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Lista de obras de Miguel A Castanho

A New Noncanonical Anionic Peptide That Translocates a Cellular Blood-Brain Barrier Model.

artículo científico publicado en 2017

A Protocol to Evaluate Retinal Vascular Response Using Optical Coherence Tomography Angiography.

artículo científico publicado en 2019

A focus on glucose-mediated drug delivery to the central nervous system.

artículo científico

A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion

artículo científico publicado en 2013

A photophysical study of the polyene antibiotic filipin. Self-aggregation and filipin--ergosterol interaction.

artículo científico publicado en 2001

Absorption and fluorescence spectra of polyene antibiotics in the presence of cholesterol

artículo científico publicado en 1992

Amidated and Ibuprofen-Conjugated Kyotorphins Promote Neuronal Rescue and Memory Recovery in Cerebral Hypoperfusion Dementia Model

artículo científico publicado en 2016

An insight on the leading HIV entry inhibitors.

scientific article published on January 2006

An overview of the biophysical applications of atomic force microscopy.

artículo científico publicado en 2004

Anti-HIV-1 Activity of pepRF1, a Proteolysis-Resistant CXCR4 Antagonist Derived from Dengue Virus Capsid Protein

scientific article published on 15 December 2020

Anti-HIV-1 antibodies 2F5 and 4E10 interact differently with lipids to bind their epitopes.

artículo científico publicado en 2011

Antibody Approaches To Treat Brain Diseases

Anticancer Peptides: Prospective Innovation in Cancer Therapy

article

Anticancer peptide SVS-1: efficacy precedes membrane neutralization

artículo científico publicado en 2012

Antimicrobial peptide rBPI21: a translational overview from bench to clinical studies

artículo científico publicado en 2012

Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations.

artículo científico publicado en 2009

Antimicrobial protein rBPI21-induced surface changes on Gram-negative and Gram-positive bacteria

artículo científico publicado en 2013

Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics

artículo científico publicado en 2014

Arginine-rich self-assembling peptides as potent antibacterial gels

artículo científico publicado en 2012

Biomedical applications of dipeptides and tripeptides.

artículo científico

Bioorthogonal Strategy for Bioprocessing of Specific-Site-Functionalized Enveloped Influenza-Virus-Like Particles

artículo científico publicado en 2016

Biophysics meets membrane-active peptides

artículo científico publicado en 2008

Broad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides.

artículo científico publicado en 2017

Brownian dynamics simulation of the unsaturated lipidic molecules oleic and docosahexaenoic acid confined in a cellular membrane

artículo científico publicado en 2002

Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix-Loop-Helix Peptides with Cell Penetrating and Tumor Suppressor Properties

artículo científico publicado en 2019

Cell-penetrating peptides and antimicrobial peptides: how different are they?

artículo científico publicado en 2006

Cell-penetrating peptides: A tool for effective delivery in gene-targeted therapies

artículo científico publicado en 2014

Challenging metastatic breast cancer with the natural defensin PvD1.

artículo científico publicado en 2017

Chemical conjugation of the neuropeptide kyotorphin and ibuprofen enhances brain targeting and analgesia.

artículo científico publicado en 2011

Chiral Recognition ofD-Kyotorphin by Lipidic Membranes: Relevance Toward Improved Analgesic Efficiency

article

Conformation and dynamic properties of a saturated hydrocarbon chain confined in a model membrane: a Brownian dynamics simulation

scientific article published on 01 January 2000

Conjugation of cholesterol to HIV-1 fusion inhibitor C34 increases peptide-membrane interactions potentiating its action

artículo científico publicado en 2013

Consequences of Nonlytic Membrane Perturbation to the Translocation of the Cell Penetrating Peptide Pep-1 in Lipidic Vesicles†

artículo científico publicado en 2004

Continuous particle size distribution analysis with dynamic light scattering. MAXAMPER: a regularization method using the maximum amplitude for the average error and the Lagrange's multipliers method.

artículo científico publicado en 1998

Correlation between membrane translocation and analgesic efficacy in kyotorphin derivatives.

artículo científico publicado en 2015

DPepH3, an Improved Peptide Shuttle for Receptor-independent Transport across the Blood-Brain Barrier

artículo científico publicado en 2020

Decoding distinct membrane interactions of HIV-1 fusion inhibitors using a combined atomic force and fluorescence microscopy approach ⬇️

artículo científico publicado el 15 de marzo de 2013

Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities

artículo científico publicado en 2011

Dengue Virus Capsid Protein Interacts Specifically with Very Low-Density Lipoproteins

artículo científico publicado en 2014

Dengue virus capsid protein binding to hepatic lipid droplets (LD) is potassium ion dependent and is mediated by LD surface proteins

artículo científico publicado en 2011

Dengue virus capsid protein interacts specifically with very low-density lipoproteins

artículo científico publicado en 2013

Design and characterization of novel antimicrobial peptides, R-BP100 and RW-BP100, with activity against Gram-negative and Gram-positive bacteria.

artículo científico publicado en 2012

Developing students' awareness of public understanding of science: A matter of survival?

artículo científico publicado en 2005

Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors

artículo científico publicado en 2016

Does aliphatic chain length influence carbocyanines' orientation in supported lipid multilayers?

artículo científico publicado en 2004

Dps from Deinococcus radiodurans: oligomeric forms of Dps1 with distinct cellular functions and Dps2 involved in metal storage.

artículo científico publicado en 2015

Effective in Vivo Targeting of Influenza Virus through a Cell-Penetrating/Fusion Inhibitor Tandem Peptide Anchored to the Plasma Membrane

artículo científico publicado en 2018

Effects of Diabetes on Microcirculation and Leukostasis in Retinal and Non-Ocular Tissues: Implications for Diabetic Retinopathy

artículo científico publicado en 2020

Effects of singlet oxygen generated by a broad-spectrum viral fusion inhibitor on membrane nanoarchitecture

artículo científico publicado en 2015

Endothelium-Mediated Action of Analogues of the Endogenous Neuropeptide Kyotorphin (Tyrosil-Arginine): Mechanistic Insights from Permeation and Effects on Microcirculation.

artículo científico publicado en 2016

Energy-independent translocation of cell-penetrating peptides occurs without formation of pores. A biophysical study with pep-1

artículo científico publicado en 2007

Enfuvirtide effects on human erythrocytes and lymphocytes functional properties.

artículo científico publicado en 2008

Enfuvirtide-Protoporphyrin IX Dual-Loaded Liposomes: In Vitro Evidence of Synergy against HIV-1 Entry into Cells

scientific article published on 19 December 2019

Escherichia coli cell surface perturbation and disruption induced by antimicrobial peptides BP100 and pepR

artículo científico publicado en 2010

Evaluation of lipopolysaccharide aggregation by light scattering spectroscopy.

artículo científico publicado en 2003

Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.

artículo científico publicado en 2012

Fast NMR method to probe solvent accessibility and disordered regions in proteins

scientific article published in Scientific Reports

Fast membrane association is a crucial factor in the peptide pep-1 translocation mechanism: a kinetic study followed by surface plasmon resonance

artículo científico publicado en 2010

Filipin and its interaction with cholesterol in aqueous media studied using static and dynamic light scattering

artículo científico publicado en 1994

Filipin fluorescence quenching by spin-labeled probes: studies in aqueous solution and in a membrane model system

artículo científico publicado en 1995

Filipin orientation revealed by linear dichroism. Implication for a model of action.

artículo científico publicado en 2004

Filipin-induced lesions in planar phospholipid bilayers imaged by atomic force microscopy

artículo científico publicado en 1998

Fluorescence quenching data interpretation in biological systems. The use of microscopic models for data analysis and interpretation of complex systems

artículos científicos

Fluorescence study of a derivatized diacylglycerol incorporated in model membranes

artículo científico publicado en 1994

Fold-unfold transitions in the selectivity and mechanism of action of the N-terminal fragment of the bactericidal/permeability-increasing protein (rBPI(21)).

artículo científico publicado en 2009

From antimicrobial to anticancer peptides. A review

artículo científico publicado en 2013

Fusing simulation and experiment: The effect of mutations on the structure and activity of the influenza fusion peptide

artículo científico publicado en 2016

Guar gum as a new antimicrobial peptide delivery system against diabetic foot ulcers Staphylococcus aureus isolates.

artículo científico publicado en 2016

HIV-1 fusion inhibitor peptides enfuvirtide and T-1249 interact with erythrocyte and lymphocyte membranes

artículo científico publicado en 2010

Hepatitis C virus core protein binding to lipid membranes: the role of domains 1 and 2.

artículo científico publicado en 2007

How to address CPP and AMP translocation? Methods to detect and quantify peptide internalization in vitro and in vivo (Review).

artículo científico publicado en 2007

Improvement of HIV fusion inhibitor C34 efficacy by membrane anchoring and enhanced exposure.

scientific article published on 23 January 2014

In Vivo Efficacy of Measles Virus Fusion Protein-Derived Peptides Is Modulated by the Properties of Self-Assembly and Membrane Residence

artículo científico publicado en 2016

In vitro blood-brain barrier models--latest advances and therapeutic applications in a chronological perspective.

artículo científico publicado en 2010

Inhibition of nociceptive responses after systemic administration of amidated kyotorphin

artículo científico publicado en 2011

Interaction between dengue virus fusion peptide and lipid bilayers depends on peptide clustering

artículo científico publicado en 2008

Interaction of antimicrobial peptides, BP100 and pepR, with model membrane systems as explored by Brownian dynamics simulations on a coarse-grained model

artículo científico publicado en 2012

Interaction of the Dengue virus fusion peptide with membranes assessed by NMR: The essential role of the envelope protein Trp101 for membrane fusion

artículo científico publicado en 2009

Intracellular nucleic acid delivery by the supercharged dengue virus capsid protein

artículo científico publicado en 2013

Is PrP(106-126) fragment involved in the membrane activity of the Prion protein?

artículo científico publicado en 2010

Joint determination by Brownian dynamics and fluorescence quenching of the in-depth location profile of biomolecules in membranes

artículo científico publicado en 2002

Lipid membrane-induced optimization for ligand-receptor docking: recent tools and insights for the "membrane catalysis" model.

artículo científico publicado en 2005

Lipidic membranes are potential "catalysts" in the ligand activity of the multifunctional pentapeptide neokyotorphin.

artículo científico publicado en 2005

Mechanisms of Vesicular Stomatitis Virus Inactivation by Protoporphyrin IX, Zinc-Protoporphyrin IX, and Mesoporphyrin IX.

artículo científico publicado en 2017

Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn(15-34), antimicrobial peptides from rattlesnake venom

artículo científico publicado en 2017

Meeting Report â Biochemical Education at the University Level, Lisbon, Portugal, October 30â 31, 1999

article

Molecular interaction studies of peptides using steady-state fluorescence intensity. Static (de)quenching revisited.

artículo científico publicado en 2008

Monitoring antibacterial permeabilization in real time using time-resolved flow cytometry

artículo científico publicado en 2014

N-terminal AH2 segment of protein NS4B from hepatitis C virus. Binding to and interaction with model biomembranes.

artículo científico publicado en 2013

Neuropeptide Kyotorphin (Tyrosyl-Arginine) has Decreased Levels in the Cerebro-Spinal Fluid of Alzheimer's Disease Patients: Potential Diagnostic and Pharmacological Implications.

artículo científico publicado en 2013

Neuropeptide Kyotorphin Impacts on Lipopolysaccharide-Induced Glucocorticoid-Mediated Inflammatory Response. A Molecular Link to Nociception, Neuroprotection, and Anti-Inflammatory Action.

artículo científico publicado en 2017

New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins

artículo científico publicado en 2017

Novel Peptides Derived from Dengue Virus Capsid Protein Translocate Reversibly the Blood-Brain Barrier through a Receptor-Free Mechanism

artículo científico publicado en 2017

Nucleic acid delivery by cell penetrating peptides derived from dengue virus capsid protein: design and mechanism of action

artículo científico publicado en 2013

Omiganan interaction with bacterial membranes and cell wall models. Assigning a biological role to saturation

artículo científico publicado en 2007

Omiganan pentahydrochloride in the front line of clinical applications of antimicrobial peptides

artículo científico publicado en 2006

Optical coherence tomography angiography study of the retinal vascular plexuses in type 1 diabetes without retinopathy

scientific article published on 04 July 2019

Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects

artículo científico publicado en 2021

Peptibodies: An elegant solution for a long-standing problem.

artículo científico publicado en 2017

Peptide Drug Discovery and Development

article

Peptides as models for the structure and function of viral capsid proteins: Insights on dengue virus capsid

artículo científico publicado en 2013

Pharmacological Potential of the Endogenous Dipeptide Kyotorphin and Selected Derivatives.

artículo científico publicado en 2016

Phosphatidylethanolamine binding is a conserved feature of cyclotide-membrane interactions

artículo científico publicado en 2012

Plant defensin PvD1 modulates the membrane composition of breast tumour-derived exosomes

scientific article published on 03 December 2019

PrP(106-126) does not interact with membranes under physiological conditions

artículo científico publicado en 2008

Prediction of antibacterial activity from physicochemical properties of antimicrobial peptides.

artículo científico publicado en 2011

Preface: The invitation of the CERC3 to organize a "Young Chemists' Workshop"

artículo científico publicado en 2006

Putative role of membranes in the HIV fusion inhibitor enfuvirtide mode of action at the molecular level

artículo científico publicado en 2004

Quantifying molecular partition into model systems of biomembranes: an emphasis on optical spectroscopic methods.

artículo científico publicado en 2003

Quantifying molecular partition of cell-penetrating peptide-cargo supramolecular complexes into lipid membranes: optimizing peptide-based drug delivery systems

artículo científico publicado en 2013

Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance

artículo científico publicado en 2017

Quantitative assessment of peptide-lipid interactions. Ubiquitous fluorescence methodologies.

artículo científico publicado en 2010

Receptors and routes of dengue virus entry into the host cells

artículo científico publicado en 2014

Rethinking the capsid proteins of enveloped viruses: multifunctionality from genome packaging to genome transfection

artículo científico

Rod-like cholesterol micelles in aqueous solution studied using polarized and depolarized dynamic light scattering

artículo científico publicado en 1992

Shifting gear in antimicrobial and anticancer peptides biophysical studies: from vesicles to cells

artículo científico publicado en 2015

Shiga toxin B-subunit sequential binding to its natural receptor in lipid membranes

artículo científico publicado en 2006

Sifuvirtide screens rigid membrane surfaces. establishment of a correlation between efficacy and membrane domain selectivity among HIV fusion inhibitor peptides.

artículo científico publicado en 2008

Simulation of the distribution and diffusion of a rigid amphipathic particle embedded in a model membrane

artículo científico publicado en 1999

Singlet oxygen effects on lipid membranes: implications for the mechanism of action of broad-spectrum viral fusion inhibitors

artículo científico publicado en 2014

Structural Studies of a Lipid-Binding Peptide from Tunicate Hemocytes with Anti-Biofilm Activity

artículo científico publicado en 2016

Structural characterization of organized systems of polysaccharides and phospholipids by light scattering spectroscopy and electron microscopy

article by Nuno C. Santos et al published May 1997 in Carbohydrate Research

Structure-Stability-Function Mechanistic Links in the Anti-Measles Virus Action of Tocopherol-Derivatized Peptide Nanoparticles

artículo científico publicado en 2018

Synergistic effects of the membrane actions of cecropin-melittin antimicrobial hybrid peptide BP100

artículo científico publicado en 2009

Synthesis and Characterization of Peptide-Chitosan Conjugates (PepChis) with Lipid Bilayer Affinity and Antibacterial Activity

artículo científico publicado en 2019

Targeting Zika Virus with New Brain- and Placenta-Crossing Peptide–Porphyrin Conjugates

artículo científico publicado en 2022

Teaching light scattering spectroscopy: the dimension and shape of tobacco mosaic virus

artículo científico publicado en 1996

The Application of Biophysical Techniques to Study Antimicrobial Peptides

article published in 2012

The Challenge of Peptide Proteolytic Stability Studies: Scarce Data, Difficult Readability, and the Need for Harmonization

artículo científico publicado en 2020

The Mechanism of Action of Antimicrobial Peptides: Lipid Vesicles vs. Bacteria

artículo científico publicado en 2012

The Use of Visual Analog Scales to Compare Pain Between Patients With Alzheimer's Disease and Patients Without Any Known Neurodegenerative Disease and Their Caregivers

artículo científico publicado en 2013

The anti-inflammatory action of the analgesic kyotorphin neuropeptide derivatives: insights of a lipid-mediated mechanism.

artículo científico publicado en 2015

The antimicrobial activity of Sub3 is dependent on membrane binding and cell-penetrating ability

artículo científico publicado en 2013

The disordered N-terminal region of dengue virus capsid protein contains a lipid-droplet-binding motif

artículo científico publicado en 2012

The influence of cholesterol on the interaction of HIV gp41 membrane proximal region-derived peptides with lipid bilayers

article

The mechanism of action of pepR, a viral-derived peptide, against Staphylococcus aureus biofilms

scientific article published on 01 September 2019

The mechanisms and quantification of the selective permeability in transport across biological barriers: the example of kyotorphin.

artículo científico publicado en 2014

The membranes' role in the HIV-1 neutralizing monoclonal antibody 2F5 mode of action needs re-evaluation.

artículo científico publicado en 2006

The pentaene macrolide antibiotic filipin prefers more rigid DPPC bilayers: a fluorescence pressure dependence study

artículo científico publicado en 1999

The role of blood cell membrane lipids on the mode of action of HIV-1 fusion inhibitor sifuvirtide

article

The toxicity of prion protein fragment PrP(106-126) is not mediated by membrane permeabilization as shown by a M112W substitution

artículo científico publicado en 2009

The transverse location of the fluorescent probe trans-parinaric acid in lipid bilayers

artículo científico publicado en 1996

Translocating the blood-brain barrier using electrostatics

artículo científico publicado en 2012

Translocation or membrane disintegration? Implication of peptide-membrane interactions in pep-1 activity

scientific article published on April 2008

Understanding Dengue Virus Capsid Protein Interaction with Key Biological Targets

artículo científico publicado en 2015

Understanding dengue virus capsid protein disordered N-Terminus and pep14-23-based inhibition

artículo científico publicado en 2014

Unravelling the molecular basis of the selectivity of the HIV-1 fusion inhibitor sifuvirtide towards phosphatidylcholine-rich rigid membranes.

artículo científico publicado en 2010

Using zeta-potential measurements to quantify peptide partition to lipid membranes

artículo científico publicado en 2011

What can light scattering spectroscopy do for membrane-active peptide studies?

artículo científico publicado en 2008

Why are HIV-1 fusion inhibitors not effective against SARS-CoV? Biophysical evaluation of molecular interactions.

artículo científico publicado en 2005

rBPI(21) promotes lipopolysaccharide aggregation and exerts its antimicrobial effects by (hemi)fusion of PG-containing membranes

artículo científico publicado en 2009

rBPI21 interacts with negative membranes endothermically promoting the formation of rigid multilamellar structures.

artículo científico publicado en 2013

siRNA-cell-penetrating peptides complexes as a combinatorial therapy against chronic myeloid leukemia using BV173 cell line as model.

artículo científico publicado en 2016

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