Lista de obras - Ralf Kühn - Dominio Público Uruguay

An RNAi-based approach to down-regulate a gene family in vivo

artículo científico publicado en 2013

CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling.

artículo científico publicado en 2011

Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons.

artículo científico publicado en 2016

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

scientific article published on 09 September 2019

Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo

artículo científico publicado en 2011

Chronic CD30 signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells

artículo científico publicado en 2019

Conditional RNAi in mice.

artículo científico publicado en 2010

Constitutive and conditional RNAi transgenesis in mice

artículo científico publicado en 2010

Control of gene editing by manipulation of DNA repair mechanisms

artículo científico publicado en 2017

Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos.

artículo científico publicado en 2014

Csk controls antigen receptor-mediated development and selection of T-lineage cells ⬇️

artículo científico publicado el 27 de agosto de 1998

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome

artículo científico publicado en 2021

Development of an intein-mediated split-Cas9 system for gene therapy

artículo científico publicado en 2015

Differential mRNA distribution of components of the ERK/MAPK signalling cascade in the adult mouse brain

artículo científico publicado en 2007

Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

artículo científico publicado en 2013

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line

artículo científico publicado en 2016

Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes

artículo científico publicado en 2016

Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector

artículo científico publicado en 2013

Enhancement of CRISPR-Cas9 induced precise gene editing by targeting histone H2A-K15 ubiquitination

artículo científico publicado en 2020

FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum

artículo científico publicado en 2014

Fusion of SpCas9 to E. coli Rec A protein enhances CRISPR-Cas9 mediated gene knockout in mammalian cells.

artículo científico publicado en 2017

Gene Editing in One-Cell Embryos by Zinc-Finger and TAL Nucleases.

artículo científico publicado en 2012

Gene editing and clonal isolation of human induced pluripotent stem cells using CRISPR/Cas9.

artículo científico publicado en 2017

Gene editing in mouse zygotes using the CRISPR/Cas9 system

artículo científico publicado en 2017

Gene knockdown in the mouse through RNAi.

artículo científico publicado en 2010

Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases

artículo científico publicado en 2010

Generating conditional knockout mice

artículo científico publicado en 2011

Generation of shRNA transgenic mice

artículo científico publicado en 2009

Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA.

artículo científico

Generation of targeted mouse mutants by embryo microinjection of TALENs

artículo científico publicado en 2014

Genetic mouse models for behavioral analysis through transgenic RNAi technology

artículo científico publicado en 2008

Genome Editing in Mice Using TALE Nucleases

artículo científico publicado en 2016

Highly efficient targeted mutagenesis in mice using TALENs

artículo científico publicado en 2013

Humanized c-Myc mouse

artículo científico publicado en 2012

In vivo functional requirement of the mouse Ifitm1 gene for germ cell development, interferon mediated immune response and somitogenesis

artículo científico publicado en 2012

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.

artículo científico publicado en 2015

Local knockdown of ERK2 in the adult mouse brain via adeno-associated virus-mediated RNA interference.

scientific article published on 04 December 2008

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

artículo científico

MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults

artículo científico publicado en 2012

Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth

artículo científico publicado en 2022

Modeling disease mutations by gene targeting in one-cell mouse embryos

artículo científico publicado en 2012

Overview on mouse mutagenesis.

artículo científico publicado en 2009

Phenotypic annotation of the mouse X chromosome

artículo científico publicado en 2010

Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb

artículo científico publicado en 2012

Pop in, pop out: a novel gene-targeting strategy for use with CRISPR-Cas9.

artículo científico publicado en 2015

Precise CRISPR-Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells

Reversible and tissue-specific activation of MAP kinase signaling by tamoxifen in Braf(V637)ER(T2) mice.

artículo científico publicado en 2013

Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo

artículo científico publicado en 2008

Target validation in mice by constitutive and conditional RNAi.

artículo científico publicado en 2013

The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4

artículo científico publicado en 2019

The functional annotation of mammalian genomes: the challenge of phenotyping

scientific article published on January 2009

Lista de obras de Ralf Kühn

An RNAi-based approach to down-regulate a gene family in vivo

CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling.

Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons.

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo

Chronic CD30 signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells

Conditional RNAi in mice.

Constitutive and conditional RNAi transgenesis in mice

Control of gene editing by manipulation of DNA repair mechanisms

Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos.

Csk controls antigen receptor-mediated development and selection of T-lineage cells ⬇️

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome

Development of an intein-mediated split-Cas9 system for gene therapy

Differential mRNA distribution of components of the ERK/MAPK signalling cascade in the adult mouse brain

Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line

Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes

Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector

Enhancement of CRISPR-Cas9 induced precise gene editing by targeting histone H2A-K15 ubiquitination

FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum

Fusion of SpCas9 to E. coli Rec A protein enhances CRISPR-Cas9 mediated gene knockout in mammalian cells.

Gene Editing in One-Cell Embryos by Zinc-Finger and TAL Nucleases.

Gene editing and clonal isolation of human induced pluripotent stem cells using CRISPR/Cas9.

Gene editing in mouse zygotes using the CRISPR/Cas9 system

Gene knockdown in the mouse through RNAi.

Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases

Generating conditional knockout mice

Generation of shRNA transgenic mice

Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA.

Generation of targeted mouse mutants by embryo microinjection of TALENs

Genetic mouse models for behavioral analysis through transgenic RNAi technology

Genome Editing in Mice Using TALE Nucleases

Highly efficient targeted mutagenesis in mice using TALENs

Humanized c-Myc mouse

In vivo functional requirement of the mouse Ifitm1 gene for germ cell development, interferon mediated immune response and somitogenesis

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.

Local knockdown of ERK2 in the adult mouse brain via adeno-associated virus-mediated RNA interference.

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults

Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth

Modeling disease mutations by gene targeting in one-cell mouse embryos

Overview on mouse mutagenesis.

Phenotypic annotation of the mouse X chromosome

Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb

Pop in, pop out: a novel gene-targeting strategy for use with CRISPR-Cas9.

Precise CRISPR-Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells

Reversible and tissue-specific activation of MAP kinase signaling by tamoxifen in Braf(V637)ER(T2) mice.

Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo

Target validation in mice by constitutive and conditional RNAi.

The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4

The functional annotation of mammalian genomes: the challenge of phenotyping