Filtros de búsqueda

Lista de obras de Colin W G Fishwick

(±) cis-Bisamido epoxides: A novel series of potent FXIII-A inhibitors ⬇️

artículo científico publicado en 2015

1,3-Dipolar cycloaddition of stabilised and non-stabilised azomethine ylides derived from uracil polyoxin C (UPoC): access to nikkomycin analogues

artículo científico publicado en 2004

2-Aminotetralones: novel inhibitors of MurA and MurZ.

artículo científico publicado en 2008

A Non-peptidic photoactivatable antagonist for mapping the antagonist binding site of the tachykinin NK2 receptor

artículo científico publicado en 1996

A chemical genomics approach to drug reprofiling in oncology: Antipsychotic drug risperidone as a potential adenocarcinoma treatment. ⬇️

artículo científico publicado en 2017

A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis.

artículo científico publicado en 2012

A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli

artículo científico publicado en 2005

A facile palladium catalysed 3-component cascade route to functionalised isoquinolinones and isoquinolines ⬇️

artículo científico publicado en 2015

A short dipolar cycloaddition approach to γ-lactam alkaloids from cynometra hankei

A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH.

artículo científico publicado en 2009

A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT.

artículo científico publicado en 2012

Activity of and development of resistance to corallopyronin A, an inhibitor of RNA polymerase

artículo científico publicado en 2011

Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action ⬇️

artículo científico publicado en 2017

An efficient route to S-N-(9-fluorenylmethoxycarbonyl)-4′-(1-azi-2,2,2-trifluoroethyl)phenylalanine

artículo científico publicado en 1994

An in silico structure-based approach to anti-infective drug discovery

artículo científico

Analysis of mupirocin resistance and fitness in Staphylococcus aureus by molecular genetic and structural modeling techniques

artículo científico publicado en 2004

Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques

artículo científico publicado en 2009

Applications of structure-based design to antibacterial drug discovery

artículo científico

Assay platform for clinically relevant metallo-β-lactamases ⬇️

artículo científico publicado en 2013

Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ).

artículo científico publicado en 2010

CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii ⬇️

artículo científico publicado en 2018

Catalytic bimetalic [Pd(0)/Ag(I) Heck-1,3-dipolar cycloaddition cascade reactions accessing spiro-oxindoles. Concomitant in situ generation of azomethine ylides and dipolarophile ⬇️

Cis‐isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels ⬇️

artículo científico publicado el 1 de septiembre de 2010

Computational methods to identify new antibacterial targets

artículo científico publicado en 2015

Cyclic Boronates Inhibit All Classes of β-Lactamases ⬇️

scientific article published on 23 January 2017

Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness ⬇️

artículo científico publicado en 2014

Cyclic-fused azomethine-, imidate-, and thioimidate methylides: An efficient regiocontrolled entry into spiro-fused pyrrolidines

artículo científico publicado en 1996

Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB).

artículo científico publicado en 2009

Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.

artículo científico publicado en 2007

Detection and mechanistic implication of a dynamic equilibrium in some novel spiro-heterocyclic systems

artículo científico publicado en 1989

Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In Vitro

artículo científico publicado en 2009

Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design. ⬇️

artículo científico publicado en 2013

Discovery of novel FabF ligands inspired by platensimycin by integrating structure-based design with diversity-oriented synthetic accessibility ⬇️

artículo científico publicado en 2013

Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening

artículo científico publicado en 2009

Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay

artículo científico publicado en 2013

Dithiolane-isocyanate imminium methylides: A rapid stereoselective entry into γ-lactams

article published in 1995

Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human ⬇️

artículo científico publicado en 2015

Enantioselective synthesis of non-proteinogenic 2-arylallyl-α-amino acids via Pd/In catalytic cascades ⬇️

Encapsulation of sodium alkyl sulfates by the cyclotriveratrylene-based, [Pd(6)L(8)](12+) stella octangula cage

artículo científico publicado en 2014

Epoxide based inhibitors of the hepatitis C virus non-structural 2 autoprotease ⬇️

artículo científico publicado en 2015

Erratum: The First Small-Molecule Inhibitors of Members of the Ribonuclease E Family ⬇️

artículo científico publicado en 2015

Facile intramolecular cycloadditions of 2-(N-Acylamino)-1-thia-1,3-dienes

artículo científico publicado en 1991

Facile palladium catalysed functionalisation of 1,2-isothiazoline-3-ones

artículo científico publicado en 1994

Facile palladium catalysed functionalisation of 1,2-isothiazoline-3-ones and the highly diastereoselective Diels-Alder reactions of 4-vinyl-1,2-isothiazoline-3-one-1-oxides

artículo científico publicado en 1999

Facile preparation of 2-imino tetrahydrofurans, pyrans and oxepans

artículo científico publicado en 1989

Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases

artículo científico publicado en 2012

Formation and mechanistic implication of a novel thiaazabicyclooctane derivative drug the cycloaddition of n-acetyl cinnamic acid thioamide

artículo científico publicado en 1991

Furanyl-rhodanines are unattractive drug candidates for development as inhibitors of bacterial RNA polymerase

artículo científico publicado en 2010

Generation and cycloadditions of 2-(N-Acylamino)-1-thia-1,3-dienes. Part II. Rationalization of reactivity using an FMO approach

artículo científico publicado en 1989

Generation and cycloadditions of 2-(N-acylamino)-1-thia-1, 3-dienes. Structural investigations using NMR methods. Part I

artículo científico publicado en 1989

Generation and cycloadditions of 2-(N-acylamino)-1-thia-1,3-dienes

artículo científico publicado en 1989

Generation and cycloadditions of 2-(N-acylamino)-1-thia-1,3-dienes part III: Control of diastereoselectivity using homochiral auxiliaries

artículo científico publicado en 1998

Generation and cycloadditions of tetrahydrofuryl, pyranyl, and oxepanyl-2-imminium methylides

artículo científico publicado en 1989

Hetero-1,3-dipolar cycloadditions of dithiolane-isocyanate imminium methylides: A novel route to 1,3-oxazolidine- and thiazolidine-2-thiones

High-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors ⬇️

artículo científico publicado en 2012

Highly efficient diastereoselective Exo Diels-Alder reactions of homochiral 2-(N-acylamino)-1-thia-1,3-dienes: A powerful entry into optically pure thiopyrans

artículo científico publicado en 1996

Hyperreactivity of adenines and conformational flexibility of a translational repression site ⬇️

artículo científico publicado el 20 de mayo de 1991

Identification of Receptor Tyrosine Kinase Inhibitors Using Cell Surface Biotinylation and Affinity Isolation

artículo científico publicado en 2015

Identification of a lead like inhibitor of the hepatitis C virus non-structural NS2 autoprotease ⬇️

artículo científico publicado en 2015

Identification of a small molecule inhibitor of Ebola virus genome replication and transcription using in silico screening ⬇️

artículo científico publicado en 2018

Identification of an Indazole-Based Pharmacophore for the Inhibition of FGFR Kinases Using Fragment-Led de Novo Design. ⬇️

artículo científico publicado en 2017

Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp ⬇️

artículo científico publicado en 2012

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors ⬇️

artículo científico publicado en 2017

In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis ⬇️

artículo científico publicado en 2014

Indolinones and anilinophthalazines differentially target VEGF-A- and basic fibroblast growth factor-mediated responses in primary human endothelial cells.

artículo científico publicado en 2012

Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine. ⬇️

artículo científico publicado en 2017

Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes ⬇️

artículo científico publicado en 2017

Intramolecular [3+2] cycloaddition versus 1,4-hydrogen shift in indolium-N-methylides

artículo científico publicado en 1989

Intramolecular [3+2] cycloadditions of non-stabilised azomethine imidate-methylides

artículo científico publicado en 1989

Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center

artículo científico publicado en 2008

Molecular mechanism of ligand recognition by membrane transport protein, Mhp1 ⬇️

artículo científico publicado en 2014

Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy

artículo científico publicado en 2008

Natural and synthetic flavonoid modulation of TRPC5 channels ⬇️

artículo científico publicado en 2015

Neighbouring group effects in a Pummerer-type rearrangement: A facile entry into 3,1-benzoxathiins

artículo científico publicado en 1995

Neighbouring group participation in Pummerer-type rearrangements of ortho-substituted arylmethyl sulphoxides

artículo científico publicado en 1995

New Opportunities in the Structure-based Design of Anti-Protozoan Agents ⬇️

artículo científico publicado en 2016

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections ⬇️

artículo científico publicado en 2016

Pd(0) catalyzed three–five-component C-2-arylallylation of active methylene heterocycles: pyrazolones, oxazolones, isoxazolones and N,N′-dimethylbarbituric acid

artículo científico publicado en 2007

Pharmacophore model of the quercetin binding site of the SIRT6 protein

artículo científico publicado en 2014

Photoactivatable analogues of a Substance P non-peptidic antagonist, for probing the antagonist binding site of the NK1 receptor

artículo científico publicado en 1995

Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone

artículo científico publicado en 2011

Preparation of methyl-2-(ω-iodoalkyl)propenoates and a facile route to 2-carbomethoxy-1,3-butadiene

artículo científico publicado en 1989

Preparation of novel 3H-trifluoromethyldiazirine-based photoactivatable potassium channel antagonists

artículo científico publicado en 2005

Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: structure based design, synthesis, SAR and antimicrobial activity ⬇️

artículo científico publicado en 2014

RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus

artículo científico publicado en 2000

Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century. ⬇️

artículo científico

Remarkably high diastereoselective exo diels-alder reactivity of 4-vinyl isothiazoline-3-one-1-oxides: The sulphoxide Syn effect

artículo científico publicado en 1995

Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel

artículo científico publicado en 2011

Selective Phosphonylation of 5'-Adenosine Monophosphate (5'-AMP) via Pyrophosphite [PPi(III)]. ⬇️

artículo científico publicado en 2016

Spatial requirements of the antagonist binding site of the NK2 receptor.

artículo científico publicado en 2001

Stereoselective palladium-catalyzed four-component cascade synthesis of pyrrolidinyl-, pyrazolidinyl-, and isoxazolidinyl isoquinolines

artículo científico publicado en 2005

Stereo‐selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids ⬇️

artículo científico publicado el 1 de abril de 2011

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates ⬇️

artículo científico publicado en 2016

Structural/mechanistic insights into the efficacy of non-classical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates. ⬇️

artículo científico publicado en 2017

Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors

artículo científico publicado en 2011

Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase

scientific article published on 05 November 2019

Structure-based design of anti-infectives

scientific article published on December 2010

Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases

artículo científico publicado en 2009

Structure-based discovery of antibacterial drugs

artículo científico publicado en 2010

Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists ⬇️

artículo científico publicado en 2016

Structure-based ligand design of novel bacterial RNA polymerase inhibitors

artículo científico publicado en 2011

Structure-switching M3L2 Ir(iii) coordination cages with photo-isomerising azo-aromatic linkers ⬇️

artículo científico publicado en 2018

Synthesis of de novo designed small-molecule inhibitors of bacterial RNA polymerase

artículo científico publicado en 2008

The Growing Role of Electron Microscopy in Anti-parasitic Drug Discovery ⬇️

artículo científico publicado en 2017

The activation peptide cleft exposed by thrombin cleavage of FXIII-A(2) contains a recognition site for the fibrinogen α chain.

artículo científico publicado en 2013

The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target

artículo científico publicado en 2014

The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

artículo científico publicado en 2005

The first de novo-designed antagonists of the human NK(2) receptor.

artículo científico publicado en 2005

The first small-molecule inhibitors of members of the ribonuclease E family ⬇️

artículo científico publicado en 2015

The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors

artículo científico publicado en 2009

The potential use of single-particle electron microscopy as a tool for structure-based inhibitor design. ⬇️

artículo científico publicado en 2017

Three-component bimetallic (Pd/In) mediated cascade allylation of C=X functionality

artículo científico publicado en 2003

Two novel amino acid derivatives containing side-chain thioamides for the synthesis of photoactivatable peptides

artículo científico publicado en 1997

Use of synthetic oligoribonucleotides to probe RNA-protein interactions in the MS2 translational operator complex ⬇️

artículo científico publicado el 25 de junio de 1990

X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery. ⬇️

artículo científico publicado en 2018

X=Y–ZH system as potential 1,3-dipoles. Part 59: Cascade 1,3-azaprotio cyclotransfer–1,3-dipolar cycloaddition (1,3-APT–1,3-DC) reactions of benzobicyclo[3.3.1]non-5-en-9-one oxime

artículo científico publicado en 2003

XY–ZH compounds as potential 1,3-dipoles. Part 65: atom economic cascade synthesis of highly functionalized pyrimidinylpyrrolidines

artículo científico publicado en 2011

[3+2] Cycloadditions of indolenine-derived azomethine ylides a rapid entry into pyrrolo [1,2-a] indolines

artículo científico publicado en 1988

pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases

artículo científico publicado en 2003

γ-Carboline AC190 analogues via palladium catalysed allene insertion stereo and regioselective 3- and 5-component cascades ⬇️

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda