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Lista de obras de John R. Engen

A conformational investigation of propeptide binding to the integral membrane protein γ-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry

artículo científico

A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase

artículo científico publicado en 2014

A redox switch regulates the structure and function of anti-apoptotic BFL-1

scientific article published on 13 July 2020

Abl N-terminal cap stabilization of SH3 domain dynamics

artículo científico publicado en 2008

Accessing the reproducibility and specificity of pepsin and other aspartic proteases

artículo científico publicado en 2012

Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts

artículo científico publicado en 2017

Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.

artículo científico publicado en 2013

Activation of the Src family kinase Hck without SH3-linker release

artículo científico publicado en 2005

Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study

artículo científico publicado en 2013

Allosteric control of Ubp6 and the proteasome via a bidirectional switch

artículo científico publicado en 2022

Allosteric inhibition of antiapoptotic MCL-1.

artículo científico publicado en 2016

Allosteric interactions between the myristate- and ATP-site of the Abl kinase

artículo científico publicado en 2011

Allosteric loss-of-function mutations in HIV-1 Nef from a long-term non-progressor

artículo científico publicado en 2007

Altered dynamics in Lck SH3 upon binding to the LBD1 domain of Herpesvirus saimiri Tip

artículo científico publicado en 2006

An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry

artículo científico publicado en 2005

Analysis of overlapped and noisy hydrogen/deuterium exchange mass spectra

artículo científico publicado en 2013

Analysis of protein complexes with hydrogen exchange and mass spectrometry.

artículo científico publicado en 2003

Analysis of protein conformation and dynamics by hydrogen/deuterium exchange MS.

artículo científico publicado en 2009

Analytical Aspects of Hydrogen Exchange Mass Spectrometry

artículo científico publicado en 2015

Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars

artículo científico publicado en 2012

Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization

artículo científico publicado en 2011

Applications of hydrogen/deuterium exchange MS from 2012 to 2014.

artículo científico publicado en 2014

Aspartic proteinases in Antarctic fish

artículo científico

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

artículo científico publicado en 2012

Chapter 4 Protein Analysis with Hydrogen–Deuterium Exchange Mass Spectrometry

Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry

artículo científico publicado en 2016

Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry

article

Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry

artículo científico publicado en 2009

Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.

artículo científico publicado en 2017

Conformational Features of the Full-Length HIV and SIV Nef Proteins Determined by Mass Spectrometry†

article

Conformational Locking upon Cooperative Assembly of Notch Transcription Complexes

artículo científico publicado en 2012

Conformational analysis of membrane proteins in phospholipid bilayer nanodiscs by hydrogen exchange mass spectrometry

artículo científico publicado en 2010

Conformational analysis of processivity clamps in solution demonstrates that tertiary structure does not correlate with protein dynamics

artículo científico publicado en 2014

Conformational analysis of recombinant monoclonal antibodies with hydrogen/deuterium exchange mass spectrometry

artículo científico publicado en 2013

Conformational differences between arrestin2 and pre-activated mutants as revealed by hydrogen exchange mass spectrometry

artículo científico publicado en 2005

Conformational disturbance in Abl kinase upon mutation and deregulation

artículo científico publicado en 2009

Conformational dynamics of the Escherichia coli DNA polymerase manager proteins UmuD and UmuD'.

artículo científico publicado en 2010

Conformational transition of membrane-associated terminally acylated HIV-1 Nef.

artículo científico publicado en 2013

Conformational transitions in the membrane scaffold protein of phospholipid bilayer nanodiscs

artículo científico publicado en 2011

Considerations in the Analysis of Hydrogen Exchange Mass Spectrometry Data

artículo científico publicado en 2020

Cumulative deamidations of the major lens protein γS-crystallin increase its aggregation during unfolding and oxidation

artículo científico publicado en 2020

Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice

scientific article published on 19 August 2019

Determining the site of spin trapping of the equine myoglobin radical by combined use of EPR, electrophoretic purification, and mass spectrometry

artículo científico publicado en 2002

Developments in Hydrogen/Deuterium Exchange Mass Spectrometry

artículo científico publicado en 2020

Differential impact of BTK active site inhibitors on the conformational state of full-length BTK

artículo científico publicado en 2020

Differential sensitivity of Src-family kinases to activation by SH3 domain displacement

artículo científico publicado en 2014

Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases

artículo científico publicado en 2016

Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD

artículo científico publicado en 2018

Dynamic and structural differences between heme oxygenase-1 and -2 are due to differences in their C-terminal regions

scientific article published on 03 April 2019

Dynamics of the Tec-family tyrosine kinase SH3 domains

artículo científico publicado en 2016

ETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurements

artículo científico publicado en 2011

Effects of Disease-Causing Mutations on the Conformation of Human Apolipoprotein A-I in Model Lipoproteins

scientific article published on 13 July 2018

Effects of HIV-1 Nef on human N-myristoyltransferase 1.

artículo científico publicado en 2011

Electron transfer control in soluble methane monooxygenase

artículo científico publicado en 2014

Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL).

artículo científico publicado en 2012

Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors

artículo científico publicado en 2013

Erratum: Corrigendum: Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

artículo científico publicado en 2013

Escherichia coli processivity clamp β from DNA polymerase III is dynamic in solution

artículo científico publicado en 2011

Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation

artículo científico publicado en 2011

Extensive Deuterium Back-Exchange in Certain Immobilized Pepsin Columns Used for H/D Exchange Mass Spectrometry

article

False EX1 signatures caused by sample carryover during HX MS analyses

artículo científico publicado en 2011

Fetal alcohol exposure alters neurosteroid levels in the developing rat brain.

artículo científico publicado en 2004

Foreword

Functional characterization and conformational analysis of the Herpesvirus saimiri Tip-C484 protein

artículo científico publicado en 2006

Gas-phase hydrogen/deuterium exchange in a traveling wave ion guide for the examination of protein conformations

artículo científico publicado en 2009

General structural features that regulate integrin affinity revealed by atypical αVβ8

scientific article published on 02 December 2019

GroEL/ES Chaperonin Modulates the Mechanism and Accelerates the Rate of TIM-Barrel Domain Folding

artículo científico publicado en 2014

HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck

artículo científico publicado en 2012

High-speed and high-resolution UPLC separation at zero degrees Celsius

artículo científico publicado en 2008

Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization

artículo científico publicado en 2020

Hydrocarbon-stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor

scientific article published on 29 April 2020

Hydrogen Exchange Mass Spectrometry of Proteins at Langmuir Monolayers

artículo científico publicado en 2015

Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants

artículo científico publicado en 2016

Hydrogen Exchange Shows Peptide Binding Stabilizes Motions in Hck SH2†

article

Hydrogen deuterium exchange mass spectrometry applied to chaperones and chaperone-assisted protein folding

scientific article published on 24 June 2019

Hydrogen exchange and covalent modification: Focus on biomolecular structure, dynamics, and function. 18th Sanibel Conference on Mass Spectrometry

article

Hydrogen exchange mass spectrometry for the analysis of protein dynamics

artículo científico publicado en 2006

Hydrogen exchange mass spectrometry: are we out of the quicksand?

artículo científico publicado en 2012

Hydrogen exchange mass spectrometry: what is it and what can it tell us?

artículo científico publicado en 2010

Hydrogen exchange-mass spectrometry measures stapled peptide conformational dynamics and predicts pharmacokinetic properties

artículo científico publicado en 2013

Hydrogen-Deuterium Exchange Mass Spectrometry to Study Protein Complexes

artículo científico publicado en 2018

Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics

artículo científico publicado en 2015

Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

artículo científico publicado en 2013

Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis

artículo científico publicado en 2006

Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry.

artículo científico publicado en 1997

Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering

artículo científico publicado en 2020

Identification of a Structural Determinant for Selective Targeting of HDMX

artículo científico publicado en 2020

Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein

artículo científico publicado en 2018

Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.

artículo científico publicado en 2015

Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region

artículo científico publicado en 2013

Investigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurements

artículo científico publicado en 2013

Investigating solution-phase protein structure and dynamics by hydrogen exchange mass spectrometry.

artículo científico publicado en 2009

Ion mobility adds an additional dimension to mass spectrometric analysis of solution-phase hydrogen/deuterium exchange

artículo científico publicado en 2008

Isotope Exchange and Covalent Modification Strategies for Studying Protein Structure and Function

KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry.

artículo científico publicado en 2017

L-canavanine is a time-controlled mechanism-based inhibitor of Pseudomonas aeruginosa arginine deiminase

artículo científico publicado en 2005

Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire

artículo científico publicado en 2013

Membrane-Associated Conformation of HIV-1 Nef Investigated with Hydrogen Exchange Mass Spectrometry at a Langmuir Monolayer

artículo científico publicado en 2015

Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding

artículo científico publicado en 2020

Molecular insight into the conformational dynamics of the Elongin BC complex and its interaction with HIV-1 Vif.

artículo científico publicado en 2010

Neutron reflectometry study of the conformation of HIV Nef bound to lipid membranes

artículo científico publicado en 2010

Noncanonical role of the PDZ4 domain of the adaptor protein PDZK1 in the regulation of the hepatic high density lipoprotein receptor scavenger receptor class B, type I (SR-BI).

artículo científico publicado en 2013

Noncognate DNA damage prevents the formation of the active conformation of the Y-family DNA polymerases DinB and DNA polymerase κ

artículo científico publicado en 2015

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

artículo científico publicado en 2009

On the solution conformation and dynamics of the HIV-1 viral infectivity factor

artículo científico publicado en 2011

Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry

artículo científico publicado en 2013

Partial unfolding of diverse SH3 domains on a wide timescale

artículo científico publicado en 2006

Pepsin immobilized on high-strength hybrid particles for continuous flow online digestion at 10,000 psi.

artículo científico publicado en 2012

Phosphorylation and structure-based functional studies reveal a positive and a negative role for the activation loop of the c-Abl tyrosine kinase.

artículo científico publicado en 2001

Post-translational modifications differentially affect IgG1 conformation and receptor binding.

artículo científico publicado en 2010

Probing Protein Interactions Using Hydrogen-Deuterium Exchange Mass Spectrometry

Purification and characterization of pepsins A1 and A2 from the Antarctic rock cod Trematomus bernacchii

artículo científico publicado en 2007

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

scientific article published on 27 June 2019

Regulation of c-Fes tyrosine kinase activity by coiled-coil and SH2 domains: analysis with Saccharomyces cerevisiae

artículo científico publicado en 2003

Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding.

artículo científico publicado en 2017

Remodeling of the Binding Site of Nucleoside Diphosphate Kinase Revealed by X-ray Structure and H/D Exchange

scientific article published on 04 March 2019

Replication in bioanalytical studies with HDX MS: aim as high as possible

artículo científico publicado en 2015

Resolving chaperone-assisted protein folding on the ribosome at the peptide level

artículo científico publicado en 2024

Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism

artículo científico publicado en 2020

Semi-automated data processing of hydrogen exchange mass spectra using HX-Express

artículo científico publicado en 2006

Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX

artículo científico publicado en 2020

Specialized Methods

book chapter published in 2007

Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity

artículo científico publicado en 2006

Steric gate residues of Y-family DNA polymerases DinB and pol kappa are crucial for dNTP-induced conformational change

artículo científico publicado en 2015

Structural Basis for Lipid Binding and Function by an Evolutionarily Conserved Protein, Serum Amyloid A

scientific article published on 06 February 2020

Structural Dynamics in Ras and Related Proteins upon Nucleotide Switching

artículo científico publicado en 2016

Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic?

artículo científico publicado en 2015

Structural analysis of lecithin:cholesterol acyltransferase bound to high density lipoprotein particles

artículo científico publicado en 2020

Structural basis of the atypical activation mechanism of KRASV14I

artículo científico publicado en 2019

Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic?

artículo científico publicado en 2016

Structure and dynamic regulation of Abl kinases

artículo científico publicado en 2013

Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4

artículo científico publicado en 2018

Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers

artículo científico publicado en 2020

Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes

scientific article published on 29 August 2020

Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.

artículo científico publicado en 2017

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

artículo científico publicado en 2019

Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor

artículo científico publicado en 2015

Sulfonyl fluoride inhibitors of fatty acid amide hydrolase

artículo científico publicado en 2012

Tag and Capture Flow Hydrogen Exchange Mass Spectrometry with a Fluorous-Immobilized Probe

artículo científico publicado en 2015

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

artículo científico publicado en 2010

Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer

artículo científico publicado en 2020

The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding

artículo científico publicado en 2007

The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation

artículo científico publicado en 2018

The heme regulatory motifs of heme oxygenase-2 contribute to the transfer of heme to the catalytic site for degradation

artículo científico publicado en 2020

The influence of adnectin binding on the extracellular domain of epidermal growth factor receptor

artículo científico publicado en 2014

The natural product cucurbitacin E inhibits depolymerization of actin filaments

artículo científico publicado en 2012

The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies

artículo científico publicado en 2010

Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor

artículo científico publicado en 2013

Tissue-Specific Oncogenic Activity of KRASA146T

artículo científico publicado en 2019

Tuning a High Transmission Ion Guide to Prevent Gas-Phase Proton Exchange During H/D Exchange MS Analysis

artículo científico publicado en 2016

Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core

artículo científico publicado en 2008

Ultra performance liquid chromatography (UPLC) further improves hydrogen/deuterium exchange mass spectrometry

article

Using hydrogen/deuterium exchange mass spectrometry to study conformational changes in granulocyte colony stimulating factor upon PEGylation

artículo científico publicado en 2012

Using stable-isotope-labeled proteins for hydrogen exchange studies in complex mixtures

artículo científico publicado en 2002

Utilizing Microchip Capillary Electrophoresis Electrospray Ionization for Hydrogen Exchange Mass Spectrometry

artículo científico publicado en 2015

What mass spectrometry can reveal about protein function

artículo científico publicado en 2004

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