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Lista de obras de Thomas Dick

1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity.

artículo científico publicado en 2017

A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis

artículo científico publicado en 2012

A novel F(420) -dependent anti-oxidant mechanism protects Mycobacterium tuberculosis against oxidative stress and bactericidal agents

artículo científico publicado en 2012

Advancing Translational Science for Pulmonary NTM Infections: A Roadmap for Research

artículo científico publicado en 2019

Amphiphilic Indole Derivatives as Antimycobacterial Agents: Structure-Activity Relationships and Membrane Targeting Properties

artículo científico publicado en 2017

Amphiphilic xanthones as a potent chemical entity of anti-mycobacterial agents with membrane-targeting properties

artículo científico publicado en 2016

Antibacterial Drug Discovery: Doing It Right

artículo científico publicado en 2015

Apparent growth phase-dependent phosphorylation of malonyl coenzyme A:acyl carrier protein transacylase (MCAT), a major fatty acid synthase II component in Mycobacterium bovis BCG.

artículo científico publicado en 2003

Bacterial and host-derived cationic proteins bind α2-laminins and enhance Mycobacterium leprae attachment to human Schwann cells

artículo científico publicado en 2000

Bedaquiline Eliminates Bactericidal Activity of β-Lactams against Mycobacterium abscessus

scientific article published on 25 July 2019

Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase

artículo científico publicado en 2016

Biochemical and structural characterization of the putative dihydropteroate synthase ortholog Rv1207 of Mycobacterium tuberculosis

artículo científico publicado en 2008

Boromycin Kills Mycobacterial Persisters without Detectable Resistance

artículo científico publicado en 2016

Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome.

artículo científico publicado en 2017

Characterization of phosphofructokinase activity in Mycobacterium tuberculosis reveals that a functional glycolytic carbon flow is necessary to limit the accumulation of toxic metabolic intermediates under hypoxia

artículo científico publicado en 2013

Chloramphenicol-induced translational activation of cat messenger RNA in vitro.

artículo científico publicado en 1990

Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis

artículo científico publicado en 2012

Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents

artículo científico publicado en 2014

Corrections to Structure−Activity Relationships of Antitubercular Nitroimidazoles. 2. Determinants of Aerobic Activity and Quantitative Structure−Activity Relationships

article published in 2009

Corrrection to Discovery of TetrahydropyrazolopyrimidineCarboxamide Derivatives As Potent and Orally Active Novel Antitubercular Agents.

artículo científico publicado en 2014

Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster

artículo científico publicado en 1996

Deletion of a unique loop in the mycobacterial F-ATP synthase γ subunit sheds light on its inhibitory role in ATP hydrolysis-driven H(+) pumping

artículo científico publicado en 2016

Dependence of expression of an inducible Staphylococcus aureus cat gene on the translation of its leader sequence.

artículo científico publicado en 1987

Design, synthesis, and biological evaluation of indole-2-carboxamides: a promising class of antituberculosis agents

artículo científico publicado en 2013

Detection and treatment of subclinical tuberculosis

article

Developmental transcriptome of resting cell formation in Mycobacterium smegmatis

artículo científico publicado en 2016

Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis

scientific article published on 14 November 2019

Draft Genome Sequence of Mycobacterium abscessus Bamboo

artículo científico publicado en 2017

Draft Genome Sequence of Mycobacterium avium 11.

artículo científico publicado en 2017

Drosophila DPP2C1, a novel member of the protein phosphatase 2C (PP2C) family

artículo científico publicado en 1997

Drug resistance among tuberculosis patients attending diagnostic and treatment centres in Makassar, Indonesia ⬇️

artículo científico publicado el 1 de abril de 2011

Eagle Effect in Nonreplicating Persister Mycobacteria

artículo científico publicado en 2015

Editorial: NTM-The New Uber-Bugs

scientific article published on 12 June 2019

Exploring the mode of action of bioactive compounds by microfluidic transcriptional profiling in mycobacteria

artículo científico publicado en 2013

Fragment-Based Whole Cell Screen Delivers Hits against M. tuberculosis and Non-tuberculous Mycobacteria

artículo científico publicado en 2016

Future target-based drug discovery for tuberculosis?

artículo científico

Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in

artículo científico publicado en 2019

Heterogeneity of Mycobacterium tuberculosis strains in Makassar, Indonesia.

artículo científico publicado en 2012

How Mycobacterium tuberculosis goes to sleep: the dormancy survival regulator DosR a decade later.

artículo científico

How antibacterials really work: impact on drug discovery.

artículo científico publicado en 2011

Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance

scientific article published on 23 September 2019

Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis

scientific journal article

Identification of new MmpL3 inhibitors by untargeted and targeted mutant screens defines MmpL3 domains with differential resistance

Impact of immunopathology on the antituberculous activity of pyrazinamide

artículo científico publicado en 2018

In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1.

artículo científico publicado en 2017

In vitro activities of mitomycin C against growing and hypoxic dormant tubercle bacilli.

artículo científico publicado en 2001

In vitro activity of the chelating agents nitroxoline and oxine against Mycobacterium bovis BCG.

artículo científico publicado en 2001

Increased alanine dehydrogenase activity during dormancy in Mycobacterium smegmatis

scientific journal article

Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis

artículo científico publicado en 2013

Indolyl Azaspiroketal Mannich Bases Are Potent Antimycobacterial Agents with Selective Membrane Permeabilizing Effects and in Vivo Activity.

artículo científico publicado en 2018

Indolylalkyltriphenylphosphonium Analogues Are Membrane-Depolarizing Mycobactericidal Agents.

artículo científico publicado en 2017

Inducibility of the Streptomyces traRts107-Ptra expression cassette in Mycobacterium smegmatis

scientific article published on 01 May 2000

Isoniazid resistance of exponentially growing Mycobacterium smegmatis biofilm culture

artículo científico publicado en 2003

Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis bacillus Calmette-Guerin

artículo científico publicado en 2010

Membrane-targeting AM-0016 kills mycobacterial persisters and shows low propensity for resistance development

artículo científico publicado en 2016

Metabolic flexibility and morphological plasticity in mycobacteria

artículo científico publicado en 2015

Mild Nutrient Starvation Triggers the Development of a Small-Cell Survival Morphotype in Mycobacteria.

artículo científico publicado en 2016

Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis

artículo científico publicado en 2016

Molecular genetic characterisation of whiB3, a mycobacterial homologue of a Streptomyces sporulation factor.

artículo científico publicado en 1999

Mycobacterial Caseinolytic Protease Gene Regulator ClgR Is a Substrate of Caseinolytic Protease

scientific article published on 15 March 2017

Mycobacterial Cell Wall Synthesis Inhibitors Cause Lethal ATP Burst

artículo científico publicado en 2018

Mycobacterium bovis BCG recA deletion mutant shows increased susceptibility to DNA-damaging agents but wild-type survival in a mouse infection model.

artículo científico publicado en 2001

Mycobacterium bovis BCG response regulator essential for hypoxic dormancy

artículo científico publicado en 2002

NTM drug discovery: status, gaps and the way forward.

artículo científico publicado en 2018

Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses

scientific journal article

Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability

artículo científico publicado en 2009

Overexpression, purification, enzymatic and microscopic characterization of recombinant mycobacterial F-ATP synthase

scientific article published on 21 November 2019

Peptide deformylase inhibitors as potent antimycobacterial agents.

artículo científico publicado en 2006

Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis

artículo científico publicado en 2014

Pharmacological and Molecular Mechanisms Behind the Sterilizing Activity of Pyrazinamide

scientific article published on 06 November 2019

Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance

artículo científico publicado en 2019

Positioning ribosomes on leader mRNA for translational activation of the message of an inducible Staphylococcus aureus cat gene.

artículo científico publicado en 1988

Proteins of Mycobacterium bovis BCG induced in the Wayne dormancy model

artículo científico publicado en 2001

Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis

artículo científico publicado en 2016

Pyrazinoic Acid Inhibits Mycobacterial Coenzyme A Biosynthesis by Binding to Aspartate Decarboxylase PanD.

artículo científico publicado en 2017

Re-Understanding the Mechanisms of Action of the Anti-Mycobacterial Drug Bedaquiline

artículo científico publicado en 2019

Reactive dirty fragments: implications for tuberculosis drug discovery.

artículo científico publicado en 2014

Recombinase-based reporter system and antisense technology to study gene expression and essentiality in hypoxic nonreplicating mycobacteria

artículo científico publicado en 2008

Reduced drug uptake in phenotypically resistant nutrient-starved nonreplicating Mycobacterium tuberculosis

artículo científico publicado en 2013

Rel Is Required for Morphogenesis of Resting Cells in Mycobacterium smegmatis

scientific article published on 31 August 2016

Repositioning rifamycins for Mycobacterium abscessus lung disease

artículo científico publicado en 2019

Resistance against membrane-inserting MmpL3 inhibitor through upregulation of MmpL5 in M. tuberculosis

scientific article published on 21 September 2020

Rifabutin Is Active against Mycobacterium abscessus Complex.

artículo científico publicado en 2017

Rifabutin Is Active against Mycobacterium abscessus in Mice

scientific article published on 27 January 2020

Role for malonyl coenzyme A:acyl carrier protein transacylase (MCAT) in the growth-inhibitory effect of the calmodulin antagonist trifluoperazine in Mycobacterium bovis BCG.

artículo científico publicado en 2004

Screening of TB Actives for Activity against Nontuberculous Mycobacteria Delivers High Hit Rates

artículo científico publicado en 2017

Spectrum of latent tuberculosis — existing tests cannot resolve the underlying phenotypes: author's reply

scientific article published in 2010

Structure and function of Mycobacterium-specific components of F-ATP synthase subunits α and ε

scientific article published on 17 October 2018

Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824

artículo científico publicado en 2012

Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824.

artículo científico publicado en 2013

Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships

artículo científico publicado en 2009

Structure-activity relationships of antitubercular nitroimidazoles. 3. Exploration of the linker and lipophilic tail of ((s)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-amino PA-824).

artículo científico publicado en 2011

Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles

artículo científico publicado en 2011

TB drug susceptibility is more than MIC

scientific article published on 01 September 2018

TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug's Uncoupler Activity

scientific article published on 27 January 2020

TBAJ-876 Retains Bedaquiline's Activity against Subunits c and ε of Mycobacterium tuberculosis F-ATP Synthase

scientific article published on 23 September 2019

TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Is Active against Mycobacterium abscessus

scientific article published on 24 March 2020

Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria

artículo científico publicado en 2015

Targeted protein degradation in antibacterial drug discovery?

scientific article published on 16 November 2019

Teicoplanin - Tigecycline Combination Shows Synergy Against Mycobacterium abscessus.

artículo científico publicado en 2018

The Mycobacterial Membrane: A Novel Target Space for Anti-tubercular Drugs

artículo científico publicado en 2018

The NMR solution structure of Mycobacterium tuberculosis F-ATP synthase subunit ε provides new insight into energy coupling inside the rotary engine.

artículo científico publicado en 2018

The new tuberculosis drug Perchlozone® shows cross-resistance with thiacetazone

scientific article published on 03 February 2015

The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

artículo científico publicado en 2008

The role of a Drosophila POU homeo domain gene in the specification of neural precursor cell identity in the developing embryonic central nervous system

artículo científico publicado en 1993

The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

artículo científico publicado en 2009

The uniqueness of subunit α of mycobacterial F-ATP synthases: An evolutionary variant for niche adaptation.

artículo científico publicado en 2017

Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism

scientific article published on 29 August 2019

Towards Selective Mycobacterial ClpP1P2 Inhibitors with Reduced Activity against the Human Proteasome

artículo científico publicado en 2017

Triacylglycerol utilization is required for regrowth of in vitro hypoxic nonreplicating Mycobacterium bovis bacillus Calmette-Guerin

artículo científico publicado en 2009

Unique structural and mechanistic properties of mycobacterial F-ATP synthases: Implications for drug design

artículo científico publicado en 2019

Upregulation of stress response genes and ABC transporters in anaerobic stationary-phase Mycobacterium smegmatis.

artículo científico

Vancomycin and Clarithromycin Show Synergy against Mycobacterium abscessus In Vitro.

artículo científico publicado en 2017

Variations of Subunit   of the Mycobacterium tuberculosis F1Fo ATP Synthase and a Novel Model for Mechanism of Action of the Tuberculosis Drug TMC207

artículo científico publicado en 2013

Verapamil targets membrane energetics in Mycobacterium tuberculosis

artículo científico publicado en 2018

Vitamin B6 biosynthesis is essential for survival and virulence of Mycobacterium tuberculosis

scientific journal article

Whole cell screen of fragment library identifies gut microbiota metabolite indole propionic acid as antitubercular

artículo científico publicado en 2017

para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis

artículo científico publicado en 2013

para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase inMycobacterium tuberculosis

artículo científico publicado en 2013

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