Filtros de búsqueda

Lista de obras de Patricia Babbitt

3-Carboxy-cis,cis-muconate lactonizing enzyme from Pseudomonas putida is homologous to the class II fumarase family: a new reaction in the evolution of a mechanistic motif

artículo científico publicado el 13 de octubre de 1992

A comparative study of human muscle and brain creatine kinases expressed in Escherichia coli

artículo científico publicado en 2000

A functionally diverse enzyme superfamily that abstracts the alpha protons of carboxylic acids

artículo científico publicado en 1995

A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets

artículo científico publicado en 2012

A global view of structure-function relationships in the tautomerase superfamily.

artículo científico publicado en 2017

A gold standard set of mechanistically diverse enzyme superfamilies

artículo científico publicado en 2006

A large-scale evaluation of computational protein function prediction

artículo científico publicado en 2013

A mapping of drug space from the viewpoint of small molecule metabolism

artículo científico publicado en 2009

A novel activity of OmpT. Proteolysis under extreme denaturing conditions.

artículo científico publicado en 1995

A novel structural basis for membrane association of a protein: construction of a chimeric soluble mutant of (S)-mandelate dehydrogenase from Pseudomonas putida

artículo científico publicado en 1993

A semiautomated approach to gene discovery through expressed sequence tag data mining: Discovery of new human transporter genes

artículo científico publicado el 1 de enero de 2003

A strategy for large-scale comparison of evolutionary- and reaction-based classifications of enzyme function

scientific article published on 01 January 2020

An Atlas of Peroxiredoxins Created Using an Active Site Profile-Based Approach to Functionally Relevant Clustering of Proteins.

artículo científico publicado en 2017

An approach to functionally relevant clustering of the protein universe: Active site profile-based clustering of protein structures and sequences

artículo científico publicado en 2017

An atlas of the thioredoxin fold class reveals the complexity of function-enabling adaptations

scientific article published on 23 October 2009

An expanded evaluation of protein function prediction methods shows an improvement in accuracy

artículo científico publicado en 2016

Ancestry of the 4-chlorobenzoate dehalogenase: analysis of amino acid sequence identities among families of acyl:adenyl ligases, enoyl-CoA hydratases/isomerases, and acyl-CoA thioesterases

artículo científico publicado el 23 de junio de 1992

Annotating Enzymes of Uncertain Function: The Deacylation of d -Amino Acids by Members of the Amidohydrolase Superfamily ,

artículo científico publicado en 2009

Annotation error in public databases: misannotation of molecular function in enzyme superfamilies

artículo científico publicado en 2009

At the periphery of the amidohydrolase superfamily: Bh0493 from Bacillus halodurans catalyzes the isomerization of D-galacturonate to D-tagaturonate

artículo científico publicado en 2008

Atlas of the Radical SAM Superfamily: Divergent Evolution of Function Using a “Plug and Play” Domain

scientific article published on 24 July 2018

Automated discovery of 3D motifs for protein function annotation

artículo científico publicado en 2006

Barrels in pieces?

artículo científico publicado en 2001

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells

artículo científico publicado en 2003

Biases in the experimental annotations of protein function and their effect on our understanding of protein function space

artículo científico publicado en 2013

Biocuration in the structure-function linkage database: the anatomy of a superfamily

artículo científico publicado en 2017

Biocuration in the structure-function linkage database: the anatomy of a superfamily.

artículo científico publicado en 2017

Biophysical studies support a predicted superhelical structure with armadillo repeats for Ric-8.

artículo científico publicado en 2009

Can sequence determine function?

artículo científico publicado en 2000

Changes to NIH Grant System May Backfire

artículo científico publicado en 2008

Cloning and expression of functional rabbit muscle creatine kinase in Escherichia coli. Addressing the problem of microheterogeneity

artículo científico publicado en 1991

Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A).

artículo científico publicado en 1997

Comparison of methods for genomic localization of gene trap sequences

artículo científico publicado en 2006

Comparison of topological clustering within protein networks using edge metrics that evaluate full sequence, full structure, and active site microenvironment similarity

artículo científico publicado en 2015

Consequences of domain insertion on sequence-structure divergence in a superfold

scientific article published on 19 August 2013

Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis

artículo científico publicado en 2012

Covalent docking predicts substrates for haloalkanoate dehalogenase superfamily phosphatases

scientific journal article

Creatine kinase protein sequence encoded by a cDNA made from Torpedo californica electric organ mRNA.

artículo científico publicado en 1984

Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat

artículo científico publicado en 2015

D-Ribulose 5-phosphate 3-epimerase: functional and structural relationships to members of the ribulose-phosphate binding (beta/alpha)8-barrel superfamily

artículo científico publicado en 2006

DASP3: identification of protein sequences belonging to functionally relevant groups

artículo científico publicado en 2016

Definitions of enzyme function for the structural genomics era.

artículo científico publicado en 2003

Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification

artículo científico publicado en 2015

Differential use of protease families for invasion by schistosome cercariae

artículo científico publicado en 2007

Discovery of a dipeptide epimerase enzymatic function guided by homology modeling and virtual screening

artículo científico publicado en 2008

Discovery of new enzymes and metabolic pathways by using structure and genome context

artículo científico publicado en 2013

Divergence of function in the thioredoxin fold suprafamily: evidence for evolution of peroxiredoxins from a thioredoxin-like ancestor

artículo científico publicado en 2004

Divergent evolution in enolase superfamily: strategies for assigning functions

artículo científico publicado en 2011

Divergent evolution in the enolase superfamily: the interplay of mechanism and specificity

artículo científico publicado en 2005

Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamilies

artículo científico publicado en 2001

Effusion: prediction of protein function from sequence similarity networks

scientific article published on 01 February 2019

Enzyme (re)design: lessons from natural evolution and computation

artículo científico publicado en 2009

Evaluating Functional Annotations of Enzymes Using the Gene Ontology

artículo científico

Evidence that pcpA encodes 2,6-dichlorohydroquinone dioxygenase, the ring cleavage enzyme required for pentachlorophenol degradation in Sphingomonas chlorophenolica strain ATCC 39723.

artículo científico publicado en 1999

Evolution of Enzymatic Activities in the Enolase Superfamily: Stereochemically Distinct Mechanisms in Two Families of cis , cis -Muconate Lactonizing Enzymes † ‡

artículo científico publicado en 2009

Evolution of Enzymatic Activities in the Enolase Superfamily: l -Rhamnonate Dehydratase † ‡

artículo científico publicado en 2008

Evolution of an enzyme active site: the structure of a new crystal form of muconate lactonizing enzyme compared with mandelate racemase and enolase

artículo científico publicado en 1998

Evolution of enzymatic activities in the enolase superfamily: D-Mannonate dehydratase from Novosphingobium aromaticivorans

artículo científico publicado en 2007

Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli

artículo científico publicado en 1998

Evolution of enzymatic activities in the enolase superfamily: crystal structure of (D)-glucarate dehydratase from Pseudomonas putida

artículo científico publicado en 1998

Evolution of enzyme superfamilies

artículo científico publicado en 2006

Evolution of function in the "two dinucleotide binding domains" flavoproteins

artículo científico publicado en 2007

Evolution of structure and function in the o-succinylbenzoate synthase/N-acylamino acid racemase family of the enolase superfamily

artículo científico publicado en 2006

Evolutionarily conserved substrate substructures for automated annotation of enzyme superfamilies

artículo científico publicado en 2008

Evolutionary and molecular foundations of multiple contemporary functions of the nitroreductase superfamily

artículo científico publicado en 2017

Evolutionary constraints on structural similarity in orthologs and paralogs

artículo científico publicado en 2009

Evolutionary potential of (beta/alpha)8-barrels: functional promiscuity produced by single substitutions in the enolase superfamily

artículo científico publicado en 2003

Evolutionary reprograming of protein-protein interaction specificity

artículo científico publicado en 2015

Exploration of the relationship between tetrachlorohydroquinone dehalogenase and the glutathione S-transferase superfamily

artículo científico publicado en 1996

Exploring the sequence, function, and evolutionary space of protein superfamilies using sequence similarity networks and phylogenetic reconstructions

scientific article published on 17 April 2019

Expression of Torpedo californica creatine kinase in Escherichia coli and purification from inclusion bodies

artículo científico publicado en 2002

Functional assignment of the 20 S proteasome from Trypanosoma brucei using mass spectrometry and new bioinformatics approaches.

artículo científico publicado en 2001

Glutathione transferases are structural and functional outliers in the thioredoxin fold

artículo científico publicado en 2009

Homologous (beta/alpha)8-barrel enzymes that catalyze unrelated reactions: orotidine 5'-monophosphate decarboxylase and 3-keto-L-gulonate 6-phosphate decarboxylase

artículo científico publicado en 2002

Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily

artículo científico publicado en 2012

Identification and characterization of a mandelamide hydrolase and an NAD(P)+-dependent benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633.

artículo científico publicado en 2003

Improving the quality of protein similarity network clustering algorithms using the network edge weight distribution

artículo científico publicado en 2010

Inference of Functional Properties from Large-scale Analysis of Enzyme Superfamilies

artículo científico publicado el 8 de noviembre de 2011

Insights into the Mechanism of Catalysis by the P−C Bond-Cleaving Enzyme Phosphonoacetaldehyde Hydrolase Derived from Gene Sequence Analysis and Mutagenesis

artículo científico publicado el 30 de junio de 1998

Integrated tools for structural and sequence alignment and analysis

artículo científico publicado en 2000

InterPro in 2017-beyond protein family and domain annotations

artículo científico publicado en 2016

InterPro in 2019: improving coverage, classification and access to protein sequence annotations

article by Alex Mitchell et al published 6 November 2018 in Nucleic Acids Research

Intersect: identification and visualization of overlaps in database search results

artículo científico publicado en 2003

Introduction to informatics approaches in structural genomics: modeling and representation of function from macromolecular structure

artículo científico publicado en 2005

Isoleucine 69 and valine 325 form a specificity pocket in human muscle creatine kinase

artículo científico publicado en 2004

Key challenges for the creation and maintenance of specialist protein resources

artículo científico publicado en 2015

Kinetic and structural characterization of a cis-3-Chloroacrylic acid dehalogenase homologue in Pseudomonas sp. UW4: A potential step between subgroups in the tautomerase superfamily

artículo científico publicado en 2017

Large-scale determination of sequence, structure, and function relationships in cytosolic glutathione transferases across the biosphere

artículo científico publicado en 2014

Leveraging enzyme structure-function relationships for functional inference and experimental design: the structure-function linkage database

artículo científico publicado en 2006

Mandelate pathway of Pseudomonas putida: sequence relationships involving mandelate racemase, (S)-mandelate dehydrogenase, and benzoylformate decarboxylase and expression of benzoylformate decarboxylase in Escherichia coli

artículo científico publicado en 1990

Mechanisms of protein evolution and their application to protein engineering

artículo científico publicado en 2007

Mechanistic and bioinformatic investigation of a conserved active site helix in α-isopropylmalate synthase from Mycobacterium tuberculosis, a member of the DRE-TIM metallolyase superfamily

artículo científico publicado en 2014

Mechanistically diverse enzyme superfamilies: the importance of chemistry in the evolution of catalysis

scientific article published on 01 October 1998

Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells

artículo científico publicado en 2007

Molecular Diversity of Terpene Synthases in the Liverwort Marchantia polymorpha

artículo científico publicado en 2016

Mutagenesis of two acidic active site residues in human muscle creatine kinase: implications for the catalytic mechanism

artículo científico publicado en 2001

Mutations in PNKD causing paroxysmal dyskinesia alters protein cleavage and stability

artículo científico publicado el 12 de abril de 2011

New computational approaches to understanding molecular protein function.

artículo científico publicado en 2018

New functions from old scaffolds: how nature reengineers enzymes for new functions

artículo científico publicado en 2000

New insights about enzyme evolution from large scale studies of sequence and structure relationships

artículo científico publicado en 2014

Novel Enzymic Hydrolytic Dehalogenation of a Chlorinated Aromatic

artículo científico publicado el 12 de julio de 1991

On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway

artículo científico publicado en 1994

Predicting the functions and specificity of triterpenoid synthases: a mechanism-based multi-intermediate docking approach

artículo científico publicado en 2014

Prediction and assignment of function for a divergent N-succinyl amino acid racemase

artículo científico publicado en 2007

Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks

scientific journal article

Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily

artículo científico publicado en 2013

Prediction of substrates for glutathione transferases by covalent docking

artículo científico publicado en 2014

Pythoscape: a framework for generation of large protein similarity networks

artículo científico publicado en 2012

Quantitative comparison of catalytic mechanisms and overall reactions in convergently evolved enzymes: implications for classification of enzyme function

artículo científico publicado en 2010

Redesigning enzymes based on adaptive evolution for optimal function in synthetic metabolic pathways

artículo científico publicado en 2008

Reengineering the glutathione S-transferase scaffold: a rational design strategy pays off.

artículo científico publicado en 2000

Removal of a proteolytic activity associated with aggregates formed from expression of creatine kinase in Escherichia coli leads to improved recovery of active enzyme

artículo científico publicado el 1 de octubre de 1990

Representing structure-function relationships in mechanistically diverse enzyme superfamilies.

artículo científico publicado en 2005

Revealing Unexplored Sequence-Function Space Using Sequence Similarity Networks

scientific article published on 27 July 2018

Sequence verification of human creatine kinase (43 kDa) isozymes by high-resolution tandem mass spectrometry

artículo científico publicado en 1995

Sequence verification of human creatine kinase (43 kDa) isozymes by high-resolution tandem mass spectrometry

scholarly article

Shotgun: getting more from sequence similarity searches

artículo científico publicado en 1999

SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni

artículo científico publicado en 2009

Stability for function trade-offs in the enolase superfamily "catalytic module"

artículo científico publicado en 2007

Structural Basis for the Asymmetry of a 4-Oxalocrotonate Tautomerase Trimer

scientific article published on 13 April 2020

Structural diversity within the mononuclear and binuclear active sites of N-acetyl-D-glucosamine-6-phosphate deacetylase

artículo científico publicado en 2007

Structural, Kinetic, and Mechanistic Analysis of an Asymmetric 4-Oxalocrotonate Tautomerase Trimer

scientific article published on 23 May 2019

Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function

artículo científico publicado en 2013

Superfamily active site templates.

artículo científico publicado en 2004

Target selection and annotation for the structural genomics of the amidohydrolase and enolase superfamilies

artículo científico publicado en 2009

The 2.1 A structure of Torpedo californica creatine kinase complexed with the ADP-Mg(2+)-NO(3)(-)-creatine transition-state analogue complex

artículo científico publicado en 2002

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

scientific article published on 19 November 2019

The Enzyme Function Initiative

artículo científico publicado en 2011

The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse

artículo científico publicado en 2006

The Nucleophilic Attack Six-Bladed β-Propeller (N6P) Superfamily

The Structure Superposition Database

artículo científico publicado en 2003

The Structure-Function Linkage Database

artículo científico publicado en 2013

The enolase superfamily: a general strategy for enzyme-catalyzed abstraction of the alpha-protons of carboxylic acids

artículo científico publicado en 1996

The evolution of function in strictosidine synthase-like proteins

artículo científico publicado en 2011

The global cysteine peptidase landscape in parasites

artículo científico publicado en 2009

The principal islet of the Coho salmon (Oncorhyncus kisutch) contains the BB isoenzyme of creatine kinase

artículo científico publicado el 1 de octubre de 1992

Topological variation in the evolution of new reactions in functionally diverse enzyme superfamilies

artículo científico publicado el 1 de abril de 2011

Toward mechanistic classification of enzyme functions

scientific article published on 12 April 2011

Understanding enzyme superfamilies. Chemistry As the fundamental determinant in the evolution of new catalytic activities

artículo científico publicado en 1997

Unexpected divergence of enzyme function and sequence: "N-acylamino acid racemase" is o-succinylbenzoate synthase

artículo científico publicado en 1999

Using sequence similarity networks for visualization of relationships across diverse protein superfamilies.

artículo científico publicado en 2009

Using the Structure-function Linkage Database to characterize functional domains in enzymes

scientific article published on 01 March 2006

Using the structure-function linkage database to characterize functional domains in enzymes

artículo científico publicado en 2014

ViewFeature: integrated feature analysis and visualization.

artículo científico publicado en 2001

[FeFe]-hydrogenase maturation: insights into the role HydE plays in dithiomethylamine biosynthesis

artículo científico publicado en 2015

structureViz: linking Cytoscape and UCSF Chimera.

artículo científico publicado en 2007