Lista de obras - Danilo Milardi - Dominio Público Uruguay

A combined scanning dilatometric and differential scanning calorimetric study of the thermal unfolding of bovine serum albumin

A model for the thermal unfolding of amicyanin

artículo científico publicado en 2002

A neglected modulator of insulin-degrading enzyme activity and conformation: The pH

artículo científico publicado en 2015

Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents

artículo científico publicado en 2017

An alternative approach in the structure-based predictions of the thermodynamics of protein unfolding

artículo científico publicado en 1997

Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: towards a unifying description of conformational transitions, oligomerization and membrane damage.

artículo científico publicado en 2013

Calorimetric evidence for different structural roles of Glu132 and Glu133 residues in human superoxide dismutase

article

Carnosine inhibits Aβ(42) aggregation by perturbing the H-bond network in and around the central hydrophobic cluster

artículo científico publicado en 2013

Cationic Porphyrins Are Reversible Proteasome Inhibitors

artículo científico publicado en 2012

Cationic porphyrins are tunable gatekeepers of the 20S proteasome.

artículo científico publicado en 2015

Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP.

artículo científico publicado en 2013

Computational Comparison of Imidazoline Association with the I2 Binding Site in Human Monoamine Oxidases

Contributions of polar and apolar groups to the thermodynamic stability of azurin

artículo científico publicado en 1996

Correction to Computational Comparison of Imidazoline Association with the I2 Binding Site in Human Monoamine Oxidases

scholarly article published in Journal of Chemical Information and Modeling

Deciphering the zinc coordination properties of the prokaryotic zinc finger domain: The solution structure characterization of Ros87 H42A functional mutant

artículo científico publicado en 2013

Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore

artículo científico publicado en 2007

Differential scanning calorimetry of the irreversible denaturation of bovine superoxide dismutase

article

Endogenous and artificial miRNAs explore a rich variety of conformations: a potential relationship between secondary structure and biological functionality

artículo científico publicado en 2020

Environmental Effects on a Prion's Helix II Domain: Copper(II) and Membrane Interactions with PrP180–193 and Its Analogues

Environmental factors differently affect human and rat IAPP: conformational preferences and membrane interactions of IAPP17-29 peptide derivatives

artículo científico publicado en 2007

Experimental model for the thermal denaturation of azurin: a kinetic study

article

Extended theoretical analysis of irreversible protein thermal unfolding.

artículo científico publicado en 1994

Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins.

artículo científico publicado en 2018

Free energy perturbation and molecular dynamics calculations of copper binding to azurin

artículo científico publicado en 2003

Inhibition of Aβ Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry.

artículo científico publicado en 2017

Inorganic stressors of ubiquitin.

artículo científico publicado en 2013

Interaction of Human Amylin with Phosphatidylcholine and Phosphatidylserine Membranes

Interactions of two O-phosphorylresveratrol derivatives with model membranes ⬇️

artículo científico publicado el 23 de marzo de 2012

Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins

scientific article published on 03 December 2020

Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: the role of copper(II) ions, pH, and membrane mimicking environments.

artículo científico publicado en 2010

Molecular and cytotoxic properties of hIAPP17–29 and rIAPP17–29 fragments: A comparative study with the respective full-length parent polypeptides

artículo científico publicado en 2014

Molecular dynamics: New advances in drug discovery

article

Phospholipids Critical Micellar Concentrations Trigger Different Mechanisms of Intrinsically Disordered Proteins Interaction with Model Membranes

artículo científico publicado en 2018

Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β-Amyloid Toxicity

scientific article published on 17 December 2019

Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study

article

Sequential application of ligand and structure based modeling approaches to index chemicals for their hH4R antagonism

artículo científico publicado en 2014

Site directed mutagenesis of insulin-degrading enzyme allows singling out the molecular basis of peptidase versus E1-like activity: the role of metal ions

scientific article published on 01 February 2019

Structural Zn(II) Implies a Switch from Fully Cooperative to Partly Downhill Folding in Highly Homologous Proteins

artículo científico publicado en 2013

Substitution of the Native Zn(II) with Cd(II), Co(II) and Ni(II) Changes the Downhill Unfolding Mechanism of Ros87 to a Completely Different Scenario

artículo científico publicado en 2020

Synthesis, biophysical characterization and anti-HIV activity of d(TG3AG) Quadruplexes bearing hydrophobic tails at the 5'-end.

artículo científico publicado en 2014

The Ionophoric Activity of a Pro-Apoptotic VEGF165 Fragment on HUVEC Cells

scientific article published on 20 April 2020

The active role of Ca2+ ions in Aβ-mediated membrane damage.

artículo científico publicado en 2018

The double faced role of copper in Aβ homeostasis: A survey on the interrelationship between metal dyshomeostasis, UPS functioning and autophagy in neurodegeneration

The effect of copper/zinc replacement on the folding free energy of wild type and Cys3Ala/Cys26Ala azurin.

artículo científico publicado en 2003

The effects of scan rate and protein concentration on DSC thermograms of bovine superoxide dismutase

article

The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin

artículo científico publicado en 2015

The interaction of a peptide with a scrambled hydrophobic/hydrophilic sequence (Pro-Asp-Ala-Asp-Ala-His-Ala-His-Ala-His-Ala-Ala-Ala-His-Gly) (PADH) with DPPC model membranes: a DSC study

The role of aromatic side-chains in amyloid growth and membrane interaction of the islet amyloid polypeptide fragment LANFLVH.

artículo científico publicado en 2010

The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: innocent bystanders or partners in a crime?

artículo científico publicado en 2014

The role of copper(II) in the aggregation of human amylin.

artículo científico publicado en 2014

The role played by the alpha-helix in the unfolding pathway and stability of azurin: switching between hierarchic and nonhierarchic folding.

artículo científico publicado en 2007

Theoretical basis for differential scanning calorimetric analysis of multimeric proteins

artículo científico publicado en 1996

Thermodynamic analysis of the contributions of the copper ion and the disulfide bridge to azurin stability: synergism among multiple depletions

artículo científico publicado en 2003

Thermodynamics and kinetics of the thermal unfolding of plastocyanin

Ubiquitin Associates with the N-Terminal Domain of Nerve Growth Factor: The Role of Copper(II) Ions

artículo científico publicado en 2016

Ubiquitin Stability and the Lys 63-Linked Polyubiquitination Site Are Compromised on Copper Binding

artículo científico publicado en 2007

Ubiquitin binds the amyloid β peptide and interferes with its clearance pathways

artículo científico publicado en 2019

Unveiling the unfolding pathway of FALS associated G37R SOD1 mutant: a computational study.

artículo científico publicado en 2010

Zinc to cadmium replacement in the prokaryotic zinc-finger domain.

artículo científico

Zinc(II) complexes of ubiquitin: speciation, affinity and binding features

artículo científico publicado en 2011

α-helical structures drive early stages of self-assembly of amyloidogenic amyloid polypeptide aggregate formation in membranes

artículo científico publicado en 2013

Lista de obras de Danilo Milardi

A combined scanning dilatometric and differential scanning calorimetric study of the thermal unfolding of bovine serum albumin

A model for the thermal unfolding of amicyanin

A neglected modulator of insulin-degrading enzyme activity and conformation: The pH

Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents

An alternative approach in the structure-based predictions of the thermodynamics of protein unfolding

Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: towards a unifying description of conformational transitions, oligomerization and membrane damage.

Calorimetric evidence for different structural roles of Glu132 and Glu133 residues in human superoxide dismutase

Carnosine inhibits Aβ(42) aggregation by perturbing the H-bond network in and around the central hydrophobic cluster

Cationic Porphyrins Are Reversible Proteasome Inhibitors

Cationic porphyrins are tunable gatekeepers of the 20S proteasome.

Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP.

Computational Comparison of Imidazoline Association with the I2 Binding Site in Human Monoamine Oxidases

Contributions of polar and apolar groups to the thermodynamic stability of azurin

Correction to Computational Comparison of Imidazoline Association with the I2 Binding Site in Human Monoamine Oxidases

Deciphering the zinc coordination properties of the prokaryotic zinc finger domain: The solution structure characterization of Ros87 H42A functional mutant

Determination of the conformation of the human VDAC1 N-terminal peptide, a protein moiety essential for the functional properties of the pore

Differential scanning calorimetry of the irreversible denaturation of bovine superoxide dismutase

Endogenous and artificial miRNAs explore a rich variety of conformations: a potential relationship between secondary structure and biological functionality

Environmental Effects on a Prion's Helix II Domain: Copper(II) and Membrane Interactions with PrP180–193 and Its Analogues

Environmental factors differently affect human and rat IAPP: conformational preferences and membrane interactions of IAPP17-29 peptide derivatives

Experimental model for the thermal denaturation of azurin: a kinetic study

Extended theoretical analysis of irreversible protein thermal unfolding.

Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins.

Free energy perturbation and molecular dynamics calculations of copper binding to azurin

Inhibition of Aβ Amyloid Growth and Toxicity by Silybins: The Crucial Role of Stereochemistry.

Inorganic stressors of ubiquitin.

Interaction of Human Amylin with Phosphatidylcholine and Phosphatidylserine Membranes

Interactions of two O-phosphorylresveratrol derivatives with model membranes ⬇️

Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins

Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: the role of copper(II) ions, pH, and membrane mimicking environments.

Molecular and cytotoxic properties of hIAPP17–29 and rIAPP17–29 fragments: A comparative study with the respective full-length parent polypeptides

Molecular dynamics: New advances in drug discovery

Phospholipids Critical Micellar Concentrations Trigger Different Mechanisms of Intrinsically Disordered Proteins Interaction with Model Membranes

Pyrazolones Activate the Proteasome by Gating Mechanisms and Protect Neuronal Cells from β-Amyloid Toxicity

Resveratrol interferes with the aggregation of membrane-bound human-IAPP: A molecular dynamics study

Sequential application of ligand and structure based modeling approaches to index chemicals for their hH4R antagonism

Site directed mutagenesis of insulin-degrading enzyme allows singling out the molecular basis of peptidase versus E1-like activity: the role of metal ions

Structural Zn(II) Implies a Switch from Fully Cooperative to Partly Downhill Folding in Highly Homologous Proteins

Substitution of the Native Zn(II) with Cd(II), Co(II) and Ni(II) Changes the Downhill Unfolding Mechanism of Ros87 to a Completely Different Scenario

Synthesis, biophysical characterization and anti-HIV activity of d(TG3AG) Quadruplexes bearing hydrophobic tails at the 5'-end.

The Ionophoric Activity of a Pro-Apoptotic VEGF165 Fragment on HUVEC Cells

The active role of Ca2+ ions in Aβ-mediated membrane damage.

The double faced role of copper in Aβ homeostasis: A survey on the interrelationship between metal dyshomeostasis, UPS functioning and autophagy in neurodegeneration

The effect of copper/zinc replacement on the folding free energy of wild type and Cys3Ala/Cys26Ala azurin.

The effects of scan rate and protein concentration on DSC thermograms of bovine superoxide dismutase

The insulin degrading enzyme activates ubiquitin and promotes the formation of K48 and K63 diubiquitin

The interaction of a peptide with a scrambled hydrophobic/hydrophilic sequence (Pro-Asp-Ala-Asp-Ala-His-Ala-His-Ala-His-Ala-Ala-Ala-His-Gly) (PADH) with DPPC model membranes: a DSC study

The role of aromatic side-chains in amyloid growth and membrane interaction of the islet amyloid polypeptide fragment LANFLVH.

The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: innocent bystanders or partners in a crime?

The role of copper(II) in the aggregation of human amylin.

The role played by the alpha-helix in the unfolding pathway and stability of azurin: switching between hierarchic and nonhierarchic folding.

Theoretical basis for differential scanning calorimetric analysis of multimeric proteins

Thermodynamic analysis of the contributions of the copper ion and the disulfide bridge to azurin stability: synergism among multiple depletions

Thermodynamics and kinetics of the thermal unfolding of plastocyanin

Ubiquitin Associates with the N-Terminal Domain of Nerve Growth Factor: The Role of Copper(II) Ions

Ubiquitin Stability and the Lys 63-Linked Polyubiquitination Site Are Compromised on Copper Binding

Ubiquitin binds the amyloid β peptide and interferes with its clearance pathways

Unveiling the unfolding pathway of FALS associated G37R SOD1 mutant: a computational study.

Zinc to cadmium replacement in the prokaryotic zinc-finger domain.

Zinc(II) complexes of ubiquitin: speciation, affinity and binding features

α-helical structures drive early stages of self-assembly of amyloidogenic amyloid polypeptide aggregate formation in membranes