Lista de obras - Giuseppe Battaglia - Dominio Público Uruguay

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

artículo científico publicado en 2003

5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice

artículo científico publicado en 2015

A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death.

artículo científico publicado en 2011

Acid-sensing ion channel 1a is required for mGlu receptor dependent long-term depression in the hippocampus.

artículo científico publicado en 2017

Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal cortex of living mice.

artículo científico publicado en 2009

Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.

artículo científico publicado en 2014

Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons

artículo científico publicado en 2009

Alterations in the α2 δ ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies.

artículo científico publicado en 2017

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain

artículo científico publicado en 2017

Analgesic effect of a single preoperative dose of the antibiotic ceftriaxone in humans.

artículo científico publicado en 2013

Antidepressant activity of fingolimod in mice.

artículo científico publicado en 2015

Bilateral benign blepharoclonus

artículo científico publicado en 2009

Brain nerve growth factor unbalance induced by anabolic androgenic steroids in rats.

artículo científico publicado en 2013

Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizygous mice modeling angelman syndrome

artículo científico publicado en 2014

Changes in the expression of genes encoding for mGlu4 and mGlu5 receptors and other regulators of the indirect pathway in acute mouse models of drug-induced parkinsonism.

artículo científico publicado en 2015

Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors.

artículo científico publicado en 2016

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

artículo científico publicado en 2018

D-aspartate activates mGlu receptors coupled to polyphosphoinositide hydrolysis in neonate rat brain slices.

artículo científico publicado en 2010

Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats

artículo científico publicado en 2008

Dickkopf-3 Upregulates VEGF in Cultured Human Endothelial Cells by Activating Activin Receptor-Like Kinase 1 (ALK1) Pathway

artículo científico publicado en 2017

Different clinical and evolutional patterns in late idiopathic and vascular parkinsonism.

artículo científico publicado en 2005

Dopamine stimulation via infusion in the lateral ventricle

artículo científico publicado en 2006

Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions

artículo científico publicado en 2004

Dual effect of 17β-estradiol on NMDA-induced neuronal death: involvement of metabotropic glutamate receptor 1.

artículo científico publicado en 2012

Dysfunction of TGF-β1 signaling in Alzheimer's disease: perspectives for neuroprotection.

artículo científico

Early defect of transforming growth factor β1 formation in Huntington's disease.

artículo científico publicado en 2011

Early life stress causes refractoriness to haloperidol-induced catalepsy.

artículo científico publicado en 2013

Effects of repeated low doses of MDMA on EEG activity and fluoro-jade B histochemistry.

artículo científico publicado en 2004

Endogenous activation of group-II metabotropic glutamate receptors inhibits the hypothalamic-pituitary-adrenocortical axis.

artículo científico publicado en 2003

Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

artículo científico publicado en 2004

Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells.

artículo científico publicado en 2005

Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells

artículo científico publicado en 2005

Enhanced expression of Harvey ras induced by serum deprivation in cultured astrocytes.

artículo científico publicado en 2008

Enhanced mGlu5-receptor dependent long-term depression at the Schaffer collateral-CA1 synapse of congenitally learned helpless rats

artículo científico publicado en 2012

Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy").

artículo científico publicado en 2008

Erratic expression of DNA polymerases by beta-amyloid causes neuronal death.

artículo científico publicado en 2002

Estrogen receptors and type 1 metabotropic glutamate receptors are interdependent in protecting cortical neurons against β-amyloid toxicity

artículo científico publicado en 2011

Exposure to predator odor and resulting anxiety enhances the expression of the α2 δ subunit of voltage-sensitive calcium channels in the amygdala.

artículo científico publicado en 2013

Expression of the K+/Cl- cotransporter, KCC2, in cerebellar Purkinje cells is regulated by group-I metabotropic glutamate receptors.

artículo científico publicado en 2016

Fingolimod protects cultured cortical neurons against excitotoxic death

artículo científico publicado en 2012

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system

artículo científico publicado en 2017

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia.

artículo científico publicado en 2017

Glutamate receptor mGlu2 and mGlu3 knockout striata are dopamine supersensitive, with elevated D2(High) receptors and marked supersensitivity to the dopamine agonist (+)PHNO.

artículo científico publicado en 2009

Immuno-pharmacological characterization of group II metabotropic glutamate receptors controlling glutamate exocytosis in mouse cortex and spinal cord.

artículo científico publicado en 2017

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.

artículo científico publicado en 2005

Induction of the Wnt antagonist Dickkopf-1 is involved in stress-induced hippocampal damage.

artículo científico publicado en 2011

Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia.

artículo científico publicado en 2008

Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy

artículo científico publicado en 2007

Interaction between Ephrins and mGlu5 metabotropic glutamate receptors in the induction of long-term synaptic depression in the hippocampus.

artículo científico publicado en 2010

Interaction between ephrins/Eph receptors and excitatory amino acid receptors: possible relevance in the regulation of synaptic plasticity and in the pathophysiology of neuronal degeneration.

artículo científico publicado en 2006

L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors.

artículo científico publicado en 2013

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation.

artículo científico publicado en 2010

Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of beta-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands.

artículo científico publicado en 2005

Metabotropic glutamate receptors as drug targets: what's new?

artículo científico publicado en 2014

Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic?

artículo científico

Metabotropic glutamate receptors in the basal ganglia motor circuit

artículo científico publicado en 2005

Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy.

artículo científico publicado en 2011

Metabotropic glutamate receptors regulate differentiation of embryonic stem cells into GABAergic neurons

artículo científico publicado en 2008

Metabotropic glutamate receptors: beyond the regulation of synaptic transmission.

artículo científico publicado en 2007

Metabotropic glutamate receptors: new targets for the control of tumor growth?

artículo científico publicado en 2007

Methamphetamine produces neuronal inclusions in the nigrostriatal system and in PC12 cells.

artículo científico publicado en 2004

Microradiosurgical cortical transections generated by synchrotron radiation.

artículo científico publicado en 2015

Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons

artículo científico publicado en 2015

Mouse hepatocytes lacking mGlu5 metabotropic glutamate receptors are less sensitive to hypoxic damage.

artículo científico publicado en 2004

N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors.

artículo científico publicado en 2012

N-Acetylcysteine causes analgesia in a mouse model of painful diabetic neuropathy

artículo científico publicado en 2020

N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans

artículo científico publicado en 2015

Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action

artículo científico publicado en 2011

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

artículo científico publicado en 2017

Optimizing levodopa pharmacokinetics in Parkinson's disease: the role of COMT inhibitor.

artículo científico publicado en 2003

PHCCC, a specific enhancer of type 4 metabotropic glutamate receptors, reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors.

artículo científico publicado en 2004

Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

artículo científico publicado en 2005

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration

artículo científico publicado en 2017

Pharmacological activation of mGlu2/3 metabotropic glutamate receptors protects retinal neurons against anoxic damage in the goldfish Carassius auratus.

artículo científico publicado en 2006

Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.

artículo científico publicado en 2006

Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

artículo científico publicado en 2006

Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo.

artículo científico publicado en 2005

Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1.

artículo científico publicado en 2013

Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures.

artículo científico publicado en 2007

Presynaptic mGlu1 and mGlu5 autoreceptors facilitate glutamate exocytosis from mouse cortical nerve endings

artículo científico publicado en 2008

Protection by apomorphine in two independent models of acute inhibition of oxidative metabolism in rodents

artículo científico publicado en 2006

Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage

artículo científico publicado en 2010

Protective role for type-1 metabotropic glutamate receptors against spike and wave discharges in the WAG/Rij rat model of absence epilepsy.

artículo científico publicado en 2011

Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

artículo científico publicado en 2003

Quantitative 3D investigation of Neuronal network in mouse spinal cord model.

artículo científico publicado en 2017

Rat sensorimotor cortex tolerance to parallel transections induced by synchrotron-generated X-ray microbeams

artículo científico publicado en 2017

Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice

artículo científico publicado en 2003

Similarities between methamphetamine toxicity and proteasome inhibition.

artículo científico publicado en 2004

Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord

artículo científico publicado en 2015

Some metabotropic glutamate receptor ligands reduce kynurenate synthesis in rats by intracellular inhibition of kynurenine aminotransferase II

scientific article published on 01 November 2000

Stabbing headache in patients with autoimmune disorders.

artículo científico publicado en 2012

Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis.

artículo científico publicado en 2008

Synchrotron-generated microbeam sensorimotor cortex transections induce seizure control without disruption of neurological functions

artículo científico publicado en 2013

Synchrotron-generated microbeams induce hippocampal transections in rats

artículo científico publicado en 2018

Synergism between fluoxetine and the mGlu2/3 receptor agonist, LY379268, in an in vitro model for antidepressant drug-induced neurogenesis

artículo científico publicado en 2007

TGF-beta 1 protects against Abeta-neurotoxicity via the phosphatidylinositol-3-kinase pathway.

artículo científico publicado en 2008

TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease

artículo científico publicado en 2009

Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mG

artículo científico publicado en 2010

Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage.

artículo científico publicado en 2015

The HIV-1 viral protein Tat increases glutamate and decreases GABA exocytosis from human and mouse neocortical nerve endings.

artículo científico publicado en 2009

The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders.

artículo científico publicado en 2008

The advent of monoclonal antibodies in the treatment of chronic autoimmune diseases.

scientific article published on January 2011

The conditioned eyeblink reflex: a potential tool for the detection of cerebellar dysfunction in multiple sclerosis.

artículo científico publicado en 2011

The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders.

artículo científico publicado en 2016

The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection

artículo científico publicado en 2007

The α2δ Subunit and Absence Epilepsy: Beyond Calcium Channels?

artículo científico publicado en 2017

Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain

artículo científico publicado en 2010

Transglutaminase 2 ablation leads to defective function of mitochondrial respiratory complex I affecting neuronal vulnerability in experimental models of extrapyramidal disorders.

artículo científico publicado en 2006

Type-1, but Not Type-5, Metabotropic Glutamate Receptors are Coupled to Polyphosphoinositide Hydrolysis in the Retina

artículo científico publicado en 2015

Type-3 metabotropic glutamate receptors negatively modulate bone morphogenetic protein receptor signaling and support the tumourigenic potential of glioma-initiating cells.

artículo científico publicado en 2008

Type-7 metabotropic glutamate receptors negatively regulate α1-adrenergic receptor signalling.

artículo científico publicado en 2016

Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?

artículo científico publicado en 2017

Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia

artículo científico publicado en 2015

mGlu1 receptor-induced LTD of NMDA receptor transmission selectively at Schaffer collateral-CA1 synapses mediates metaplasticity

artículo científico publicado en 2014

Lista de obras de Giuseppe Battaglia

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

5-HT(2C) serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice

A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death.

Acid-sensing ion channel 1a is required for mGlu receptor dependent long-term depression in the hippocampus.

Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal cortex of living mice.

Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis.

Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons

Alterations in the α2 δ ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies.

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain

Analgesic effect of a single preoperative dose of the antibiotic ceftriaxone in humans.

Antidepressant activity of fingolimod in mice.

Bilateral benign blepharoclonus

Brain nerve growth factor unbalance induced by anabolic androgenic steroids in rats.

Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizygous mice modeling angelman syndrome

Changes in the expression of genes encoding for mGlu4 and mGlu5 receptors and other regulators of the indirect pathway in acute mouse models of drug-induced parkinsonism.

Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors.

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

D-aspartate activates mGlu receptors coupled to polyphosphoinositide hydrolysis in neonate rat brain slices.

Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats

Dickkopf-3 Upregulates VEGF in Cultured Human Endothelial Cells by Activating Activin Receptor-Like Kinase 1 (ALK1) Pathway

Different clinical and evolutional patterns in late idiopathic and vascular parkinsonism.

Dopamine stimulation via infusion in the lateral ventricle

Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions

Dual effect of 17β-estradiol on NMDA-induced neuronal death: involvement of metabotropic glutamate receptor 1.

Dysfunction of TGF-β1 signaling in Alzheimer's disease: perspectives for neuroprotection.

Early defect of transforming growth factor β1 formation in Huntington's disease.

Early life stress causes refractoriness to haloperidol-induced catalepsy.

Effects of repeated low doses of MDMA on EEG activity and fluoro-jade B histochemistry.

Endogenous activation of group-II metabotropic glutamate receptors inhibits the hypothalamic-pituitary-adrenocortical axis.

Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells.

Endogenous activation of metabotropic glutamate receptors supports the proliferation and survival of neural progenitor cells

Enhanced expression of Harvey ras induced by serum deprivation in cultured astrocytes.

Enhanced mGlu5-receptor dependent long-term depression at the Schaffer collateral-CA1 synapse of congenitally learned helpless rats

Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy").

Erratic expression of DNA polymerases by beta-amyloid causes neuronal death.

Estrogen receptors and type 1 metabotropic glutamate receptors are interdependent in protecting cortical neurons against β-amyloid toxicity

Exposure to predator odor and resulting anxiety enhances the expression of the α2 δ subunit of voltage-sensitive calcium channels in the amygdala.

Expression of the K+/Cl- cotransporter, KCC2, in cerebellar Purkinje cells is regulated by group-I metabotropic glutamate receptors.

Fingolimod protects cultured cortical neurons against excitotoxic death

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia.

Glutamate receptor mGlu2 and mGlu3 knockout striata are dopamine supersensitive, with elevated D2(High) receptors and marked supersensitivity to the dopamine agonist (+)PHNO.

Immuno-pharmacological characterization of group II metabotropic glutamate receptors controlling glutamate exocytosis in mouse cortex and spinal cord.

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.

Induction of the Wnt antagonist Dickkopf-1 is involved in stress-induced hippocampal damage.

Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia.

Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy

Interaction between Ephrins and mGlu5 metabotropic glutamate receptors in the induction of long-term synaptic depression in the hippocampus.

Interaction between ephrins/Eph receptors and excitatory amino acid receptors: possible relevance in the regulation of synaptic plasticity and in the pathophysiology of neuronal degeneration.

L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors.

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation.

Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of beta-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands.

Metabotropic glutamate receptors as drug targets: what's new?

Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic?

Metabotropic glutamate receptors in the basal ganglia motor circuit

Metabotropic glutamate receptors in the thalamocortical network: strategic targets for the treatment of absence epilepsy.

Metabotropic glutamate receptors regulate differentiation of embryonic stem cells into GABAergic neurons

Metabotropic glutamate receptors: beyond the regulation of synaptic transmission.

Metabotropic glutamate receptors: new targets for the control of tumor growth?

Methamphetamine produces neuronal inclusions in the nigrostriatal system and in PC12 cells.

Microradiosurgical cortical transections generated by synchrotron radiation.

Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons

Mouse hepatocytes lacking mGlu5 metabotropic glutamate receptors are less sensitive to hypoxic damage.

N-Acetyl-cysteine causes analgesia by reinforcing the endogenous activation of type-2 metabotropic glutamate receptors.

N-Acetylcysteine causes analgesia in a mouse model of painful diabetic neuropathy

N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans

Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

Optimizing levodopa pharmacokinetics in Parkinson's disease: the role of COMT inhibitor.

PHCCC, a specific enhancer of type 4 metabotropic glutamate receptors, reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors.

Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration

Pharmacological activation of mGlu2/3 metabotropic glutamate receptors protects retinal neurons against anoxic damage in the goldfish Carassius auratus.

Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.

Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo.

Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1.

Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures.