Lista de obras - Carmen Blanco-Aparicio - Dominio Público Uruguay

A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis

artículo científico publicado en 2022

A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes

artículo científico publicado en 2014

A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase

artículo científico publicado en 1999

Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation

artículo científico publicado en 2008

Anti-tumor effects of PIM/PI3K/mTOR triple kinase inhibitor IBL-302 in neuroblastoma

scientific article published on 01 January 2020

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

artículo científico publicado en 2015

Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia

artículo científico publicado en 2013

Correction: Conditional Transgenic Expression of PIM1 Kinase in Prostate Induces Inflammation-Dependent Neoplasia.

artículo científico publicado en 2013

Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors

artículo científico publicado en 2019

Disruptive chemicals, senescence and immortality

artículo científico publicado en 2015

Down-regulation of spinophilin in lung tumours contributes to tumourigenesis

artículo científico publicado en 2011

ETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis.

artículo científico publicado en 2016

Exome sequencing of plasma DNA portrays the mutation landscape of colorectal cancer and discovers mutated VEGFR2 receptors as modulators of anti-angiogenic therapies.

artículo científico publicado en 2018

Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models

artículo científico publicado en 2010

Extreme sensitivity to Yondelis® (Trabectedin, ET-743) in low passaged sarcoma cell lines correlates with mutated p53

artículo científico publicado en 2007

Genetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and Carcinogens.

artículo científico publicado en 2014

Genetic modelling of the PTEN/AKT pathway in cancer research

artículo científico publicado en 2008

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

artículo científico publicado en 2020

Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors

artículo científico publicado en 2012

Identification of novel PI3K inhibitors through a scaffold hopping strategy.

artículo científico publicado en 2017

Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells

artículo científico publicado en 2020

Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus.

artículo científico publicado en 2017

Inhibiting PI3K as a therapeutic strategy against cancer

scientific article published on September 2009

Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts

artículo científico publicado en 2017

Inhibition of phosphatidylinositol-3-kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria

artículo científico publicado en 2005

Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis

artículo científico publicado en 2014

Levels of p27(kip1) determine Aplidin sensitivity

artículo científico publicado en 2007

Lysosomal trapping of palbociclib and its functional implications

artículo científico publicado en 2019

MAP17 enhances the malignant behavior of tumor cells through ROS increase

artículo científico publicado en 2007

MAP17 overexpression is a common characteristic of carcinomas

artículo científico publicado en 2007

Mechanism of action of potato carboxypeptidase inhibitor (PCI) as an EGF blocker

artículo científico publicado en 2005

Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer

Modulation of telomere protection by the PI3K/AKT pathway

artículo científico publicado en 2017

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate

artículo científico

Multiple cancer pathways regulate telomere protection

artículo científico publicado en 2019

Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway.

artículo científico publicado en 2014

PIM kinases as potential therapeutic targets in a subset of peripheral T cell lymphoma cases.

artículo científico publicado en 2014

PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma

artículo científico publicado en 2011

PTEN, more than the AKT pathway

artículo científico publicado en 2007

Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition

artículo científico publicado en 2010

Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities ⬇️

artículo científico publicado el 5 de octubre de 2012

Potato Carboxypeptidase Inhibitor, a T-knot Protein, Is an Epidermal Growth Factor Antagonist That Inhibits Tumor Cell Growth ⬇️

artículo científico publicado el 15 de mayo de 1998

Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer

artículo científico publicado en 2020

Protein similarities beyond disulphide bridge topology

artículo científico publicado en 1998

Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR.

artículo científico publicado en 2012

Regulation of MAPK cascades by protein tyrosine phosphatases.

artículo científico publicado en 2004

S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis.

artículo científico publicado en 2008

Screening protocol for the identification of modulators by immunofluorescent cell-based assay

artículo científico publicado en 2019

Simultaneous inhibition of pan-phosphatidylinositol-3-kinases and MEK as a potential therapeutic strategy in peripheral T-cell lymphomas.

artículo científico publicado en 2012

Spinophilin loss contributes to tumorigenesis in vivo

artículo científico publicado en 2011

The PIM family of serine/threonine kinases in cancer

artículo científico

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

artículo científico publicado en 2008

The essential role of PIM kinases in sarcoma growth and bone invasion

artículo científico publicado en 2012

The mTOR pathway is necessary for survival of mice with short telomeres

artículo científico publicado en 2020

The role of PIM1/PIM2 kinases in tumors of the male reproductive system

artículo científico publicado en 2016

The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status

scientific article published on 28 November 2019

Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage

artículo científico publicado en 2015

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo.

artículo científico publicado en 2016

Two clusters of residues at the docking groove of mitogen-activated protein kinases differentially mediate their functional interaction with the tyrosine phosphatases PTP-SL and STEP.

artículo científico publicado en 2001

p38α limits the contribution of MAP17 to cancer progression in breast tumors

artículo científico publicado en 2012

Lista de obras de Carmen Blanco-Aparicio

A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis

A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes

A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase

Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation

Anti-tumor effects of PIM/PI3K/mTOR triple kinase inhibitor IBL-302 in neuroblastoma

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia

Correction: Conditional Transgenic Expression of PIM1 Kinase in Prostate Induces Inflammation-Dependent Neoplasia.

Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors

Disruptive chemicals, senescence and immortality

Down-regulation of spinophilin in lung tumours contributes to tumourigenesis

ETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis.

Exome sequencing of plasma DNA portrays the mutation landscape of colorectal cancer and discovers mutated VEGFR2 receptors as modulators of anti-angiogenic therapies.

Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models

Extreme sensitivity to Yondelis® (Trabectedin, ET-743) in low passaged sarcoma cell lines correlates with mutated p53

Genetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and Carcinogens.

Genetic modelling of the PTEN/AKT pathway in cancer research

Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases

Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors

Identification of novel PI3K inhibitors through a scaffold hopping strategy.

Induction of Lysosome Membrane Permeabilization as a Therapeutic Strategy to Target Pancreatic Cancer Stem Cells

Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus.

Inhibiting PI3K as a therapeutic strategy against cancer

Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts

Inhibition of phosphatidylinositol-3-kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria

Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis

Levels of p27(kip1) determine Aplidin sensitivity

Lysosomal trapping of palbociclib and its functional implications

MAP17 enhances the malignant behavior of tumor cells through ROS increase

MAP17 overexpression is a common characteristic of carcinomas

Mechanism of action of potato carboxypeptidase inhibitor (PCI) as an EGF blocker

Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer

Modulation of telomere protection by the PI3K/AKT pathway

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate

Multiple cancer pathways regulate telomere protection

Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway.

PIM kinases as potential therapeutic targets in a subset of peripheral T cell lymphoma cases.

PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma

PTEN, more than the AKT pathway

Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition

Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities ⬇️

Potato Carboxypeptidase Inhibitor, a T-knot Protein, Is an Epidermal Growth Factor Antagonist That Inhibits Tumor Cell Growth ⬇️

Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer

Protein similarities beyond disulphide bridge topology

Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR.

Regulation of MAPK cascades by protein tyrosine phosphatases.

S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis.

Screening protocol for the identification of modulators by immunofluorescent cell-based assay

Simultaneous inhibition of pan-phosphatidylinositol-3-kinases and MEK as a potential therapeutic strategy in peripheral T-cell lymphomas.

Spinophilin loss contributes to tumorigenesis in vivo

The PIM family of serine/threonine kinases in cancer

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

The essential role of PIM kinases in sarcoma growth and bone invasion

The mTOR pathway is necessary for survival of mice with short telomeres

The role of PIM1/PIM2 kinases in tumors of the male reproductive system

The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status

Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo.

Two clusters of residues at the docking groove of mitogen-activated protein kinases differentially mediate their functional interaction with the tyrosine phosphatases PTP-SL and STEP.

p38α limits the contribution of MAP17 to cancer progression in breast tumors