Lista de obras - Peter J. Crouch - Dominio Público Uruguay

A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease

artículo científico

A potential copper-regulatory role for cytosolic expression of the DNA repair protein XRCC5

artículo científico publicado en 2011

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation

artículo científico publicado en 2013

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

artículo científico publicado en 2013

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII.

artículo científico publicado en 2011

Anatomical redistribution of endogenous copper in embryonic mice overexpressing SOD1

artículo científico publicado en 2019

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

artículo científico publicado en 2011

Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex.

artículo científico publicado en 2010

Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture.

artículo científico publicado en 2016

Clioquinol promotes cancer cell toxicity through tumor necrosis factor alpha release from macrophages

artículo científico publicado en 2007

Comment: Cu-ATSM to treat and image amyotrophic lateral sclerosis

artículo científico publicado en 2015

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD

artículo científico publicado en 2016

Copper modulates the large dense core vesicle secretory pathway in PC12 cells.

artículo científico publicado en 2013

Copper(II) complexes of hybrid hydroxyquinoline-thiosemicarbazone ligands: GSK3β inhibition due to intracellular delivery of copper.

artículo científico publicado en 2010

Copper-ATSM as a Treatment for ALS: Support from Mutant SOD1 Models and Beyond

scientific article published on 04 November 2020

Copper-dependent inhibition of cytochrome c oxidase by Abeta(1-42) requires reduced methionine at residue 35 of the Abeta peptide

artículo científico publicado en 2006

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

artículo científico publicado en 2005

CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord

artículo científico publicado en 2017

Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?

artículo científico publicado en 2014

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

artículo científico publicado en 2014

Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

artículo científico publicado en 2011

Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

artículo científico publicado en 2007

Editorial: Metals and neurodegeneration: restoring the balance.

artículo científico publicado en 2015

Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS.

artículo científico publicado en 2016

Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates

artículo científico publicado en 2012

Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model.

artículo científico publicado en 2013

Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice

artículo científico publicado en 2016

Gene knockout of tau expression does not contribute to the pathogenesis of prion disease

artículo científico publicado en 2011

Glycogen synthase kinase-3.

artículo científico publicado en 2011

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS).

artículo científico publicado en 2017

Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

artículo científico publicado en 2014

Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis

artículo científico publicado en 2013

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

scholarly article

Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes

artículo científico publicado en 2012

Intracellular distribution of fluorescent copper and zinc bis(thiosemicarbazonato) complexes measured with fluorescence lifetime spectroscopy

artículo científico publicado en 2015

Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays

artículo científico publicado en 2008

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

artículo científico publicado en 2013

Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex

artículo científico publicado en 2016

Linker histone H1 binds to disease associated amyloid-like fibrils

artículo científico publicado en 2006

Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease

artículo científico publicado en 2013

Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.

artículo científico publicado en 2014

Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes.

artículo científico publicado en 2011

Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease

artículo científico publicado en 2007

Membrane-targeted strategies for modulating APP and Abeta-mediated toxicity.

scientific article published on February 2009

Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

artículo científico publicado en 2011

Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein

artículo científico publicado en 2013

Mitochondria in aging and Alzheimer's disease.

artículo científico publicado en 2007

Modulation of ceramide-induced cell death and superoxide production by mitochondrial DNA-encoded respiratory chain defects in Rattus xenocybrid mouse cells

artículo científico publicado en 2013

N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington's disease.

artículo científico publicado en 2016

Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.

artículo científico publicado en 2014

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.

artículo científico publicado en 2014

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.

artículo científico publicado en 2014

Prion protein "gamma-cleavage": characterizing a novel endoproteolytic processing event.

artículo científico publicado en 2015

Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function

artículo científico publicado en 2022

Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation

artículo científico publicado en 2009

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice.

artículo científico publicado en 2010

Subcellular localization of a fluorescent derivative of CuII(atsm) offers insight into the neuroprotective action of CuII(atsm).

artículo científico publicado en 2011

Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity.

artículo científico publicado en 2009

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.

artículo científico publicado en 2017

The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

artículo científico publicado en 2011

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

artículo científico publicado en 2012

The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease

artículo científico publicado en 2007

The role of metals in modulating metalloprotease activity in the AD brain.

artículo científico publicado en 2008

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis.

artículo científico publicado en 2013

Therapeutic redistribution of metal ions to treat Alzheimer's disease

artículo científico publicado en 2012

Therapeutic treatment of Alzheimer's disease using metal complexing agents.

artículo científico publicado en 2007

Therapeutic treatments for Alzheimer's disease based on metal bioavailability

artículo científico publicado en 2006

Toward hypoxia-selective rhenium and technetium tricarbonyl complexes

artículo científico publicado en 2015

X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder

artículo científico publicado en 2014

Zn II(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism.

artículo científico publicado en 2015

Lista de obras de Peter J. Crouch

A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease

A potential copper-regulatory role for cytosolic expression of the DNA repair protein XRCC5

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation

Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII.

Anatomical redistribution of endogenous copper in embryonic mice overexpressing SOD1

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex.

Circumventing the Crabtree Effect: A method to induce lactate consumption and increase oxidative phosphorylation in cell culture.

Clioquinol promotes cancer cell toxicity through tumor necrosis factor alpha release from macrophages

Comment: Cu-ATSM to treat and image amyotrophic lateral sclerosis

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD

Copper modulates the large dense core vesicle secretory pathway in PC12 cells.

Copper(II) complexes of hybrid hydroxyquinoline-thiosemicarbazone ligands: GSK3β inhibition due to intracellular delivery of copper.

Copper-ATSM as a Treatment for ALS: Support from Mutant SOD1 Models and Beyond

Copper-dependent inhibition of cytochrome c oxidase by Abeta(1-42) requires reduced methionine at residue 35 of the Abeta peptide

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord

Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands.

Editorial: Metals and neurodegeneration: restoring the balance.

Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS.

Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates

Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model.

Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice

Gene knockout of tau expression does not contribute to the pathogenesis of prion disease

Glycogen synthase kinase-3.

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS).

Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis

Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation

Inhibition of TDP-43 accumulation by bis(thiosemicarbazonato)-copper complexes

Intracellular distribution of fluorescent copper and zinc bis(thiosemicarbazonato) complexes measured with fluorescence lifetime spectroscopy

Investigating copper-regulated protein expression in Menkes fibroblasts using antibody microarrays

Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress

Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex

Linker histone H1 binds to disease associated amyloid-like fibrils

Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease

Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain.

Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes.

Mechanisms of A beta mediated neurodegeneration in Alzheimer's disease

Membrane-targeted strategies for modulating APP and Abeta-mediated toxicity.

Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein

Mitochondria in aging and Alzheimer's disease.

Modulation of ceramide-induced cell death and superoxide production by mitochondrial DNA-encoded respiratory chain defects in Rattus xenocybrid mouse cells

N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington's disease.

Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation.

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.

Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.

Prion protein "gamma-cleavage": characterizing a novel endoproteolytic processing event.

Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function

Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation

Serum matrix metalloproteinase-9 activity is dysregulated with disease progression in the mutant SOD1 transgenic mice.

Subcellular localization of a fluorescent derivative of CuII(atsm) offers insight into the neuroprotective action of CuII(atsm).

Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity.

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.

The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease

The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease

The role of metals in modulating metalloprotease activity in the AD brain.

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis.

Therapeutic redistribution of metal ions to treat Alzheimer's disease

Therapeutic treatment of Alzheimer's disease using metal complexing agents.

Therapeutic treatments for Alzheimer's disease based on metal bioavailability

Toward hypoxia-selective rhenium and technetium tricarbonyl complexes

X-ray fluorescence imaging reveals subcellular biometal disturbances in a childhood neurodegenerative disorder

Zn II(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism.