Lista de obras - Stina Syvänen - Dominio Público Uruguay

(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model.

artículo científico publicado en 2014

(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

artículo científico publicado en 2011

A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging

artículo científico publicado en 2017

A computerized infusion pump for control of tissue tracer concentration during positron emission tomography in vivo pharmacokinetic/pharmacodynamic measurements

artículo científico publicado en 2008

Advances in PET Imaging of P-Glycoprotein Function at the Blood-Brain Barrier ⬇️

artículo científico publicado el 4 de diciembre de 2012

Alteration in P-glycoprotein Functionality Affects Intrabrain Distribution of Quinidine More Than Brain Entry—A Study in Rats Subjected to Status Epilepticus by Kainate ⬇️

artículo científico publicado el 4 de enero de 2012

Altered GABAA receptor density and unaltered blood-brain barrier transport in a kainate model of epilepsy: an in vivo study using 11C-flumazenil and PET.

artículo científico publicado en 2012

Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

artículo científico publicado en 2018

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

artículo científico

Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease

artículo científico publicado en 2018

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor.

artículo científico publicado en 2017

Blood-brain barrier integrity in a mouse model of Alzheimer's disease with or without acute 3D6 immunotherapy

artículo científico publicado en 2018

Blood-brain barrier penetration of zolmitriptan--modelling of positron emission tomography data

artículo científico publicado en 2006

Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [11C]ABP688 PET imaging and ex vivo immunoblotting.

artículo científico publicado en 2016

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

artículo científico publicado en 2021

Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')2 fragment.

artículo científico publicado en 2017

Chemical imaging of evolving amyloid plaque pathology and associated Aβ peptide aggregation in a transgenic mouse model of Alzheimer's disease

scientific article published on 06 November 2019

Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry.

artículo científico publicado en 2016

Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET.

artículo científico publicado en 2006

Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells.

artículo científico publicado en 2017

Engineered antibodies: new possibilities for brain PET?

scientific article published on 24 July 2019

Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain

artículo científico publicado en 2021

Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

artículo científico publicado en 2020

Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

artículo científico publicado en 2022

High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain

artículo científico publicado en 2018

In Vivo Studies of Drug BBB Transport: Translational Challenges and the Role of Brain Imaging

scientific article published on 03 January 2021

Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease

artículo científico publicado en 2019

On the rate and extent of drug delivery to the brain.

artículo científico publicado en 2008

P-glycoprotein protein expression versus functionality at the blood-brain barrier using immunohistochemistry, microdialysis and mathematical modeling

artículo científico publicado en 2018

Pharmacokinetic consequences of active drug efflux at the blood-brain barrier

artículo científico publicado en 2006

Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood-brain barriers studied with (R)-[11C]verapamil positron emission tomography

artículo científico publicado en 2012

Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β.

artículo científico publicado en 2017

Predicting brain concentrations of drug using positron emission tomography and venous input: modeling of arterial-venous concentration differences

artículo científico publicado en 2006

Probing amyloid-β pathology in transgenic Alzheimer's disease (tgArcSwe) mice using MALDI imaging mass spectrometry

artículo científico publicado en 2016

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer's disease

scientific article published on 21 September 2020

Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: comparison of full saturation and steady state methods

artículo científico publicado en 2011

Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

artículo científico publicado en 2008

Specific uptake of an amyloid-β protofibril-binding antibody-tracer in AβPP transgenic mouse brain.

artículo científico publicado en 2013

Synthesis and preclinical evaluation of [11C]D617, a metabolite of (R)-[11C]verapamil

artículo científico publicado en 2012

Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression

artículo científico publicado en 2018

Synthesis of two potential NK1-receptor ligands using [1-11C]ethyl iodide and [1-11C]propyl iodide and initial PET-imaging

artículo científico publicado en 2007

Using PET studies of P-gp function to elucidate mechanisms underlying the disposition of drugs.

artículo científico publicado en 2010

Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

artículo científico publicado en 2021

[11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein

artículo científico publicado en 2012

[11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats

artículo científico publicado en 2012

[11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness

artículo científico publicado en 2013

Lista de obras de Stina Syvänen

(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model.

(R)-[11C]verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging

A computerized infusion pump for control of tissue tracer concentration during positron emission tomography in vivo pharmacokinetic/pharmacodynamic measurements

Advances in PET Imaging of P-Glycoprotein Function at the Blood-Brain Barrier ⬇️

Alteration in P-glycoprotein Functionality Affects Intrabrain Distribution of Quinidine More Than Brain Entry—A Study in Rats Subjected to Status Epilepticus by Kainate ⬇️

Altered GABAA receptor density and unaltered blood-brain barrier transport in a kainate model of epilepsy: an in vivo study using 11C-flumazenil and PET.

Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor.

Blood-brain barrier integrity in a mouse model of Alzheimer's disease with or without acute 3D6 immunotherapy

Blood-brain barrier penetration of zolmitriptan--modelling of positron emission tomography data

Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [11C]ABP688 PET imaging and ex vivo immunoblotting.

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')2 fragment.

Chemical imaging of evolving amyloid plaque pathology and associated Aβ peptide aggregation in a transgenic mouse model of Alzheimer's disease

Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer's Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry.

Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET.

Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells.

Engineered antibodies: new possibilities for brain PET?

Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain

Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain

In Vivo Studies of Drug BBB Transport: Translational Challenges and the Role of Brain Imaging

Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease

On the rate and extent of drug delivery to the brain.

P-glycoprotein protein expression versus functionality at the blood-brain barrier using immunohistochemistry, microdialysis and mathematical modeling

Pharmacokinetic consequences of active drug efflux at the blood-brain barrier

Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood-brain barriers studied with (R)-[11C]verapamil positron emission tomography

Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β.

Predicting brain concentrations of drug using positron emission tomography and venous input: modeling of arterial-venous concentration differences

Probing amyloid-β pathology in transgenic Alzheimer's disease (tgArcSwe) mice using MALDI imaging mass spectrometry

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer's disease

Simultaneous in vivo measurements of receptor density and affinity using [11C]flumazenil and positron emission tomography: comparison of full saturation and steady state methods

Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport

Specific uptake of an amyloid-β protofibril-binding antibody-tracer in AβPP transgenic mouse brain.

Synthesis and preclinical evaluation of [11C]D617, a metabolite of (R)-[11C]verapamil

Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression

Synthesis of two potential NK1-receptor ligands using [1-11C]ethyl iodide and [1-11C]propyl iodide and initial PET-imaging

Using PET studies of P-gp function to elucidate mechanisms underlying the disposition of drugs.

Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

[11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein

[11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats

[11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness