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Lista de obras de Benjamin Cravatt III

"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates

artículo científico publicado en 2017

(P2) Activity-Based Proteomics–Applications for Enzyme and Inhibitor Discovery

(−)‐FR182877 Is a Potent and Selective Inhibitor of Carboxylesterase‐1 ⬇️

artículo científico publicado el 17 de noviembre de 2003

3-Oxo-β-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling

scientific article published on 20 March 2020

A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex

scientific article published on 11 February 2020

A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex

artículo científico publicado en 2020

A FAAH-regulated class of N-acyl taurines that activates TRP ion channels

artículo científico publicado en 2006

A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells.

artículo científico publicado en 2015

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells

artículo científico publicado en 2019

A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A.

artículo científico publicado en 2017

A brain detoxifying enzyme for organophosphorus nerve poisons

artículo científico publicado en 2005

A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines

artículo científico publicado en 2016

A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation

artículo científico publicado en 2016

A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles

artículo científico publicado en 2013

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

artículo científico publicado en 2007

A fluopol-ABPP HTS assay to identify PAD inhibitors ⬇️

artículo científico publicado el 25 de agosto de 2010

A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases

artículo científico publicado en 2007

A masked zinger to block GPX4

scientific article published on 30 March 2020

A missense mutation in human fatty acid amide hydrolase associated with problem drug use.

artículo científico publicado en 2002

A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis

artículo científico publicado en 2011

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

artículo científico publicado en 2014

A second fatty acid amide hydrolase with variable distribution among placental mammals

artículo científico publicado en 2006

A small molecule accelerates neuronal differentiation in the adult rat.

artículo científico publicado en 2010

A streamlined platform for high-content functional proteomics of primary human specimens

artículo científico publicado en 2005

A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors

artículo científico publicado en 2011

A suite of activity-based probes for human cytochrome P450 enzymes

artículo científico publicado en 2009

A tandem orthogonal proteolysis strategy for high-content chemical proteomics

artículo científico publicado en 2005

ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease

artículo científico publicado en 2020

ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC

scientific journal article

ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth

artículo científico publicado en 2021

ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system

artículo científico publicado en 2015

ABHD4-dependent developmental anoikis safeguards the embryonic brain

scientific article published on 31 August 2020

ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice

artículo científico publicado en 2014

AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs

artículo científico publicado en 2016

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

artículo científico publicado en 2011

Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos

artículo científico publicado en 2010

Activation of the endocannabinoid system by organophosphorus nerve agents

artículo científico publicado en 2008

Activity-Based Protein Profiling (ABPP) and Click Chemistry (CC)-ABPP by MudPIT Mass Spectrometry

artículo científico publicado en 2009

Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer

artículo científico publicado en 2015

Activity-based labeling of matrix metalloproteinases in living vertebrate embryos

artículo científico publicado en 2012

Activity-based probes for monitoring postproline protease activity

artículo científico publicado en 2009

Activity-based probes for proteomic profiling of histone deacetylase complexes

artículo científico publicado en 2007

Activity-based probes for the proteomic profiling of metalloproteases

artículo científico publicado en 2004

Activity-based probes that target functional subclasses of phospholipases in proteomes

artículo científico publicado en 2010

Activity-based protein profiling for biochemical pathway discovery in cancer

artículo científico publicado en 2010

Activity-based protein profiling for the functional annotation of enzymes

artículo científico publicado en 2007

Activity-based protein profiling implicates urokinase activation as a key step in human fibrosarcoma intravasation

artículo científico publicado en 2006

Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition

artículo científico publicado en 2003

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.

artículo científico publicado en 2017

Activity-based protein profiling: from enzyme chemistry to proteomic chemistry

artículo científico publicado en 2008

Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study

artículo científico publicado en 2010

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

artículo científico publicado en 2015

Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice

artículo científico publicado en 2011

An Alternative Terminal Step of the General Secretory Pathway in Staphylococcus aureus

artículo científico publicado en 2015

An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers

artículo científico publicado en 2016

An activity-based imaging probe for the integral membrane hydrolase KIAA1363.

artículo científico publicado en 2011

An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase

artículo científico publicado en 2010

An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

artículo científico publicado en 2006

An in vivo multiplexed small-molecule screening platform

artículo científico publicado en 2016

An orthogonal active site identification system (OASIS) for proteomic profiling of natural product biosynthesis

artículo científico publicado en 2009

Analytical platforms for activity-based protein profiling--exploiting the versatility of chemistry for functional proteomics

artículo científico publicado en 2006

Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain

artículo científico publicado en 2008

Anandamide externally added to lipid vesicles containing trapped fatty acid amide hydrolase (FAAH) is readily hydrolyzed in a sterol-modulated fashion

artículo científico publicado en 2012

Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum

artículo científico publicado en 2008

Application of activity-based protein profiling to study enzyme function in adipocytes

artículo científico publicado en 2014

Architecture of cannabinoid signaling in mouse retina

artículo científico publicado en 2010

Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue

artículo científico publicado en 2016

Assessing enzyme activities using stable isotope labeling and mass spectrometry

artículo científico publicado en 2007

Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB1 receptors

artículo científico publicado en 2006

Assignment of endogenous substrates to enzymes by global metabolite profiling

artículo científico publicado en 2004

Assignment of protein function in the postgenomic era.

artículo científico publicado en 2005

Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells

artículo científico publicado en 2008

Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice

artículo científico publicado en 2007

Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)

artículo científico publicado en 2009

Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by α-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures

artículo científico publicado en 2009

Biomarkers of endocannabinoid system activation in severe obesity

artículo científico publicado en 2010

Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling

artículo científico publicado en 2009

Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity

artículo científico publicado en 2014

Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice

artículo científico publicado en 2011

Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells

scientific article published on 20 March 2020

Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase

artículo científico publicado en 2016

Breast cancer cell lines grown in vivo: what goes in isn't always the same as what comes out.

artículo científico publicado en 2005

Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis

artículo científico publicado en 2011

Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo

scholarly article

Cell surface proteomics identifies molecules functionally linked to tumor cell intravasation

artículo científico publicado en 2008

Cell-Based Ligand Discovery for the ENL YEATS Domain

scientific article published on 19 March 2020

Challenges for the 'chemical-systems' biologist

artículo científico publicado en 2008

Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo

artículo científico publicado en 2010

Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism

artículo científico publicado en 2009

Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study

artículo científico publicado en 2012

Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase

artículo científico publicado en 2004

Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases

artículo científico publicado en 2010

ChemInform Abstract: Click Chemistry-Led Advances in High Content Functional Proteomics

artículo científico publicado en 2008

ChemInform Abstract: Remodeling Natural Products: Chemistry and Serine Hydrolase Activity of a Rocaglate-Derived β-Lactone

Chemical Proteomic Profiling of Human Methyltransferases

artículo científico publicado en 2016

Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.

artículo científico publicado en 2017

Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs

artículo científico publicado en 2017

Chemical biology meets biological chemistry minireview series

artículo científico publicado en 2010

Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion

artículo científico publicado en 2011

Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells

artículo científico publicado en 2016

Chemical proteomic probes for profiling cytochrome p450 activities and drug interactions in vivo

artículo científico publicado en 2007

Chemical proteomics with sulfonyl fluoride probes reveals selective labeling of functional tyrosines in glutathione transferases

artículo científico publicado en 2013

Chemical strategies for activity-based proteomics

artículo científico publicado en 2004

Chemical strategies for functional proteomics

artículo científico publicado en 2002

Chemoproteomic profiling and discovery of protein electrophiles in human cells

scientific article published on 31 October 2016

Chemoselective probes for metabolite enrichment and profiling

artículo científico publicado en 2007

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system ⬇️

artículo científico publicado el 22 de agosto de 2010

Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling.

artículo científico publicado en 2004

Class assignment of sequence-unrelated members of enzyme superfamilies by activity-based protein profiling

artículo científico publicado en 2005

Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors

artículo científico publicado en 2011

Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase().

artículo científico publicado en 2011

Closing the gate to the active site: effect of the inhibitor methoxyarachidonyl fluorophosphonate on the conformation and membrane binding of fatty acid amide hydrolase

scientific journal article

Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide

artículo científico publicado en 2005

Combined inhibition of FAAH and COX produces enhanced anti-allodynic effects in mouse neuropathic and inflammatory pain models

artículo científico publicado en 2014

Combining cross-metathesis and activity-based protein profiling: new β-lactone motifs for targeting serine hydrolases

artículo científico publicado en 2015

Comparative assessment of large-scale proteomic studies of apoptotic proteolysis

artículo científico publicado en 2009

Comparison of anandamide transport in FAAH wild-type and knockout neurons: evidence for contributions by both FAAH and the CB1 receptor to anandamide uptake

artículo científico publicado en 2004

Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition

artículo científico publicado en 2012

Comprehensive Analysis of Structure-Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors

artículo científico publicado en 2015

Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes

artículo científico publicado en 2012

Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system

artículo científico publicado en 2005

Coordinated regulation of endocannabinoid-mediated retrograde synaptic suppression in the cerebellum by neuronal and astrocytic monoacylglycerol lipase

artículo científico publicado en 2016

Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase

artículo científico publicado en 2008

Covalent Modulators of the Vacuolar ATPase.

artículo científico publicado en 2016

Crystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme Inactivation

artículo científico publicado en 2010

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses

artículo científico publicado en 2012

DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells

artículo científico publicado en 2011

Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase

artículo científico publicado en 2007

Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination

artículo científico publicado en 2018

Design of Benzoxathiazin-3-one 1,1-Dioxides as a New Class of Irreversible Serine Hydrolase Inhibitors: Discovery of a Uniquely Selective PNPLA4 Inhibitor.

artículo científico publicado en 2017

Design of activated serine–containing catalytic triads with atomic-level accuracy

artículo científico publicado en 2014

Design, Synthesis, and Evaluation of 18F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes

artículo científico publicado en 2019

Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton

artículo científico publicado en 2019

Design, synthesis, and biological evaluation of a biyouyanagin compound library

artículo científico publicado en 2011

Design, synthesis, and characterization of α-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase

artículo científico publicado en 2014

Determining target engagement in living systems

scientific article published on April 2013

Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis

artículo científico publicado en 2013

Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure

artículo científico publicado en 2016

Diced electrophoresis gel assay for screening enzymes with specified activities

artículo científico publicado en 2013

Differential effects of endocannabinoid catabolic inhibitors on morphine withdrawal in mice

artículo científico publicado en 2014

Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation

artículo científico publicado en 2006

Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes

artículo científico publicado en 2018

Discovering disease-associated enzymes by proteome reactivity profiling

artículo científico publicado en 2004

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes ⬇️

artículo científico publicado el 12 de mayo de 2003

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

artículo científico publicado en 2009

Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase α/β-Hydrolase Domain-Containing 12 (ABHD12)

artículo científico publicado en 2019

Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6)

scientific article published on 23 October 2013

Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.

artículo científico publicado en 2011

Discovery metabolite profiling--forging functional connections between the proteome and metabolome

artículo científico publicado en 2005

Discovery of Enzymatic Targets of Transcriptional Activators via in Vivo Covalent Chemical Capture

artículo científico publicado en 2016

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

artículo científico publicado en 2011

Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases

artículo científico publicado en 2017

Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

scientific article published on 11 May 2020

Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics

artículo científico publicado en 2005

Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity

artículo científico publicado en 2005

Discovery of small-molecule enzyme activators by activity-based protein profiling

artículo científico publicado en 2020

Discriminative Stimulus Properties of the Endocannabinoid Catabolic Enzyme Inhibitor SA-57 in Mice

artículo científico publicado en 2016

Disparate proteome reactivity profiles of carbon electrophiles

artículo científico publicado en 2008

Diversity of serine hydrolase activities of unchallenged and botrytis-infected Arabidopsis thaliana

artículo científico publicado en 2009

Double Dissociation of Monoacylglycerol Lipase Inhibition and CB1 Antagonism in the Central Amygdala, Basolateral Amygdala, and the Interoceptive Insular Cortex on the Affective Properties of Acute Naloxone-Precipitated Morphine Withdrawal in Rats

artículo científico publicado en 2015

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.

artículo científico publicado en 2009

Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice

artículo científico publicado en 2012

Dual inhibition of endocannabinoid catabolic enzymes produces enhanced antiwithdrawal effects in morphine-dependent mice

artículo científico publicado en 2013

Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification

artículo científico publicado en 2007

Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus

artículo científico publicado en 2014

Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats

artículo científico publicado en 2015

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

artículo científico publicado en 2019

Elevation of 2-AG by monoacylglycerol lipase inhibition in the visceral insular cortex interferes with anticipatory nausea in a rat model

artículo científico publicado en 2016

Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis ⬇️

artículo científico publicado en 2011

Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge

artículo científico publicado en 2015

Endocannabinoid Overload: Fig. 1 ⬇️

artículo científico publicado el 15 de octubre de 2010

Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway

artículo científico publicado en 2006

Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation

artículo científico publicado en 2011

Endocannabinoid metabolism in the absence of fatty acid amide hydrolase (FAAH): discovery of phosphorylcholine derivatives of N-acyl ethanolamines

artículo científico publicado en 2006

Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus

artículo científico publicado en 2009

Endocannabinoid regulation of amyloid-induced neuroinflammation.

artículo científico publicado en 2015

Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex

artículo científico publicado en 2015

Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling

artículo científico publicado en 2014

Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies.

artículo científico publicado en 2015

Endogenous molecules stimulating N-acylethanolamine-hydrolyzing acid amidase (NAAA).

artículo científico publicado en 2012

Enrichment tags for enhanced-resolution profiling of the polar metabolome

artículo científico publicado en 2007

Enzymatic pathways that regulate endocannabinoid signaling in the nervous system

artículo científico publicado en 2008

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness

artículo científico publicado en 2002

Enzyme inhibitor discovery by activity-based protein profiling

artículo científico publicado en 2014

Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors

artículo científico publicado en 2013

Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice.

artículo científico publicado en 2018

Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality

artículo científico publicado en 2007

Evaluation of fatty acid amides in the carrageenan-induced paw edema model

artículo científico publicado en 2007

Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase

scientific journal article

Expedited Mapping of the Ligandable Proteome Using Fully Functionalized Enantiomeric Probe Pairs

Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs

scientific article published on 28 October 2019

Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase

artículo científico publicado en 2008

FAAH genetic variation enhances fronto-amygdala function in mouse and human

artículo científico publicado en 2015

FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration

artículo científico publicado en 2010

Facile synthesis of borofragments and their evaluation in activity-based protein profiling

artículo científico publicado en 2015

Fatty acid amide hydrolase (-/-) mice exhibit an increased sensitivity to the disruptive effects of anandamide or oleamide in a working memory water maze task

artículo científico publicado en 2005

Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens

artículo científico publicado en 2017

Fatty acid amide hydrolase (FAAH) inhibitors exert pharmacological effects, but lack antinociceptive efficacy in rats with neuropathic spinal cord injury pain

artículo científico publicado en 2014

Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.

artículo científico publicado en 2012

Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms.

artículo científico publicado en 2010

Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders

artículo científico publicado en 2009

Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice

artículo científico publicado en 2011

Fatty acid amide hydrolase deficiency limits early pregnancy events

artículo científico publicado en 2006

Fatty acid amide hydrolase determines anandamide-induced cell death in the liver

artículo científico publicado en 2006

Fatty acid amide hydrolase in brain ventricular epithelium: mutually exclusive patterns of expression in mouse and rat.

artículo científico publicado en 2004

Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury

artículo científico publicado en 2011

Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice

artículo científico publicado en 2010

Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system

artículo científico publicado en 2003

Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis

artículo científico publicado en 2006

Fluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray Crystallographic Analysis of an Exceptionally Potent α-Ketoheterocycle Inhibitor of Fatty Acid Amide Hydrolase ⬇️

artículo científico publicado el 28 de febrero de 2011

Food for thought: endocannabinoid modulation of lipogenesis

artículo científico publicado en 2005

Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry

artículo científico publicado en 2004

Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice

artículo científico publicado en 2015

Fully functionalized small-molecule probes for integrated phenotypic screening and target identification

artículo científico publicado en 2012

Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets.

artículo científico publicado en 2017

Functional Proteomic and Structural Insights into Molecular Recognition in the Nitrilase Family Enzymes † ‡

artículo científico publicado en 2008

Functional disassociation of the central and peripheral fatty acid amide signaling systems

artículo científico publicado en 2004

Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome

artículo científico publicado en 2012

Functional lysine modification by an intrinsically reactive primary glycolytic metabolite

scientific article published on August 2013

Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum

artículo científico publicado en 2011

Genetic loss of Faah compromises male fertility in mice

artículo científico publicado en 2008

Genomics and proteomics

artículo científico publicado en 2007

Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10-2474

artículo científico publicado en 2019

Global mapping of the topography and magnitude of proteolytic events in apoptosis

artículo científico publicado en 2008

Global profiling of dynamic protein palmitoylation

artículo científico publicado en 2012

Global profiling of lysine reactivity and ligandability in the human proteome.

artículo científico publicado en 2017

Global profiling of proteolysis during rupture of Plasmodium falciparum from the host erythrocyte ⬇️

artículo científico publicado en 2010

Global profiling strategies for mapping dysregulated metabolic pathways in cancer

artículo científico publicado en 2012

Global strategies to integrate the proteome and metabolome

artículo científico publicado en 2005

Glycoproteomics enabled by tagging sialic acid- or galactose-terminated glycans

artículo científico publicado en 2012

Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase

artículo científico publicado en 2005

Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons

artículo científico publicado en 2015

Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates

artículo científico publicado en 2012

How chemoproteomics can enable drug discovery and development

artículo científico publicado en 2012

How many human proteoforms are there?

artículo científico publicado en 2018

Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome.

artículo científico publicado en 2013

Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver

artículo científico publicado en 2011

Hyperglycemia induces apoptosis via CB1 activation through the decrease of FAAH 1 in retinal pigment epithelial cells

artículo científico publicado en 2012

Identification of protein pheromones that promote aggressive behaviour

artículo científico publicado en 2007

Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes

artículo científico publicado en 2009

Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells

artículo científico publicado en 2014

Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei

artículo científico publicado en 2008

Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay

artículo científico publicado en 2015

In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies.

artículo científico publicado en 2018

In situ trans ligands of CD22 identified by glycan-protein photocross-linking-enabled proteomics

artículo científico publicado en 2010

Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids

artículo científico publicado en 2006

Increased Seizure Susceptibility and Proconvulsant Activity of Anandamide in Mice Lacking Fatty Acid Amide Hydrolase ⬇️

artículo científico publicado el 1 de mayo de 2003

Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice

artículo científico publicado en 2006

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay ⬇️

artículo científico publicado el 8 de diciembre de 2010

Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task

artículo científico publicado en 2006

Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice

artículo científico publicado en 2011

Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats

artículo científico publicado en 2012

Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver

Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB1 receptor-mediated discriminative stimulus in mice

artículo científico publicado en 2017

Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects

artículo científico publicado en 2010

Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice

scientific article published on 09 May 2009

Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

artículo científico publicado en 2013

Integrative X-ray Structure and Molecular Modeling for the Rationalization of Procaspase-8 Inhibitor Potency and Selectivity

artículo científico publicado en 2020

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet

artículo científico publicado en 2016

Investigation of Diacylglycerol Lipase Alpha Inhibition in the Mouse Lipopolysaccharide Inflammatory Pain Model

artículo científico publicado en 2017

Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice

artículo científico publicado en 2016

Kinase chemical genomics--a new rule for the exceptions

artículo científico publicado en 2005

LDL Receptor-Related Protein 1 Regulates the Abundance of Diverse Cell-Signaling Proteins in the Plasma Membrane Proteome ⬇️

artículo científico publicado el 28 de octubre de 2010

Large-scale profiling of protein palmitoylation in mammalian cells

artículo científico publicado en 2009

Ligand and Target Discovery by Fragment-Based Screening in Human Cells.

artículo científico publicado en 2017

Ligands in crystal structures that aid in functional characterization ⬇️

artículo científico publicado el 30 de septiembre de 2010

Lipid metabolism in cancer

artículo científico publicado en 2013

Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor

artículo científico publicado en 2003

Live chemical reports from the cell surface

artículo científico publicado en 2005

Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules

artículo científico publicado en 2008

Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury.

artículo científico publicado en 2009

Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics

artículo científico publicado en 2017

Mapping enzyme active sites in complex proteomes

artículo científico publicado en 2004

Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells

artículo científico publicado en 2014

Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk

artículo científico publicado en 2007

Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes

artículo científico publicado en 2005

Mechanism-based profiling of enzyme families

artículo científico publicado en 2006

Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain

artículo científico publicado en 2011

Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides

artículo científico publicado en 2007

Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry--activity-based protein profiling

artículo científico publicado en 2013

Membrane lipids are key modulators of the endocannabinoid-hydrolase FAAH.

artículo científico publicado en 2014

Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action

artículo científico publicado en 2015

Metabolically Labile Fumarate Esters Impart Kinetic Selectivity to Irreversible Inhibitors

artículo científico publicado en 2016

Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids

artículo científico publicado en 2011

Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium

artículo científico publicado en 2006

Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia

artículo científico publicado en 2004

Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism

artículo científico publicado en 2016

Microarray platform for profiling enzyme activities in complex proteomes

artículo científico publicado en 2004

Molecular medicine and neurodegenerative diseases

artículo científico publicado en 2014

Monoacylglycerol Lipase Regulates Fever Response

artículo científico publicado en 2015

Monoacylglycerol lipase controls endocannabinoid and eicosanoid signaling and hepatic injury in mice

artículo científico publicado en 2013

Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer

artículo científico publicado en 2011

Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling

artículo científico publicado en 2014

Monoacylglycerol lipase inhibitors reverse paclitaxel-induced nociceptive behavior and proinflammatory markers in a mouse model of chemotherapy-induced neuropathy.

artículo científico publicado en 2018

Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons

artículo científico publicado en 2009

Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis

artículo científico publicado en 2010

Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors.

artículo científico publicado en 2017

Multiplexed proteomic profiling of cysteine reactivity and ligandability in human T cells

artículo científico publicado en 2021

N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons

artículo científico publicado en 2008

NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

artículo científico publicado en 2013

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1

artículo científico publicado en 2012

Neuronal and Astrocytic Monoacylglycerol Lipase Limit the Spread of Endocannabinoid Signaling in the Cerebellum

artículo científico publicado en 2016

Novel inhibitors for PRMT1 discovered by high-throughput screening using activity-based fluorescence polarization

artículo científico publicado en 2012

Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity

artículo científico publicado en 2007

O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors

artículo científico publicado en 2011

Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation.

artículo científico publicado en 2017

Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes

artículo científico publicado en 2008

Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine

artículo científico publicado en 2008

Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9).

artículo científico publicado en 2010

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing

scientific article published on 13 August 2018

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

artículo científico publicado en 2016

Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.

artículo científico publicado en 2017

Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo

artículo científico publicado en 2002

Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan

artículo científico publicado en 2019

Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners

artículo científico publicado en 2011

Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development

artículo científico publicado en 2020

Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase

artículo científico publicado en 2007

Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance

artículo científico publicado en 2011

Practical 4'-phosphopantetheine active site discovery from proteomic samples

artículo científico publicado en 2010

Preservation of striatal cannabinoid CB1 receptor function correlates with the antianxiety effects of fatty acid amide hydrolase inhibition

artículo científico publicado en 2010

Profiling enzyme activities in vivo using click chemistry methods

artículo científico publicado en 2004

Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout mice

artículo científico publicado en 2014

Protein-reactive natural products

artículo científico publicado en 2005

Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors

artículo científico publicado en 2017

Proteome-wide covalent ligand discovery in native biological systems

artículo científico publicado en 2016

Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa.

artículo científico publicado en 2018

Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells

artículo científico publicado en 2013

Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria

artículo científico publicado en 2013

Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition

artículo científico publicado en 2013

Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype

artículo científico publicado en 2002

Proteomic profiling of metalloprotease activities with cocktails of active-site probes

artículo científico publicado en 2006

Proteomics--advances, applications and the challenges that remain

artículo científico publicado en 2002

Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions

artículo científico publicado en 2013

Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites

artículo científico publicado en 2017

Quantitative reactivity profiling predicts functional cysteines in proteomes

artículo científico publicado en 2010

RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia

artículo científico publicado en 2009

Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study

artículo científico publicado en 2008

Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition

artículo científico publicado en 2015

Rapid development of a potent photo-triggered inhibitor of the serine hydrolase RBBP9

artículo científico publicado en 2012

Rational Design of Fatty Acid Amide Hydrolase Inhibitors That Act by Covalently Bonding to Two Active Site Residues

artículo científico publicado en 2013

Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis

artículo científico publicado en 2018

Recombinant expression, purification, and comparative characterization of torsinA and its torsion dystonia-associated variant Delta E-torsinA.

artículo científico publicado en 2003

Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use.

artículo científico publicado en 2004

Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2.

artículo científico publicado en 2017

Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase

artículo científico publicado en 2010

Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor

artículo científico publicado en 2008

Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived β-lactone

artículo científico publicado en 2014

Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects ⬇️

artículo científico publicado en 2013

Resin-based investigation of acyl carrier protein interaction networks in Escherichia coli

artículo científico publicado en 2011

Retrograde endocannabinoid signaling in the cerebellar cortex

artículo científico publicado en 2006

Reversible Competitive α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting Analgesics ⬇️

artículo científico publicado el 23 de marzo de 2011

Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity

artículo científico publicado en 2004

Robust anti-nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain

scientific article published on 07 August 2016

Role of endocannabinoids in alcohol consumption and intoxication: studies of mice lacking fatty acid amide hydrolase

artículo científico publicado en 2006

Role of the satiety factor oleoylethanolamide in alcoholism

artículo científico publicado en 2015

Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling.

artículo científico publicado en 2018

Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases

artículo científico publicado en 2015

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

artículo científico publicado en 2009

Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo

article

Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP.

artículo científico publicado en 2011

Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival

artículo científico publicado en 2015

Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2)

artículo científico publicado en 2012

Selective monoacylglycerol lipase inhibitors: antinociceptive versus cannabimimetic effects in mice

artículo científico publicado en 2015

Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling

artículo científico publicado en 2008

Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions

artículo científico publicado en 2006

Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation

artículo científico publicado en 2013

Simultaneous inhibition of fatty acid amide hydrolase and monoacylglycerol lipase shares discriminative stimulus effects with Δ9-tetrahydrocannabinol in mice

artículo científico publicado en 2015

Simultaneous structure-activity studies and arming of natural products by C-H amination reveal cellular targets of eupalmerin acetate

artículo científico publicado en 2013

Steady-state hydrogen peroxide induces glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa

artículo científico publicado en 2014

Strategies for discovering and derisking covalent, irreversible enzyme inhibitors

artículo científico publicado en 2010

Stress Promotes Drug Seeking Through Glucocorticoid-Dependent Endocannabinoid Mobilization in the Prelimbic Cortex

artículo científico publicado en 2017

Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling

artículo científico publicado en 2002

Structural commonalities among integral membrane enzymes

artículo científico publicado en 2004

Structure and function of fatty acid amide hydrolase

artículo científico publicado en 2005

Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase

artículo científico publicado en 2007

Structure-based design of a FAAH variant that discriminates between the N-acyl ethanolamine and taurine families of signaling lipids

artículo científico publicado en 2006

Structure-guided inhibitor design for human FAAH by interspecies active site conversion

artículo científico publicado en 2008

Substrate mimicry in an activity-based probe that targets the nitrilase family of enzymes

artículo científico publicado en 2006

Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

artículo científico publicado en 2010

Synergistic interactions between cannabinoids and environmental stress in the activation of the central amygdala

artículo científico publicado en 2005

Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception

scientific article published on 31 December 2008

Synthesis and Sulfur Electrophilicity of theNupharThiaspirane Pharmacophore

artículo científico publicado en 2016

Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes

artículo científico publicado en 2007

Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)--a general method for mapping sites of probe modification in proteomes

artículo científico publicado en 2007

Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling

artículo científico publicado en 2005

Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis

artículo científico publicado en 2014

Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice

artículo científico publicado en 2008

Tetrahedron young investigator award 2008.

artículo científico publicado en 2008

The Endocannabinoid System Alleviates Pain in a Murine Model of Cancer-Induced Bone Pain

artículo científico publicado en 2020

The Endocannabinoid System: From Basic Research toTranslational Opportunity.

artículo científico publicado en 2012

The Proteome-Wide Potential for Reversible Covalency at Cysteine

artículo científico publicado en 2019

The RON-receptor regulates pancreatic cancer cell migration through phosphorylation-dependent breakdown of the hemidesmosome

artículo científico publicado en 2012

The Scripps Molecular Screening Center and Translational Research Institute

scientific article published on 25 January 2019

The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model

artículo científico publicado en 2016

The Spastic Paraplegia-Associated Phospholipase DDHD1 Is a Primary Brain Phosphatidylinositol Lipase

artículo científico publicado en 2018

The biological impact of mass-spectrometry-based proteomics

artículo científico publicado en 2007

The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine

scientific article published on 30 June 2009

The development and application of methods for activity-based protein profiling

artículo científico publicado en 2004

The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways

artículo científico publicado en 2009

The endocannabinoid hydrolysis inhibitor SA-57: Intrinsic antinociceptive effects, augmented morphine-induced antinociception, and attenuated heroin seeking behavior in mice

artículo científico publicado en 2016

The endogenous cannabinoid system and its role in nociceptive behavior

artículo científico publicado en 2004

The endogenous cannabinoid system protects against colonic inflammation

artículo científico publicado en 2004

The enzymatic inactivation of the fatty acid amide class of signaling lipids

artículo científico publicado en 2002

The expanding role of mass spectrometry in metabolite profiling and characterization

artículo científico publicado en 2005

The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice

artículo científico publicado en 2012

The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice

artículo científico publicado en 2010

The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase

scientific journal article

The metabolic serine hydrolases and their functions in mammalian physiology and disease

artículo científico publicado en 2011

The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model

artículo científico publicado en 2012

The pharmacological landscape and therapeutic potential of serine hydrolases

artículo científico publicado en 2012

The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity

artículo científico publicado en 2004

The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases

artículo científico publicado en 2006

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

artículo científico publicado en 2010

The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH).

artículo científico publicado en 2012

ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue

artículo científico publicado en 2014

Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms

Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding.

artículo científico publicado en 2016

Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes

artículo científico publicado en 2002

Two novel mutations in ABHD12: expansion of the mutation spectrum in PHARC and assessment of their functional effects

artículo científico publicado en 2013

X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

artículo científico publicado en 2010

Δ9-tetrahydrocannabinol and endocannabinoid degradative enzyme inhibitors attenuate intracranial self-stimulation in mice

artículo científico publicado en 2014

β-Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB₁ or CB₂ receptors

artículo científico publicado en 2012

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