Lista de obras - E Sousa - Dominio Público Uruguay

1,2-Dihydroxyxanthone: Effect on A375-C5 Melanoma Cell Growth Associated with Interference with THP-1 Human Macrophage Activity

scientific article published on 04 June 2019

11(th) National Meeting of Organic Chemistry and 4(th) Meeting of Therapeutic Chemistry

artículo científico publicado en 2016

A Century of Thioxanthones: Through Synthesis and Biological Applications ⬇️

artículo científico publicado el 1 de enero de 2013

A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.

artículo científico publicado en 2016

An antifouling model from the sea: a review of 25 years of zosteric acid studies.

artículo científico publicado en 2017

Anthraquinones, Diphenyl Ethers, and Their Derivatives from the Culture of the Marine Sponge-Associated Fungus Neosartorya spinosa KUFA 1047 ⬇️

scientific article published in 2021

Anticancer and cancer preventive compounds from edible marine organisms

artículo científico publicado en 2017

Antifouling potential of Nature-inspired sulfated compounds.

artículo científico publicado en 2017

Antifungal Activity of Xanthones: Evaluation of their Effect on Ergosterol Biosynthesis by High-performance Liquid Chromatography

scientific article published on 19 January 2011

Antithrombotics from the Sea: Polysaccharides and Beyond

artículo científico publicado en 2019

Antitumor Activity of Quinazolinone Alkaloids Inspired by Marine Natural Products

artículo científico publicado en 2018

BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer's Disease

artículo científico publicado en 2019

BDDE-Inspired Chalcone Derivatives to Fight Bacterial and Fungal Infections

artículo científico publicado en 2022

Bioactive xanthones with effect on P-glycoprotein and prediction of intestinal absorption

Boronic Acids and Their Derivatives in Medicinal Chemistry: Synthesis and Biological Applications

scientific article published on 21 September 2020

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2.

artículo científico publicado en 2017

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3

scientific article published on 30 June 2018

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

scientific article published on 30 June 2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6

scientific article published on 28 December 2019

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4

scientific article published on 31 December 2018

Bromoalkoxyxanthones as promising antitumor agents: synthesis, crystal structure and effect on human tumor cell lines.

artículo científico publicado en 2009

Chemistry of the fumiquinazolines and structurally related alkaloids

artículo científico publicado en 2018

Chiral Thioxanthones as Modulators of P-glycoprotein: Synthesis and Enantioselectivity Studies.

artículo científico publicado en 2018

Comparative Studies on the Photoreactivity, Efficacy, and Safety of Depigmenting Agents

artículo científico publicado en 2023

Curcumin as a Modulator of P-Glycoprotein in Cancer: Challenges and Perspectives

artículo científico publicado en 2016

Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold

Development of novel rifampicin-derived P-glycoprotein activators/inducers. synthesis, in silico analysis and application in the RBE4 cell model, using paraquat as substrate

artículo científico publicado en 2013

Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome Formulations

article

Discovery of a new small-molecule inhibitor of p53–MDM2 interaction using a yeast-based approach ⬇️

artículo científico publicado el 18 de febrero de 2013

Dual anticoagulant/antiplatelet persulfated small molecules

artículo científico publicado en 2011

Dual inhibitors of P-glycoprotein and tumor cell growth: (re)discovering thioxanthones.

artículo científico publicado en 2011

Efficacy, Stability, and Safety Evaluation of New Polyphenolic Xanthones Towards Identification of Bioactive Compounds to Fight Skin Photoaging

scientific article published on 16 June 2020

Emerging sulfated flavonoids and other polyphenols as drugs: nature as an inspiration.

artículo científico publicado en 2013

Evolution of the use of antioxidants in anti-ageing cosmetics

scientific article published on 01 August 2019

Flavonoids with an oligopolysulfated moiety: a new class of anticoagulant agents.

artículo científico publicado en 2010

From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones

artículo científico publicado en 2021

From Natural Xanthones to Synthetic C-1 Aminated 3,4-Dioxygenated Xanthones as Optimized Antifouling Agents

artículo científico

Histological and toxicological evaluation, in rat, of a P-glycoprotein inducer and activator: 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5)

artículo científico publicado en 2019

Immobilized imidazolium-based ionic liquids in C18 for solid-phase extraction

scientific article published on 19 February 2020

Induction and activation of P-glycoprotein by dihydroxylated xanthones protect against the cytotoxicity of the P-glycoprotein substrate paraquat

artículo científico publicado en 2014

Inhibition of protein kinase C by synthetic xanthone derivatives.

artículo científico publicado en 2003

Insights into the in vitro antitumor mechanism of action of a new pyranoxanthone.

artículo científico publicado en 2010

Lichen Xanthones as Models for New Antifungal Agents

artículo científico publicado en 2018

Lipid reducing activity and toxicity profiles of a library of polyphenol derivatives.

artículo científico publicado en 2018

Marine Natural Products as Models to Circumvent Multidrug Resistance

artículo científico publicado en 2016

Marine-Derived Compounds and Prospects for Their Antifungal Application

artículo científico publicado en 2020

Marine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics

artículo científico publicado en 2020

Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.

artículo científico publicado en 2016

Medicinal Chemistry Updates on Bacterial Efflux Pump Modulators.

artículo científico publicado en 2018

Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants

scientific article published in 2021

Microbial interaction between a CTXM-15 -producing Escherichia coli and a susceptible Pseudomonas aeruginosa isolated from bronchoalveolar lavage: influence of cefotaxime in the dual-species biofilm formation

artículo científico publicado en 2015

Modulation of Autophagy by a Thioxanthone Decreases the Viability of Melanoma Cells.

artículo científico publicado en 2016

Modulation of VEGF signaling in a mouse model of diabetes by xanthohumol and 8-prenylnaringenin: Unveiling the angiogenic paradox and metabolism interplay.

artículo científico publicado en 2016

Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy

artículo científico publicado en 2016

New Hybrid Phenalenone Dimer, Highly Conjugated Dihydroxylated C28 Steroid and Azaphilone from the Culture Extract of a Marine Sponge-Associated Fungus, Talaromyces pinophilus KUFA 1767

scientific article published in 2023

New Uses for Old Drugs: Pharmacophore‐Based Screening for the Discovery of P‐Glycoprotein Inhibitors ⬇️

artículo científico publicado el 29 de marzo de 2011

New chiral derivatives of xanthones: synthesis and investigation of enantioselectivity as inhibitors of growth of human tumor cell lines

artículo científico publicado en 2013

New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma

scientific article published on 19 January 2019

New marine-derived indolymethyl pyrazinoquinazoline alkaloids with promising antimicrobial profiles

artículo científico publicado en 2020

Newly Synthesized Oxygenated Xanthones as Potential P-Glycoprotein Activators: , , and Studies

artículo científico publicado en 2019

Old Drugs as New Treatments for Neurodegenerative Diseases

artículo científico publicado en 2018

Omadacycline: A Newly Approved Antibacterial from the Class of Tetracyclines

scientific article published on 21 April 2019

One Step Forward towards the Development of Eco-Friendly Antifouling Coatings: Immobilization of a Sulfated Marine-Inspired Compound

artículo científico publicado en 2020

Overcoming environmental problems of biocides: Synthetic bile acid derivatives as a sustainable alternative

scientific article published on 24 October 2019

P-glycoprotein activation by 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) in rat distal ileum: ex vivo and in vivo studies

scientific article published on 19 November 2019

P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents paraquat cytotoxicity.

artículo científico publicado en 2014

Pentaketides and 5-p-Hydroxyphenyl-2-pyridone Derivative from the Culture Extract of a Marine Sponge-Associated Fungus Hamigera avellanea KUFA0732

scientific article published in 2023

Polysulfated xanthones: multipathway development of a new generation of dual anticoagulant/antiplatelet agents.

artículo científico publicado en 2011

Potential benefits of a sulfated resveratrol derivative for topical application.

artículo científico publicado en 2018

Preliminary Virtual Screening Studies to Identify GRP78 Inhibitors Which May Interfere with SARS-CoV-2 Infection

artículo científico publicado en 2020

Prenylated phenylbutyrolactones from cultures of a marine sponge-associated fungus Aspergillus flavipes KUFA1152

scientific article published in 2021

Quantification of 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5), a newly synthetized P-glycoprotein inducer/activator, in biological samples: method development and validation.

artículo científico publicado en 2016

Quantification of a Sulfated Marine-Inspired Antifouling Compound in Several Aqueous Matrices: Biodegradation Studies and Leaching Assays from Polydimethylsiloxane Coatings

artículo científico publicado en 2022

Screening a Small Library of Xanthones for Antitumor Activity and Identification of a Hit Compound which Induces Apoptosis

artículo científico publicado en 2016

Sources and Biological Activities of Marine Sulfated Steroids

artículo científico publicado en 2018

Strategies to Overcome Heparins' Low Oral Bioavailability

artículo científico publicado en 2016

Structure and Ligand-based Design of P-glycoprotein Inhibitors: A Historical Perspective ⬇️

artículo científico publicado el 1 de enero de 2012

Structure based design, synthesis, and evaluation of potential inhibitors of steroid sulfatase

artículo científico publicado en 2014

Structure-Antifouling Activity Relationship and Molecular Targets of Bio-Inspired(thio)xanthones

scientific article published on 30 July 2020

Structure-activity relationship studies for multitarget antithrombotic drugs

artículo científico publicado en 2016

Sulfated small molecules targeting eBV in Burkitt lymphoma: from in silico screening to the evidence of in vitro effect on viral episomal DNA.

artículo científico publicado en 2013

Synergistic Effects Between Thioxanthones and Oxacillin Against Methicillin-Resistant Staphylococcus aureus.

artículo científico publicado en 2015

Synthesis and in vivo modulatory activity of protein kinase C of xanthone derivatives.

artículo científico publicado en 2002

Synthesis of New Glycosylated Flavonoids with Inhibitory Activity on Cell Growth

artículo científico publicado en 2018

Synthesis of New Proteomimetic Quinazolinone Alkaloids and Evaluation of Their Neuroprotective and Antitumor Effects

artículo científico publicado en 2019

Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents

artículo científico publicado en 2019

The Antitumor Activity of a Lead Thioxanthone is Associated with Alterations in Cholesterol Localization

artículo científico publicado en 2018

The Main Metabolites of Fluorouracil + Adriamycin + Cyclophosphamide (FAC) Are Not Major Contributors to FAC Toxicity in H9c2 Cardiac Differentiated Cells ⬇️

article

The importance of drug metabolites synthesis: the case-study of cardiotoxic anticancer drugs

artículo científico publicado en 2017

The network of P-glycoprotein and microRNAs interactions

artículo científico publicado en 2013

Three decades of P-gp inhibitors: skimming through several generations and scaffolds.

artículo científico

Transcription profiling of the Neurospora crassa response to a group of synthetic (thio)xanthones and a natural acetophenone

artículo científico publicado en 2015

Xanthone derivatives: new insights in biological activities.

artículo científico publicado en 2005

Xanthones as inhibitors of growth of human cancer cell lines and their effects on the proliferation of human lymphocytes in vitro.

artículo científico publicado en 2002

Α-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach.

artículo científico publicado en 2013

Lista de obras de E Sousa

1,2-Dihydroxyxanthone: Effect on A375-C5 Melanoma Cell Growth Associated with Interference with THP-1 Human Macrophage Activity

11(th) National Meeting of Organic Chemistry and 4(th) Meeting of Therapeutic Chemistry

A Century of Thioxanthones: Through Synthesis and Biological Applications ⬇️

A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.

An antifouling model from the sea: a review of 25 years of zosteric acid studies.

Anthraquinones, Diphenyl Ethers, and Their Derivatives from the Culture of the Marine Sponge-Associated Fungus Neosartorya spinosa KUFA 1047 ⬇️

Anticancer and cancer preventive compounds from edible marine organisms

Antifouling potential of Nature-inspired sulfated compounds.

Antifungal Activity of Xanthones: Evaluation of their Effect on Ergosterol Biosynthesis by High-performance Liquid Chromatography

Antithrombotics from the Sea: Polysaccharides and Beyond

Antitumor Activity of Quinazolinone Alkaloids Inspired by Marine Natural Products

BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer's Disease

BDDE-Inspired Chalcone Derivatives to Fight Bacterial and Fungal Infections

Bioactive xanthones with effect on P-glycoprotein and prediction of intestinal absorption

Boronic Acids and Their Derivatives in Medicinal Chemistry: Synthesis and Biological Applications

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-5

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes⁻4

Bromoalkoxyxanthones as promising antitumor agents: synthesis, crystal structure and effect on human tumor cell lines.

Chemistry of the fumiquinazolines and structurally related alkaloids

Chiral Thioxanthones as Modulators of P-glycoprotein: Synthesis and Enantioselectivity Studies.

Comparative Studies on the Photoreactivity, Efficacy, and Safety of Depigmenting Agents

Curcumin as a Modulator of P-Glycoprotein in Cancer: Challenges and Perspectives

Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold

Development of novel rifampicin-derived P-glycoprotein activators/inducers. synthesis, in silico analysis and application in the RBE4 cell model, using paraquat as substrate

Discovery of a New Xanthone against Glioma: Synthesis and Development of (Pro)liposome Formulations

Discovery of a new small-molecule inhibitor of p53–MDM2 interaction using a yeast-based approach ⬇️

Dual anticoagulant/antiplatelet persulfated small molecules

Dual inhibitors of P-glycoprotein and tumor cell growth: (re)discovering thioxanthones.

Efficacy, Stability, and Safety Evaluation of New Polyphenolic Xanthones Towards Identification of Bioactive Compounds to Fight Skin Photoaging

Emerging sulfated flavonoids and other polyphenols as drugs: nature as an inspiration.

Evolution of the use of antioxidants in anti-ageing cosmetics

Flavonoids with an oligopolysulfated moiety: a new class of anticoagulant agents.

From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones

From Natural Xanthones to Synthetic C-1 Aminated 3,4-Dioxygenated Xanthones as Optimized Antifouling Agents

Histological and toxicological evaluation, in rat, of a P-glycoprotein inducer and activator: 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5)

Immobilized imidazolium-based ionic liquids in C18 for solid-phase extraction

Induction and activation of P-glycoprotein by dihydroxylated xanthones protect against the cytotoxicity of the P-glycoprotein substrate paraquat

Inhibition of protein kinase C by synthetic xanthone derivatives.

Insights into the in vitro antitumor mechanism of action of a new pyranoxanthone.

Lichen Xanthones as Models for New Antifungal Agents

Lipid reducing activity and toxicity profiles of a library of polyphenol derivatives.

Marine Natural Products as Models to Circumvent Multidrug Resistance

Marine-Derived Compounds and Prospects for Their Antifungal Application

Marine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics

Medicinal Chemistry Strategies to Disrupt the p53-MDM2/MDMX Interaction.

Medicinal Chemistry Updates on Bacterial Efflux Pump Modulators.

Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants

Microbial interaction between a CTXM-15 -producing Escherichia coli and a susceptible Pseudomonas aeruginosa isolated from bronchoalveolar lavage: influence of cefotaxime in the dual-species biofilm formation

Modulation of Autophagy by a Thioxanthone Decreases the Viability of Melanoma Cells.

Modulation of VEGF signaling in a mouse model of diabetes by xanthohumol and 8-prenylnaringenin: Unveiling the angiogenic paradox and metabolism interplay.

Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy

New Hybrid Phenalenone Dimer, Highly Conjugated Dihydroxylated C28 Steroid and Azaphilone from the Culture Extract of a Marine Sponge-Associated Fungus, Talaromyces pinophilus KUFA 1767

New Uses for Old Drugs: Pharmacophore‐Based Screening for the Discovery of P‐Glycoprotein Inhibitors ⬇️

New chiral derivatives of xanthones: synthesis and investigation of enantioselectivity as inhibitors of growth of human tumor cell lines

New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma

New marine-derived indolymethyl pyrazinoquinazoline alkaloids with promising antimicrobial profiles

Newly Synthesized Oxygenated Xanthones as Potential P-Glycoprotein Activators: , , and Studies

Old Drugs as New Treatments for Neurodegenerative Diseases

Omadacycline: A Newly Approved Antibacterial from the Class of Tetracyclines

One Step Forward towards the Development of Eco-Friendly Antifouling Coatings: Immobilization of a Sulfated Marine-Inspired Compound

Overcoming environmental problems of biocides: Synthetic bile acid derivatives as a sustainable alternative

P-glycoprotein activation by 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) in rat distal ileum: ex vivo and in vivo studies

P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents paraquat cytotoxicity.

Pentaketides and 5-p-Hydroxyphenyl-2-pyridone Derivative from the Culture Extract of a Marine Sponge-Associated Fungus Hamigera avellanea KUFA0732

Polysulfated xanthones: multipathway development of a new generation of dual anticoagulant/antiplatelet agents.

Potential benefits of a sulfated resveratrol derivative for topical application.

Preliminary Virtual Screening Studies to Identify GRP78 Inhibitors Which May Interfere with SARS-CoV-2 Infection

Prenylated phenylbutyrolactones from cultures of a marine sponge-associated fungus Aspergillus flavipes KUFA1152

Quantification of 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5), a newly synthetized P-glycoprotein inducer/activator, in biological samples: method development and validation.

Quantification of a Sulfated Marine-Inspired Antifouling Compound in Several Aqueous Matrices: Biodegradation Studies and Leaching Assays from Polydimethylsiloxane Coatings

Screening a Small Library of Xanthones for Antitumor Activity and Identification of a Hit Compound which Induces Apoptosis

Sources and Biological Activities of Marine Sulfated Steroids

Strategies to Overcome Heparins' Low Oral Bioavailability

Structure and Ligand-based Design of P-glycoprotein Inhibitors: A Historical Perspective ⬇️

Structure based design, synthesis, and evaluation of potential inhibitors of steroid sulfatase

Structure-Antifouling Activity Relationship and Molecular Targets of Bio-Inspired(thio)xanthones