Lista de obras - Daniel G. Bracewell - Dominio Público Uruguay

A framework for the prediction of scale-up when using compressible chromatographic packings

artículo científico publicado en 2007

A microscale approach for predicting the performance of chromatography columns used to recover therapeutic polyclonal antibodies

scientific article published on 20 September 2009

A microscale yeast cell disruption technique for integrated process development strategies.

artículo científico publicado en 2008

A rational approach to improving titer in E. coli-based cell-free protein synthesis reactions

artículo científico publicado en 2020

Adenovirus 5 recovery using nanofiber ion-exchange adsorbents

artículo científico publicado en 2019

Advances in product release strategies and impact on bioprocess design.

scientific article published on July 2009

An automated microscale chromatographic purification of virus-like particles as a strategy for process development.

artículo científico publicado en 2007

An automated packed Protein G micro-pipette tip assay for rapid quantification of polyclonal antibodies in ovine serum

artículo científico publicado en 2010

An integrated experimental and economic evaluation of cell therapy affinity purification technologies.

artículo científico publicado en 2017

An optical biosensor for real-time chromatography monitoring: Breakthrough determination

scientific article published on 01 October 1998

An ultra scale-down approach identifies host cell protein differences across a panel of mAb producing CHO cell line variants

artículo científico publicado en 2015

Assessment of the manufacturability of Escherichia coli high cell density fermentations.

artículo científico publicado en 2011

Bioprocess engineering issues that would be faced in producing a DNA vaccine at up to 100 m3 fermentation scale for an influenza pandemic.

artículo científico publicado en 2005

Bioprocess monitoring: An optical biosensor for rapid bioproduct analysis

article

Characterization and feasibility of a miniaturized stirred tank bioreactor to perform E. coli high cell density fed-batch fermentations.

artículo científico publicado en 2011

Chemical and biological characterisation of a sensor surface for bioprocess monitoring.

artículo científico publicado en 2010

Chromatography modelling to describe protein adsorption at bead level

artículo científico publicado en 2013

Comparison of Techniques for Monitoring Antibody Fragment Production in E. coli Fermentation Cultures

article

Demonstration of the use of windows of operation to visualize the effects of fouling on the performance of a chromatographic step

scientific article published on 12 May 2011

Design and characterization of a microfluidic packed bed system for protein breakthrough and dynamic binding capacity determination

artículo científico publicado en 2009

Design of high productivity antibody capture by protein A chromatography using an integrated experimental and modeling approach

artículo científico publicado en 2012

Determining antibody stability: creation of solid-liquid interfacial effects within a high shear environment

artículo científico publicado en 2007

Drying techniques for the visualisation of agarose-based chromatography media by scanning electron microscopy

artículo científico publicado en 2016

Dual Data-Independent Acquisition Approach Combining Global HCP Profiling and Absolute Quantification of Key Impurities during Bioprocess Development.

artículo científico publicado en 2017

Dual salt precipitation for the recovery of a recombinant protein from Escherichia coli.

artículo científico publicado en 2011

Dynamic Simulation of a Batch Aqueous Two-Phase Extraction Process for α-Amylase

Effects of lysosomal biotherapeutic recombinant protein expression on cell stress and protease and general host cell protein release in Chinese hamster ovary cells.

artículo científico publicado en 2017

Escherichia coli-Based Cell-Free Protein Synthesis for Iterative Design of Tandem-Core Virus-Like Particles

artículo científico publicado en 2021

Evaluation of fluorescent dyes to measure protein aggregation within mammalian cell culture supernatants.

artículo científico publicado en 2018

Exploiting the intracellular compartmentalization characteristics of the S. cerevisiae host cell for enhancing primary purification of lipid-envelope virus-like particles.

artículo científico publicado en 2010

Fabricating electrospun cellulose nanofibre adsorbents for ion-exchange chromatography.

artículo científico publicado en 2014

Factors influencing antibody stability at solid-liquid interfaces in a high shear environment

artículo científico publicado en 2009

Flocculation on a chip: a novel screening approach to determine floc growth rates and select flocculating agents.

artículo científico publicado en 2018

Fluorescence based real time monitoring of fouling in process chromatography.

artículo científico publicado en 2017

Holistic process development to mitigate proteolysis of a subunit rotavirus vaccine candidate produced in Pichia pastoris by means of an acid pH pulse during fed-batch fermentation

artículo científico publicado en 2020

Host cell protein adsorption characteristics during protein A chromatography.

artículo científico publicado en 2012

Host cell protein dynamics in the supernatant of a mAb producing CHO cell line ⬇️

artículo científico publicado el 12 de diciembre de 2011

Identification of upstream culture conditions and harvest time parameters that affect host cell protein clearance

artículo científico publicado en 2019

Impact of aeration strategy on CHO cell performance during antibody production

artículo científico publicado en 2012

Impact of clarification strategy on chromatographic separations: Pre-processing of cell homogenates.

artículo científico publicado en 2008

Improving the reaction mix of a Pichia pastoris cell-free system using a design of experiments approach to minimise experimental effort

artículo científico publicado en 2020

In situ neutron scattering of antibody adsorption during protein A chromatography

scientific article published on 09 January 2020

Integration of scale-down experimentation and general rate modelling to predict manufacturing scale chromatographic separations

artículo científico publicado en 2010

Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture

artículo científico publicado en 2018

Manufacturing Exosomes: A Promising Therapeutic Platform

artículo científico publicado en 2018

Masking of the Fc region in human IgG4 by constrained X-ray scattering modelling: implications for antibody function and therapy

article

Mass spectrometry to describe product and contaminant adsorption properties for bioprocess development.

artículo científico publicado en 2011

Measurement and control of host cell proteins (HCPs) in CHO cell bioprocesses

artículo científico publicado en 2014

Measurement of uptake curves and adsorption isotherms by automated microscale chromatography pipette tips

artículo científico publicado en 2014

Mechanical characterisation of agarose-based chromatography resins for biopharmaceutical manufacture.

artículo científico publicado en 2017

Nanofiber adsorbents for high productivity continuous downstream processing

artículo científico publicado en 2015

Nanofiber adsorbents for high productivity downstream processing

artículo científico publicado en 2012

Neutron reflectivity measurement of protein A-antibody complex at the solid-liquid interface.

artículo científico publicado en 2017

Novel constructs and 1-step chromatography protocols for the production of Porcine Circovirus 2d (PCV2d) and Circovirus 3 (PCV3) subunit vaccine candidates

Optimising the design and operation of semi-continuous affinity chromatography for clinical and commercial manufacture.

artículo científico publicado en 2013

Packed bed compression visualisation and flow simulation using an erosion-dilation approach

artículo científico publicado en 2019

Performance prediction of industrial centrifuges using scale-down models

artículo científico publicado en 2003

Precipitation as an Enabling Technology for the Intensification of Biopharmaceutical Manufacture

artículo científico publicado en 2018

Principal component score modeling for the rapid description of chromatographic separations.

artículo científico publicado en 2008

Product and contaminant measurement in bioprocess development by SELDI-MS.

artículo científico publicado en 2010

Protein A Chromatography Resin Lifetime - Impact of Feed Composition.

artículo científico publicado en 2018

Protein A chromatography increases monoclonal antibody aggregation rate during subsequent low pH virus inactivation hold.

artículo científico publicado en 2015

Protein denaturation and protein:drugs interactions from intrinsic protein fluorescence measurements at the nanolitre scale

artículo científico publicado en 2010

Quantifying process tradeoffs in the operation of chromatographic sequences.

artículo científico publicado en 2003

Report and recommendation of a workshop on education and training for measurement, monitoring, modelling and control (M3C) in biochemical engineering

scientific article published on 01 April 2010

Residual on column host cell protein analysis during lifetime studies of protein A chromatography

artículo científico publicado en 2016

Scale-down characterization of post-centrifuge flocculation processes for high-throughput process development

artículo científico publicado en 2014

Shear effects on aluminum phosphate adjuvant particle properties in vaccine drug products

artículo científico publicado en 2014

Soft sensors in bioprocessing: A status report and recommendations

artículo científico publicado en 2012

Step change in the efficiency of centrifugation through cell engineering: co-expression of Staphylococcal nuclease to reduce the viscosity of the bioprocess feedstock.

artículo científico publicado en 2009

The challenges of product- and process-related impurities to an evolving biopharmaceutical industry.

artículo científico publicado en 2013

The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control.

artículo científico publicado en 2015

Three dimensional characterisation of chromatography bead internal structure using X-ray computed tomography and focused ion beam microscopy

scientific article published on 25 June 2018

Ultra scale-down approach to correct dispersive and retentive effects in small-scale columns when predicting larger scale elution profiles

artículo científico publicado en 2009

Ultra scale-down approaches to study the centrifugal harvest for viral vaccine production

artículo científico publicado en 2018

Ultra scale-down to define and improve the relationship between flocculation and disc-stack centrifugation

artículo científico publicado en 2008

Understanding the relationship between biotherapeutic protein stability and solid-liquid interfacial shear in constant region mutants of IgG1 and IgG4

artículo científico publicado en 2013

X-ray computed tomography of packed bed chromatography columns for three dimensional imaging and analysis

artículo científico publicado en 2017

Lista de obras de Daniel G. Bracewell

A framework for the prediction of scale-up when using compressible chromatographic packings

A microscale approach for predicting the performance of chromatography columns used to recover therapeutic polyclonal antibodies

A microscale yeast cell disruption technique for integrated process development strategies.

A rational approach to improving titer in E. coli-based cell-free protein synthesis reactions

Adenovirus 5 recovery using nanofiber ion-exchange adsorbents

Advances in product release strategies and impact on bioprocess design.

An automated microscale chromatographic purification of virus-like particles as a strategy for process development.

An automated packed Protein G micro-pipette tip assay for rapid quantification of polyclonal antibodies in ovine serum

An integrated experimental and economic evaluation of cell therapy affinity purification technologies.

An optical biosensor for real-time chromatography monitoring: Breakthrough determination

An ultra scale-down approach identifies host cell protein differences across a panel of mAb producing CHO cell line variants

Assessment of the manufacturability of Escherichia coli high cell density fermentations.

Bioprocess engineering issues that would be faced in producing a DNA vaccine at up to 100 m3 fermentation scale for an influenza pandemic.

Bioprocess monitoring: An optical biosensor for rapid bioproduct analysis

Characterization and feasibility of a miniaturized stirred tank bioreactor to perform E. coli high cell density fed-batch fermentations.

Chemical and biological characterisation of a sensor surface for bioprocess monitoring.

Chromatography modelling to describe protein adsorption at bead level

Comparison of Techniques for Monitoring Antibody Fragment Production in E. coli Fermentation Cultures

Demonstration of the use of windows of operation to visualize the effects of fouling on the performance of a chromatographic step

Design and characterization of a microfluidic packed bed system for protein breakthrough and dynamic binding capacity determination

Design of high productivity antibody capture by protein A chromatography using an integrated experimental and modeling approach

Determining antibody stability: creation of solid-liquid interfacial effects within a high shear environment

Drying techniques for the visualisation of agarose-based chromatography media by scanning electron microscopy

Dual Data-Independent Acquisition Approach Combining Global HCP Profiling and Absolute Quantification of Key Impurities during Bioprocess Development.

Dual salt precipitation for the recovery of a recombinant protein from Escherichia coli.

Dynamic Simulation of a Batch Aqueous Two-Phase Extraction Process for α-Amylase

Effects of lysosomal biotherapeutic recombinant protein expression on cell stress and protease and general host cell protein release in Chinese hamster ovary cells.

Escherichia coli-Based Cell-Free Protein Synthesis for Iterative Design of Tandem-Core Virus-Like Particles

Evaluation of fluorescent dyes to measure protein aggregation within mammalian cell culture supernatants.

Exploiting the intracellular compartmentalization characteristics of the S. cerevisiae host cell for enhancing primary purification of lipid-envelope virus-like particles.

Fabricating electrospun cellulose nanofibre adsorbents for ion-exchange chromatography.

Factors influencing antibody stability at solid-liquid interfaces in a high shear environment

Flocculation on a chip: a novel screening approach to determine floc growth rates and select flocculating agents.

Fluorescence based real time monitoring of fouling in process chromatography.

Holistic process development to mitigate proteolysis of a subunit rotavirus vaccine candidate produced in Pichia pastoris by means of an acid pH pulse during fed-batch fermentation

Host cell protein adsorption characteristics during protein A chromatography.

Host cell protein dynamics in the supernatant of a mAb producing CHO cell line ⬇️

Identification of upstream culture conditions and harvest time parameters that affect host cell protein clearance

Impact of aeration strategy on CHO cell performance during antibody production

Impact of clarification strategy on chromatographic separations: Pre-processing of cell homogenates.

Improving the reaction mix of a Pichia pastoris cell-free system using a design of experiments approach to minimise experimental effort

In situ neutron scattering of antibody adsorption during protein A chromatography

Integration of scale-down experimentation and general rate modelling to predict manufacturing scale chromatographic separations

Lifetime and Aging of Chromatography Resins during Biopharmaceutical Manufacture

Manufacturing Exosomes: A Promising Therapeutic Platform

Masking of the Fc region in human IgG4 by constrained X-ray scattering modelling: implications for antibody function and therapy

Mass spectrometry to describe product and contaminant adsorption properties for bioprocess development.

Measurement and control of host cell proteins (HCPs) in CHO cell bioprocesses

Measurement of uptake curves and adsorption isotherms by automated microscale chromatography pipette tips

Mechanical characterisation of agarose-based chromatography resins for biopharmaceutical manufacture.

Nanofiber adsorbents for high productivity continuous downstream processing

Nanofiber adsorbents for high productivity downstream processing

Neutron reflectivity measurement of protein A-antibody complex at the solid-liquid interface.

Novel constructs and 1-step chromatography protocols for the production of Porcine Circovirus 2d (PCV2d) and Circovirus 3 (PCV3) subunit vaccine candidates

Optimising the design and operation of semi-continuous affinity chromatography for clinical and commercial manufacture.

Packed bed compression visualisation and flow simulation using an erosion-dilation approach

Performance prediction of industrial centrifuges using scale-down models

Precipitation as an Enabling Technology for the Intensification of Biopharmaceutical Manufacture

Principal component score modeling for the rapid description of chromatographic separations.

Product and contaminant measurement in bioprocess development by SELDI-MS.

Protein A Chromatography Resin Lifetime - Impact of Feed Composition.

Protein A chromatography increases monoclonal antibody aggregation rate during subsequent low pH virus inactivation hold.

Protein denaturation and protein:drugs interactions from intrinsic protein fluorescence measurements at the nanolitre scale

Quantifying process tradeoffs in the operation of chromatographic sequences.

Report and recommendation of a workshop on education and training for measurement, monitoring, modelling and control (M3C) in biochemical engineering

Residual on column host cell protein analysis during lifetime studies of protein A chromatography

Scale-down characterization of post-centrifuge flocculation processes for high-throughput process development

Shear effects on aluminum phosphate adjuvant particle properties in vaccine drug products

Soft sensors in bioprocessing: A status report and recommendations

Step change in the efficiency of centrifugation through cell engineering: co-expression of Staphylococcal nuclease to reduce the viscosity of the bioprocess feedstock.

The challenges of product- and process-related impurities to an evolving biopharmaceutical industry.

The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control.

Three dimensional characterisation of chromatography bead internal structure using X-ray computed tomography and focused ion beam microscopy

Ultra scale-down approach to correct dispersive and retentive effects in small-scale columns when predicting larger scale elution profiles

Ultra scale-down approaches to study the centrifugal harvest for viral vaccine production

Ultra scale-down to define and improve the relationship between flocculation and disc-stack centrifugation

Understanding the relationship between biotherapeutic protein stability and solid-liquid interfacial shear in constant region mutants of IgG1 and IgG4

X-ray computed tomography of packed bed chromatography columns for three dimensional imaging and analysis