Lista de obras - Colm Cunningham - Dominio Público Uruguay

A double dissociation between the effects of sub-pyrogenic systemic inflammation and hippocampal lesions on learning

artículo científico publicado en 2009

Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium

artículo científico publicado en 2020

Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms

artículo científico publicado en 2018

Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease

artículo científico publicado en 2007

Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies

artículo científico publicado en 2017

Association of postoperative delirium with markers of neurodegeneration and brain amyloidosis: a pilot study

artículo científico publicado en 2017

Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1β and TNF-α.

artículo científico publicado en 2015

Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity

scientific article published on 17 November 2018

At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei.

artículo científico publicado en 2015

Atypical inflammation in the central nervous system in prion disease

artículo científico publicado en 2002

Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration.

artículo científico publicado en 2005

Cerebrospinal fluid interleukin-8 levels are higher in people with hip fracture with perioperative delirium than in controls

artículo científico publicado en 2011

Cerebrospinal fluid markers of neuroinflammation in delirium: a role for interleukin-1β in delirium after hip fracture

artículo científico publicado en 2014

Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression

scientific article published on 25 January 2019

Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research.

artículo científico

Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ME7 model of prion disease

artículo científico publicado en 2005

Correction: A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1β, TNF-α and IL-6 Challenges in C57BL/6 Mice.

artículo científico publicado en 2013

Correction: Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms

scientific article published on 01 October 2019

Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction

artículo científico publicado en 2013

Cytokines and the ageing brain

artículo científico publicado en 2002

DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease

artículo científico publicado en 2015

Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study

artículo científico publicado en 2012

Differential response of hippocampal and prefrontal oscillations to systemic LPS application

artículo científico publicado en 2017

Early Hippocampal Synaptic Loss Precedes Neuronal Loss and Associates with Early Behavioural Deficits in Three Distinct Strains of Prion Disease.

artículo científico publicado en 2013

Endogenous IL-1 in cognitive function and anxiety: a study in IL-1RI-/- mice

artículo científico publicado en 2013

Environmental influences on antibody-enhanced dengue disease outcomes.

artículo científico publicado en 2012

Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6 ⬇️

artículo científico publicado el 17 de mayo de 2011

Hippocampal lesions can enhance discrimination learning despite normal sensitivity to interference from incidental information

artículo científico publicado en 2011

In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis

artículo científico publicado en 2017

Increased brain synthesis of prostaglandin E2 and F2-isoprostane in human and experimental transmissible spongiform encephalopathies

artículo científico publicado en 2000

Influence of enriched environment on viral encephalitis outcomes: behavioral and neuropathological changes in albino Swiss mice

artículo científico publicado en 2011

Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C.

artículo científico publicado en 2015

Losing Sleep Over Delirium

scientific article published on 01 June 2018

Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring.

artículo científico publicado en 2008

MCP-1 and murine prion disease: separation of early behavioural dysfunction from overt clinical disease

artículo científico publicado en 2005

Malaise in the water maze: untangling the effects of LPS and IL-1beta on learning and memory.

artículo científico publicado en 2008

Microglia and neurodegeneration: the role of systemic inflammation.

artículo científico

Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation.

artículo científico publicado en 2010

Neuroinflammation in delirium: a postmortem case-control study

artículo científico publicado en 2011

Neuropil and neuronal changes in hippocampal NADPH-diaphorase histochemistry in the ME7 model of murine prion disease.

artículo científico publicado en 2004

New horizons in the pathogenesis, assessment and management of delirium.

artículo científico publicado en 2013

Non-steroidal anti-inflammatory drugs and cognitive function: are prostaglandins at the heart of cognitive impairment in dementia and delirium?

artículo científico publicado en 2012

Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease

artículo científico publicado en 2002

Proinflammatory cytokines, sickness behavior, and Alzheimer disease ⬇️

artículo científico publicado el 13 de julio de 2011

Reduce the burden of dementia now

artículo científico publicado en 2018

Risk factors for postoperative delirium.

artículo científico publicado en 2014

Sub-pyrogenic systemic inflammation impacts on brain and behavior, independent of cytokines.

artículo científico publicado en 2007

Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease

artículo científico publicado en 2003

Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration

artículo científico publicado en 2016

Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegeneration

artículo científico publicado en 2010

Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease.

artículo científico publicado en 2003

Systemic inflammation and delirium: important co-factors in the progression of dementia.

artículo científico

Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease

scientific article published on 18 September 2008

Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium.

artículo científico publicado en 2010

Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration

artículo científico publicado en 2007

TGFbeta1 regulates the inflammatory response during chronic neurodegeneration

artículo científico publicado en 2006

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

artículo científico publicado en 2016

The impact of systemic infection on the progression of neurodegenerative disease.

artículo científico publicado en 2003

Transforming growth factor beta1, the dominant cytokine in murine prion disease: influence on inflammatory cytokine synthesis and alteration of vascular extracellular matrix

artículo científico publicado en 2002

Unaltered SNARE complex formation in an in vivo model of prion disease

artículo científico publicado en 2008

Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses

artículo científico publicado en 2008

Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium

artículo científico publicado en 2014

Lista de obras de Colm Cunningham

A double dissociation between the effects of sub-pyrogenic systemic inflammation and hippocampal lesions on learning

Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium

Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms

Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease

Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies

Association of postoperative delirium with markers of neurodegeneration and brain amyloidosis: a pilot study

Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1β and TNF-α.

Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity

At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei.

Atypical inflammation in the central nervous system in prion disease

Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration.

Cerebrospinal fluid interleukin-8 levels are higher in people with hip fracture with perioperative delirium than in controls

Cerebrospinal fluid markers of neuroinflammation in delirium: a role for interleukin-1β in delirium after hip fracture

Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression

Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research.

Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ME7 model of prion disease

Correction: A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1β, TNF-α and IL-6 Challenges in C57BL/6 Mice.

Correction: Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms

Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction

Cytokines and the ageing brain

DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease

Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study

Differential response of hippocampal and prefrontal oscillations to systemic LPS application

Early Hippocampal Synaptic Loss Precedes Neuronal Loss and Associates with Early Behavioural Deficits in Three Distinct Strains of Prion Disease.

Endogenous IL-1 in cognitive function and anxiety: a study in IL-1RI-/- mice

Environmental influences on antibody-enhanced dengue disease outcomes.

Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6 ⬇️

Hippocampal lesions can enhance discrimination learning despite normal sensitivity to interference from incidental information

In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis

Increased brain synthesis of prostaglandin E2 and F2-isoprostane in human and experimental transmissible spongiform encephalopathies

Influence of enriched environment on viral encephalitis outcomes: behavioral and neuropathological changes in albino Swiss mice

Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C.

Losing Sleep Over Delirium

Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring.

MCP-1 and murine prion disease: separation of early behavioural dysfunction from overt clinical disease

Malaise in the water maze: untangling the effects of LPS and IL-1beta on learning and memory.

Microglia and neurodegeneration: the role of systemic inflammation.

Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation.

Neuroinflammation in delirium: a postmortem case-control study

Neuropil and neuronal changes in hippocampal NADPH-diaphorase histochemistry in the ME7 model of murine prion disease.

New horizons in the pathogenesis, assessment and management of delirium.

Non-steroidal anti-inflammatory drugs and cognitive function: are prostaglandins at the heart of cognitive impairment in dementia and delirium?

Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease

Proinflammatory cytokines, sickness behavior, and Alzheimer disease ⬇️

Reduce the burden of dementia now

Risk factors for postoperative delirium.

Sub-pyrogenic systemic inflammation impacts on brain and behavior, independent of cytokines.

Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease

Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration

Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegeneration

Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease.

Systemic inflammation and delirium: important co-factors in the progression of dementia.

Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease

Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium.

Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration

TGFbeta1 regulates the inflammatory response during chronic neurodegeneration

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

The impact of systemic infection on the progression of neurodegenerative disease.

Transforming growth factor beta1, the dominant cytokine in murine prion disease: influence on inflammatory cytokine synthesis and alteration of vascular extracellular matrix

Unaltered SNARE complex formation in an in vivo model of prion disease

Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses

Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium