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Lista de obras de Lieve Naesens

(R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine is a potent inhibitor of feline immunodeficiency virus infection.

artículo científico publicado en 1995

1,6-Bis[(benzyloxy)methyl]uracil derivatives-Novel antivirals with activity against HIV-1 and influenza H1N1 virus.

artículo científico publicado en 2016

2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections

artículo científico publicado en 2002

3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.

artículo científico publicado en 2013

4"-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action

artículo científico publicado en 2008

6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity

artículo científico publicado en 2002

6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity

artículo científico publicado en 2004

6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs

artículo científico publicado en 2011

9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo

artículo científico publicado en 1989

9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys

artículo científico publicado en 1991

<i>In Vitro</i> Characterization of the Carbohydrate-Binding Agents HHA, GNA and UDA as Inhibitors of Influenza a and B Virus Replication

artículo científico publicado en 2020

A few atoms make the difference: synthetic, CD, NMR and computational studies on antiviral and antibacterial activities of glycopeptide antibiotic aglycon derivatives.

artículo científico publicado en 2015

A versatile salicyl hydrazonic ligand and its metal complexes as antiviral agents

artículo científico publicado en 2015

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity

artículo científico publicado en 2013

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of the 6-oxopurine phosphoribosyltransferases and have antimalarial activity.

artículo científico publicado en 2014

Acyclic/carbocyclic guanosine analogues as anti-herpesvirus agents.

artículo científico publicado en 2001

Adefovir dipivoxil

Adefovir serum levels do not differ between responders and nonresponders

artículo científico publicado en 2011

Adjuvant low-dose cidofovir therapy for BK polyomavirus interstitial nephritis in renal transplant recipients.

artículo científico publicado en 2005

Airway proteases: an emerging drug target for influenza and other respiratory virus infections.

artículo científico publicado en 2017

Alkylamino derivatives of N-benzylpyrazine-2-carboxamide: synthesis and antimycobacterial evaluation

Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics

artículo científico publicado en 2015

Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity.

artículo científico publicado en 2017

An integrated biological approach to guide the development of metal-chelating inhibitors of influenza virus PA endonuclease

artículo científico publicado en 2014

Aniline-based inhibitors of influenza H1N1 virus acting on hemagglutinin-mediated fusion.

artículo científico publicado en 2017

Anti-herpesvirus activity of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl)-cycloprop-1'-yl]methyl] x guanine (A-5021) in vitro and in vivo.

artículo científico publicado en 2001

Anti-influenza virus activity and structure-activity relationship of aglycoristocetin derivatives with cyclobutenedione carrying hydrophobic chains.

artículo científico publicado en 2009

Antiadenovirus activities of several classes of nucleoside and nucleotide analogues

artículo científico publicado en 2005

Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases

artículo científico publicado en 2015

Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine

artículo científico publicado en 1996

Antiretroviral activity of metal-chelating HIV-1 integrase inhibitors

artículo científico publicado en 2014

Antitumor Potential of Acyclic Nucleoside Phosphonates

artículo científico publicado en 1999

Antiviral activity and metal ion-binding properties of some 2-hydroxy-3-methoxyphenyl acylhydrazones

artículo científico publicado en 2017

Antiviral activity of diverse classes of broad-acting agents and natural compounds in HHV-6-infected lymphoblasts

artículo científico publicado en 2006

Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6.

artículo científico publicado en 1995

Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds

artículo científico publicado en 2007

Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8.

artículo científico publicado en 2001

Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines

artículo científico publicado en 2005

Antiviral properties of new arylsulfone derivatives with activity against human betaherpesviruses

artículo científico publicado en 2006

Antiviral therapies on the horizon for influenza

artículo científico publicado en 2016

Antiviral therapy for adenovirus infections.

artículo científico publicado en 2006

Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection

artículo científico publicado en 2005

Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin.

artículo científico publicado en 2010

Aryl-substituted and benzo-annulated cyc/osal-derivatives of 2',3'-dideoxy-2',3'-didehydrothymidine monophosphate--correlation of structure, hydrolysis properties and anti-HIV activity

artículo científico publicado en 2002

Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents

artículo científico publicado en 2012

Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents

artículo científico publicado en 2015

Azapropellanes with anti-influenza a virus activity.

artículo científico publicado en 2014

Carrier mechanisms involved in the transepithelial transport of bis(POM)-PMEA and its metabolites across Caco-2 monolayers

artículo científico publicado en 1998

Cell line-dependent activation and antiviral activity of T-1105, the non-fluorinated analogue of T-705 (favipiravir)

scientific article published on 02 April 2019

Characterization of a cidofovir-resistant HHV-6 mutant obtained by in vitro selection.

artículo científico publicado en 2008

Characterization of the catalytic subunit of the human herpesvirus 6 (HHV-6) DNA polymerase expressed in an in vitro transcription/translation assay

artículo científico publicado en 2003

Chelation Motifs Affecting Metal-dependent Viral Enzymes: N'-acylhydrazone Ligands as Dual Target Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain

artículo científico publicado en 2017

Cidofovir is active against human papillomavirus positive and negative head and neck and cervical tumor cells by causing DNA damage as one of its working mechanisms

scientific article published on 16 June 2016

Cidofovir selectivity is based on the different response of normal and cancer cells to DNA damage

artículo científico publicado en 2013

Cidofovir treatment improves the pathology caused by the growth of human papillomavirus-positive cervical carcinoma xenografts in athymic nude mice

artículo científico publicado en 2012

Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity.

artículo científico publicado en 2010

Clinical features and treatment of adenovirus infections

artículo científico publicado en 2008

Comparative study of bis(benzyl)phosphate triesters of 2',3'-dideoxy-2',3'-didehydrothymidine (d4T) and cyclosal-d4TMP--hydrolysis, mechanistic insights and anti-HIV activity

artículo científico publicado en 2002

Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers

artículo científico publicado en 1998

Conservation of HHV-6 DNA polymerase processivity factor sequence and predicted structure suggests it as a target for antiviral development

artículo científico publicado en 2010

Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.

artículo científico publicado en 1997

Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase

scientific article published on 27 October 2016

Cytostatic and antiviral activity evaluations of hydroxamic derivatives of some non-steroidal anti-inflammatory drugs

artículo científico publicado en 2009

Cytotoxicity of natural compounds isolated from the seeds of Garcinia afzelii

artículo científico publicado en 2009

Design and synthesis of 1,2-annulated adamantane piperidines with anti-influenza virus activity

artículo científico publicado en 2009

Design and synthesis of bioactive 1,2-annulated adamantane derivatives.

artículo científico publicado en 2008

Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines

artículo científico publicado en 2010

Design and synthesis of bioactive adamantane spiro heterocycles

artículo científico publicado en 2007

Design and synthesis of novel Imidazo[2,1-b]thiazole derivatives as potent antiviral and antimycobacterial agents

artículo científico publicado en 2019

Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.

artículo científico publicado en 2017

Design, synthesis, antitubercular and antiviral properties of new spirocyclic indole derivatives

artículo científico publicado en 2019

Diazo transfer-click reaction route to new, lipophilic teicoplanin and ristocetin aglycon derivatives with high antibacterial and anti-influenza virus activity: an aggregation and receptor binding study.

artículo científico publicado en 2009

Diclofenac-Based Hydrazones and Spirothiazolidinones: Synthesis, Characterization, and Antimicrobial Properties.

artículo científico publicado en 2017

Different mutations in the HHV-6 DNA polymerase gene accounting for resistance to foscarnet

artículo científico publicado en 2007

Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine

artículo científico publicado en 1993

Discovery of dihydro-alkyloxy-benzyl-oxopyrimidines as promising anti-influenza virus agents

artículo científico publicado en 2011

Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors

artículo científico publicado en 2019

Distinct Effects of T-705 (Favipiravir) and Ribavirin on Influenza Virus Replication and Viral RNA Synthesis.

artículo científico publicado en 2016

Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus

artículo científico publicado en 2014

Editorial overview: Antiviral strategies: Antiviral drug design: creating new ideas against old and new bugs

artículo científico publicado en 2017

Effects of 2',3'-dideoxycytidine and 2',3'-dideoxycytidine 5'-triphosphate on phospholipid metabolism in permeabilized rat hepatocytes

artículo científico publicado en 1997

Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice

scientific article published on 01 May 1992

Efficacy of oral 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice

scientific article published on 01 February 1993

Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus

artículo científico publicado en 1998

Emerging antiviral strategies to interfere with influenza virus entry

artículo científico publicado en 2013

Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity

artículo científico publicado en 2007

Evaluation of novel acyclic nucleoside phosphonates against human and animal gammaherpesviruses revealed an altered metabolism of cyclic prodrugs upon Epstein-Barr virus reactivation in P3HR-1 cells

artículo científico publicado en 2013

Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA

artículo científico publicado en 1999

Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus

artículo científico

Favipiravir Does Not Inhibit Chikungunya Virus Replication in Mosquito Cells and Aedes aegypti Mosquitoes

artículo científico publicado en 2021

First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity

artículo científico publicado en 2015

First discovery of novel 3-hydroxy-quinazoline-2,4(1H,3H)-diones as specific anti-vaccinia and adenovirus agents via 'privileged scaffold' refining approach

artículo científico publicado en 2016

Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways

scientific article published on 12 December 2019

Heterocyclic rimantadine analogues with antiviral activity

artículo científico publicado en 2006

Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus

artículo científico publicado en 2017

Human herpesvirus 6 DNA polymerase: enzymatic parameters, sensitivity to ganciclovir and determination of the role of the A961V mutation in HHV-6 ganciclovir resistance

artículo científico publicado en 2004

Human herpesvirus 6 infection arrests cord blood mononuclear cells in G(2) phase of the cell cycle

artículo científico publicado en 2004

Identification and Mechanistic Studies on a Novel Class of Influenza Virus Fusion Inhibitors

artículo científico publicado en 2009

Identification of Bicyclic Sulfone Inhibitors of HHV-6 Targeting the HHV-6 U77 Helicase

artículo científico publicado en 2011

Identification of influenza PA-Nter endonuclease inhibitors using pharmacophore- and docking-based virtual screening

artículo científico publicado en 2018

In Vitro, Ex Vivo, and In Situ Intestinal Absorption Characteristics of the Antiviral Ester Prodrug Adefovir Dipivoxil

artículo científico publicado en 2000

In search of effective anti-HHV-6 agents

artículo científico publicado en 2006

In vitro and in vivo inhibitory activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against rat choriocarcinoma

scientific article published on 01 January 1998

In vivo Antiretroviral Efficacy of Oral bis(POM)-PMEA, the bis(Pivaloyloxymethyl)prodrug of 9-(2-Phosphonylmethoxyethyl) adenine (PMEA)

Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor β signalling pathway

artículo científico publicado en 2019

Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study

scientific article published on 01 July 1999

Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents

artículo científico publicado en 2013

Inhibition of the in vitro growth of Plasmodium falciparum by acyclic nucleoside phosphonates

artículo científico publicado en 1999

Inhibitory Effect of 2,3,5,6-Tetrafluoro-4-[4-(aryl)-1H-1,2,3-triazol-1-yl]benzenesulfonamide Derivatives on HIV Reverse Transcriptase Associated RNase H Activities.

artículo científico publicado en 2016

Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine on visna virus infection in lambs: a model for in vivo testing of candidate anti-human immunodeficiency virus drugs

artículo científico publicado en 1995

Inhibitory effects of 9-(2-phosphonylmethoxyethyl)adenine and 3'-azido-2',3'-dideoxythymidine on tumor development in mice inoculated intracerebrally with Moloney murine sarcoma virus

artículo científico publicado en 1990

Interaction between mouse adenovirus type 1 and cell surface heparan sulfate proteoglycans

artículo científico publicado en 2012

Intestinal absorption characteristics of the low solubility thiocarboxanilide UC-781.

artículo científico publicado en 2002

Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures.

artículo científico publicado en 2002

Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine

artículo científico publicado en 2008

Intracytoplasmic trapping of influenza virus by a lipophilic derivative of aglycoristocetin.

artículo científico publicado en 2012

Introduction to the Special Issue dedicated to Prof. Erik De Clercq for reaching the Professor Emeritus status at the Katholieke Universiteit Leuven

artículo científico publicado en 2006

Investigation of the salicylaldehyde thiosemicarbazone scaffold for inhibition of influenza virus PA endonuclease

artículo científico publicado en 2015

List of Contributors

Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent

artículo científico publicado en 1989

Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives

artículo científico publicado en 1996

Mechanistic Studies on a Novel Hydrophobic Derivative of Aglycoristocetin with Potent and Broad Activity Against Influenza Viruses

article published in 2011

Mediastinal Myeloid Sarcoma with TP53 Mutation Preceding Acute Myeloid Leukemia with a PICALM-MLLT10 Fusion Gene

artículo científico publicado en 2018

Metabolic and pharmacological characteristics of the bicyclic nucleoside analogues (BCNAs) as highly selective inhibitors of varicella-zoster virus (VZV).

artículo científico publicado en 2003

Metabolism and anti-HIV activity of phosphoramidate derivatives of D4T-MP with variations in the amino acid moiety

artículo científico publicado en 1998

Metabolism and pharmacokinetics of the anti-HIV-1-specific inhibitor [1-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]-3-N- methyl-thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dio xide).

artículo científico publicado en 1993

Metal-chelating 2-hydroxyphenyl amide pharmacophore for inhibition of influenza virus endonuclease

artículo científico publicado en 2013

Microwave assisted synthesis and anti-influenza virus activity of 1-adamantyl substituted N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives

artículo científico publicado en 2012

Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting

artículo científico publicado en 2009

Mouse adenovirus type 1 attachment is not mediated by the coxsackie-adenovirus receptor.

artículo científico publicado en 2006

Mouse adenovirus type 1 infection in SCID mice: an experimental model for antiviral therapy of systemic adenovirus infections

artículo científico publicado en 2005

Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease

artículo científico publicado en 2013

N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes

artículo científico publicado en 2016

N6-cyclopropyl-PMEDAP: a novel derivative of 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) with distinct metabolic, antiproliferative, and differentiation-inducing properties

artículo científico publicado en 1999

New antivirals - mechanism of action and resistance development

artículo científico publicado en 1998

New polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding mode.

artículo científico publicado en 2015

Norbornane-based nucleoside and nucleotide analogues locked in North conformation

artículo científico publicado en 2014

Novel N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives as potent and selective influenza virus fusion inhibitors

artículo científico publicado en 2019

Novel indole–flutimide heterocycles with activity against influenza PA endonuclease and hepatitis C virus

Novel inhibitors of influenza virus fusion: structure-activity relationship and interaction with the viral hemagglutinin

artículo científico publicado en 2010

Partial purification and characterization of mitochondrial DNA polymerase from Plasmodium falciparum.

artículo científico publicado en 2000

Phosphoramidate derivatives of d4T as inhibitors of HIV: the effect of amino acid variation.

artículo científico publicado en 1997

Physicochemical characterization of solid dispersions of the antiviral agent UC-781 with polyethylene glycol 6000 and Gelucire 44/14.

artículo científico publicado en 2000

Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy

artículo científico publicado en 2010

Polycyclic N-benzamido imides with potent activity against vaccinia virus.

artículo científico publicado en 2010

Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats

artículo científico publicado en 1998

Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model

scientific article published on 01 October 1998

Potent, selective and cell-mediated inhibition of human herpesvirus 6 at an early stage of viral replication by the non-nucleoside compound CMV423.

artículo científico publicado en 2004

Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus

artículo científico publicado en 2007

Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent.

artículo científico publicado en 1998

Prodrugs of the Phosphoribosylated Forms of Hydroxypyrazinecarboxamide Pseudobase T-705 and Its De-Fluoro Analogue T-1105 as Potent Influenza Virus Inhibitors

scientific article published on 03 July 2018

Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates

artículo científico publicado en 2015

Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase

artículo científico publicado en 2018

Quantitative analysis of human herpesvirus 6 cell tropism

artículo científico publicado en 2005

Recovery of humoral immunity is critical for successful antiviral therapy in disseminated mouse adenovirus type 1 infection

artículo científico publicado en 2008

Reprogramming of the Antibacterial Drug Vancomycin Results in Potent Antiviral Agents Devoid of Antibacterial Activity

artículo científico publicado en 2020

Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP/CMP kinase 1

artículo científico publicado en 2016

Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir)

artículo científico publicado en 2013

Role of the human herpesvirus 6 u69-encoded kinase in the phosphorylation of ganciclovir

artículo científico publicado en 2002

Role of the viral hemagglutinin in the anti-influenza virus activity of newly synthesized polycyclic amine compounds.

artículo científico publicado en 2013

Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).

artículo científico publicado en 1998

Semisynthetic teicoplanin derivatives as new influenza virus binding inhibitors: synthesis and antiviral studies.

artículo científico publicado en 2014

Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo

artículo científico publicado en 1991

Slow but Steady Wins the Race: Dissimilarities among New Dual Inhibitors of the Wild-Type and the V27A Mutant M2 Channels of Influenza A Virus

artículo científico publicado en 2017

Solid state properties of pure UC-781 and solid dispersions with polyvinylpyrrolidone (PVP K30).

artículo científico publicado en 2001

Specific recognition of the bicyclic pyrimidine nucleoside analogs, a new class of highly potent and selective inhibitors of varicella-zoster virus (VZV), by the VZV-encoded thymidine kinase

artículo científico publicado en 2002

Stability of UC-781, in intestinal mucosal homogenates of the rat, rabbit, and pig

scientific article published on 01 November 1998

Structure-activity relationship studies of lipophilic teicoplanin pseudoaglycon derivatives as new anti-influenza virus agents

artículo científico publicado en 2018

Structure–Activity Relationship of a Novel Class of Aglycoristocetin Derivatives with Potent and Broad Activity Against Influenza Viruses

artículo científico publicado en 2009

Study of different substituted cyclic and acyclic benzylpronucleotides of d4T relative to their hydrolytic stability and antiviral activity.

artículo científico publicado en 2003

Suboptimal response to adefovir dipivoxil therapy for chronic hepatitis B in nucleoside-naive patients is not due to pre-existing drug-resistant mutants.

artículo científico publicado en 2008

Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in an 8-year-old girl with pulmonary papillomatosis

artículo científico publicado en 2005

Superior inhibition of influenza virus hemagglutinin-mediated fusion by indole-substituted spirothiazolidinones

scientific article published on 08 November 2019

Synthesis and Anti-influenza A Virus Activity of 2,2-Dialkylamantadines and Related Compounds.

artículo científico publicado en 2012

Synthesis and Antimicrobial Evaluation of 6-Alkylamino-N-phenylpyrazine-2-carboxamides

artículo científico publicado en 2015

Synthesis and Antiviral Activity of Various N4-Acyl Derivatives of Cidofovir and its 5-Azacytosine Counterpart, 1-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]-5-Azacytosine

artículo científico publicado en 2008

Synthesis and Biological Evaluation of N-Alkyl-3-(alkylamino)-pyrazine-2-carboxamides.

artículo científico publicado en 2015

Synthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory Viruses

artículo científico publicado en 2020

Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase.

artículo científico publicado en 2017

Synthesis and Preliminary Antiviral Activities of Piperidine-substituted Purines against HIV and Influenza A/H1N1 Infections

artículo científico publicado en 2015

Synthesis and Structure-Activity Relationship of N-(3-Oxo-1-Thia-4-Azaspiro[4.5]Decan-4-Yl)Carboxamide Inhibitors of Influenza Virus Hemagglutinin Mediated Fusion

Synthesis and absolute configuration of novel N,O-psiconucleosides using (R)-N-phenylpantolactam as a resolution agent

artículo científico publicado en 2008

Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure.

artículo científico publicado en 2008

Synthesis and antiviral evaluation of bisnoradamantane sulfites and related compounds

artículo científico publicado en 2011

Synthesis and antiviral properties of novel indole-based thiosemicarbazides and 4-thiazolidinones

artículo científico publicado en 2015

Synthesis and anti‐coronavirus activity of a series of 1‐thia‐4‐azaspiro[4.5]decan‐3‐one derivatives

artículo científico publicado en 2019

Synthesis and biological evaluation of lipophilic teicoplanin pseudoaglycon derivatives containing a substituted triazole function.

artículo científico publicado en 2016

Synthesis and biological evaluation of purine 2'-fluoro-2'-deoxyriboside ProTides as anti-influenza virus agents

artículo científico publicado en 2013

Synthesis and biological evaluation of pyrimidine nucleoside monophosphate prodrugs targeted against influenza virus ⬇️

artículo científico publicado el 28 de enero de 2012

Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs

artículo científico publicado en 2017

Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones.

artículo científico publicado en 2016

Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines.

artículo científico publicado en 2009

Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs

artículo científico publicado en 2008

Synthesis of 1,2-annulated adamantane heterocycles: structural determination studies of a bioactive cyclic sulfite

Synthesis of a cluster-forming sialylthio-D-galactose fullerene conjugate and evaluation of its interaction with influenza virus hemagglutinin and neuraminidase

artículo científico publicado en 2014

Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.

artículo científico publicado en 2011

Synthesis of ester prodrugs of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as anti-poxvirus agents

artículo científico publicado en 2010

Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities

scientific article published on 25 October 2012

Synthesis of isoindole and benzoisoindole derivatives of teicoplanin pseudoaglycon with remarkable antibacterial and antiviral activities

artículo científico publicado en 2012

Synthesis of novel aza-analogues of tiazofurin with 2-[5,5-bis(hydroxymethyl)pyrrolidin-2-yl] framework as sugar mimic.

artículo científico publicado en 2012

Synthesis, biological evaluation and molecular modeling of novel azaspiro dihydrotriazines as influenza virus inhibitors targeting the host factor dihydrofolate reductase (DHFR)

artículo científico publicado en 2018

Synthesis, cytostatic and anti-HIV evaluations of the new unsaturated acyclic C-5 pyrimidine nucleoside analogues.

artículo científico publicado en 2008

The Influenza Virus Polymerase Complex: An Update on Its Structure, Functions, and Significance for Antiviral Drug Design

artículo científico publicado en 2016

Therapeutic Approaches to HHV-6 Infection

Thermal characterization of the antiviral drug UC-781 and stability of its glass

Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2)

artículo científico publicado en 1997

Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine].

artículo científico publicado en 1998

Treatment of visna virus infection in lambs with the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)adenine (PMEA).

artículo científico publicado en 1998

Update on human herpesvirus 6 biology, clinical features, and therapy

artículo científico publicado en 2005

Virtual Screening and Biological Validation of Novel Influenza Virus PA Endonuclease Inhibitors.

artículo científico publicado en 2015

Visna in sheep as a model for chemotherapy of lentiviral central nervous system infections

artículo científico publicado en 1998

synthesis and preliminary biologic evaluation of 5-substituted-2-(4-substituted phenyl)-1,3-benzoxazoles as a novel class of influenza virus A inhibitors

artículo científico publicado en 2012

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