Lista de obras - Roger M. Phillips - Dominio Público Uruguay

3-substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro.

artículo científico publicado en 2003

A critical appraisal of the predictive value of in vitro chemosensitivity assays.

artículo científico

A hybrid cellular automaton model of solid tumor growth and bioreductive drug transport

artículo científico publicado en 2012

A novel strategy for NQO1 (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of EO9

artículo científico publicado en 2001

AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

artículo científico publicado en 2000

Analysis of cell-cycle kinetics and sulfur amino acid metabolism in methionine-dependent tumor cell lines; the effect of homocysteine supplementation.

artículo científico publicado en 2004

Anticancer metallohelices: nanomolar potency and high selectivity

artículo científico publicado en 2015

Asymmetric triplex metallohelices with high and selective activity against cancer cells.

artículo científico publicado en 2014

Avascular tumour growth dynamics and the constraints of protein binding for drug transportation.

artículo científico publicado en 2012

Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships.

artículo científico publicado en 1999

Bis-picolinamide Ruthenium(III) Dihalide Complexes: Dichloride-to-Diiodide Exchange Generates Single trans Isomers with High Potency and Cancer Cell Selectivity ⬇️

artículo científico publicado en 2017

Cannabinoid pharmacology in cancer research: A new hope for cancer patients?

artículo científico publicado en 2016

Carbophilic 3-component cascades: access to complex bioactive cyclopropyl diindolylmethanes.

artículo científico publicado en 2012

Cellular Uptake and Efflux of Palbociclib In Vitro in Single Cell and Spheroid Models

scientific article published on 12 June 2019

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group

artículo científico publicado en 2017

Characterization of changes in the proteome in different regions of 3D multicell tumor spheroids.

artículo científico publicado en 2012

Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1 targeted tripartite quinone drug delivery system.

artículo científico publicado en 2007

Comet assay and flow cytometry analysis of DNA repair in normal and cancer cells treated with known mutagens with different mechanisms of action.

artículo científico publicado en 2003

Corrigendum to “Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands” [Canc. Lett. 403 (2017) 98–107] ⬇️

scientific article published on 19 June 2018

Development and characterization of a microfluidic model of the tumour microenvironment

artículo científico publicado en 2016

Drug delivery in a tumour cord model: a computational simulation ⬇️

artículo científico publicado en 2017

Efficacy, pharmacokinetic and pharmacodynamic evaluation of apaziquone in the treatment of non-muscle invasive bladder cancer

artículo científico

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands.

artículo científico publicado en 2012

Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours.

artículo científico publicado en 1998

Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth.

artículo científico publicado en 2014

Evaluation of the anti-tumour action and acute toxicity of kosins from Hagenia abyssinica

artículo científico publicado en 1992

Experimental correlations of in vitro drug sensitivity with in vivo responses to ThioTEPA in a panel of murine colon tumours

artículo científico publicado en 1988

Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid).

artículo científico publicado en 1987

Flavone Acetic Acid: Is Vascular Shutdown the Crucial Mechanism of Action ⬇️

artículo científico publicado el 1 de julio de 1991

Genotyping of NAD(P)H:quinone oxidoreductase (NQO1) in a panel of human tumor xenografts: relationship between genotype status, NQO1 activity and the response of xenografts to Mitomycin C chemotherapy in vivo(1).

artículo científico publicado en 2001

Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies.

artículo científico publicado en 2007

Health care for all: effective, community supported, healthcare with innovative use of telemedicine technology.

artículo científico publicado en 2018

Hollow fiber assay for tumor angiogenesis

scientific article published on 01 January 2001

Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors

artículo científico publicado en 2014

Hypoxia-Sensitive Metal β-Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis ⬇️

artículo científico publicado en 2015

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

artículo científico publicado en 2014

Imatinib radiosensitizes bladder cancer by targeting homologous recombination.

artículo científico publicado en 2013

Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy.

artículo científico

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog

artículo científico publicado en 2014

In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity.

artículo científico publicado en 1992

In vitro and in vivo activity of LS 4477 and LS 4559, novel analogues of the tubulin binder estramustine.

artículo científico publicado en 2002

In vitro and in vivo responses of a panel of murine colon tumours to TCNU: a positive correlation

scientific article published on 01 August 1988

Inactivation of apaziquone by haematuria: implications for the design of phase III clinical trials against non-muscle invasive bladder cancer

artículo científico publicado en 2019

Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes. ⬇️

artículo científico publicado en 2016

Influence of drug exposure parameters on the activity of paclitaxel in multicellular spheroids

scientific article published on 01 July 1997

Influence of site on the chemosensitivity of transplantable murine colon tumours to flavone acetic acid (LM975, NSC 347512).

artículo científico publicado en 1989

Influence of the tissue distribution of ThioTEPA and its metabolite, TEPA, on the response of murine colon tumours

scientific article published on 01 January 1987

Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development

scientific article published on 01 July 1999

Intrinsic chemotherapy resistance to the tubulin-binding antimitotic agents in renal cell carcinoma.

artículo científico publicado en 2005

Mathematical and computational models of drug transport in tumours.

artículo científico

Measles virus causes immunogenic cell death in human melanoma.

artículo científico publicado en 2011

Mechanistic and cytotoxicity studies of group IV β-diketonate complexes.

artículo científico publicado en 2014

Methionine dependence of tumours: a biochemical strategy for optimizing paclitaxel chemosensitivity in vitro.

artículo científico publicado en 2006

Minor structural modifications to alchemix influence mechanism of action and pharmacological activity.

artículo científico publicado en 2012

NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide

artículo científico publicado en 2014

Obtaining archived pathological material for biomedical research.

artículo científico publicado en 2003

Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs

artículo científico publicado en 2004

Pharmacological approach towards the development of indolequinone bioreductive drugs based on the clinically inactive agent EO9.

artículo científico publicado en 2002

Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice

scientific article published on 01 April 2000

Plateau-phase cultures: an experimental model for identifying drugs which are bioactivated within the microenvironment of solid tumours.

artículo científico publicado en 1997

Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands ⬇️

artículo científico publicado en 2017

Response of multiple recurrent TaT1 bladder cancer to intravesical apaziquone (EO9): comparative analysis of tumor recurrence rates.

artículo científico publicado en 2009

Revisiting Bromohexitols as a Novel Class of Microenvironment-Activated Prodrugs for Cancer Therapy

scientific article published on 26 November 2019

Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents. ⬇️

artículo científico publicado en 2014

Ruthenium-Containing Linear Helicates and Mesocates with Tuneable p53-Selective Cytotoxicity in Colorectal Cancer Cells

artículo científico publicado en 2018

Selective in vitro anti-cancer activity of non-alkylating minor groove binders

scientific article published on 18 July 2019

Strategy for Imidazotetrazine Prodrugs with Anticancer Activity Independent of MGMT and MMR.

artículo científico publicado en 2012

Synthesis and anticancer activity evaluation of η(5)-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands.

artículo científico publicado en 2015

Synthesis and anticancer activity of silver(I)-N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine ⬇️

artículo científico publicado en 2015

Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents.

artículo científico publicado en 2001

Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53.

artículo científico publicado en 2013

Synthesis of cryptolepine analogues as potential bioreducible anticancer agents.

artículo científico publicado en 2007

Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents.

artículo científico publicado en 2012

Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs

artículo científico publicado en 2016

The relationship between the in vitro chemosensitivity of tumor cells and tumor response in vivo in an experimental tumor model

scientific article published on 01 March 1991

The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions

artículo científico publicado en 2000

Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds

artículo científico publicado en 2020

Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts

artículo científico publicado en 2003

Lista de obras de Roger M. Phillips

3-substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro.

A critical appraisal of the predictive value of in vitro chemosensitivity assays.

A hybrid cellular automaton model of solid tumor growth and bioreductive drug transport

A novel strategy for NQO1 (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of EO9

AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

Analysis of cell-cycle kinetics and sulfur amino acid metabolism in methionine-dependent tumor cell lines; the effect of homocysteine supplementation.

Anticancer metallohelices: nanomolar potency and high selectivity

Asymmetric triplex metallohelices with high and selective activity against cancer cells.

Avascular tumour growth dynamics and the constraints of protein binding for drug transportation.

Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships.

Bis-picolinamide Ruthenium(III) Dihalide Complexes: Dichloride-to-Diiodide Exchange Generates Single trans Isomers with High Potency and Cancer Cell Selectivity ⬇️

Cannabinoid pharmacology in cancer research: A new hope for cancer patients?

Carbophilic 3-component cascades: access to complex bioactive cyclopropyl diindolylmethanes.

Cellular Uptake and Efflux of Palbociclib In Vitro in Single Cell and Spheroid Models

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group

Characterization of changes in the proteome in different regions of 3D multicell tumor spheroids.

Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1 targeted tripartite quinone drug delivery system.

Comet assay and flow cytometry analysis of DNA repair in normal and cancer cells treated with known mutagens with different mechanisms of action.

Corrigendum to “Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands” [Canc. Lett. 403 (2017) 98–107] ⬇️

Development and characterization of a microfluidic model of the tumour microenvironment

Drug delivery in a tumour cord model: a computational simulation ⬇️

Efficacy, pharmacokinetic and pharmacodynamic evaluation of apaziquone in the treatment of non-muscle invasive bladder cancer

Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands.

Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours.

Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth.

Evaluation of the anti-tumour action and acute toxicity of kosins from Hagenia abyssinica

Experimental correlations of in vitro drug sensitivity with in vivo responses to ThioTEPA in a panel of murine colon tumours

Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid).

Flavone Acetic Acid: Is Vascular Shutdown the Crucial Mechanism of Action ⬇️

Genotyping of NAD(P)H:quinone oxidoreductase (NQO1) in a panel of human tumor xenografts: relationship between genotype status, NQO1 activity and the response of xenografts to Mitomycin C chemotherapy in vivo(1).

Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies.

Health care for all: effective, community supported, healthcare with innovative use of telemedicine technology.

Hollow fiber assay for tumor angiogenesis

Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors

Hypoxia-Sensitive Metal β-Ketoiminato Complexes Showing Induced Single-Strand DNA Breaks and Cancer Cell Death by Apoptosis ⬇️

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

Imatinib radiosensitizes bladder cancer by targeting homologous recombination.

Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy.

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog

In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity.

In vitro and in vivo activity of LS 4477 and LS 4559, novel analogues of the tubulin binder estramustine.

In vitro and in vivo responses of a panel of murine colon tumours to TCNU: a positive correlation

Inactivation of apaziquone by haematuria: implications for the design of phase III clinical trials against non-muscle invasive bladder cancer

Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes. ⬇️

Influence of drug exposure parameters on the activity of paclitaxel in multicellular spheroids

Influence of site on the chemosensitivity of transplantable murine colon tumours to flavone acetic acid (LM975, NSC 347512).

Influence of the tissue distribution of ThioTEPA and its metabolite, TEPA, on the response of murine colon tumours

Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development

Intrinsic chemotherapy resistance to the tubulin-binding antimitotic agents in renal cell carcinoma.

Mathematical and computational models of drug transport in tumours.

Measles virus causes immunogenic cell death in human melanoma.

Mechanistic and cytotoxicity studies of group IV β-diketonate complexes.

Methionine dependence of tumours: a biochemical strategy for optimizing paclitaxel chemosensitivity in vitro.

Minor structural modifications to alchemix influence mechanism of action and pharmacological activity.

NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide

Obtaining archived pathological material for biomedical research.

Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs

Pharmacological approach towards the development of indolequinone bioreductive drugs based on the clinically inactive agent EO9.

Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice

Plateau-phase cultures: an experimental model for identifying drugs which are bioactivated within the microenvironment of solid tumours.

Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands ⬇️

Response of multiple recurrent TaT1 bladder cancer to intravesical apaziquone (EO9): comparative analysis of tumor recurrence rates.

Revisiting Bromohexitols as a Novel Class of Microenvironment-Activated Prodrugs for Cancer Therapy

Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents. ⬇️

Ruthenium-Containing Linear Helicates and Mesocates with Tuneable p53-Selective Cytotoxicity in Colorectal Cancer Cells

Selective in vitro anti-cancer activity of non-alkylating minor groove binders

Strategy for Imidazotetrazine Prodrugs with Anticancer Activity Independent of MGMT and MMR.

Synthesis and anticancer activity evaluation of η(5)-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands.

Synthesis and anticancer activity of silver(I)-N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine ⬇️

Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents.

Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53.

Synthesis of cryptolepine analogues as potential bioreducible anticancer agents.

Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents.

Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs

The relationship between the in vitro chemosensitivity of tumor cells and tumor response in vivo in an experimental tumor model

The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions

Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds

Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts