Lista de obras - Peter Rutledge - Dominio Público Uruguay

(2S,4S)-3-Benzoyl-4-benzyl-2-tert-but-yl-1,3-oxazolidin-5-one

artículo científico publicado en 2012

A Fluorescent “Allosteric Scorpionand” Complex Visualizes a Biological Recognition Event ⬇️

artículo científico publicado el 9 de enero de 2013

A click fluorophore sensor that can distinguish Cu(II) and Hg(II) via selective anion-induced demetallation

artículo científico publicado en 2011

A cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthase

artículo científico publicado en 2007

A direct method for the N-tetraalkylation of azamacrocycles

artículo científico publicado en 2016

Active-site-mediated elimination of hydrogen fluoride from a fluorinated substrate analogue by isopenicillin N synthase

artículo científico publicado en 2004

Antitubercular Bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and in Vivo Studies.

artículo científico publicado en 2018

Bengamides display potent activity against drug-resistant Mycobacterium tuberculosis

artículo científico publicado en 2019

Bio-inspired nitrile hydration by peptidic ligands based on L-cysteine, L-methionine or L-penicillamine and pyridine-2,6-dicarboxylic acid.

artículo científico publicado en 2014

Boronated phosphonium salts containing arylboronic acid, closo-carborane, or nido-carborane: synthesis, X-ray diffraction, in vitro cytotoxicity, and cellular uptake

artículo científico publicado en 2010

Chemical sensors that incorporate click-derived triazoles

artículo científico publicado en 2011

Combined "dual" absorption and fluorescence smartphone spectrometers

artículo científico publicado en 2015

Conglobatins B-E: cytotoxic analogues of the C2-symmetric macrodiolide conglobatin ⬇️

scientific article published on 17 June 2020

Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with "click" chemistry and are noncytotoxic

artículo científico publicado en 2011

Correction: Metal complexes as a promising source for new antibiotics

artículo científico publicado en 2020

Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase

artículo científico publicado en 2010

Cyclobutanone Analogues of β-Lactam Antibiotics: β-Lactamase Inhibitors with Untapped Potential?

artículo científico publicado en 2016

Design and synthesis of a tetradentate '3-amine-1-carboxylate' ligand to mimic the metal binding environment at the non-heme iron(II) oxidase active site

artículo científico publicado en 2010

Diketoacid Inhibitors of HIV-1 Integrase: From L-708,906 to Raltegravir and Beyond ⬇️

artículo científico publicado el 1 de enero de 2012

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

artículo científico

Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis

artículo científico publicado en 2018

Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Brønsted acids

artículo científico publicado en 2015

Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates

artículo científico publicado en 2014

Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity without Inducing Cytotoxicity

artículo científico publicado en 2013

Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI)

artículo científico publicado en 2010

Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight

artículo científico publicado en 2007

Iron complexes of tetramine ligands catalyse allylic hydroxyamination via a nitroso-ene mechanism

artículo científico publicado en 2015

Isopenicillin N synthase binds δ-(L-α-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms

artículo científico publicado en 2011

Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase?

artículo científico publicado en 2008

Metal complexes as a promising source for new antibiotics

artículo científico publicado en 2020

Molecular Switches for any pH: A Systematic Study of the Versatile Coordination Behaviour of Cyclam Scorpionands

artículo científico publicado en 2017

Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis ⬇️

artículo científico publicado en 2019

Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid β.

artículo científico publicado en 2014

Nontoxic Metal-Cyclam Complexes, a New Class of Compounds with Potency against Drug-Resistant Mycobacterium tuberculosis

artículo científico publicado en 2016

Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal

artículo científico publicado en 2011

Recent Advances in Macrocyclic Fluorescent Probes for Ion Sensing.

artículo científico publicado en 2017

Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue

artículo científico publicado en 2009

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate

artículo científico publicado en 2003

Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine

artículo científico publicado en 2005

Substrate range and enantioselectivity of epoxidation reactions mediated by the ethene-oxidising Mycobacterium strain NBB4.

artículo científico publicado en 2012

Synthesis and Evaluation of 1,8-Disubstituted-Cyclam/Naphthalimide Conjugates as Probes for Metal Ions

scientific article published on 03 August 2016

Synthesis and structural characterisation of amides from picolinic acid and pyridine-2,6-dicarboxylic acid.

artículo científico publicado en 2015

Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases

artículo científico publicado en 2017

The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase

artículo científico publicado en 2010

The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site

artículo científico publicado en 2013

The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue

artículo científico publicado en 2013

The crystal structure of isopenicillin N synthase with δ-((L)-α-aminoadipoyl)-(L)-cysteinyl-(D)-methionine reveals thioether coordination to iron

artículo científico publicado en 2011

The interaction of isopenicillin N synthase with homologated substrate analogues δ-(L-α-aminoadipoyl)-L-homocysteinyl-D-Xaa characterised by protein crystallography

artículo científico publicado en 2013

The properties and performance of a pH-responsive functionalised nanoparticle

artículo científico publicado en 2014

Time-resolved and temperature tuneable measurements of fluorescent intensity using a smartphone fluorimeter

artículo científico publicado en 2017

Unexpected oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N synthase

artículo científico publicado en 2006

tert-Butyl-dimethyl-silanol hemihydrate

artículo científico publicado en 2008

Structural studies on the reaction cycle of isopenicillin N synthase

tesis doctoral

Lista de obras de Peter Rutledge

(2S,4S)-3-Benzoyl-4-benzyl-2-tert-but-yl-1,3-oxazolidin-5-one

A Fluorescent “Allosteric Scorpionand” Complex Visualizes a Biological Recognition Event ⬇️

A click fluorophore sensor that can distinguish Cu(II) and Hg(II) via selective anion-induced demetallation

A cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthase

A direct method for the N-tetraalkylation of azamacrocycles

Active-site-mediated elimination of hydrogen fluoride from a fluorinated substrate analogue by isopenicillin N synthase

Antitubercular Bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and in Vivo Studies.

Bengamides display potent activity against drug-resistant Mycobacterium tuberculosis

Bio-inspired nitrile hydration by peptidic ligands based on L-cysteine, L-methionine or L-penicillamine and pyridine-2,6-dicarboxylic acid.

Boronated phosphonium salts containing arylboronic acid, closo-carborane, or nido-carborane: synthesis, X-ray diffraction, in vitro cytotoxicity, and cellular uptake

Chemical sensors that incorporate click-derived triazoles

Combined "dual" absorption and fluorescence smartphone spectrometers

Conglobatins B-E: cytotoxic analogues of the C2-symmetric macrodiolide conglobatin ⬇️

Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with "click" chemistry and are noncytotoxic

Correction: Metal complexes as a promising source for new antibiotics

Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase

Cyclobutanone Analogues of β-Lactam Antibiotics: β-Lactamase Inhibitors with Untapped Potential?

Design and synthesis of a tetradentate '3-amine-1-carboxylate' ligand to mimic the metal binding environment at the non-heme iron(II) oxidase active site

Diketoacid Inhibitors of HIV-1 Integrase: From L-708,906 to Raltegravir and Beyond ⬇️

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis

Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Brønsted acids

Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates

Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity without Inducing Cytotoxicity

Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI)

Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight

Iron complexes of tetramine ligands catalyse allylic hydroxyamination via a nitroso-ene mechanism

Isopenicillin N synthase binds δ-(L-α-aminoadipoyl)-L-cysteinyl-D-thia-allo-isoleucine through both sulfur atoms

Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase?

Metal complexes as a promising source for new antibiotics

Molecular Switches for any pH: A Systematic Study of the Versatile Coordination Behaviour of Cyclam Scorpionands

Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis ⬇️

Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid β.

Nontoxic Metal-Cyclam Complexes, a New Class of Compounds with Potency against Drug-Resistant Mycobacterium tuberculosis

Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal

Recent Advances in Macrocyclic Fluorescent Probes for Ion Sensing.

Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue delta-(l-alpha-aminoadipoyl)-l-cysteinyl-d-alpha-aminobutyrate

Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-alpha-aminoadipoyl)-L-cysteinyl-glycine and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alanine

Substrate range and enantioselectivity of epoxidation reactions mediated by the ethene-oxidising Mycobacterium strain NBB4.

Synthesis and Evaluation of 1,8-Disubstituted-Cyclam/Naphthalimide Conjugates as Probes for Metal Ions

Synthesis and structural characterisation of amides from picolinic acid and pyridine-2,6-dicarboxylic acid.

Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases

The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase

The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site

The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue

The crystal structure of isopenicillin N synthase with δ-((L)-α-aminoadipoyl)-(L)-cysteinyl-(D)-methionine reveals thioether coordination to iron

The interaction of isopenicillin N synthase with homologated substrate analogues δ-(L-α-aminoadipoyl)-L-homocysteinyl-D-Xaa characterised by protein crystallography

The properties and performance of a pH-responsive functionalised nanoparticle

Time-resolved and temperature tuneable measurements of fluorescent intensity using a smartphone fluorimeter

Unexpected oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N synthase

tert-Butyl-dimethyl-silanol hemihydrate

Structural studies on the reaction cycle of isopenicillin N synthase