/mass spectrometry

artículo científico publicado en 2002

Validated electrospray liquid chromatographic-mass spectrometric assay for the determination of the mushroom toxins alpha- and beta-amanitin in urine after immunoaffinity extraction

artículo científico publicado en 2000

Lista de obras de Thomas Kraemer

(Un)targeted hair metabolomics: first considerations and systematic evaluation on the impact of sample preparation

A Comprehensive Multi-Analyte Method for Hair Analysis: Substance-Specific Quantification Ranges and Tool for Task-Oriented Data Evaluation

A machine learning approach for handling big data produced by high resolution mass spectrometry after data independent acquisition of small molecules - Proof of concept study using an artificial neural network for sample classification

A new metabolomics-based strategy for identification of endogenous markers of urine adulteration attempts exemplified for potassium nitrite

A novel bedtime pulsatile-release caffeine formula ameliorates sleep inertia symptoms immediately upon awakening

A possible new oxidation marker for hair adulteration: Detection of PTeCA (1H-pyrrole-2,3,4,5-tetracarboxylic acid) in bleached hair

Acute and Chronic Lead Exposure in Four Avian Scavenger Species in Switzerland

Acute death associated with Citrobacter freundii infection in an African elephant (Loxodonta africana).

Analysis of drugs of abuse in hair: evaluation of the immunochemical method VMA-T vs. LC-MS/MS or GC-MS

Analytical considerations for (un)-targeted metabolomic studies with special focus on forensic applications

Analytical considerations for postmortem metabolomics using GC-high-resolution MS

Assessment of simpler calibration models in the development and validation of a fast postmortem multi-analyte LC-QTOF quantitation method in whole blood with simultaneous screening capabilities using SWATH acquisition.

Bioanalytical procedures for determination of drugs of abuse in blood

Blood alcohol analysis alone versus comprehensive toxicological analysis - Systematic investigation of missed co-ingested other drugs in suspected alcohol-impaired drivers

CYP3A4-Catalyzed Simvastatin Metabolism as a Non-Invasive Marker of Small Intestinal Health in Celiac Disease ⬇️

Cheating on forensic hair testing? Detection of potential biomarkers for cosmetically altered hair samples using untargeted hair metabolomics

Chemistry, Pharmacology, Toxicology, and Hepatic Metabolism of Designer Drugs of the Amphetamine (Ecstasy), Piperazine, and Pyrrolidinophenone Types

Chiral Plasma Pharmacokinetics of 3,4-Methylenedioxymethamphetamine and its Phase I and II Metabolites following Controlled Administration to Humans.

Chiral analysis of amphetamines in hair by liquid chromatography-tandem mass spectrometry: compliance-monitoring of attention deficit hyperactivity disorder (ADHD) patients under Elvanse® therapy and identification after controlled low-dose applicat

Cocaine Hydroxy Metabolites in Hair: Indicators for Cocaine Use Versus External Contamination☆

Cocaine adulteration with the anthelminthic tetramisole (levamisole/dexamisole): Long-term monitoring of its intake by chiral LC-MS/MS analysis of cocaine-positive hair samples

Comparison of conventional liquid chromatography-tandem mass spectrometry versus microflow liquid chromatography-tandem mass spectrometry within the framework of full method validation for simultaneous quantification of 40 antidepressants and neurol

Concentrations and ratios of amphetamine, methamphetamine, MDA, MDMA, and MDEA enantiomers determined in plasma samples from clinical toxicology and driving under the influence of drugs cases by GC-NICI-MS.

Convenient gram-scale metabolite synthesis by engineered fission yeast strains expressing functional human P450 systems

Cytochrome P450 dependent metabolism of the new designer drug 1-(3-trifluoromethylphenyl)piperazine (TFMPP). In vivo studies in Wistar and Dark Agouti rats as well as in vitro studies in human liver microsomes.

Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine.

Detection and validated quantification of 21 benzodiazepines and 3 "z-drugs" in human hair by LC-MS/MS.

Detection and validated quantification of nine herbal phenalkylamines and methcathinone in human blood plasma by LC-MS/MS with electrospray ionization

Detection and validated quantification of the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, tadalafil, and 2 of their metabolites in human blood plasma by LC-MS/MS--application to forensic and therapeutic drug monitoring cases.

Detection and validated quantification of toxic alkaloids in human blood plasma--comparison of LC-APCI-MS with LC-ESI-MS/MS

Determination of amphetamine, methamphetamine and amphetamine-derived designer drugs or medicaments in blood and urine ⬇️

Determination of drugs of abuse in blood

Development and validation of a dynamic range-extended LC-MS/MS multi-analyte method for 11 different postmortem matrices for redistribution studies applying solvent calibration and additional (13)C isotope monitoring.

Development and validation of an LC-MS/MS method after chiral derivatization for the simultaneous stereoselective determination of methylenedioxy-methamphetamine (MDMA) and its phase I and II metabolites in human blood plasma

Development and validation of an ultra-fast and sensitive microflow liquid chromatography-tandem mass spectrometry (MFLC-MS/MS) method for quantification of LSD and its metabolites in plasma and application to a controlled LSD administration study i

Development of CT-guided biopsy sampling for time-dependent postmortem redistribution investigations in blood and alternative matrices--proof of concept and application on two cases.

Development of a high-speed MALDI-triple quadrupole mass spectrometric method for the determination of 3,4-methylenedioxymethamphetamine (MDMA) in oral fluid

Development of an LC-MS/MS method for the determination of endogenous cortisol in hair using (13)C3-labeled cortisol as surrogate analyte

Discrete memory impairments in largely pure chronic users of MDMA.

Drug testing in blood: validated negative-ion chemical ionization gas chromatographic-mass spectrometric assay for determination of amphetamine and methamphetamine enantiomers and its application to toxicology cases.

Drug testing in blood: validated negative-ion chemical ionization gas chromatographic-mass spectrometric assay for enantioselective measurement of the designer drugs MDEA, MDMA, and MDA and its application to samples from a controlled study with MDM

Drugs of abuse monitoring in blood for control of driving under the influence of drugs.

Endogenous cortisol in keratinized matrices: Systematic determination of baseline cortisol levels in hair and the influence of sex, age and hair color

Endogenous steroid hormones in hair: Investigations on different hair types, pigmentation effects and correlation to nails

Erratum to: Long-term monitoring of opioid, sedative and anti-inflammatory drugs in horse hair using a selective and sensitive LC-MS/MS procedure

Evaluation of drug incorporation into hair segments and nails by enantiomeric analysis following controlled single MDMA intakes

Evaluation of endogenous urinary biomarkers for indirect detection of urine adulteration attempts by five different chemical adulterants in mass spectrometry methods

Fatal poisoning involving cyclopropylfentanyl - Investigation of time-dependent postmortem redistribution

Feasibility of a group cessation program for co-smokers of cannabis and tobacco.

Fenproporex N-dealkylation to amphetamine--enantioselective in vitro studies in human liver microsomes as well as enantioselective in vivo studies in Wistar and Dark Agouti rats.

First Time View on Human Metabolome Changes after a Single Intake of 3,4-Methylenedioxymethamphetamine in Healthy Placebo-Controlled Subjects.

From the Cover: Zebrafish Larvae Are Insensitive to Stimulation by Cocaine: Importance of Exposure Route and Toxicokinetics

Gadolinium Distribution in Cerebrospinal Fluid after Administration of a Gadolinium-based MR Contrast Agent in Humans

Gas chromatographic-mass spectrometric procedures for determination of the catechol-O-methyltransferase (COMT) activity and for detection of unstable catecholic metabolites in human and rat liver preparations after COMT catalyzed in statu nascendi d

Hair Analysis: Contamination versus Incorporation from the Circulatory System-Investigations on Single Hair Samples Using Time-of-Flight Secondary Ion Mass Spectrometry and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

Hair analysis for opiates: hydromorphone and hydrocodone as indicators of heroin use.

Human Metabolome Changes after a Single Dose of 3,4-Methylenedioxymethamphetamine (MDMA) with Special Focus on Steroid Metabolism and Inflammation Processes

Identification of cytochrome p450 enzymes involved in the metabolism of 4'-methyl-alpha-pyrrolidinopropiophenone, a novel scheduled designer drug, in human liver microsomes.

Identification of famprofazone ingestion

Identification of human cytochrome P450 2D6 as major enzyme involved in the O-demethylation of the designer drug p-methoxymethamphetamine.

Identification of new urinary gamma-hydroxybutyric acid markers applying untargeted metabolomics analysis following placebo-controlled administration to humans.

Identification of urinary metabolites of the synthetic cannabinoid 5F-CUMYL-P7AICA in human casework

Impact of Cytochrome P450 2D6 Function on the Chiral Blood Plasma Pharmacokinetics of 3,4-Methylenedioxymethamphetamine (MDMA) and Its Phase I and II Metabolites in Humans.

Impact of bispectral index monitoring on stress response and propofol consumption in patients undergoing coronary artery bypass surgery.

Importance of Toxicokinetics to Assess the Utility of Zebrafish Larvae as Model for Psychoactive Drug Screening Using Meta-Chlorophenylpiperazine (mCPP) as Example.

Improved and validated method for the determination of Delta(9)-tetrahydrocannabinol (THC), 11-hydroxy-THC and 11-nor-9-carboxy-THC in serum, and in human liver microsomal preparations using gas chromatography-mass spectrometry

In situ postmortem ethanol quantification in the cerebrospinal fluid by non-water-suppressed proton MRS

In vitro metabolism of the synthetic cannabinoids CUMYL-PINACA, 5F-CUMYL-PINACA, CUMYL-4CN-BINACA, 5F-CUMYL-P7AICA and CUMYL-4CN-B7AICA.

Influence of Different Sewer Biofilms on Transformation Rates of Drugs

Inhibition potential of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites on the in vitro monoamine oxidase (MAO)-catalyzed deamination of the neurotransmitters serotonin and dopamine.

Large scale consumption monitoring of benzodiazepines and z-drugs by hair analysis

Liquid chromatography, in combination with a quadrupole time-of-flight instrument (LC QTOF), with sequential window acquisition of all theoretical fragment-ion spectra (SWATH) acquisition: systematic studies on its use for screenings in clinical and

Liquid chromatography, in combination with a quadrupole time-of-flight instrument, with sequential window acquisition of all theoretical fragment-ion spectra acquisition: validated quantification of 39 antidepressants in whole blood as part of a sim

Liquid chromatography-tandem mass spectrometry screening method using information-dependent acquisition of enhanced product ion mass spectra for synthetic cannabinoids including metabolites in urine

Long-term monitoring of opioid, sedative and anti-inflammatory drugs in horse hair using a selective and sensitive LC-MS/MS procedure

MALDI-MS drug analysis in biological samples: opportunities and challenges.

Measuring the accuracy of propofol target-controlled infusion (TCI) before and after surgery with major blood loss

Metabolite to parent drug concentration ratios in hair for the differentiation of tramadol intake from external contamination and passive exposure

Metabolomic Strategies in Biomarker Research–New Approach for Indirect Identification of Drug Consumption and Sample Manipulation in Clinical and Forensic Toxicology?