Lista de obras - Takamitsu Hosoya - Dominio Público Uruguay

(Hexafluoroacetylacetonato)copper(I)-cycloalkyne complexes as protected cycloalkynes

artículo científico publicado en 2020

1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin beta, a substrate of parkin, and reduces its polyubiquitination.

artículo científico publicado en 2010

11C-cetrozole: an improved C-11C-methylated PET probe for aromatase imaging in the brain.

artículo científico publicado en 2014

2-Azidoacrylamides as compact platforms for efficient modular synthesis

artículo científico publicado en 2020

3-Azidodifluoromethyl-3H-diazirin-3-yl group as an all-in-one functional group for radioisotope-free photoaffinity labeling

artículo científico publicado en 2007

3-Thioaryne Intermediates for the Synthesis of Diverse Thioarenes

artículo científico publicado en 2019

A facile preparation of functional cycloalkynes via an azide-to-cycloalkyne switching approach

artículo científico publicado en 2019

A mild and facile synthesis of aryl and alkenyl sulfides via copper-catalyzed deborylthiolation of organoborons with thiosulfonates

artículo científico publicado en 2015

A single starfish Aurora kinase performs the combined functions of Aurora-A and Aurora-B in human cells.

artículo científico publicado en 2010

A study on an unusual SN2 mechanism in the methylation of benzyne through nickel-complexation.

artículo científico publicado en 2017

An Alternative Method for Generating Arynes from ortho-Silylaryl Triflates: Activation by Cesium Carbonate in the Presence of a Crown Ether

artículo científico publicado en 2015

An efficient generation method and remarkable reactivities of 3-triflyloxybenzyne

artículo científico publicado en 2014

Application of new semisynthetic aequorins with long half-decay time of luminescence to G-protein-coupled receptor assay ⬇️

artículo científico publicado el 25 de agosto de 2010

Aryne Relay Chemistry en Route to Aminoarenes: Synthesis of 3-Aminoaryne Precursors via Regioselective Silylamination of 3-(Triflyloxy)arynes

scientific article published on 22 November 2016

Assembly of four modules onto a tetraazide platform by consecutive 1,2,3-triazole formations

artículo científico publicado en 2020

Association between aromatase in human brains and personality traits

artículo científico publicado en 2018

Blood-brain barrier permeability of ginkgolide: Comparison of the behavior of PET probes 7α-[18F]fluoro- and 10-O-p-[11C]methylbenzyl ginkgolide B in monkey and rat brains

artículo científico publicado en 2016

Boracene-based alkylborate enabled Ni/Ir hybrid catalysis

scientific article published on 19 August 2020

Boron-selective biaryl coupling approach to versatile dibenzoxaborins and application to concise synthesis of defucogilvocarcin M.

artículo científico publicado en 2014

C6-Deoxy coelenterazine analogues as an efficient substrate for glow luminescence reaction of nanoKAZ: the mutated catalytic 19 kDa component of Oplophorus luciferase.

artículo científico publicado en 2013

CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia

artículo científico publicado en 2018

CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses

artículo científico publicado en 2014

Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus

artículo científico publicado en 2009

Chiral deaza-coelenterazine analogs for probing a substrate-binding site in the Ca2+-binding photoprotein aequorin

artículo científico publicado en 2021

Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A

scientific article published on 01 March 2008

Comparison of pharmacokinetics of newly discovered aromatase inhibitors by a cassette microdosing approach in healthy Japanese subjects.

artículo científico publicado en 2017

Concise Synthesis of v-Coelenterazines

artículo científico publicado en 2015

Consecutive Aryne Generation Strategy for the Synthesis of 1,3-Diarylpyrazoles

scientific article published on 24 February 2020

Construction of Condensed Polycyclic Aromatic Frameworks through Intramolecular Cycloaddition Reactions Involving Arynes Bearing an Internal Alkyne Moiety

artículo científico publicado en 2017

Convergent Synthesis of Fluoroalkenes Using a Dual-Reactive Unit

artículo científico publicado en 2021

Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions

artículo científico publicado en 2018

Copper-Catalyzed Regioselective Monodefluoroborylation of Polyfluoroalkenes en Route to Diverse Fluoroalkenes.

artículo científico publicado en 2017

Crystal structure of nanoKAZ: The mutated 19 kDa component of Oplophorus luciferase catalyzing the bioluminescent reaction with coelenterazine

artículo científico publicado en 2016

Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca2+ release from sarcoplasmic reticulum of mouse skeletal muscle.

artículo científico publicado en 2003

Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis

artículo científico publicado en 2015

Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle.

artículo científico publicado en 2005

Detection of structural changes in a cofactor binding protein by using a wheat germ cell-free protein synthesis system coupled with unnatural amino acid probing

artículo científico publicado en 2007

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

artículo científico publicado en 2010

Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy

artículo científico publicado en 2017

Development of bis-unsaturated ester aldehydes as amino-glue probes: sequential double azaelectrocyclization as a promising strategy for bioconjugation

artículo científico publicado en 2013

Direct thioamination of arynes via reaction with sulfilimines and migratory N-arylation

artículo científico publicado en 2015

Enhanced clickability of doubly sterically-hindered aryl azides.

artículo científico publicado en 2011

Expression, purification and luminescence properties of coelenterazine-utilizing luciferases from Renilla, Oplophorus and Gaussia: comparison of substrate specificity for C2-modified coelenterazines

artículo científico publicado en 2012

Facile assembly of three cycloalkyne-modules onto a platform compound bearing thiophene S,S-dioxide moiety and two azido groups

artículo científico publicado en 2020

Further enhancement of the clickability of doubly sterically-hindered aryl azides by para-amino substitution

article

Generation of arynes via ate complexes of arylboronic esters with an ortho-leaving group

scientific article published on 21 May 2013

Generation of cycloheptynes and cyclooctynes via a sulfoxide-magnesium exchange reaction of readily synthesized 2-sulfinylcycloalkenyl triflates

artículo científico publicado en 2015

Hydrosilyl Group-directed Iridium-catalyzed peri-Selective C–H Borylation of Ring-fused (Hetero)Arenes

scholarly article by Yuto Sumida et al published 5 October 2018 in Chemistry Letters

IOP-lowering effect of isoquinoline-5-sulfonamide compounds in ocular normotensive monkeys

artículo científico publicado en 2013

Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ.

artículo científico publicado en 2015

Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice

artículo científico publicado en 2015

Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids: PET study with [11C]vorozole.

artículo científico publicado en 2011

Indolizines Enabling Rapid Uncaging of Alcohols and Carboxylic Acids by Red Light-Induced Photooxidation

artículo científico publicado en 2020

Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.

artículo científico publicado en 2002

Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation.

artículo científico publicado en 2016

Investigation of the effect of active efflux at the blood–brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system ⬇️

artículo científico publicado el 27 de mayo de 2013

Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface

artículo científico publicado en 2018

Luminescence enhancement of the catalytic 19 kDa protein (KAZ) of Oplophorus luciferase by three amino acid substitutions.

artículo científico publicado en 2014

Manipulation of alternative splicing by a newly developed inhibitor of Clks

artículo científico publicado en 2004

Modular synthesis of bis- and tris-1,2,3-triazoles by permutable sequential azide-aryne and azide-alkyne cycloadditions

artículo científico publicado en 2014

Neuroprotection by a central nervous system-type prostacyclin receptor ligand demonstrated in monkeys subjected to middle cerebral artery occlusion and reperfusion: a positron emission tomography study

artículo científico publicado en 2006

Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalizations

artículo científico publicado en 2015

PET of Aromatase in Gastric Parietal Cells Using 11C-Vorozole ⬇️

artículo científico publicado el 9 de noviembre de 2011

Palladium(0)-mediated rapid methylation and fluoromethylation on carbon frameworks by reacting methyl and fluoromethyl iodide with aryl and alkenyl boronic acid esters: useful for the synthesis of [11C]CH(3)--C- and [18F]FCH2--C-Containing PET trace

artículo científico publicado en 2009

Palladium(ii)-mediated rapid C-cyanation of (hetero)arylborons

artículo científico publicado en 2018

Palladium-catalyzed regio- and stereoselective hydrosilylation of electron-deficient alkynes

artículo científico publicado en 2012

Pd(0)-Mediated rapid coupling between methyl iodide and heteroarylstannanes: an efficient and general method for the incorporation of a positron-emitting (11)C radionuclide into heteroaromatic frameworks.

artículo científico publicado en 2009

Pd0-mediated rapid cross-coupling reactions, the rapid C-[11C]methylations, revolutionarily advancing the syntheses of short-lived PET molecular probes

artículo científico publicado en 2014

Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice.

artículo científico publicado en 2017

Preparation of Aryne–Nickel Complexes from ortho-Borylaryl Triflates

artículo científico publicado en 2016

Quantification of receptor activation by oxytocin and vasopressin in endocytosis-coupled bioluminescence reduction assay using nanoKAZ.

artículo científico publicado en 2018

Rapid methylation of terminal acetylenes by the Stille coupling of methyl iodide with alkynyltributylstannanes: a general protocol potentially useful for the synthesis of short-lived 11CH3-labeled PET tracers with a 1-propynyl group.

artículo científico publicado en 2003

Rapid methylation on carbon frameworks useful for the synthesis of 11CH3-incorporated PET tracers: Pd(0)-mediated rapid coupling of methyl iodide with an alkenyltributylstannane leading to a 1-methylalkene

artículo científico publicado en 2006

Reconstitution of blue fluorescent protein from recombinant apoaequorin and synthetic coelenteramide.

artículo científico publicado en 2009

Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia

artículo científico publicado en 2015

Rhodium-Catalyzed Decarbonylative Borylation of Aromatic Thioesters for Facile Diversification of Aromatic Carboxylic Acids.

artículo científico publicado en 2017

Rhodium-Catalyzed ipso-Borylation of Alkylthioarenes via C-S Bond Cleavage.

artículo científico publicado en 2016

Rhodium-catalyzed odorless synthesis of diaryl sulfides from borylarenes and S-aryl thiosulfonates.

artículo científico publicado en 2017

Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039.

artículo científico publicado en 2015

Selective inhibition of the kinase DYRK1A by targeting its folding process

artículo científico publicado en 2016

Selective strain-promoted azide-alkyne cycloadditions through transient protection of bicyclo[6.1.0]nonynes with silver or gold

scientific article published on 27 July 2020

Single C-F Bond Cleavage of Trifluoromethylarenes with an ortho-Silyl Group

artículo científico publicado en 2016

Single C-F Transformations of o-Hydrosilyl Benzotrifluorides with Trityl Compounds as All-in-One Reagents

artículo científico publicado en 2020

Site-selective post-translational modification of proteins using an unnatural amino acid, 3-azidotyrosine

artículo científico publicado en 2007

Site-specific attachment of a protein to a carbon nanotube end without loss of protein function

artículo científico publicado en 2012

Slow luminescence kinetics of semi-synthetic aequorin: expression, purification and structure determination of cf3-aequorin

scholarly article by Satoshi Inouye published in May 2018

Specific ligand for a central type prostacyclin receptor attenuates neuronal damage in a rat model of focal cerebral ischemia ⬇️

artículo científico publicado el 25 de enero de 2002

Staudinger reaction using 2,6-dichlorophenyl azide derivatives for robust aza-ylide formation applicable to bioconjugation in living cells

artículo científico publicado en 2018

Stereoinversion of Stereocongested Carbocyclic Alcohols via Triflylation and Subsequent Treatment with Aqueous N,N-Dimethylformamide

scientific article published on 11 November 2016

Substituted 5,6,11,12-tetradehydrodibenzo[a,e]cyclooctenes: syntheses, properties, and DFT studies of substituted Sondheimer-Wong diynes

scientific article published on 25 November 2014

Sulfoxide synthesis from sulfinate esters under Pummerer-like conditions

scientific article published on 14 April 2020

Synthesis of (2,2-Diborylvinyl)arenes by Rhodium-Catalyzed Desulfanylative gem-Diborylation of 2-Arylvinyl Sulfides

artículo científico publicado en 2019

Synthesis of Alkynyl Sulfides by Copper-Catalyzed Thiolation of Terminal Alkynes Using Thiosulfonates

scientific article published on 19 April 2019

Synthesis of Dibenzofurans by Cu-Catalyzed Deborylative Ring Contraction of Dibenzoxaborins

artículo científico publicado en 2020

Synthesis of Diverse o-Arylthio-Substituted Diaryl Ethers by Direct Oxythiolation of Arynes with Diaryl Sulfoxides Involving Migratory O-Arylation

artículo científico publicado en 2017

Synthesis of Diverse γ-Aryl-β-ketoesters via Aryne Intermediates Generated by C-C Bond Cleavage

scientific article published on 24 October 2019

Synthesis of Functionalized Benzopyran/Coumarin-Derived Aryne Precursors and Their Applications

artículo científico publicado en 2020

Synthesis of Unsymmetrical Tertiary Phosphine Oxides via Sequential Substitution Reaction of Phosphonic Acid Dithioesters with Grignard Reagents

artículo científico publicado en 2017

Synthesis of benzyl sulfides via substitution reaction at the sulfur of phosphinic acid thioesters

scientific article published on 22 April 2020

Synthesis of multisubstituted cycloalkenes through carbomagnesiation of strained cycloalkynes

artículo científico publicado en 2020

The kinase inhibitor SFV785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly

artículo científico publicado en 2011

The mevalonate pathway regulates primitive streak formation via protein farnesylation

artículo científico publicado en 2016

Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation

artículo científico publicado en 2020

Thiazolobenzyne: a versatile intermediate for multisubstituted benzothiazoles.

artículo científico publicado en 2016

Three-Component Coupling of Triflyloxy-Substituted Benzocyclobutenones, Organolithium Reagents, and Arynophiles Promoted by Generation of Aryne via Carbon-Carbon Bond Cleavage

artículo científico publicado en 2017

Three-Dimensional Localization of an Individual Fluorescent Molecule with Angstrom Precision.

artículo científico publicado en 2017

Transient Protection of Organic Azides from Click Reactions with Alkynes by Phosphazide Formation

artículo científico publicado en 2018

Transient protection of strained alkynes from click reaction via complexation with copper

artículo científico publicado en 2014

Triazole formation of phosphinyl alkynes with azides through transient protection of phosphine by copper

artículo científico publicado en 2020

Unconventional secretion of the mutated 19 kDa protein of Oplophorus luciferase (nanoKAZ) in mammalian cells

artículo científico publicado en 2014

[35S]S-[5-(4-benzoylphenyl)pentyl]glutathione: a versatile radioligand targeting GS-X pumps with the ability of photoaffinity labeling

artículo científico publicado en 1999

Lista de obras de Takamitsu Hosoya

(Hexafluoroacetylacetonato)copper(I)-cycloalkyne complexes as protected cycloalkynes

1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin beta, a substrate of parkin, and reduces its polyubiquitination.

11C-cetrozole: an improved C-11C-methylated PET probe for aromatase imaging in the brain.

2-Azidoacrylamides as compact platforms for efficient modular synthesis

3-Azidodifluoromethyl-3H-diazirin-3-yl group as an all-in-one functional group for radioisotope-free photoaffinity labeling

3-Thioaryne Intermediates for the Synthesis of Diverse Thioarenes

A facile preparation of functional cycloalkynes via an azide-to-cycloalkyne switching approach

A mild and facile synthesis of aryl and alkenyl sulfides via copper-catalyzed deborylthiolation of organoborons with thiosulfonates

A single starfish Aurora kinase performs the combined functions of Aurora-A and Aurora-B in human cells.

A study on an unusual SN2 mechanism in the methylation of benzyne through nickel-complexation.

An Alternative Method for Generating Arynes from ortho-Silylaryl Triflates: Activation by Cesium Carbonate in the Presence of a Crown Ether

An efficient generation method and remarkable reactivities of 3-triflyloxybenzyne

Application of new semisynthetic aequorins with long half-decay time of luminescence to G-protein-coupled receptor assay ⬇️

Aryne Relay Chemistry en Route to Aminoarenes: Synthesis of 3-Aminoaryne Precursors via Regioselective Silylamination of 3-(Triflyloxy)arynes

Assembly of four modules onto a tetraazide platform by consecutive 1,2,3-triazole formations

Association between aromatase in human brains and personality traits

Blood-brain barrier permeability of ginkgolide: Comparison of the behavior of PET probes 7α-[18F]fluoro- and 10-O-p-[11C]methylbenzyl ginkgolide B in monkey and rat brains

Boracene-based alkylborate enabled Ni/Ir hybrid catalysis

Boron-selective biaryl coupling approach to versatile dibenzoxaborins and application to concise synthesis of defucogilvocarcin M.

C6-Deoxy coelenterazine analogues as an efficient substrate for glow luminescence reaction of nanoKAZ: the mutated catalytic 19 kDa component of Oplophorus luciferase.

CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia

CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses

Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus

Chiral deaza-coelenterazine analogs for probing a substrate-binding site in the Ca2+-binding photoprotein aequorin

Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A

Comparison of pharmacokinetics of newly discovered aromatase inhibitors by a cassette microdosing approach in healthy Japanese subjects.

Concise Synthesis of v-Coelenterazines

Consecutive Aryne Generation Strategy for the Synthesis of 1,3-Diarylpyrazoles

Construction of Condensed Polycyclic Aromatic Frameworks through Intramolecular Cycloaddition Reactions Involving Arynes Bearing an Internal Alkyne Moiety

Convergent Synthesis of Fluoroalkenes Using a Dual-Reactive Unit

Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions

Copper-Catalyzed Regioselective Monodefluoroborylation of Polyfluoroalkenes en Route to Diverse Fluoroalkenes.

Crystal structure of nanoKAZ: The mutated 19 kDa component of Oplophorus luciferase catalyzing the bioluminescent reaction with coelenterazine

Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca2+ release from sarcoplasmic reticulum of mouse skeletal muscle.

Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis

Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle.

Detection of structural changes in a cofactor binding protein by using a wheat germ cell-free protein synthesis system coupled with unnatural amino acid probing

Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy

Development of bis-unsaturated ester aldehydes as amino-glue probes: sequential double azaelectrocyclization as a promising strategy for bioconjugation

Direct thioamination of arynes via reaction with sulfilimines and migratory N-arylation

Enhanced clickability of doubly sterically-hindered aryl azides.

Expression, purification and luminescence properties of coelenterazine-utilizing luciferases from Renilla, Oplophorus and Gaussia: comparison of substrate specificity for C2-modified coelenterazines

Facile assembly of three cycloalkyne-modules onto a platform compound bearing thiophene S,S-dioxide moiety and two azido groups

Further enhancement of the clickability of doubly sterically-hindered aryl azides by para-amino substitution

Generation of arynes via ate complexes of arylboronic esters with an ortho-leaving group

Generation of cycloheptynes and cyclooctynes via a sulfoxide-magnesium exchange reaction of readily synthesized 2-sulfinylcycloalkenyl triflates

Hydrosilyl Group-directed Iridium-catalyzed peri-Selective C–H Borylation of Ring-fused (Hetero)Arenes

IOP-lowering effect of isoquinoline-5-sulfonamide compounds in ocular normotensive monkeys

Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ.

Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice

Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids: PET study with [11C]vorozole.

Indolizines Enabling Rapid Uncaging of Alcohols and Carboxylic Acids by Red Light-Induced Photooxidation

Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.

Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation.

Investigation of the effect of active efflux at the blood–brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system ⬇️

Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface

Luminescence enhancement of the catalytic 19 kDa protein (KAZ) of Oplophorus luciferase by three amino acid substitutions.

Manipulation of alternative splicing by a newly developed inhibitor of Clks

Modular synthesis of bis- and tris-1,2,3-triazoles by permutable sequential azide-aryne and azide-alkyne cycloadditions

Neuroprotection by a central nervous system-type prostacyclin receptor ligand demonstrated in monkeys subjected to middle cerebral artery occlusion and reperfusion: a positron emission tomography study

Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalizations

PET of Aromatase in Gastric Parietal Cells Using 11C-Vorozole ⬇️

Palladium(0)-mediated rapid methylation and fluoromethylation on carbon frameworks by reacting methyl and fluoromethyl iodide with aryl and alkenyl boronic acid esters: useful for the synthesis of [11C]CH(3)--C- and [18F]FCH2--C-Containing PET trace

Palladium(ii)-mediated rapid C-cyanation of (hetero)arylborons

Palladium-catalyzed regio- and stereoselective hydrosilylation of electron-deficient alkynes

Pd(0)-Mediated rapid coupling between methyl iodide and heteroarylstannanes: an efficient and general method for the incorporation of a positron-emitting (11)C radionuclide into heteroaromatic frameworks.

Pd0-mediated rapid cross-coupling reactions, the rapid C-[11C]methylations, revolutionarily advancing the syntheses of short-lived PET molecular probes

Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice.

Preparation of Aryne–Nickel Complexes from ortho-Borylaryl Triflates

Quantification of receptor activation by oxytocin and vasopressin in endocytosis-coupled bioluminescence reduction assay using nanoKAZ.

Rapid methylation of terminal acetylenes by the Stille coupling of methyl iodide with alkynyltributylstannanes: a general protocol potentially useful for the synthesis of short-lived 11CH3-labeled PET tracers with a 1-propynyl group.

Rapid methylation on carbon frameworks useful for the synthesis of 11CH3-incorporated PET tracers: Pd(0)-mediated rapid coupling of methyl iodide with an alkenyltributylstannane leading to a 1-methylalkene

Reconstitution of blue fluorescent protein from recombinant apoaequorin and synthetic coelenteramide.

Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia

Rhodium-Catalyzed Decarbonylative Borylation of Aromatic Thioesters for Facile Diversification of Aromatic Carboxylic Acids.

Rhodium-Catalyzed ipso-Borylation of Alkylthioarenes via C-S Bond Cleavage.

Rhodium-catalyzed odorless synthesis of diaryl sulfides from borylarenes and S-aryl thiosulfonates.

Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039.